Cynthia M. Simbulan-Rosenthal

Sequestration of E12/E47 and suppression of p27KIP1 play a role in Id2-induced proliferation and tumorigenesis (2009)

Trabosh, Valerie A., Divito, Kyle A., D. Aguda, Baltazar, Simbulan-Rosenthal, Cynthia M., Rosenthal, Dean S.

Id2 is a member of the helix-loop-helix (HLH) family of transcription regulators known to antagonize basic HLH transcription factors and proteins of the retinoblastoma tumor suppressor family and is...

Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy (2001)

Simbulan-Rosenthal, Cynthia M., Rosenthal, Dean S., Luo, RuiBai, Li, Jia-He, Zhang, Jie, Smulson, Mark E.

Poly(ADP-ribose) polymerase (PARP) knockout mice are resistant to murine models of human diseases such as cerebral and myocardial ischemia, traumatic brain injury, diabetes, Parkinsonism, endotoxic...

Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase

Simbulan-Rosenthal, Cynthia M., Ly, Danith H., Rosenthal, Dean S., Konopka, Genevieve, Luo, RuiBai, Wang, Zhao-Qi, ...

Poly(ADP-ribose) polymerase (PARP) is implicated in the maintenance of genomic integrity, given that inhibition or depletion of this enzyme increases genomic instability in cells exposed to genotoxic...

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

Mandir, Allen S., Przedborski, Serge, Jackson-Lewis, Vernice, Wang, Zhao-Qi, Simbulan-Rosenthal, Cynthia M., Smulson, Mark E., ...

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that causes parkinsonism in humans and nonhuman animals, and its use has led to greater understanding of the pathogenesis of...

Chromosomal aberrations in PARP−/− mice: Genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA

Simbulan-Rosenthal, Cynthia M., Haddad, Bassem R., Rosenthal, Dean S., Weaver, Zoë, Coleman, Allen, Luo, RuiBai, ...

Depletion of poly(ADP-ribose) polymerase (PARP) increases the frequency of recombination, gene amplification, sister chromatid exchanges, and micronuclei formation in cells exposed to genotoxic...

Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy

Simbulan-Rosenthal, Cynthia M., Rosenthal, Dean S., Luo, RuiBai, Li, Jia-He, Zhang, Jie, Smulson, Mark E.

Poly(ADP-ribose) polymerase (PARP) knockout mice are resistant to murine models of human diseases such as cerebral and myocardial ischemia, traumatic brain injury, diabetes, Parkinsonism, endotoxic...

Identification of Poly(ADP-Ribose) Polymerase as a Transcriptional Coactivator of the Human T-Cell Leukemia Virus Type 1 Tax Protein

Anderson, Mark G., Scoggin, Kirsten E. S., Simbulan-Rosenthal, Cynthia M., Steadman, Jennifer A.

Human T-cell leukemia virus type 1 (HTLV-1) encodes a transcriptional activator, Tax, whose activity is believed to contribute significantly to cellular transformation. Tax stimulates transcription...

Poly(ADP-ribosyl)ation of p53 In Vitro and In Vivo Modulates Binding to its DNA Consensus Sequence1

Simbulan-Rosenthal, Cynthia M, Rosenthal, Dean S, Luo, RuiBai, Samara, Raed, Jung, Mira, Dritschilo, Anatoly, ...

The tumor-suppressor p53 undergoes extensive poly(ADP-ribosyl)ation early during apoptosis in human osteosarcoma cells, and degradation of poly(ADP-ribose) (PAR) attached to p53 coincides with...

Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase

Simbulan-Rosenthal, Cynthia M., Ly, Danith H., Rosenthal, Dean S., Konopka, Genevieve, Luo, RuiBai, Wang, Zhao-Qi, ...

Poly(ADP-ribose) polymerase (PARP) is implicated in the maintenance of genomic integrity, given that inhibition or depletion of this enzyme increases genomic instability in cells exposed to genotoxic...

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

Mandir, Allen S., Przedborski, Serge, Jackson-Lewis, Vernice, Wang, Zhao-Qi, Simbulan-Rosenthal, Cynthia M., Smulson, Mark E., ...

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that causes parkinsonism in humans and nonhuman animals, and its use has led to greater understanding of the pathogenesis of...

Chromosomal aberrations in PARP−/− mice: Genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA

Simbulan-Rosenthal, Cynthia M., Haddad, Bassem R., Rosenthal, Dean S., Weaver, Zoë, Coleman, Allen, Luo, RuiBai, ...

Depletion of poly(ADP-ribose) polymerase (PARP) increases the frequency of recombination, gene amplification, sister chromatid exchanges, and micronuclei formation in cells exposed to genotoxic...

Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy

Simbulan-Rosenthal, Cynthia M., Rosenthal, Dean S., Luo, RuiBai, Li, Jia-He, Zhang, Jie, Smulson, Mark E.

Poly(ADP-ribose) polymerase (PARP) knockout mice are resistant to murine models of human diseases such as cerebral and myocardial ischemia, traumatic brain injury, diabetes, Parkinsonism, endotoxic...

Identification of Poly(ADP-Ribose) Polymerase as a Transcriptional Coactivator of the Human T-Cell Leukemia Virus Type 1 Tax Protein

Anderson, Mark G., Scoggin, Kirsten E. S., Simbulan-Rosenthal, Cynthia M., Steadman, Jennifer A.

Human T-cell leukemia virus type 1 (HTLV-1) encodes a transcriptional activator, Tax, whose activity is believed to contribute significantly to cellular transformation. Tax stimulates transcription...

Poly(ADP-ribosyl)ation of p53 In Vitro and In Vivo Modulates Binding to its DNA Consensus Sequence1

Simbulan-Rosenthal, Cynthia M, Rosenthal, Dean S, Luo, RuiBai, Samara, Raed, Jung, Mira, Dritschilo, Anatoly, ...

The tumor-suppressor p53 undergoes extensive poly(ADP-ribosyl)ation early during apoptosis in human osteosarcoma cells, and degradation of poly(ADP-ribose) (PAR) attached to p53 coincides with...