Robinson, Siân, Syddall, Holly, Jameson, Karen, Batelaan Batelaan, Sue, Martin, Helen, Dennison, Elaine M., ...
Background: dietary patterns analysis takes account of the combined effects of foods and may be a more meaningful way of assessing dietary exposure than considering individual nutrients. Little is...
Crozier, Sarah R., Robinson, Siân. M., Borland, Sharon E., Godfrey, Keith M., Cooper, Cyrus, Inskip, Hazel M.
A woman's life style choices before and during pregnancy have important implications for her unborn child, but information on behaviour can be unreliable when data are collected retrospectively. In...
Syddall, Holly, Evandrou, Maria, Cooper, Cyrus, Sayer, Avan Aihie
Objectives: To explore social inequalities in grip strength, SF-36 physical functioning (PF), and falls among older people. Methods: We analyzed data from 3,225 men and women (age 59-73 years) who...
Robinson, Siân. M., Marriott, Lynne D., Harvey, Nick C., Gale, Catharine R., Inskip, Hazel M., ...
Context: most studies of infant diet and later body composition focus on milk feeding; few consider the influence of variations in the weaning diet. Objective: our objective was to examine how...
Dietary patterns in infancy and cognitive and neuropsychological function in childhood (2009)
Gale, Catharine R., Martyn, Christopher N., Marriott, Lynne D., Limmond, Jennifer, Crozier, Sarah, Inskip, Hazel M., ...
Background: trials in developing countries suggest that improving young children's diet may benefit cognitive development. Whether dietary composition influences young children's cognition in...
Dennison, Elaine M., Syddall, Holly E., Jameson, Karen A., Sayer, Avan Aihie, Gaunt, Tom R., Rodriguez, Santiago, ...
Objective: we sought evidence of association of candidate single nucleotide polymorphisms (SNP) within the growth hormone-insulin-like growth factor 1 (IGF1) axis, largely selected on the basis of...
Finucane, Francis M, Horton, Jessica, Purslow, Lisa R, Savage, David B, Brage, Soren, Besson, Hervé, ...
Abstract Background While there are compelling observational data confirming that individuals who exercise are healthier, the efficacy of aerobic exercise interventions to reduce metabolic risk and...
Finucane, Francis M., Horton, Jessica, Purslow, Lisa R., Savage, David B., Brage, Soren, Besson, Hervé, ...
Background: while there are compelling observational data confirming that individuals who exercise are healthier, the efficacy of aerobic exercise interventions to reduce metabolic risk and improve...
Educational attainment, perceived control and the quality of women's diets (2009)
Barker, Mary, Lawrence, Wendy, Crozier, Sarah, Robinson, Siân, Baird, Janis, Margetts, Barrie, ...
Objective: data from the Southampton Women's Survey have established that women of lower educational attainment have poorer quality diets than those of higher educational attainment. This...
Harvey, Nicholas C., Robinson, Sian M., Crozier, Sarah R., Marriott, Lynne D., Gale, Catharine R., Cole, Zoe A., ...
The impact of variations in current infant feeding practice on bone mineral accrual is not known. We examined the associations between duration of breast-feeding and compliance with infant dietary...
Maternal dietary patterns during pregnancy and childhood bone mass: a longitudinal study (2009)
Cole, Zoe A., Gale, Catharine R., Javaid, M. Kassim, Robinson, Sian M., Law, Catherine M., Boucher, Barbara J., ...
Maternal nutrition is a potentially important determinant of intrauterine skeletal development. Previous studies have examined the effects of individual nutrients, but the pattern of food consumption...
Maternal dietary patterns during pregnancy and childhood bone mass: a longitudinal study (2009)
Cole, Zoe A., Gale, Catharine R., Javaid, M. Kassim, Robinson, Sian M., Law, Catherine, Boucher, Barbara J., ...
Maternal nutrition is a potentially important determinant of intrauterine skeletal development. Previous studies have examined the effects of individual nutrients, but the pattern of food consumption...
Inskip, Hazel M., Crozier, Sarah R., Godfrey, Keith M., Borland, Sharon E., Cooper, Cyrus, Robinson, Siân M.
Objective To examine the extent to which women planning a pregnancy comply with recommendations for nutrition and lifestyle. Design Prospective cohort study. Setting Southampton, United Kingdom....
The use of 3D ultrasound to investigate fetal bone development (2009)
Pamela A. Mahon, Cyrus Cooper, Sarah R. Crozier, Keith M. Godfrey
Robinson, Siân, Syddall, Holly, Jameson, Karen, Batelaan, Sue, Martin, Helen, Dennison, Elaine M., ...
Background: dietary patterns analysis takes account of the combined effects of foods and may be a more meaningful way of assessing dietary exposure than considering individual nutrients. Little is...
Maternal nutrition and bone health in the offspring. (2009)
Williams, Emma L., Harvey, Nicholas C., Dennison, Elaine M., Edwards, Christopher C., Cooper, Cyrus
Osteoporosis is a major public health issue as well as a considerable socioeconomic burden owing to its association with fragility fractures. Bone mass (a composite of bone size and mineral density)...
The use of 3D ultrasound to investigate fetal bone development (2009)
Mahon, Pamela A., Cooper, Cyrus, Crozier, Sarah R., Godfrey, Keith M.
Epidemiological studies suggest impaired fetal skeletal development has lifelong consequences for bone health. To examine the feasibility of using 3-dimensional ultrasound (3DUS) to investigate...
Inskip, Hazel M., Crozier, Sarah R., Godfrey, Keith M., Borland, Sharon E., Cooper, Cyrus, Robinson, Sian M.
Objective: to examine the extent to which women planning a pregnancy comply with recommendations for nutrition and lifestyle. Design: prospective cohort study. Setting: Southampton, United Kingdom....
The impact of methods for estimating bone health and the global burden of bone disease (2009)
Cole, Zoë A., Dennison, Elaine M., Cooper, Cyrus
Osteoporosis constitutes a major public health problem through its association with age related fractures. Fracture rates are generally higher in caucasian women than in other populations. Important...
Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system (2008)
Bruyère, Olivier, Burlet, Nansa, Delmas, Pierre D, Rizzoli, René, Cooper, Cyrus, Reginster, Jean-Yves
Abstract Background Symptomatic slow-acting drugs (SYSADOA) have been largely studied over the last decade. The objective of this study is to prepare a document providing recommendations for the use...
Update on the treatment of post-menopausal osteoporosis (2008)
Cole, Zoë, Dennison, Elaine, Cooper, Cyrus
BACKGROUND: Osteoporosis has a huge impact on public health, through the increased morbidity, mortality and economic costs associated with resultant fractures. The goal is to evaluate and identify...
Costello, Paula M., Rowlerson, Anthea, Astaman, Nur Aida, Anthony, Fred Erick W., Sayer, Avan Aihie, Cooper, Cyrus, ...
Poor prenatal nutrition is associated with a greater risk of adult glucose intolerance and insulin insensitivity in the offspring. Skeletal muscle is the primary tissue for glucose utilization, and...
Common variants near MC4R are associated with fat mass, weight and risk of obesity (2008)
Loos, Ruth J.F., Lindgren, Cecilia M., Li, Shengxu, Wheeler, Eleanor, Zhao, Jing Hua, Prokopenko, Inga, ...
To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the...
Three Dimensional Functional Motion Analysis of Silver Ring Splints in Rheumatoid Arthritis (2008)
Adams, Jo, Metcalf, Cheryl, Macleod, Christina, Spicka, Caroline, Burridge, Jane, Cooper, Cyrus, ...
Three Dimensional Functional Motion Analysis of Silver Ring Splints in Rheumatoid Arthritis (2008)
Adams, Jo, Metcalf, Cheryl, Macleod, Christina, Spicka, Caroline, Burridge, Jane, Cooper, Cyrus, ...
Three dimensional functional motion analysis of silver ring splints in rheumatoid arthritis (2008)
Adams, Jo, Metcalf, Cheryl, Macleod, Christina, Spicka, Caroline, Burridge, Jane, Cooper, Cyrus, ...
Proceedings of the Eighth Annual Santa Fe Bone Symposium, August 3-4, 2007 (2008)
Lewiecki, E. Michael, Bilezikian, John P., Cooper, Cyrus, Hochberg, Marc C., Luckey, Marjorie M., Maricic, Michael, ...
The Eighth Annual Santa Fe Bone Symposium convened August 3-4, 2007, in Santa Fe, New Mexico, USA, immediately preceded by the Research Symposium in Metabolic Bone Disease and Osteoporosis Update for...
Individualizing the risks and benefits of postmenopausal hormone therapy (2008)
Van Staa, Tjeerd P., Cooper, Cyrus, Barlow, David, Leufkens, Hubert G.M.
OBJECTIVE: The objective was to develop an individualized risk-benefit model quantifying the impact of combined use of estrogen and progestogen on chronic diseases. DESIGN: The study population...
Dunn, Nick, Inskip, Hazel, Kendrick, Tony, Oestmann, Anne, Barnett, Jane, Godfrey, Keith, ...
Background: Social and financial environment has an influence on the incidence of depression. We studied perceived financial strain as a risk factor for development of depression among a large cohort...
Inskip, Hazel M., Dunn, Nick, Godfrey, Keith M., Cooper, Cyrus, Kendrick, Tony
Although some studies have shown negative associations between birth weight and risk of depression, others have not. Studies also differ regarding the age and gender specificity of reported...
Effect of in utero and early-life conditions on adult health and disease (2008)
Gluckman, Peter D., Hanson, Mark A., Cooper, Cyrus, Thornburg, Kent L.
A long latency period between an environmental trigger and the onset of subsequent disease is widely recognized in the etiology of certain cancers, yet this phenomenon is not generally considered in...
Educating nursing home staff on fracture prevention: a cluster randomised trial (2008)
Cox, Helen, Puffer, Suezann, Morton, Veronica, Cooper, Cyrus, Hodson, Jean, Masud, Tahir, ...
Objective: to assess whether specialist osteoporosis nurses delivering training to care home staff can reduce fractures and improve the prescription of treatments to reduce fractures versus usual...
Inskip, Hazel M., Dunn, Nick, Godfrey, Keith M., Cooper, Cyrus, Kendrick, Tony
Although some studies have shown negative associations between birth weight and risk of depression, others have not. Studies also differ regarding the age and gender specificity of reported...
Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system. (2008)
Bruyère, Olivier, Burlet, Nansa, Delmas, Pierre D, Rizzoli, Rene, Cooper, Cyrus, Reginster, Jean-Yves
BACKGROUND: Symptomatic slow-acting drugs (SYSADOA) have been largely studied over the last decade. The objective of this study is to prepare a document providing recommendations for the use of...
Batty, G. David, Smith, George Davey, Fall, Caroline H.D., Sayer, Avan Aihie, Dennison, Elaine, Cooper, Cyrus, ...
BACKGROUND: There is a suggestion that acute dehydration in childhood may lead to elevated blood pressure. We examined if episodes of diarrhoea in childhood, a recognized proxy for acute dehydration,...
Inskip, Hazel M., Dunn, Nick, Godfrey, Keith M., Cooper, Cyrus, Kendrick, Tony
Although some studies have shown negative associations between birth weight and risk of depression, others have not. Studies also differ regarding the age and gender specificity of reported...
Van Staa, Tjeerd-Peter, Kanis, John A., Geusens, Piet, Boonen, Annelies, Leufkens, Hubert G.M., Cooper, Cyrus
OBJECTIVES: Cost-effectiveness analyses are routinely based on data from group averages, restricting its generalizibility to those with below- or above-average risk. A pharmaco-economic model that...
Maternal size in pregnancy and body composition in children (2007)
Gale, Catharine R., Javaid, M. Kassim, Robinson, Sian M., Law, Catherine M., Godfrey, Keith M., Cooper, Cyrus
Context: Evidence suggests that babies' fat mass at birth is greater if their mothers were themselves fatter during pregnancy, but it is unclear whether this association persists into childhood....
Readiness of elders to use assistive devices to maintain their independence in the home (2007)
Pain, Helen, Gale, Catharine R, Watson, Clare, Cox, Vanessa, Cooper, Cyrus, Sayer, Avan Aihie
Pain, Helen, Gale, Catherine R., Watson, Clare, Cox, Vanessa, Cooper, Cyrus, Aihie Sayer, Avan Aihie
SIR—With an increasing proportion of the population surviving into old age, it is important that as many people as possible are enabled to maintain their health and independence. Assistive devices,...
Readiness of elders to use assistive devices to maintain their independence in the home (2007)
Pain, Helen, Gale, Catharine R., Watson, Clare, Cox, Vanessa, Cooper, Cyrus, Aihie Sayer, Avan
Use of beta-2 agonists and risk of hip/femur fracture: a population-based case-control study (2007)
De Vries, Frank, Pouwels, Sander, Bracke, Madelon, Leufkens, Hubert G.M., Cooper, Cyrus, Lammers, Jan-Willem J., ...
INTRODUCTION: Administration of beta-2 agonists decreased bone mineral density in rats. But the association between bronchodilators and fracture risk has not been studied in humans. OBJECTIVES: To...
Grip strength, body composition, and mortality (2007)
Gale, Catharine R, Martyn, Christopher N, Cooper, Cyrus, Sayer, Avan Aihie
Background Several studies in older people have shown that grip strength predicts all-cause mortality. The mechanisms are unclear. Muscle strength declines with age, accompanied by a loss of muscle...
Abdollahi, Mohammad R., Lewis, Rohan M., Gaunt, Tom R., Cumming, Debbie V., Rodriguez, Santiago, Rose-Zerilli, Matthew, ...
The angiotensin II type 1 receptor (AGTR1) is the main target through which angiotensin II influences cardiovascular tone, cell growth, and fluid and electrolyte balance. AGTR1 polymorphism has been...
Lips, Mirjam A., Syddall, Holly E., Gaunt, Tom R., Rodriguez, Santiago, Day, Ian N.M., Cooper, Cyrus, ...
OBJECTIVE: We sought evidence of interaction between single-nucleotide polymorphisms (SNP) in the calcium-sensing receptor (CASR) gene and early life in determination of bone mineral density (BMD)...
Schlotz, Wolff, Ambery, Phil, Syddall, Holly E., Crozier, Sarah R., Sayer, Avan Aihie, Cooper, Cyrus, ...
Insulin resistance is a metabolic abnormality that underlies Type 2 diabetes, the metabolic syndrome and cardiovascular disease, but it may also be associated with more global health deficits. This...
Alharbi, Khalid K., Spanakis, Emmanuel, Tan, Karen, Smith, Matt J., Aldahmesh, Mohammed A., O'Dell, Sandra D., ...
Identification of unknown mutations has remained laborious, expensive, and only viable for studies of selected cases. Population-based "reference ranges" of rarer sequence diversity are not...
Grip strength, body composition, and mortality (2007)
Gale, Catharine R., Martyn, Christopher N., Cooper, Cyrus, Sayer, Avan Aihie
BACKGROUND: Several studies in older people have shown that grip strength predicts all-cause mortality. The mechanisms are unclear. Muscle strength declines with age, accompanied by a loss of muscle...
Van Staa, Tjeerd-Peter, Kanis, John A., GEUSENS, Piet, Boonen, Annelies, Leufkens, Hubert G. M., Cooper, Cyrus
Objectives: Cost-effectiveness analyses are routinely based on data from group averages, restricting its generalizibility to those with below- or above-average risk. A pharmaco-economic model that...
Van Staa, Tjeerd-Peter, Kanis, John A., GEUSENS, Piet, Boonen, Annelies, Leufkens, Hubert G. M., Cooper, Cyrus
Objectives: Cost-effectiveness analyses are routinely based on data from group averages, restricting its generalizibility to those with below- or above-average risk. A pharmaco-economic model that...
PTHR1 polymorphisms influence BMD variation through effects on the growing skeleton (2007)
Vilarino-Guell, Carles, Miles, Lisa J., Duncan, Emma L., Ralston, Stuart H., Compston, Juliet E., Cooper, Cyrus, ...
We investigated whether polymorphisms in PTHR1 are associated with bone mineral density (BMD), to determine whether the association of this gene with BMD was due to effects on attainment of peak bone...
PTHR1 polymorphisms influence BMD variation through effects on the growing skeleton (2007)
Vilarino-Guell, Carles, Miles, Lisa J., Duncan, Emma L., Ralston, Stuart H., Compston, Juliet E., Cooper, Cyrus, ...
We investigated whether polymorphisms in PTHR1 are associated with bone mineral density (BMD), to determine whether the association of this gene with BMD was due to effects on attainment of peak bone...
Aging, sarcopenia and the life course (2007)
Aihie Sayer, Avan, Cooper, Cyrus
There is growing support for characterizing human aging from a life-course perspective, in terms of recognizing important influences operating from conception to death, and this approach provides a...
Robinson, Sian, Marriott, Lynne, Poole, Jason, Crozier, Sarah S., Lawrence, Wendy, Law, Catherine, ...
It is not known what constitutes an optimal diet in infancy. There are relatively few studies of weaning practice in the UK, and there is a need for prospective data on the effects of infant diet and...
PTHR1 polymorphisms influence BMD variation through effects on the growing skeleton (2007)
Vilarino-Guell, Carles, Miles, Lisa J., Duncan, Emma L., Ralston, Stuart H., Compston, Juliet E., Cooper, Cyrus, ...
We investigated whether polymorphisms in PTHR1 are associated with bone mineral density (BMD), to determine whether the association of this gene with BMD was due to effects on attainment of peak bone...
Batty, G David, Smith, George Davey, Fall, Caroline H D, Sayer, Avan Aihie, Dennison, Elaine, Cooper, Cyrus, ...
Background There is a suggestion that acute dehydration in childhood may lead to elevated blood pressure. We examined if episodes of diarrhoea in childhood, a recognized proxy for acute dehydration,...
Liu, Bette, Balkwill, Angela, Banks, Emily, Cooper, Cyrus, Green, Jane, Beral, Valerie, ...
Objectives. To examine the effect of height, weight and body mass index (BMI) on the risk of hip and knee replacement in middle-aged women. Methods. In a prospective cohort study 490 532 women aged...
Liu, Bette, Balkwill, Angela, Banks, Emily, Cooper, Cyrus, Green, Jane, Beral, Valerie, ...
Objectives. To examine the effect of height, weight and body mass index (BMI) on the risk of hip and knee replacement in middle-aged women. Methods. In a prospective cohort study 490 532 women aged...
Epidemiology of Paget's disease in Europe: the prevalence is decreasing (2006)
Poor, Gyula, Donath, Judit, Fornet, Béla, Cooper, Cyrus
This study estimated changes in the age- and sex-specific prevalence of Paget’s disease of bone in six European towns over a 20-year period. Declines in prevalence were observed in this disorder,...
Osteoporosis: best practice & research compendium (2006)
Contents: Epidemiology of osteoporosis Fractures in the elderly: epidemiology and demography Pathogenesis of osteoporosis Prenatal and childhood influences on osteoporosis Corticosteroid osteoporosis...
Sayer, Avan Aihie, Syddall, Holly E, Martin, Helen J., Dennison, Elaine M., Roberts, Helen C., Cooper, Cyrus
Objective: to investigate the relationship between grip strength and health-related quality of life (HRQoL). Design: cross-sectional survey within a cohort study design. Setting: the county of...
Who is at risk of osteoporosis? (2006)
Dennison, Elaine, Medley, Judith, Cooper, Cyrus
This contribution assesses who is at risk of osteoporosis, by delineating the key risk factors involved in the condition. Osteoporosis represents a major public health problem through its association...
Prevalence and clinical features of Paget's disease of bone in Japan (2006)
Hashimoto, Jun, Ohno, Ikko, Nakatsuka, Kiyoshi, Yoshimura, Noriko, Takata, Shinjiro, Zamma, Masaaki, ...
The present study aimed to evaluate the prevalence and clinical presentation of Paget's disease of bone (PDB) in Japan. As PDB is a very rare disease in Japan, a nationwide mail survey was conducted...
Yang, Xuebin B., Webb, Derek, Blaker, Jonny, Boccaccini, Aldo R., Maquet, Veronique, Cooper, Cyrus, ...
Bone tissue engineering using human bone marrow mesenchymal stem cells (HBMCs) and biocompatible materials provides an attractive approach to regenerate bone tissue to meet the major clinical need....
Walker-Bone, Karen, Reading, Isabel, Coggon, David, Cooper, Cyrus, Palmer, Keith T.
Background Few community-based epidemiological investigations of upper limb disorders (ULDs) have classified cases by validated procedures involving a structured clinical examination. Aim To compare...
Risk factors for knee osteoarthritis in Japanese men: a case-control study (2006)
Yoshimura, Noriko, Kinoshita, Hirofumi, Hori, Noriaki, Nishioka, Taira, Ryujin, Masahiko, Mantani, Yoshihiko, ...
Risk of knee osteoarthritis (OA) was assessed in a population-based case-control study of Japanese men. The study covered three health districts in Wakayama and Osaka prefectures, Japan. Subjects...
Rodriguez, Santiago, Gaunt, Tom R., Dennison, Elaine, Chen, Xiao-he, Syddall, Holly E., Phillips, Davide I.W., ...
Interindividual variation of the IGF2-INS-TH region influences risk of a variety of diseases and complex traits. Previous studies identified a haplotype (designated IGF2-INS-TH(*)5 and tagged by...
Infant growth influences proximal femoral geometry in adulthood (2006)
Javaid, M. Kassim, Lekamwasam, Sarath, Clark, Judith, Dennison, Elaine M., Syddall, Holly E., Loveridge, Nigel, ...
The relationship between early growth and adult femoral geometry has not been studied previously. In 333 adults, we were able to show that infant weight predicts femoral width and cross-sectional...
Reginster, Jean-Yves, Felsenberg, Dieter, Cooper, Cyrus, Stakkestad, Jacob A., Miller, Paul D., Kendler, David L., ...
Oral daily and weekly bisphosphonates represent the current mainstay of treatment for postmenopausal osteoporosis (PMO). However, the inconvenience of frequent dosing is known to negatively affect...
The developmental environment: clinical perspectives on effects on the musculoskeletal system (2006)
Sayer, Avan Aihie, Syddall, Holly E., Martin, Helen J., Dennison, Elaine M., Roberts, Helen C., Cooper, Cyrus
Objective: to investigate the relationship between grip strength and health-related quality of life (HRQoL). Design: cross-sectional survey within a cohort study design. Setting: the county of...
De Vries, Frank, De Vries, Corinne, Cooper, Cyrus, Leufkens, Bert, Van Staa, Tjeerd-Pieter
Background Two recent case–control studies by Meier et al. and van Staa et al. used the UK General Practice Research Database (GPRD) to examine the association between the use of statins and the...
Falls, Sarcopenia, and Growth in Early Life: Findings from the Hertfordshire Cohort Study (2006)
Sayer, Avan Aihie, Syddall, Holly E., Martin, Helen J., Dennison, Elaine M., Anderson, Frazer H., Cooper, Cyrus
Recent studies have shown that people whose early growth is poor have an increased risk of sarcopenia. Sarcopenia is an important risk factor for falls, but it is not known whether poor early growth...
Developmental Origins of Midlife Physical Performance: Evidence from a British Birth Cohort (2006)
Kuh, Diana, Hardy, Rebecca, Butterworth, Suzanne, Okell, Lucy, Richards, Marcus, Wadsworth, Michael, ...
The authors hypothesized that 1) physical growth, as a marker of the early development of muscle fibers, and 2) advanced childhood motor and cognitive abilities, as markers of central nervous system...
Walker-Bone, Karen, Reading, Isabel, Coggon, David, Cooper, Cyrus, Palmer, Keith T.
Background Few community-based epidemiological investigations of upper limb disorders (ULDs) have classified cases by validated procedures involving a structured clinical examination. Aim To compare...
Grip strength and length of stay (2006)
Sayer, Avan Aihie, Briggs, Roger, Turner, Gillian, Cooper, Cyrus, Syddall, Holly, Kerr, Alastair
Sayer, Avan Aihie, Syddall, Holly E., Martin, Helen J., Dennison, Elaine M., Roberts, Helen C., Cooper, Cyrus
Objective: To investigate the relationship between grip strength and health-related quality of life (HRQoL). Design: Cross-sectional survey within a cohort study design. Setting: The county of...
Walker-Bone, Karen, Reading, Isabel, Coggon, David, Cooper, Cyrus, Palmer, Keith T.
Background Few community-based epidemiological investigations of upper limb disorders (ULDs) have classified cases by validated procedures involving a structured clinical examination. Aim To compare...
Grip strength, body composition, and mortality (2006)
Gale, Catharine R., Martyn, Christopher N., Cooper, Cyrus, Sayer, Avan Aihie
Background Several studies in older people have shown that grip strength predicts all-cause mortality. The mechanisms are unclear. Muscle strength declines with age, accompanied by a loss of muscle...
Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg? (2005)
Aihie-Sayer, Avan, Dennison, Elaine M., Syddall, Holly E., Gilbody, Helen J., Phillips, David I.W., Cooper, Cyrus
Cooper, Mark S., Syddall, Holly E., Fall, Caroline H., Wood, Peter J., Stewart, Paul M., Cooper, Cyrus, ...
OBJECTIVE: Cortisone is an endogenous corticosteroid that has negligible intrinsic glucocorticoid activity but can be converted to the active corticosteroid cortisol by the enzyme...
Mesenchymal stem cells: lineage, plasticity and skeletal therapeutic potential (2005)
Oreffo, Richard O.C., Cooper, Cyrus, Mason, Christopher, Clements, Mark
The tremendous capacity of bone to regenerate is indicative of the presence of stem cells with the capability, by definition, to self-renew as well as to give rise to daughter cells. These primitive...
Alharbi, Khalid K., Aldahmesh, Mohammed A, Spanakis, Emmanuel, Haddad, Lema, Whittall, Roslyn A, Chen, Xiao-he, ...
We have developed a mutation-scanning approach suitable for whole population screening for unknown mutations. The method, meltMADGE, combines thermal ramp electrophoresis with MADGE to achieve...
Alharbi, Khalid K., Aldahmesh, Mohammed A., Spanakis, Emmanuel, Haddad, Lema, Whittall, Roslyn A., Chen, Xiao-he, ...
We have developed a mutation-scanning approach suitable for whole population screening for unknown mutations. The method, meltMADGE, combines thermal ramp electrophoresis with MADGE to achieve...
Cohort profile: The Southampton Women's Survey (2005)
Inskip, Hazel M., Godfrey, Keith M., Robinson, Siân M., Law, Catherine M., Barker, David J. P., Cooper, Cyrus, ...
Johnell, Olof, Kanis, John A, Cooper, Cyrus, Lamraski, Guyve, ...
Based on data searches and life-table analyses, we determined the long-term (remaining lifetime) and short-term (10- and 5-year) absolute risks of hip fracture after sustaining a Colles' or spine...
Day, Ian N. M., Chen, Xiao-He, Gaunt, Tom R., King, Tabitha H. T., Voropanov, Anca, Ye, Shu, ...
Low rates of fetal and infant growth are associated with the metabolic syndrome and cardiovascular disease in later life. We investigated common genetic variation in the GH-CSH gene cluster on...
Walker-Bone, Karen, Reading, Isabel, Coggon, David, Cooper, Cyrus, Palmer, Keith T.
Little is known about the distribution and determinants of pain at multiple sites in the neck and upper limb. To investigate the prevalence, pattern, and clustering of such pains and the association...
Is grip strength a useful single marker of frailty? (2003)
Syddall, Holly, Cooper, Cyrus, Martin, Finbarr, Briggs, Roger, Aihie-Sayer, Avan
Background: chronological age is widely used as a marker of frailty in clinical practice. However there can be wide variation in frailty between individuals of a similar age. Grip strength is a...
Gaunt, Tom R., Chen, Xiao-he, King, Tabitha H.T., Voropanov, Anca, Shu, Ye, Rodriguez, Santiago, ...
Reading, Isabel, Walker-Bone, Karen, Palmer, Keith T., Cooper, Cyrus, Coggon, David
To explore whether different distributions of numbness and tingling in the hand can be usefully distinguished in epidemiologic studies of disorders such as carpal tunnel syndrome, the authors used a...
Is grip strength a useful single marker of frailty? (2003)
Syddall, Holly, Cooper, Cyrus, Martin, Finbarr, Briggs, Roger, Aihie Sayer, Avan
Background:chronological age is widely used as a marker of frailty in clinical practice. However there can be wide variation in frailty between individuals of a similar age. Grip strength is a...
Polymorphism of the IGF2 gene, birth weight and grip strength in adult men (2002)
Sayer, Avan Aihie, Syddall, Holly, O'Dell, Sandra D., Chen, Xiao-he, Briggs, Patricia J., Briggs, R., ...
BACKGROUND: Grip strength is a simple measure of skeletal muscle function but a powerful predictor of disability, morbidity and mortality. Recent evidence has shown that prenatal and infant growth...
Insulin-like growth factor-I genotype and birthweight (2002)
Day, Ian N.M., King, Tabitha H.T., Chen, Xiao-he, Voropanov, Anca M., Ye, Shu, Syddall, Holly E., ...
Palmer, Keith T., Griffin, Michael J., Syddall, Holly, Cooper, Cyrus, Coggon, David
Objectives: To investigate the association between functional difficulties in using the upper limb and extent and frequency of finger blanching, and the merits of these markers in grading the...
Kuh, Diana, Bassey, Joan, Hardy, Rebecca, Aihie Sayer, Avan, Wadsworth, Michael, Cooper, Cyrus
Environmental influences during gestation may have long-term effects on adult muscle strength. It is not known how early in adult life such effects are manifest and whether they are modified by...
Polymorphism of the IGF2 gene, birth weight and grip strength in adult men (2002)
Sayer, Avan Aihie, Syddall, Holly, O'Dell, Sandra D., Chen, Xiao-he, Briggs, Patricia J., Briggs, R., ...
Background: grip strength is a simple measure of skeletal muscle function but a powerful predictor of disability, morbidity and mortality. Recent evidence has shown that prenatal and infant growth...
Birthweight, vitamin D receptor genotype and the programming of osteoporosis (2001)
Dennison, Elaine M., Arden, Nigel K., Keen, Richard W., Syddall, Holly, Day, Ian N. M., Spector, Timothy D., ...
Studies of the association between polymorphisms of the gene for the vitamin D receptor (VDR) and adult bone mass have been inconsistent, pointing to the possibility that gene--environment...
Use of statins and risk of fractures (2001)
Van Staa, Tjeerd-Pieter, Wegman, Sebastiaan, De Vries, Frank, Leufkens, Bert, Cooper, Cyrus
Context: Previous studies have reported lower fracture risks in patients taking 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins). Objective: To investigate risk of fracture among...
Palmer, Keith T., Griffin, Michael J., Syddall, Holly, Pannett, Brian, Cooper, Cyrus, Coggon, David
BACKGROUND: Although some occupational sources of hand-transmitted vibration (HTV) have been extensively investigated, the risks associated with others are poorly characterized. METHODS: A...
Risk of new vertebral fracture in the year following a fracture (2001)
Lindsay, Robert, Silverman, Stuart L., Cooper, Cyrus, Hanley, David A., Barton, Ian, Broy, Susan B., ...
Context: Vertebral fractures significantly increase lifetime risk of future fractures, but risk of further vertebral fractures in the period immediately following a vertebral fracture has not been...
Fizičko opterećenje pri radu i osteoartroza kuka (2000)
Cvijetić, Selma, Dekanić-Ožegović, Darinka, Campbell, Lesley, Cooper, Cyrus, Potočki, Kristina
U brojnim epidemiološkim istraživanjimaa procjenjivan je utjecaj zanimanja i fizičkog opterećenja na pojavu osteoartroze. U ovom istraživanju ispitivan je utjecaj fizičkog opterećenja vezanog...
Are rates of ageing determined in utero? (1998)
SAYER, AVAN AIHIE, COOPER, CYRUS, EVANS, JENNIFER R., RAUF, ABDUL, WORMALD, RICHARD P. L, OSMOND, CLIVE, ...
Background: epidemiological studies have shown that poor early growth is associated with cardiovascular and other degenerative diseases. This has been explained by programming, whereby undernutrition...
McColl, Alastair, Roderick, Paul, Cooper, Cyrus
Background We investigated the validity of routine hospital and mortality hip fracture data in one English Region and estimated trends in hip fracture between 1978–1981 and 1993–1995. Methods We...
Will elderly rest home residents wear hip protectors? (1998)
VILLAR, M. TRACEY A., HILL, PRIM, INSKIP, HAZEL, THOMPSON, PAUL, COOPER, CYRUS
Background: hip fracture is a common cause of morbidity and mortality in elderly people, for whom osteoporosis, the risk of falling and direct trauma to the hip during the fall are the major risk...
Is screening for osteoporosis worthwhile? (1998)
Walker-Bone, Karen, Reid, David M, Cooper, Cyrus
Osteoporosis is a common condition, which is recognised by the occurrence of fragility fractures and leads to considerable mortality and morbidity with huge financial implications world-wide. Based...
Individual Risk factors for Hip Osteoarthritis: Obesity, Hip Injury and Physical Activity (1998)
Cooper, Cyrus, Inskip, Hazel, Croft, Peter, Campbell, Lesley, Smith, Gillian, Mclearn, Magnus, ...
Hip osteoarthritis is a major cause of pain and disability. The authors explored individual risk factors for hip osteoarthritis in a population-based case-control study. The study was performed in...
Osteoarthritis of the Hip and Occupational Lifting (1998)
Cogon, David, Kellingray, Samanatha, Inskip, Hazel, Croft, Peter, Campbell, Lesley, Cooper, Cyrus
To test the hypothesis that occupational lifting is a cause of hip osteoarthritis, the authors examined associations with lifting and other occupational activities in a case-control study. The study...
Population-Based Study of Survival after Osteoporotic Fractures (1993)
Cooper, Cyrus, Atkinson, Elizabeth J., Jacobsen, Steven J., OFallon, W. Michael, Melton, L. Joseph
Vertebral fractures are the most frequent of the fractures associated with osteoporosis, yet little is known of their impact on health in the United States. To aid in this understanding, the authors...
DEFINING OSTEOARTHRITIS OF THE HIP FOR EPIDEMIOLOGIC STUDIES (1990)
CROFT, PETER, COOPER, CYRUS, WICKHAM, CAROL, COGGON, DAVID
The authors compared seven radiologic indices of hip osteoarthritis to establish which provided the best definition of the disease for epidemiologic purposes. Hip joints were assessed from...
The epidemiology of hip fractures in the elderly. (1988)
Thesis (MD)--University of Southampton, 1988.
Osteoporosis constitutes a major public health problem through its association with fractures at several skeletal sites, most notably the hip, wrist and vertebra. The lifetime risk of hip fracture in...
Growth in early life predicts bone strength in late adulthood: The Hertfordshire Cohort Study
Oliver, Helen, Jameson, Karen A., Sayer, Avan Aihie, Cooper, Cyrus, Dennison, Elaine M.
Infant growth is a determinant of adult bone mass, and poor childhood growth is a risk factor for adult hip fracture. Peripheral quantitative computed tomography (pQCT) allows non-invasive assessment...
Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system
Bruyère, Olivier, Burlet, Nansa, Delmas, Pierre D, Rizzoli, René, Cooper, Cyrus, Reginster, Jean-Yves
Inskip, Hazel M, Crozier, Sarah R, Godfrey, Keith M, Borland, Sharon E, Cooper, Cyrus, Robinson, Siân M
Objective To examine the extent to which women planning a pregnancy comply with recommendations for nutrition and lifestyle.
Costello, Paula M, Rowlerson, Anthea, Astaman, Nur Aida, Anthony, Fred Erick W, Sayer, Avan Aihie, Cooper, Cyrus, ...
Poor prenatal nutrition is associated with a greater risk of adult glucose intolerance and insulin insensitivity in the offspring. Skeletal muscle is the primary tissue for glucose utilization, and...
Lindgren, Cecilia M., Heid, Iris M., Randall, Joshua C., Lamina, Claudia, Steinthorsdottir, Valgerdur, Qi, Lu, ...
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist...
Finucane, Francis M, Horton, Jessica, Purslow, Lisa R, Savage, David B, Brage, Soren, Besson, Hervé, ...
Lindgren, Cecilia M., Heid, Iris M., Randall, Joshua C., Lamina, Claudia, Steinthorsdottir, Valgerdur, Qi, Lu, ...
Fawcett, Katherine A., Grimsey, Neil, Loos, Ruth J.F., Wheeler, Eleanor, Daly, Allan, Soos, Maria, ...
OBJECTIVE— Loss of lipin 1 activity causes lipodystrophy and insulin resistance in the fld mouse, and LPIN1 expression and common genetic variation were recently suggested to influence adiposity...