Cyril Fisher

Primary Adult Renal Ewing's Sarcoma: A Rare Entity (2009)

Ravindra Mukkunda, Ramachandran Venkitaraman, Khin Thway, Toon Min, Cyril Fisher, Alan Horwich, ...

Background. Ewing's sarcoma of extraskeletal origin is uncommon and that is of primary renal origin in adults are rare. There is no consensus on the optimal management of Ewing's tumors of...

Histopathological Diagnostic Discrepancies in Soft Tissue Tumours Referred to a Specialist Centre (2009)

Khin Thway, Cyril Fisher

Aims. A study was performed to determine areas of diagnostic discrepancy in the reporting of cases of soft tissue tumours referred to a specialist sarcoma unit. This was to pinpoint common...

Primary Adult Renal Ewing's Sarcoma: A Rare Entity (2009)

Ravindra Mukkunda, Ramachandran Venkitaraman, Khin Thway, Toon Min, Cyril Fisher, Alan Horwich, ...

Background. Ewing's sarcoma of extraskeletal origin is uncommon and that is of primary renal origin in adults are rare. There is no consensus on the optimal management of Ewing's tumors of renal...

Histopathological Diagnostic Discrepancies in Soft Tissue Tumours Referred to a Specialist Centre (2009)

Khin Thway, Cyril Fisher

Aims. A study was performed to determine areas of diagnostic discrepancy in the reporting of cases of soft tissue tumours referred to a specialist sarcoma unit. This was to pinpoint common...

How we do it: a method of neck dissection for histopathological analysis (2007)

Upile, Tahwinder, Jerjes, Waseem, Nouraei, Seyed, Singh, Sandeep, Clarke, Peter, Rhys-Evans, Peter, ...

Abstract Background Dissection of the lymphatic structures in the neck is an integral part of the management of many head and neck cancers. We describe a technique of surgical dissection, preparing...

Recent technological developments: in situhistopathological interrogation of surgical tissues and resection margins (2007)

Upile, Tahwinder, Fisher, Cyril, Jerjes, Waseem, El Maaytah, Mohammed, Singh, Sandeep, Sudhoff, Holger, ...

Abstract Objectives The tumour margin is an important surgical concept significantly affecting patient morbidity and mortality. We aimed in this prospective study to apply the microendoscope on...

Inflammatory myofibroblastic tumour of the gallbladder (2005)

Behranwala, Kasim A, Straker, Peter, Wan, Andrew, Fisher, Cyril, Thompson, Jeremy N

Abstract Background Inflammatory myofibroblastic tumour (IMT) is a benign, nonmetastasizing proliferation of myofibroblasts with a potential for local infiltration, recurrence and persistent local...

Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene (2005)

Fletcher, Christopher D M, Antonescu, Cristina R, Coindre, Jean-Michel, Colecchia, Maurizio, Domanski, Henryk A, ...

Low-grade fibromyxoid sarcoma (LGFMS) is an indolent, late-metastasizing malignant soft-tissue tumor that is often mistaken for either more benign or more malignant tumor types. Cytogenetic analyses...

Relationship between MYCN copy number and expression in rhabdomyosarcomas and correlation with adverse prognosis in the alveolar subtype (2005)

Lu, Yong-Jie, Gordon, Tony, Kelsey, Anna, Fisher, Cyril, ...

PURPOSE: Amplification of the transcription factor MYCN is an important molecular diagnostic tool in stratifying treatment for neuroblastoma. Increased copy number and overexpression of MYCN in the...

Changing concepts in the pathological basis of soft tissue and bone sarcoma treatment (2004)

Collin, Françoise, Daugaard, Søren, Dei Tos, A Paolo, Fisher, Cyril, Schneider, Ulrike, ...

Though soft tissue sarcomas are rare considerable progress has been made in the clinical and biological understanding of these neoplasms. This has led to the launch of a new WHO classification of...

Small bowel gastrointestinal stromal tumours and ampullary cancer in Type 1 neurofibromatosis (2004)

Behranwala, Kasim A, Spalding, Duncan, Wotherspoon, Andrew, Fisher, Cyril, Thompson, Jeremy N

Abstract Background Type 1 neurofibromatosis (NF-1) is an autosomal dominant disorder with variable penetrance; approximately 50% of cases present as new mutations Case report We report a case of a...

Susceptibility of Fibromatosis Cells in Short-Term Culture to Ifosfamide: A Possible Experimental Treatment in Clinically Aggressive Cases (1999)

Mark W. Verrill, Helen M. Coley, Ian R. Judson, Cyril Fisher

Purpose. Deep fibromatoses are large, often rapidly growing but benign soft tissue tumours. Although surgery is the mainstay of treatment, in unremitting and aggressive cases the use of cytotoxic...

Pulmonary Tumour Embolism Complicating a Case of Leiomyosarcoma (1998)

Stephen Gentle, Cyril Fisher, Neil Soni, Sue Hill, J. Meirion Thomas

Patient. A case of peripheral leiomyosarcoma presenting with features of pulmonary thromboembolism is described.Discussion. Persistence of the embolus despite triple-armed thrombolytic therapy and...

Amplification and Over-Expression of the MDM2 Gene in Human Soft Tissue Tumours (1997)

Helen Patterson, Diana Barnes, Sandra Gill, James Spicer, Cyril Fisher, Merion Thomas, ...

Purpose. Amplification of genetic sequences on chromosome 12q13 is frequently found in soft tissue tumours. However, for the MDM2 gene, over-expression of the MDM2 protein has not always been shown...

Amplification and Over-Expression of the MDM2 Gene in Human Soft Tissue Tumours (1997)

Helen Patterson, Diana Barnes, Sandra Gill, James Spicer, Cyril Fisher, Merion Thomas, ...

Purpose. Amplification of genetic sequences on chromosome 12q13 is frequently found in soft tissue tumours. However, for the MDM2 gene, over-expression of the MDM2 protein has not always been shown...

Distribution of human herpesvirus-8 latently infected cells in Kaposi’s sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma

Dupin, Nicolas, Fisher, Cyril, Kellam, Paul, Ariad, Sam, Tulliez, Micheline, Franck, Nathalie, ...

Human herpesvirus 8 (HHV-8, also called KSHV) is linked to the etiopathogenesis of Kaposi’s sarcoma (KS), multicentric Castleman’s disease (MCD), and primary effusion lymphoma (PEL). The...

Characterization of Monoclonal Antibodies Raised against the Latent Nuclear Antigen of Human Herpesvirus 8

Kellam, Paul, Bourboulia, Dimitra, Dupin, Nicolas, Shotton, Chris, Fisher, Cyril, Talbot, Simon, ...

Human herpesvirus 8 (HHV-8; also designated Kaposi’s sarcoma-associated herpesvirus) is the likely etiological agent of Kaposi’s sarcoma (KS). HHV-8 encodes a latent nuclear antigen (LNA) which...

Distribution of human herpesvirus-8 latently infected cells in Kaposi’s sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma

Dupin, Nicolas, Fisher, Cyril, Kellam, Paul, Ariad, Sam, Tulliez, Micheline, Franck, Nathalie, ...

Human herpesvirus 8 (HHV-8, also called KSHV) is linked to the etiopathogenesis of Kaposi’s sarcoma (KS), multicentric Castleman’s disease (MCD), and primary effusion lymphoma (PEL). The...

Characterization of Monoclonal Antibodies Raised against the Latent Nuclear Antigen of Human Herpesvirus 8

Kellam, Paul, Bourboulia, Dimitra, Dupin, Nicolas, Shotton, Chris, Fisher, Cyril, Talbot, Simon, ...

Human herpesvirus 8 (HHV-8; also designated Kaposi’s sarcoma-associated herpesvirus) is the likely etiological agent of Kaposi’s sarcoma (KS). HHV-8 encodes a latent nuclear antigen (LNA) which...

Immunoblot Analysis of CD34 Expression in Histologically Diverse Neoplasms

Natkunam, Yasodha, Rouse, Robert V., Zhu, Shirley, Fisher, Cyril, Van De Rijn, Matthijs

CD34 is a heavily glycosylated transmembrane protein of ∼110 kd whose function is essentially uncharacterized. First identified in a myeloid leukemia cell line, immunohistological reactivity with...

Amplification and Over-Expression of the MDM2 Gene in Human Soft Tissue Tumours

Patterson, Helen, Barnes, Diana, Gill, Sandra, Spicer, James, Fisher, Cyril, Thomas, Merion, ...

Purpose. Amplification of genetic sequences on chromosome 12q13 is frequently found in soft tissue tumours. However, for the MDM2 gene, over-expression of the MDM2 protein has not always been shown...

Pulmonary Tumour Embolism Complicating a Case of Leiomyosarcoma

Gentle, Stephen, Fisher, Cyril, Soni, Neil, Hill, Sue, Thomas, J. Meirion

Patient. A case of peripheral leiomyosarcoma presenting with features of pulmonary thromboembolism is described.

Susceptibility of Fibromatosis Cells in Short-Term Culture to Ifosfamide: A Possible Experimental Treatment in Clinically Aggressive Cases

Verrill, Mark W., Coley, Helen M., Judson, Ian R., Fisher, Cyril

Purpose. Deep fibromatoses are large, often rapidly growing but benign soft tissue tumours. Although surgery is the mainstay of treatment, in unremitting and aggressive cases the use of cytotoxic...

Detection of TMPRSS2-ERG Translocations in Human Prostate Cancer by Expression Profiling Using GeneChip Human Exon 1.0 ST Arrays

Jhavar, Sameer, Reid, Alison, Clark, Jeremy, Kote-Jarai, Zsofia, Christmas, Timothy, Thompson, Alan, ...

Translocation of TMPRSS2 to the ERG gene, found in a high proportion of human prostate cancer, results in overexpression of the 3′-ERG sequences joined to the 5′-TMPRSS2 promoter. The studies...

Primary Adult Renal Ewing's Sarcoma: A Rare Entity

Mukkunda, Ravindra, Venkitaraman, Ramachandran, Thway, Khin, Min, Toon, Fisher, Cyril, Horwich, Alan, ...

Background. Ewing's sarcoma of extraskeletal origin is uncommon and that is of primary renal origin in adults are rare. There is no consensus on the optimal management of Ewing's tumors of renal...

Histopathological Diagnostic Discrepancies in Soft Tissue Tumours Referred to a Specialist Centre

Thway, Khin, Fisher, Cyril

Aims. A study was performed to determine areas of diagnostic discrepancy in the reporting of cases of soft tissue tumours referred to a specialist sarcoma unit. This was to pinpoint common...