Cyrille J. Cohen

Extrathymic Generation of Tumor-Specific T Cells from Genetically Engineered Human Hematopoietic Stem Cells via Notch Signaling (2008)

Yangbing Zhao, Maria R. Parkhurst, Zhili Zheng, Cyrille J. Cohen, John P. Riley, Luca Gattinoni, ...

Adoptive cell transfer (ACT) of tumor-reactive lymphocytes has been shown to be an effective treatment for cancer patients. Studies in murine models of ACT indicated that antitumor efficacy of...

Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene

Hsu, Cary, Jones, Stephanie A., Cohen, Cyrille J., Zheng, Zhili, Kerstann, Keith, Zhou, Juhua, ...

Malignancies arising from retrovirally transduced hematopoietic stem cells have been reported in animal models and human gene therapy trials. Whether mature lymphocytes are susceptible to insertional...