Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation (2003)
Sakamoto, Kathleen M., Kim, Kyung B., Verma, Rati, Ransick, Andy, Stein, Bernd, Crews, Craig M., ...
The proteome contains hundreds of proteins that in theory could be excellent therapeutic targets for the treatment of human diseases. However, many of these proteins are from functional classes that...
Sakamoto, Kathleen M., Kim, Kyung B., Kumagai, Akiko, Mercurio, Frank, Crews, Craig M., Deshaies, Raymond J.
The intracellular levels of many proteins are regulated by ubiquitin-dependent proteolysis. One of the best-characterized enzymes that catalyzes the attachment of ubiquitin to proteins is a ubiquitin...
Princiotta, Michael F., Schubert, Ulrich, Chen, Weisan, Bennink, Jack R., Myung, Jayhyuk, Crews, Craig M., ...
The proteasome is the primary protease used by cells for degrading proteins and generating peptide ligands for class I molecules of the major histocompatibility complex. Based on the properties of...
Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity
Meng, Lihao, Mohan, Royce, Kwok, Benjamin H. B., Elofsson, Mikael, Sin, Ny, Crews, Craig M.
The proteasome regulates cellular processes as diverse as cell cycle progression and NF-κB activation. In this study, we show that the potent antitumor natural product epoxomicin specifically...
The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest
Yeh, Jing-Ruey J., Mohan, Royce, Crews, Craig M.
Targeting the endothelial cell cycle as an antiangiogenic strategy has been difficult given the ubiquitous expression of critical cell cycle regulators. Here, we show that the antiangiogenic drug...
Sin, Ny, Meng, Lihao, Wang, Margaret Q. W., Wen, James J., Bornmann, William G., Crews, Craig M.
The inhibition of new blood vessel formation (angiogenesis) is an effective means of limiting both the size and metastasis of solid tumors. The leading anti-angiogenic compound, TNP-470, has proven...
Sakamoto, Kathleen M., Kim, Kyung B., Kumagai, Akiko, Mercurio, Frank, Crews, Craig M., Deshaies, Raymond J.
The intracellular levels of many proteins are regulated by ubiquitin-dependent proteolysis. One of the best-characterized enzymes that catalyzes the attachment of ubiquitin to proteins is a ubiquitin...
Princiotta, Michael F., Schubert, Ulrich, Chen, Weisan, Bennink, Jack R., Myung, Jayhyuk, Crews, Craig M., ...
The proteasome is the primary protease used by cells for degrading proteins and generating peptide ligands for class I molecules of the major histocompatibility complex. Based on the properties of...
Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity
Meng, Lihao, Mohan, Royce, Kwok, Benjamin H. B., Elofsson, Mikael, Sin, Ny, Crews, Craig M.
The proteasome regulates cellular processes as diverse as cell cycle progression and NF-κB activation. In this study, we show that the potent antitumor natural product epoxomicin specifically...
The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest
Yeh, Jing-Ruey J., Mohan, Royce, Crews, Craig M.
Targeting the endothelial cell cycle as an antiangiogenic strategy has been difficult given the ubiquitous expression of critical cell cycle regulators. Here, we show that the antiangiogenic drug...
Sin, Ny, Meng, Lihao, Wang, Margaret Q. W., Wen, James J., Bornmann, William G., Crews, Craig M.
The inhibition of new blood vessel formation (angiogenesis) is an effective means of limiting both the size and metastasis of solid tumors. The leading anti-angiogenic compound, TNP-470, has proven...
Sakamoto, Kathleen M., Kim, Kyung B., Kumagai, Akiko, Mercurio, Frank, Crews, Craig M., Deshaies, Raymond J.
The intracellular levels of many proteins are regulated by ubiquitin-dependent proteolysis. One of the best-characterized enzymes that catalyzes the attachment of ubiquitin to proteins is a ubiquitin...
Yeh, Jing-Ruey J., Ju, Rong, Brdlik, Cathleen M., Zhang, Wenjun, Zhang, Yi, Matyskiela, Mary E., ...
The antiangiogenic agent fumagillin (Fg) and its analog TNP-470 bind to intracellular metalloprotease methionine aminopeptidase-2 (MetAP-2) and inhibit endothelial cell growth in a p53-dependent...
Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease
Leuenroth, Stephanie J., Okuhara, Dayne, Shotwell, Joseph D., Markowitz, Glen S., Yu, Zhiheng, Somlo, Stefan, ...
During kidney organogenesis, tubular epithelial cells proliferate until a functional tubule is formed as sensed by cilia bending in response to fluid flow. This flow-induced ciliary mechanosensation...
Triptolide Reduces Cystogenesis in a Model of ADPKD
Leuenroth, Stephanie J., Bencivenga, Natasha, Igarashi, Peter, Somlo, Stefan, Crews, Craig M.
Mutations in PKD1 result in autosomal dominant polycystic kidney disease, which is characterized by increased proliferation of tubule cells leading to cyst initiation and subsequent expansion. Given...