Batuca, J. R., Ames, P. R. J., Amaral, M., Favas, C., Isenberg, D. A., Delgado Alves, J.
Objective. To determine whether antibodies against high-density lipoprotein (aHDL) and apolipoprotein A-I (aApo A-I) interfere with the anti-atherogenic functions of high-density lipoprotein (HDL)...
Petri, M, Kasitanon, N, Lee, SS, Link, K, Magder, L, Bae, SC, ...
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Barry, R. J., Sutcliffe, N., Isenberg, D. A., Price, E., Goldblatt, F., Adler, M., ...
Objective. To validate a tool for assessment of accumulated damage in patients with Primary SS (PSS). Methods. Of the total 114 patients fulfilling American–European Consensus Group (AECG) criteria...
Aggressive CNS lupus vasculitis in the absence of systemic disease activity (2008)
Everett, C. M., Graves, T. D., Lad, S., Jäger, H. R., Thom, M., Isenberg, D. A., ...
Jeffery, R. C., Narshi, C. B., Isenberg, D. A.
Objective. This study addresses the issue of risk factors and management of critical peripheral ischaemia (CPI) and gangrene in SLE and proposes rituximab as a novel therapy. Method. We conducted a...
SLE patients with renal damage incur higher health care costs (2008)
Clarke, A. E., Panopalis, P., Petri, M., Manzi, S., Isenberg, D. A., Gordon, C., ...
Objectives. To compare costs and quality of life (QoL) between SLE patients with and without renal damage. Methods. Seven hundred and fifteen patients were surveyed semi-annually over 4 yrs on health...
The British Society for Rheumatology Biologics Register: 6 years on (2008)
Hyrich, K. L., Watson, K. D., Isenberg, D. A., Symmons, D. P. M.
Pego-Reigosa, J. M., Isenberg, D. A.
Objective. To determine the prevalence, characteristics and long-term outcome of psychosis due to SLE defined according to the ACR nomenclature for neuropsychiatric (NP) syndromes. Methods. All the...
Lambrianides, A., Giles, I., Ioannou, Y., Mason, L., Latchman, D.S., Manson, J.J., ...
Objective: Previous studies have shown the importance of somatic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic anti-double-stranded DNA (anti-dsDNA)...
Ioannou, Y., Pericleous, C., Latchman, D.S., Isenberg, D.A., Rahman, A., Giles, I.
Objective: Pathogenic antiphospholipid antibodies (aPL) bind the self antigen N-terminal domain (domain I) of 2-glycoprotein I (2GPI), with residues G40-R43 being important. However, peptides...
Bowman, S. J., Sutcliffe, N., Isenberg, D. A., Goldblatt, F., Adler, M., Price, E., ...
Objective. This article describes the development of the Sjögren's Systemic Clinical Activity Index (SCAI) for the measurement of systemic disease activity in patients with primary Sjögren's...
Bessant, R., Duncan, R., Ambler , G., Swanton, J., Isenberg, D.A., Gordon, C., ...
Objective: Patients with systemic lupus erythematosus (SLE) are significantly more likely to experience a myocardial infarction or a stroke than age-matched controls. We compared the prevalence of...
Jury, E.C., Isenberg, D.A., Mauri, C., Ehrenstein, M.R.
Loss of tolerance to self-Ags in patients with systemic lupus erythematosus (SLE), a prototypic autoimmune disease, is associated with dysregulation of T cell signaling, including the depletion of...
Incidence of cancer in a cohort of patients with primary Sjogren's syndrome (2006)
Lazarus, M. N., Robinson, D., Mak, V., Møller, H., Isenberg, D. A.
Objective. To compare the incidence of subsequent cancers in a cohort of patients with primary Sjögren's syndrome (pSS) with that of the general population in the same region of England. Methods. A...
Allen, E., Farewell, V. T., Isenberg, D. A., Gordon, C.
Objectives. To develop models for disease activity in patients with systemic lupus erythematosus (SLE) and to examine the hypothesis that possible subsets exist within the disease, notably renal...
Incidence of cancer in a cohort of patients with primary Sjogren's syndrome (2006)
Lazarus, M. N., Robinson, D., Mak, V., Møller, H., Isenberg, D. A.
Objective. To compare the incidence of subsequent cancers in a cohort of patients with primary Sjögren's syndrome (pSS) with that of the general population in the same region of England. Methods. A...
Incidence of cancer in a cohort of patients with primary Sjogren's syndrome (2006)
Lazarus, M. N., Robinson, D., Mak, V., Møller, H., Isenberg, D. A.
Objective. To compare the incidence of subsequent cancers in a cohort of patients with primary Sjögren's syndrome (pSS) with that of the general population in the same region of England. Methods. A...
Kumar, S., Nagl, S., Kalsi, J.K., Ravirajan, C.T., Athwal, D., Latchman, D.S., ...
We have recently shown that the anti-cardiolipin activity of human anti-phospholipid antibody UK4 (lambda) resides on its heavy chain. We now show that UK4 possesses strong reactivity to the...
Panopalis, P., Petri, M., Manzi, S., Isenberg, D. A., Gordon, C., ...
Objective. We have shown that SLE patients in Canada and the UK incurred 20% and 13% lower health costs than those in the US, respectively, but did not experience worse outcomes as...
Panopalis, P., Petri, M., Manzi, S., Isenberg, D. A., Gordon, C., ...
Objective. We have shown that SLE patients in Canada and the UK incurred 20% and 13% lower health costs than those in the US, respectively, but did not experience worse outcomes as expressed by the...
Isenberg, D. A., Rahman, A., Allen, E., Farewell, V., Akil, M., Bruce, I. N., ...
Objective. To devise a more discriminating version of the British Isles Lupus Assessment Group (BILAG) disease activity index and to show that it is reliable. Methods. A nominal consensus approach...
Annus mirabilis--a guide to the 6th European Lupus Meeting, 3-5 March 2005 (2005)
Rahman, A., Bowman, S. J., Giles, I. P., Ioannou, Y., Isenberg, D. A.
Delgado Alves, J., Mason, L. J., Ames, P. R. J., Chen, P. P., Rauch, J., Levine, J. S., ...
Objective. Oxidative stress contributes to atherosclerosis, and evidence of enhanced oxidative stress exists in antiphospholipid syndrome (APS). In a non-lupus murine model, we evaluated whether...
Leandro, M. J., Cambridge, G., Edwards, J. C., Ehrenstein, M. R., Isenberg, D. A.
Objectives. To assess the clinical and basic serological consequences of B-cell depletion with rituximab in the treatment of patients with systemic lupus erythematosus (SLE) who have failed...
Allen, E., Farewell, V. T., Isenberg, D. A., Gordon, C.
Objectives. To develop models for disease activity in patients with systemic lupus erythematosus (SLE) and to examine the hypothesis that possible subsets exist within the disease, notably renal...
Isenberg, D. A., Rahman, A., Allen, E., Farewell, V., Akil, M., Bruce, I. N., ...
Objective. To devise a more discriminating version of the British Isles Lupus Assessment Group (BILAG) disease activity index and to show that it is reliable. Methods. A nominal consensus approach...
Leandro, M. J., Cambridge, G., Edwards, J. C., Ehrenstein, M. R., Isenberg, D. A.
Objectives. To assess the clinical and basic serological consequences of B-cell depletion with rituximab in the treatment of patients with systemic lupus erythematosus (SLE) who have failed...
Annus mirabilis--a guide to the 6th European Lupus Meeting, 3-5 March 2005 (2005)
Rahman, A., Bowman, S. J., Giles, I. P., Ioannou, Y., Isenberg, D. A.
Ehrenstein, M.R., Evans, J.G., Singh, A., Moore, S., Warnes, G., Isenberg, D.A., ...
Regulatory T cells have been clearly implicated in the control of disease in murine models of autoimmunity. The paucity of data regarding the role of these lymphocytes in human autoimmune disease has...
Jury, E.C., Kabouridis, P.S., Flores-Borja, F., Mageed, R.A., Isenberg, D.A.
Systemic lupus erythematosus (SLE) is characterized by abnormalities in T lymphocyte receptor–mediated signal transduction pathways. Our previous studies have established that lymphocyte-specific...
Is α-actinin a target for pathogenic anti-DNA antibodies in lupus nephritis? (2004)
Mason, L.J., Ravirajan, C.T., Rahman, A., Putterman, C., Isenberg , D.A.
Objective: Following recent reports that pathogenic murine anti-DNA antibodies bind to -actinin, it was obviously of interest to assess the ability of human pathogenic anti-double-stranded DNA...
Haley, J., Mason, L.J., Nagl, S., Giles, I., Latchman, D.S., Isenberg, D.A., ...
Autoantibodies to a wide variety of antigens are associated with systemic lupus erythematosus (SLE). Antibodies to double-stranded DNA (anti-dsDNA) are thought to be particularly closely related to...
Ravirajan, C. T., Wang, Y., Matis, L. A., Papadaki, L., Griffiths, M. H., Latchman, D. S., ...
Objectives. There is considerable evidence suggesting that anti-double-stranded deoxyribonucleic acid (anti-dsDNA) antibodies are involved in the pathogenesis of lupus nephritis. It was shown...
Bessant, R., Hingorani, A., Patel, L., MacGregor, A., Isenberg, D. A., Rahman, A.
Objectives. Patients with systemic lupus erythematosus (SLE) are at increased risk of myocardial infarction and stroke. We sought to determine how much of this risk was dependent on recognized...
Clarke, A. E., Petri, M., Manzi, S., Isenberg, D. A., Gordon, C., ...
Objective. Health consumption and health status in SLE in three countries with different health funding structures were compared. Methods. Seven hundred and fifteen SLE patients (Canada 231, USA 269,...
Stoll, T., Sutcliffe, N., Mach, J., Klaghofer, R., Isenberg, D. A.
Objective. To determine whether initial damage, disease duration, age, initial health status, average disease activity over the 5 yr or an average medication score covering the follow-up period would...
Bessant, R., Hingorani, A., Patel, L., MacGregor, A., Isenberg, D. A., Rahman, A.
Objectives. Patients with systemic lupus erythematosus (SLE) are at increased risk of myocardial infarction and stroke. We sought to determine how much of this risk was dependent on recognized...
Clarke, A. E., Petri, M., Manzi, S., Isenberg, D. A., Gordon, C., ...
Objective. Health consumption and health status in SLE in three countries with different health funding structures were compared. Methods. Seven hundred and fifteen SLE patients (Canada 231, USA 269,...
Stoll, T., Sutcliffe, N., Mach, J., Klaghofer, R., Isenberg, D. A.
Objective. To determine whether initial damage, disease duration, age, initial health status, average disease activity over the 5 yr or an average medication score covering the follow-up period...
Isenberg, D. A., Allen, E., Farewell, V., Ehrenstein, M. R., Hanna, M. G., Lundberg, I. E., ...
Objective. To devise new tools to assess activity and damage in patients with idiopathic myopathies (IIM). Methods. An international multidisciplinary consensus effort to standardize the conduct and...
Ravirajan, C. T., Wang, Y., Matis, L. A., Papadaki, L., Griffiths, M. H., Latchman, D. S., ...
Objectives. There is considerable evidence suggesting that anti-double-stranded deoxyribonucleic acid (anti-dsDNA) antibodies are involved in the pathogenesis of lupus nephritis. It was shown...
Ravirajan, C. T., Wang, Y., Matis, L. A., Papadaki, L., Griffiths, M. H., Latchman, D. S., ...
Objectives. There is considerable evidence suggesting that anti-double-stranded deoxyribonucleic acid (anti-dsDNA) antibodies are involved in the pathogenesis of lupus nephritis. It was shown...
Bessant, R., Hingorani, A., Patel, L., MacGregor, A., Isenberg, D. A., Rahman, A.
Objectives. Patients with systemic lupus erythematosus (SLE) are at increased risk of myocardial infarction and stroke. We sought to determine how much of this risk was dependent on recognized...
Clarke, A. E., Petri, M., Manzi, S., Isenberg, D. A., Gordon, C., ...
Objective. Health consumption and health status in SLE in three countries with different health funding structures were compared. Methods. Seven hundred and fifteen SLE patients (Canada 231, USA 269,...
Stoll, T., Sutcliffe, N., Mach, J., Klaghofer, R., Isenberg, D. A.
Objective. To determine whether initial damage, disease duration, age, initial health status, average disease activity over the 5 yr or an average medication score covering the follow-up period would...
Anti-cardiolipin/β-2 glycoprotein activities co-exist on human anti-DNA antibody light chains (2003)
Kumar, S., Nagl, S., Kalsi, J.K., Ravirajan, C.T., Athwal, D., Latchman, D.S., ...
We have recently shown that the human anti-DNA antibodies B3 and 33H11 also bind cardiolipin and that the anti-autoantigen activity resides predominantly on their λ light chains. We now show that...
Giles, I.P., Haley, J., Nagl, S., Latchman, D.S., Chen, P.P., Chukwuocha, R.U., ...
Introduction: Previous studies have suggested the importance of somatic mutations and arginine, asparagine and lysine residues in the complementarity determining regions (CDRs) of antiphospholipid...
Jury, E.C., Kabouridis, P.S., Abba, A., Mageed , R.A., Isenberg, D.A.
Objective: To explore regulation of proximal signaling and composition of lipid rafts in T lymphocytes from patients with systemic lupus erythematosus (SLE). Methods: The expression, phosphorylation,...
Bates, Ruth L., Payne, Sarah J., Drury, S.L., Nelson, Paul N., Isenberg, D.A., Murphy, John J., ...
Metadata record only
Pregnancy outcome in adult-onset idiopathic inflammatory myopathy (2003)
Silva, C. A., Sultan, S. M., Isenberg, D. A.
Objectives. To assess the prevalence of pregnancy in 28 females with dermatomyositis (DM) and polymyositis (PM), assess the outcome in those who became pregnant after the onset of the disease and...
Sultan, S. M., Begum, S., Isenberg, D. A.
Objective. To evaluate the prevalence of major haemolytic disease—severe autoimmune haemolytic anaemia and severe thrombocytopenia—and to assess when these features develop. We also sought to...
Delgado Alves, J., Kumar, S., Isenberg, D. A.
Objectives. Atherosclerosis is an important complication of patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). One suggested mechanism may be the action of...
Pregnancy outcome in adult-onset idiopathic inflammatory myopathy (2003)
Silva, C. A., Sultan, S. M., Isenberg, D. A.
Objectives. To assess the prevalence of pregnancy in 28 females with dermatomyositis (DM) and polymyositis (PM), assess the outcome in those who became pregnant after the onset of the disease and...
Definition and treatment of lupus flares measured by the BILAG index (2003)
Gordon, C., Sutcliffe, N., Skan, J., Stoll, T., Isenberg, D. A.
Objectives. The BILAG index is a clinical measure of lupus disease activity. It is valid, reliable and sensitive to change. Scoring in the BILAG index is based upon the physician's intention to...
Isenberg, D. A., Allen, E., Farewell, V., Ehrenstein, M. R., Hanna, M. G., Lundberg, I. E., ...
Objective. To devise new tools to assess activity and damage in patients with idiopathic inflammatory myopathies (IIM). Methods. An international multidisciplinary consensus effort to standardize the...
Definition and treatment of lupus flares measured by the BILAG index (2003)
Gordon, C., Sutcliffe, N., Skan, J., Stoll, T., Isenberg, D. A.
Objectives. The BILAG index is a clinical measure of lupus disease activity. It is valid, reliable and sensitive to change. Scoring in the BILAG index is based upon the physician's intention to...
Delgado Alves, J., Kumar, S., Isenberg, D. A.
Objectives. Atherosclerosis is an important complication of patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). One suggested mechanism may be the action of...
Pregnancy outcome in adult-onset idiopathic inflammatory myopathy (2003)
Silva, C. A., Sultan, S. M., Isenberg, D. A.
Objectives. To assess the prevalence of pregnancy in 28 females with dermatomyositis (DM) and polymyositis (PM), assess the outcome in those who became pregnant after the onset of the disease and...
Definition and treatment of lupus flares measured by the BILAG index (2003)
Gordon, C., Sutcliffe, N., Skan, J., Stoll, T., Isenberg, D. A.
Objectives. The BILAG index is a clinical measure of lupus disease activity. It is valid, reliable and sensitive to change. Scoring in the BILAG index is based upon the physician's intention to...
Isenberg, D. A., Allen, E., Farewell, V., Ehrenstein, M. R., Hanna, M. G., Lundberg, I. E., ...
Objective. To devise new tools to assess activity and damage in patients with idiopathic inflammatory myopathies (IIM). Methods. An international multidisciplinary consensus effort to standardize the...
Choy, E.H.S., Isenberg, D.A., Garrood, T., Farrow, S., Ioannou, Y., Bird, H., ...
Objective: To investigate the safety and efficacy of MRA, a recombinant human anti-interleukin-6 (anti-IL-6) receptor monoclonal antibody of the IgG1 subclass that inhibits the function of IL-6, in...
An open study of B lymphocyte depletion in systemic lupus erythematosus (2002)
Leandro, M.J., Edwards, J.C., Cambridge, G., Ehrenstein, M.R., Isenberg, D.A.
Objective: To gain preliminary evidence for the safety and efficacy of B lymphocyte depletion therapy in refractory systemic lupus erythematosus (SLE). Methods: Six female patients with active SLE,...
Alves, J.D., Ames, P.R.J., Donohue, S., Stanyer, L., Noorouz-Zadeh, J., Ravirajan, C., ...
Objective: To determine the prevalence of anti-high-density lipoprotein (anti-HDL) antibodies and to establish a possible relationship between anti-HDL, anticardiolipin antibodies (aCL),...
Disturbances in peripheral blood B cell subpopulations in autoimmune patients (2002)
Potter, K.N., Mockridge, C.I., Rahman, A., Buchan, S., Hamblin, T., Davidson, B., ...
A variety of cell surface markers are being used to identify B cell subpopulations in peripheral blood. Currently at least eight subpopulations have been identified. Analyses of healthy individuals...
Choy, E. H. S., Hazleman, B., Smith, M., Moss, K., Lisi, L., Scott, D. G. I., ...
Objective. Biological products that neutralize tumour necrosis factor α (TNF‐α) are beneficial in rheumatoid arthritis (RA). We studied the effects of CDP870, a novel...
Outcome in patients with idiopathic inflammatory myositis: morbidity and mortality (2002)
Sultan, S. M., Ioannou, Y., Moss, K., Isenberg, D. A.
Objective. To assess the long‐term outcome of a cohort of 46 patients with idiopathic myositis by assessing both health status, as measured by the SF‐36, and cumulative survival...
Treatment of dermatomyositis and polymyositis (2002)
Choy, E. H. S., Isenberg, D. A.
Since idiopathic inflammatory myositis is relatively uncommon, randomized placebo controlled trials are rare. Although corticosteroids have not been tested in randomized controlled trials, general...
Rahman, A., Haley, J., Radway-Bright, E., Nagl, S., Low, D.G., Latchman, D.S., ...
2a2 is the most commonly rearranged gene in the human Vλ locus. It has been postulated that certain immunoglobulin genes (including 2a2) are rearranged preferentially because their germline...
Ravirajan, C. T., Rowse, L., MacGowan, J. R., Isenberg, D. A.
Objective. To establish the correlation between lupus nephritis‐associated autoantibody levels and the presence/activity of lupus nephritis and global disease activity using...
Miller, F. W., Rider, L. G., Cooper, R., Danko, K., Farewell, V., ...
In order to develop a preliminary core set of disease outcome measures for use in clinical trials of idiopathic inflammatory myopathies (IIM), we evaluated those measures used in previous...
Objective. To ascertain the clinical presentation, histopathology and outcome of renal involvement in patients with primary antiphospholipid syndrome (PAPS), antiphospholipid syndrome...
Total costs and predictors of costs in patients with systemic lupus erythematosus (2001)
Sutcliffe, N., Clarke, A. E., Taylor, R., Frost, C., Isenberg, D. A.
Objective. To determine the annual direct, indirect and total costs and predictors of costs in patients with systemic lupus erythematosus (SLE). Methods. One hundred and five patients...
Frampton, G., Moriya, S., Pearson, J. D., Isenberg, D. A., Ward, F. J., Smith, T. A., ...
Objective. To attempt to characterize the diversity and nature of antigens recognized by anti‐endothelial cell antibodies (AECA) in patients with systemic lupus erythematosus...
Sultan, S. M., Ioannou, Y., Isenberg, D. A.
Objective. To estimate the risk of malignancy in a UK cohort of patients with systemic lupus erythematosus (SLE) under long‐term review. Method. The University College London...
Radway-Bright, E. L., Ravirajan, C. T., Isenberg, D. A.
Objectives. Antiphospholipid antibodies (aPL) have been associated with syndromes involving thrombosis, fetal loss and thrombocytopenia. Genetic and environmental conditions are among the...
Sutcliffe, N., Smith, C., Speight, P. M., Isenberg, D. A.
We report two patients with rheumatoid arthritis and secondary Sjögren's syndrome whose disease was complicated by a mucosa‐associated lymphoid tissue (MALT) lymphoma. Although this...
Sutcliffe, N., Clarke, A. E., Gordon, C., Farewell, V., Isenberg, D. A.
Objective. To determine the relationship between socio-economic status, race, psychosocial factors and outcome in patients with systemic lupus erythematosus (SLE). Methods. One hundred and...
A review of gastrointestinal manifestations of systemic lupus erythematosus (1999)
Sultan, S. M., Ioannou, Y., Isenberg, D. A.
In this review, we analyse critically the effects of systemic lupus erythematosus (SLE) on the gastrointestinal (GI) tract from mouth to anus, attempting to distinguish the features that are most...
ULTRAVIOLET IRRADIATION IN SYSTEMIC LUPUS ERYTHEMATOSUS: FRIEND OR FOE? (1996)
The long established notion that UV irradiation is always harmful to patients with systemic lupus erythematosus has been challenged by some recent reports of benefit using a form of phototherapy with...
STOLL, T., SEIFERT, B., ISENBERG, D. A.
We investigated the Systemic Lupus International Collaborative Clinics/American College of Rheumatology (SLICC/ACR) Damage Index as a predictor of severe outcome and an indicator of morbidity...
Antibodies to Heat Shock Proteins in Autoimmune Disease (1996)
CONROY, S. E., FAULDS, G. B., ISENBERG, D. A., LATCHMAN, D. S.
T-LYMPHOCYTE IMMUNOPHENOTYPING IN POLYMYOSITIS AND DERMATOMYOSITIS (1996)
IANNONE, F., CAULI, A., YANNI, G., KINGSLEY, G. H., ISENBERG, D. A., CORRIGALL, V., ...
The objective was to elucidate the immunological abnormalities underlying polymyositis (PM) and dermatomyositis (DM). The phenotype of peripheral blood mononuclear cell (PBMNC) subsets and cell...
NEWKIRK, M. M., SHIROKY, J. B., JOHNSON, N., DANOFF, D., ISENBERG, D. A., SHUSTIK, C., ...
The IgG response to Epstein-Barr virus (EBV) early antigens [BHRF1 (pl7.1), the viral homologue of bcl-2, and BMRF1 (p50.10), a DNA binding protein] was measured in patients with rheumatic disease to...
EHRENSTEIN, M. R., CONROY, S. E., HEATH, J., LATCHMAN, D. S., ISENBERG, D. A.
This study examines the occurrence, nature and distribution of disease flares in systemic lupus erythematosus (SLE) according to organ involvement. One-hundred-and-fourteen patients were seen in the...
ROSE, L. M., LATCHMAN, D. S., ISENBERG, D. A.
It has been postulated that the high levels of autoantibodies observed in systemic lupus erythematosus (SLE) patients could result from abnormal longevity of polyclonally activated B-cells. This...
RANKIN, E. C. C., CHOY, E. H. S., KASSIMOS, D., KINGSLEY, G. H., SOPWTTH, A. M., ISENBERG, D. A., ...
Pro-inflammatory cytoldnes such as tumour necrosis factor alpha (TNFα) have been implicated in the pathogenesis of rheumatoid arthritis (RA), and have therefore become therapeutic targets. An...
A number of studies have demonstrated an association between thyroid autoimmune disease and systemic lupus erythematosus (SLE), but there is little information on the course of thyroid autoimmunity...
McNALLY, T., MACKIE, I. J., MACHIN, S. J., ISENBERG, D. A.
β2 Glycoprotein-I (β2GPI), a plasma component with in vitro anticoagulant properties, has been identified as a cofactor for the binding of some antiphospholipid antibodies (aPAs). In order to...
ACQUIRED BROWN'S SYNDROME IN SYSTEMIC LUPUS ERYTHEMATOSUS (1995)
WHITEFIELD, L., ISENBERG, D. A., BRAZIER, D. J., FORBES, J.
A 33-yr-old woman with systemic lupus erythematosus (SLE) and concomitant development of Brown's syndrome is described. This rare complication of SLE is discussed.
CONROY, S. E., FAULDS, G. B., WILLIAMS, W., LATCHMAN, D. S., ISENBERG, D. A.
Expression of the highly conserved 90 kDa heat shock protein (Hsp90) is elevated in the peripheral blood mononuclear cells of approximately 25% of patients with SLE. Conflicting data have been...
C3 nephritic factor and SLE: report of four cases and review of the literature (1994)
WALPORT, M.J., DAVIES, K.A., BOTTO, M., NAUGHTON, M.A., ISENBERG, D.A., BIASI, D., ...
We present four patients with C3 nephritic factor associated with partial lipodystrophy and/or mes-angiocapillary glomerulonephritis type II. Each of these patients subsequently developed...
DHILLON, V.B., McCALLUM, S., LATCHMAN, D.S., ISENBERG, D.A.
We have previously shown that the 90 kDa heat- shock protein (hsp9o) is notably elevated in lupus patients with active neuro-psychiatric (NP) and/or cardio-respiratory (CR) disease. This...
TEH, L. S., LEE, M. K., WANG, F., MANIVASAGAR, M., CHARLES, P. J., NICHOLSON, G. D., ...
We report a significantly increased prevalence of antiribosomal P protein antibodies in Malaysian Chinese patients (38%) with SLE compared to white Caucasian (13%) and Afro-Caribbean...
ANTI-DNA ANTIBODIES IN THE PRIMARY ANTIPHOSPHOLIPID SYNDROME (PAPS) (1993)
EHRENSTEIN, M. R., SWANA, M., KEELING, D., ASHERSON, R., HUGHES, G. R. V., ISENBERG, D. A.
Primary antiphospholipid syndrome (PAPS) is considered a distinct entity from SLE and patients with PAPS are generally regarded as being dsDNA antibody negative. Levels of IgG and IgM ss and ds DNA...
HAY, E.M., BACON, P.A., GORDON, C., ISENBERG, D.A., MADDISON, P., SNAITH, M.L., ...
The British Isles Lupus Assessment Group (BILAG) index is a computerized index for measuring clinical disease activity in systemic lupus erythematosus (SLE), which was developed according to the...
AUTOANTIBODIES IN CENTRAL NERVOUS SYSTEM LUPUS (1993)
Central nervous system (CNS) involvement in patients with lupus remains both a diagnostic and a therapeutic challenge. The role of autoantibodies in the pathogenesis of CNS lupus and/or as...
TREPONEMAL INFECTION COEXISTING WITH SYSTEMIC LUPUS ERYTHEMATOSUS (1992)
DHILLON, V. B., KEELING, D. M., RIDGWAY, G. L., SNAITH, M. L., ISENBERG, D. A.
A patient with systemic lupus erythematosus (SLE)/erosive arthritis overlap is described who was also shown to have late latent treponemal infection. The possibility of serological reactivation...
WORRALL, J. G., SNAITH, M. L., BATCHELOR, J. R., ISENBERG, D. A.
Clinical features and immunogenetics were assessed in 100 SLE patients attending a rheumatology clinic for periods ranging from six months to 11 years (mean five years). Five-year survival was 88 per...
SJOGREN'S SYNDROME: ASSOCIATION WITH TYPE-1 DIABETES MELLITUS (1989)
BINDER, A., MADDISON, P. J., SKINNER, P., KURTZ, A., ISENBERG, D. A.
This study of 102 unselected type-1 diabetic patients has shown that sicca symptoms affect 55% of the patients, although sometimes only during hyperglycaemic phases. While these symptoms might...
ANTI La(SSB) IDENTIFIES A DISTINCTIVE SUBGROUP OF SYSTEMIC LUPUS ERYTHEMATOSUS (1988)
MADDISON, P. J., ISENBERG, D. A., GOULDING, N. J., LEDDY, J., SKINNER, R. P.
The relevance of antibodies for La(SSB) as a marker of a distinctive systemic lupus erythematosus (SLE) subset was studied in 185 lupus patients. Anti La was detected in 39 (21%) and was...
YARDUMIAN, D. A., ISENBERG, D. A., RUSTIN, M., BELCHER, G., SNAITH, M. L., DOWD, P. M., ...
Twelve female patients with severe secondary Raynaud's phenomenon were treated in a randomized order with both placebo and Iloprost infusions. Infusions were for 5 hours on 3 consecutive days and...
ISENBERG, D. A., FELDMAN, R., DUDENEY, C., KONIKOFF, F., JONES, D., EBRINGER, A., ...
Recent studies have indicated that both ankylosing spondylitis and the anti-DNA antibodies found in systemic lupus erythematosus may be related to Klebsiella surface antigens. In order to explore...
RENAL ABNORMALITIES IN ANKYLOSING SPONDYLITIS (1987)
JONES, D. W., MANSELL, M. A., SAMUELL, C. T., ISENBERG, D. A.
The incidence of renal abnormalities is increased in patients with ankylosing spondylitis (AS). Possible mechanisms include the effects of nonsteroidal anti-inflammatory drugs (NSAIDs), an increased...
RAPID DEVELOPMENT OF CEREBRAL ATROPHY IN SYSTEMIC LUPUS ERYTHEMATOSUS (1986)
GORDON, TANIA, MADDISON, P. J., ISENBERG, D. A.
A 21-year-old female is described who developed severe cerebral lupus 9 months after the onset of her disease. A dramatic change in her CT brain scan from normal to gross cerebral atrophy was...
HAEMATOLOGICAL REASSESSMENT OF RHEUMATOID ARTHRITIS USING AN AUTOMATED METHOD (1986)
ISENBERG, D. A., MARTIN, P., HAJIROUSOU, V., TODD-POKROPEK, A., GOLDSTONE, A. H., SNAITH, M. L.
Thirteen haematological parameters were measured in 44 patients with rheumatoid arthritis (RA) and 39 disease control patients with ankylosing spondylitis (AS). Using a 10 000 cells per sample...
PRELIMINARY EVIDENCE FOR GUT INVOLVEMENT IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS? (1986)
SEGAL, A. W., ISENBERG, D. A., HAJIROUSOU, V., TOLFREE, SUSAN, CLARK, JILL, SNAITH, M. L.
111Indium leucocyte scans were performed on 26 patients with active rheumatoid arthritis. An abnormal localization of radioactivity was observed in the gut of 12 of these patients, generally in the...
LUPUS-LIKE NEPHRITIS HERALDING THE DEFINITIVE MANIFESTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS (1985)
FISHER, C., GIBB, W. R. G., COHEN, S. L., COLLINS, C. R., POTTER, ANN, ISENBERG, D. A.
Four patients presented with the nephrotic syndrome. The histological appearances on renal biopsy were in three characteristic and in one suggestive of lupus nephritis. These patients did not...
MUSCLE CHANGES IN ANKYLOSING SPONDYLITIS (1983)
HOPKINS, G. O., MCDOUGALL, J., MILLS, K. R., ISENBERG, D. A., EBRINGER, A.
Muscle biopsy of the quadriceps femoris was carried out in 20 patients with classical ankylosing spondylitis (AS). Histological and histochemical studies revealed changes in all biopsies to a varying...
Immunoglobulin Deposition in Skeletal Muscle in Primary Muscle Disease (1983)
Using direct Immunofluorescence the deposition of lgG, IgM, IgA, Clq and C3 was studied on muscle biopsies from 39 patients with polymyositis/dermotomyositis, 21 patients with muscular dystrophy,...
Useful Laboratory Measurements in the Management of Systemic Lupus Erythematosus (1982)
MORROW, W. J. W., ISENBERG, D. A., TODD-POKROPER, A., PARRY, H. F., SNAITH, M. L.
Thirty-five patients with systemic lupus erythematosus (SLE) have been monitored clinically and serologically for up to three and a half years. The data collected was analysed by computer using the...
Serological and genetic characterization of a human monoclonal immunoglobulin G anti-DNA idiotype.
Ehrenstein, M R, Longhurst, C M, Latchman, D S, Isenberg, D A
This study analyzed the distribution of an idiotype, B3-Id, in patients with active SLE, classified according to organ involvement, normal controls, and other autoimmune rheumatic diseases. A...
Cross-reactive anti-DNA antibody idiotypes have been identified on tissue-bound immunoglobulins in a study of renal biopsies from 26 systemic lupus erythematosus (SLE) patients. 12 (46%) biopsies...
Changes in normal glycosylation mechanisms in autoimmune rheumatic disease.
Axford, J S, Sumar, N, Alavi, A, Isenberg, D A, Young, A, Bodman, K B, ...
To investigate potential mechanisms controlling protein glycosylation we have studied the interrelationship between lymphocytic galactosyltransferase (GTase) activity and serum agalactosylated...
Keeling, D M, Wilson, A J, Mackie, I J, Isenberg, D A, Machin, S J
AIMS--To determine whether beta 2 glycoprotein I (beta 2GPI) dependent anticardiolipin (aCL) antibodies detected in solid phase enzyme linked immunosorbent assays can also have lupus anticoagulant...
Role of beta 2-glycoprotein I and anti-phospholipid antibodies in activation of protein C in vitro.
Keeling, D M, Wilson, A J, Mackie, I J, Isenberg, D A, Machin, S J
AIMS--To investigate the effect of beta 2-glycoprotein I (beta 2 GPI) on the thrombin/thrombomodulin dependent activation of protein C; and to determine whether beta 2 GPI dependent anticardiolipin...
Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus.
Tsao, B P, Cantor, R M, Kalunian, K C, Chen, C J, Badsha, H, Singh, R, ...
Genetic susceptibility confers significant risk for systemic lupus erythematosus (SLE). The MHC region and other polymorphic loci have been associated with SLE. Because more compelling evidence for...
Interleukin 6 activates heat-shock protein 90 beta gene expression.
Stephanou, A, Amin, V, Isenberg, D A, Akira, S, Kishimoto, T, Latchman, D S
The levels of the cytokine interleukin-6 (IL-6) and the heat-shock protein hsp90 have both been reported to be elevated in patients with active systemic lupus erythematosus (SLE). We show that hsp90...
Stephanou, A, Isenberg, D A, Akira, S, Kishimoto, T, Latchman, D S
The levels of the 90 kDa heat-shock protein (hsp90) and the activity of the hsp90beta gene promoter are increased in response to treatment by interleukin (IL)-6. The hsp90beta gene promoter contains...
Predictive value of SS-B precipitating antibodies in Sjoögren's syndrome.
Isenberg, D A, Hammond, L, Fisher, C, Griffiths, M, Stewart, J, Bottazzo, G F
As part of a screening programme several patients were identified with antibodies to the nuclear antigen SS-B. Fifteen were examined and 11 found to have Sjögren's syndrome, though this had not been...
Serological and genetic characterization of a human monoclonal immunoglobulin G anti-DNA idiotype.
Ehrenstein, M R, Longhurst, C M, Latchman, D S, Isenberg, D A
This study analyzed the distribution of an idiotype, B3-Id, in patients with active SLE, classified according to organ involvement, normal controls, and other autoimmune rheumatic diseases. A...
Cross-reactive anti-DNA antibody idiotypes have been identified on tissue-bound immunoglobulins in a study of renal biopsies from 26 systemic lupus erythematosus (SLE) patients. 12 (46%) biopsies...
Changes in normal glycosylation mechanisms in autoimmune rheumatic disease.
Axford, J S, Sumar, N, Alavi, A, Isenberg, D A, Young, A, Bodman, K B, ...
To investigate potential mechanisms controlling protein glycosylation we have studied the interrelationship between lymphocytic galactosyltransferase (GTase) activity and serum agalactosylated...
Keeling, D M, Wilson, A J, Mackie, I J, Isenberg, D A, Machin, S J
AIMS--To determine whether beta 2 glycoprotein I (beta 2GPI) dependent anticardiolipin (aCL) antibodies detected in solid phase enzyme linked immunosorbent assays can also have lupus anticoagulant...
Role of beta 2-glycoprotein I and anti-phospholipid antibodies in activation of protein C in vitro.
Keeling, D M, Wilson, A J, Mackie, I J, Isenberg, D A, Machin, S J
AIMS--To investigate the effect of beta 2-glycoprotein I (beta 2 GPI) on the thrombin/thrombomodulin dependent activation of protein C; and to determine whether beta 2 GPI dependent anticardiolipin...
Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus.
Tsao, B P, Cantor, R M, Kalunian, K C, Chen, C J, Badsha, H, Singh, R, ...
Genetic susceptibility confers significant risk for systemic lupus erythematosus (SLE). The MHC region and other polymorphic loci have been associated with SLE. Because more compelling evidence for...
Interleukin 6 activates heat-shock protein 90 beta gene expression.
Stephanou, A, Amin, V, Isenberg, D A, Akira, S, Kishimoto, T, Latchman, D S
The levels of the cytokine interleukin-6 (IL-6) and the heat-shock protein hsp90 have both been reported to be elevated in patients with active systemic lupus erythematosus (SLE). We show that hsp90...
Stephanou, A, Isenberg, D A, Akira, S, Kishimoto, T, Latchman, D S
The levels of the 90 kDa heat-shock protein (hsp90) and the activity of the hsp90beta gene promoter are increased in response to treatment by interleukin (IL)-6. The hsp90beta gene promoter contains...
Predictive value of SS-B precipitating antibodies in Sjoögren's syndrome.
Isenberg, D A, Hammond, L, Fisher, C, Griffiths, M, Stewart, J, Bottazzo, G F
As part of a screening programme several patients were identified with antibodies to the nuclear antigen SS-B. Fifteen were examined and 11 found to have Sjögren's syndrome, though this had not been...
Demaison, C, Ravirajan, C T, Isenberg, D A, Zouali, M
We have analysed the heavy and light chain variable region genes of two monoclonal antibodies, specific for the Sm antigen (RSP1; IgG kappa) and for cardiolipin (RSP4; IgM lambda), derived from a...
Jeddi, P A, Bodman-Smith, K B, Lund, T, Lydyard, P M, Mengle-Gaw, L, Isenberg, D A, ...
Reduced galactosylation of immunoglobulin G (IgG) is well documented in rheumatoid arthritis (RA), but the reason for this defect is still unknown. There is some evidence supporting a defect in the...
Longhurst, C, Ehrenstein, M R, Leaker, B, Stevenson, F K, Spellerberg, M, Chapman, C, ...
Circulating antibodies to myeloperoxidase (MPO) are associated primarily with pauci-immune glomerulonephritis and systemic vasculitis. Anti-MPO antibodies belong to a group of autoantibodies,...
Locniskar, M, Zumla, A, Mudd, D W, Isenberg, D A, Williams, W, McAdam, K P
Human monoclonal antibodies (mAb) were produced by hybridomas derived from fusion of the GM4672 lymphoblastoid cell line and peripheral blood mononuclear cells from leprosy patients. Hybridoma...
Watts, R A, Ravirajan, C T, Staines, N A, Isenberg, D A
A human DNA-binding monoclonal antibody was produced by fusing the hepatocytes from a 12-week-old human fetus with the lymphoblastoid cell line GM 4672 using polyethylene glycol. This antibody,...
Staines, N A, Ward, F J, Denbury, A N, Mitchiner, J, Hartley, O, Eilat, D, ...
In this study, the primary sequence and location of the idiotopes of monoclonal antibody (mAb) V-88 have been examined. V-88 was derived from an adult (NZB x NZW)F1 mouse, has been partially defined...
Shared idiotypes are expressed on mouse and human anti-DNA autoantibodies.
Morgan, A, Isenberg, D A, Naparstek, Y, Rauch, J, Duggan, D, Khiroya, R, ...
The expression of common idiotypes on human and mouse anti-DNA monoclonal autoantibodies made by hybridomas was examined by their competitive binding to anti-idiotype antibodies. Some murine...
Isenberg, D A, Crisp, A J, Morrow, W J, Newham, D, Snaith, M L
Circulating immune complexes (CIC) were measured in 4 normal controls and 8 patients with systemic lupus erythematosus (SLE) by a polyethylene glycol precipitation (PEG) method during a 24-hour...
A study of migraine in systemic lupus erythematosus.
Isenberg, D A, Meyrick-Thomas, D, Snaith, M L, McKeran, R O, Royston, J P
An increased prevalence of classical migraine was found in 30 female patients with systemic lupus erythematosus (SLE) compared with an age and sex-matched control group by means of a detailed...
Neutrophil function in systemic lupus erythematosus and other collagen diseases.
Al-Hadithy, H, Isenberg, D A, Addison, I E, Goldstone, A H, Snaith, M L
Using a whole blood technique we assessed neutrophil migration, phagocytosis, and killing in a group of 20 patients with systemic lupus erythematosus (SLE) and in 8 patients with other connective...
Methyl prednisolone pulse therapy in the treatment of systemic lupus erythematosus.
Isenberg, D A, Morrow, W J, Snaith, M L
Twenty patients with active systemic lupus erythematosus (SLE) were treated with methyl prednisolone pulse therapy (MPPT) and followed up for up to 24 weeks (mean 18 weeks). Beneficial effects of...
Morrow, W J, Isenberg, D A, Parry, H F, Shen, L, Okolie, E E, Farzaneh, F, ...
Sera from 41 patients with systemic lupus erythematosus (SLE), 87 controls with various diseases, and 30 normal subjects were examined for poly (adenosine diphosphate-ribose) and ds DNA binding....
Morrow, W J, Williams, D J, Ferec, C, Casburn-Budd, R, Isenberg, D A, Paice, E, ...
Plasma samples from 44 patients with systemic lupus erythematosus (SLE) and 43 with rheumatoid arthritis (RA) were assayed for C3d, a breakdown product of the third component of complement (C3),...
An immunohistological study of secondary Sjögren's syndrome.
Isenberg, D A, Rowe, D, Tookman, A, Hopp, A, Griffiths, M, Paice, E, ...
The labial biopsies from 13 patients with secondary Sjögren's syndrome (SS) and four disease controls were examined with a panel of monoclonal antibodies to human leucocyte antigens. Large numbers...
Boghossian, S H, Isenberg, D A, Wright, G, Snaith, M L, Segal, A W
Circulating phagocytes play a major role in the defence of the host against microbial infection. In an attempt to identify the reason for the unusual susceptibility to infection of patients with...
A 28-year-old woman presenting with subacute onset of a tetraplegia is described who was shown to have active systemic lupus erythematosus in association with high circulating anticardiolipin binding...
Dudeney, C, Shoenfeld, Y, Rauch, J, Jones, M, Mackworth Young, C, Tavassoli, M, ...
The genetic background of systemic lupus erythematosus (SLE) has been reexamined in a study of the serum of 31 lupus patients and 80 asymptomatic first degree relatives by measuring a common, cross...
Measurement of anti-DNA antibodies: a reappraisal using five different methods.
Isenberg, D A, Dudeney, C, Williams, W, Addison, I, Charles, S, Clarke, J, ...
One hundred and thirty coded sera, 60 from patients with systemic lupus erythematosus (SLE) and 70 from patients with other autoimmune rheumatic diseases were tested for deoxyribonucleic acid (DNA)...
Rowe, D, Griffiths, M, Stewart, J, Novick, D, Beverley, P C, Isenberg, D A
Labial biopsy specimens from eight patients with primary Sjögren's syndrome (SS), 10 patients with secondary SS, and three healthy controls were studied with monoclonal antibodies identifying HLA...
Edwards, J C, Snaith, M L, Isenberg, D A
Twenty one patients with severe systemic lupus erythematosus (SLE) were treated with three daily infusions of either 100 mg or 1 g of methylprednisolone on a randomised double blind basis. Nine...
Isenberg, D A, Dudeney, C, Williams, W, Todd-Pokropek, A, Stollar, B D
Antibodies to dDNA, nDNA, Z-DNA, poly(dT), poly(I), poly(dG.dC), poly(dA.dT), and total IgG and IgM were measured in five serial bleeds from 39 patients with systemic lupus erythematosus (SLE). The...
Senaldi, G, Makinde, V A, Vergani, D, Isenberg, D A
Levels of C4d, a fragment of C4 generated during activation of the classical complement pathway, were measured in the plasma of 48 patients with systemic lupus erythematosus, 11 with inactive (group...
Does rheumatoid factor protect lupus patients from the development of nephritis?
Turner-Stokes, L, Jones, M, Addison, I, Mansell, M, Isenberg, D A
It has been suggested again recently that the presence of rheumatoid factor (RF) in the serum of patients with systemic lupus erythematosus (SLE) protects them from the development of nephritis. In...
Raised serum IgG and IgA antibodies to mycobacterial antigens in rheumatoid arthritis.
Tsoulfa, G, Rook, G A, Van-Embden, J D, Young, D B, Mehlert, A, Isenberg, D A, ...
Autoantigens cross reactive with mycobacteria are implicated in the pathogenesis of adjuvant arthritis in the rat, and there are reports of changes in the immune response to mycobacteria in human...
Serological abnormalities, including common idiotype PR4, in families with rheumatoid arthritis.
Youinou, P, Williams, W, Le Goff, P, Tuaillon, N, Jouquan, J, Muller, S, ...
A broad range of autoreactivity among a group of 12 French patients with rheumatoid arthritis (RA) and 58 of their healthy first degree relatives has been identified. Over 15% of the patients were...
Yousef, G E, Isenberg, D A, Mowbray, J F
A subgenomic cDNA probe with broad specificity for a range of enteroviruses was used to test by an in situ hybridisation technique for the presence of enterovirus specific genomic sequences in muscle...
Gompertz, N R, Isenberg, D A, Turner, B M
An attempt was made to define the correlation between the clinical features of systemic lupus erythematosus and levels of circulating antihistone antibodies of the IgG, IgA, and IgM isotypes. Serum...
Dhillon, V B, Davies, M C, Hall, M L, Round, J M, Ell, P J, Jacobs, H S, ...
Dual energy x ray absorptiometry and a wide range of blood and urine tests were used to assess the propensity of patients with systemic lupus erythematosus to develop an impairment of bone mineral...
Sequi, J, Leigh, I, Isenberg, D A
Antinuclear activity was assessed in serum samples from a series of 40 patients with differing clinical subsets (including renal and neurological disease) of systemic lupus erythematosus (SLE)...
Influence of C4 null alleles on C4 activation in systemic lupus erythematosus.
Briggs, D C, Senaldi, G, Isenberg, D A, Welsh, K I, Vergani, D
Deficiencies of early components of the classical complement pathway are known to be associated with systemic lupus erythematosus (SLE). C4 null alleles, C4A Q0 and C4B Q0, are prime candidates for...
Dietary fish oil and the severity of symptoms in patients with systemic lupus erythematosus.
Walton, A J, Snaith, M L, Locniskar, M, Cumberland, A G, Morrow, W J, Isenberg, D A
A prospective, double blind, cross over study assessing the effects of a low fat, high marine oil diet in 27 patients with active systemic lupus erythematosus has been performed. The patients were...
Turner-Stokes, L, Jones, D, Patterson, K G, Todd-Pokropek, A, Isenberg, D A, Goldstone, A H
Two automated counters, the H1 (Technicon) and the H6000 (Technicon), which count 10,000 cells per sample, were compared and used to examine the clinical relevance of the additional haematological...
Sumar, N, Isenberg, D A, Bodman, K B, Soltys, A, Young, A, Leak, A M, ...
Glycosylation changes in patients with juvenile chronic and adult onset rheumatoid arthritis have been studied using a novel binding method. Both these major types of arthritis showed decreased...
Idiopathic myositis: a rheumatological view.
Ehrenstein, M R, Snaith, M L, Isenberg, D A
Twenty five patients with idiopathic myositis attended this department for long term follow up from 1980 to 1989. Twelve patients had primary polymyositis (four men, eight women) and six had primary...
Antibodies to protein P in systemic lupus erythematosus.
Teh, L S, Bedwell, A E, Isenberg, D A, Gordon, C, Emery, P, Charles, P J, ...
A synthetic peptide was used to develop an enzyme linked immunosorbent assay (ELISA) to detect antibodies to the ribosomal proteins P0, P1, and P2. Significantly increased levels of IgG antibodies to...
Expression of public idiotypes in patients with Lyme arthritis.
Axford, J S, Watts, R A, Long, A A, Isenberg, D A, Steere, A C
OBJECTIVE: Joints are often affected in Lyme disease and in some instances this may be due to immune autoreactivity. To characterise further the immune response in this disease investigations were...
Dhillon, V B, McCallum, S, Norton, P, Twomey, B M, Erkeller-Yuksel, F, Lydyard, P, ...
OBJECTIVES--To determine which heat shock proteins (hsps) are overexpressed in systemic lupus erythematosus (SLE), and to examine the relevance of these findings to clinical disease activity....
Edwards, J C, Wilkinson, L S, Speight, P, Isenberg, D A
OBJECTIVES--Interactions between vascular cell adhesion molecule 1 (VCAM-1) and its ligand, the alpha 4/beta 1 integrin, have been shown to be important in a number of cellular events in vitro. To...
Nelson, P N, Lever, A M, Bruckner, F E, Isenberg, D A, Kessaris, N, Hay, F C
OBJECTIVES--To investigate the presence of antibodies to HTLV and HIV retroviral antigens in the rheumatological diseases rheumatoid arthritis (RA), polymyositis/dermatomyositis (PM/DM), primary...
MacGregor, A J, Dhillon, V B, Binder, A, Forte, C A, Knight, B C, Betteridge, D J, ...
Fasting cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, apoprotein AI, and apoprotein B were measured in 64 patients with systemic lupus...
Ravirajan, C T, Harmer, I, McNally, T, Hohmann, A, Mackworth-Young, C G, Isenberg, D A
OBJECTIVE--To analyse the phospholipid binding specificity, functional characteristics and idiotype expression of human hybridoma derived monoclonal autoantibodies (MAb) derived from the spleens of...
Stoll, T, Stucki, G, Malik, J, Pyke, S, Isenberg, D A
OBJECTIVE: To examine the association among the BILAG disease activity index components and their relations with global assessments, health status, and laboratory tests with regard to the validity of...
Ricchiuti, V, Briand, J P, Meyer, O, Isenberg, D A, Pruijn, G, Muller, S
The reactivity of autoantibodies present in the sera of 489 patients with Sjögren's syndrome (SS), systemic lupus erythematosus (SLE) and other autoimmune diseases was investigated by ELISA using...
Watts, R A, Ravirajan, C T, Wilkinson, L S, Williams, W, Griffiths, M, Butcher, D, ...
The expression in tissue and serum of a panel of murine and human common DNA antibody idiotypes (Ids) (BEG 2, PR 4, F-423, I-402, II-28, IV-228, V-88) has been investigated. The murine V-88 Id was...
Monoclonal antibodies to human leucocyte antigens in polymyositis and muscular dystrophy.
Rowe, D, Isenberg, D A, Beverley, P C
Biopsy specimens from patients with treated or untreated polymyositis and muscular dystrophy controls were examined by indirect immunoperoxidase staining with a panel of monoclonal antibodies to...
Rowe, D J, Isenberg, D A, McDougall, J, Beverley, P C
Frozen serial sections of muscle from 15 patients with polymyositis and three normal controls were studied by indirect immunofluorescence with a panel of mouse monoclonal antibodies to various human...
Dar, O, Salaman, M R, Seifert, M H, Isenberg, D A
IgG antibodies to DNA, influenza virus haemagglutinin (HA), adenovirus hexon (HX) and mannan from Candida albicans (MN) have been determined in supernatants from 2-day unstimulated cultures of...
Le Page, S H, Williams, W, Parkhouse, D, Cambridge, G, MacKenzie, L, Lydyard, P M, ...
Forty-two patients with systemic lupus erythematosus (SLE), 65 of their healthy relatives and 20 spouses were studied for the presence of lymphocytotoxic antibodies (LCA), anti-lymphocyte antibodies...
Roberts, P J, Isenberg, D A, Segal, A W
The digestion of bacterial DNA by peripheral blood monocytes was impaired both in patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE). The monocytes of these...
El-Roiey, A, Sela, O, Isenberg, D A, Feldman, R, Colaco, B C, Kennedy, R C, ...
In view of recent reports linking Klebsiella pneumoniae with autoimmunity, we have examined the sera of 52 patients with urinary tract infection or septicaemia from this Gram-negative pathogen, for...
Isenberg, D. A., Maddison, P., Swana, G., Skinner, R. P., Swana, M., Jones, M., ...
Autoantibody profiles were examined in the sera of untreated patients with tuberculosis, and those with klebsiella septicaemia, and klebsiella and E. coli urinary tract infections. Rheumatoid factors...
Devey, M E, Bleasdale, K, Isenberg, D A
Significant differences in both the affinity and IgG subclass of antibodies produced after immunization with tetanus toxoid have been demonstrated in patients with systemic lupus erythematosus (SLE)...
Blanco, F, Kalsi, J, Isenberg, D A
The frequency and clinical associations of anti-RNA antibodies measured by ELISA were assessed in 138 patients with systemic lupus erythematosus (SLE). Of the sera from these patients 9.4% had...
Lymphocytes from patients with rheumatoid arthritis produce agalactosylated IgG in vitro.
Bodman, K B, Sumar, N, Mackenzie, L E, Isenberg, D A, Hay, F C, Roitt, I M, ...
The percentage of oligosaccharide chains lacking galactose was measured in IgG obtained from pokeweed mitogen-activated cultures of blood lymphocytes from patients with rheumatoid arthritis and...
Induction of adjuvant arthritis in mice.
Knight, B, Katz, D R, Isenberg, D A, Ibrahim, M A, Le Page, S, Hutchings, P, ...
Adjuvant arthritis, induced by injections of Freund's complete adjuvant into the footpads of some rat strains, has been recognized as a useful animal model for many years. There has, however, been...
Twomey, B M, McCallum, S, Isenberg, D A, Latchman, D S
During the phorbol myristate acetate (PMA)-induced differentiation of U937 cells to a macrophage-like phenotype, the levels of the heat shock proteins hsp90, hsp72 and hsp65 increased dramatically to...
Ehrenstein, M, Longhurst, C, Isenberg, D A
This study compares recently devised methods for producing IgG anti-DNA MoAbs from patients with SLE and analyses the antibodies generated from one patient at different phases of disease. Lymphocytes...
Localization of interferons and interleukin 2 in polymyositis and muscular dystrophy.
Isenberg, D A, Rowe, D, Shearer, M, Novick, D, Beverley, P C
Muscle biopsies from nine patients with polymyositis, six with muscular dystrophy, six with other muscle diseases and three controls have been studied with a panel of 10 monoclonal antibodies (MoAb)...
New therapies for rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease, which continues to cause significant morbidity in affected persons. In the past few years, a number of new exciting therapeutic...
New therapies for systemic lupus erythematosus
In the past 40 years, prognosis for patients with systemic lupus erythematosus (SLE) has improved, with 10-year survival now approximately 90%. This is due probably to a combination of earlier...
Green, M R J, Kennell, A S M, Larche, M J, Seifert, M H, Isenberg, D A, Salaman, M R
Natural killer (NK) cell cytotoxic activity and cell frequency, expressed as a percentage of total lymphocytes, have been determined in peripheral blood mononuclear cells from first-degree relatives...
Bourne, T, Zukowska-Cooper, M, Salaman, M R, Seifert, M H, Isenberg, D A
Cells spontaneously secreting IgG or IgM (ISC) are present at a high level in the blood of patients with systemic lupus erythematosus (SLE). By use of magnetic-bead techniques, mononuclear cells from...
Mockridge, C I, Chapman, C J, Spellerberg, M B, Sheth, B, Fleming, T P, Isenberg, D A, ...
SLE is an autoimmune disease characterized by the presence of autoantibodies against double-stranded (ds)DNA. A large proportion (approx. 40%) of patients with lupus also have increased levels of...
Pittoni, V, Ravirajan, C T, Donohoe, S, Machin, S J, Lydyard, P M, Isenberg, D A
The ability of an anti-phospholipid (LJ1) and an anti-β2-GPI (RSP-57) human MoAb to bind to apoptotic but not viable cells was demonstrated in this study. Both MoAbs were derived from patients with...
Tyrrell-Price, J, Lydyard, P M, Isenberg, D A
IL-10 and IL-12 are cytokines which are important in regulating immune responses. Plasma levels of IL-10 and autoantibodies against double-stranded DNA (dsDNA) often mirror disease activity in...
Mason, L J, Ravirajan, C T, Latchman, D S, Isenberg, D A
There are few studies assessing the pathogenicity of human monoclonal anti-DNA antibodies. The use of SCID mice avoids the problem of rejection of the human hybridoma cells thus allowing in vivo...
WILLIAMS, W M, WHALLEY, A S, COMACCHIO, R M, ROSENBERG, J, WATTS, R A, ISENBERG, D A, ...
Levels of autoantibodies specific for the histone, H2B, were measured in individuals with HIV infection. In comparison with normal (uninfected) controls, infected patients, particularly those with...
FcγRIIa polymorphism in systemic lupus erythematosus (SLE): no association with disease
BOTTO, M, THEODORIDIS, E, THOMPSON, E M, BEYNON, H L C, BRIGGS, D, ISENBERG, D A, ...
An allotypic variant of FcγRIIa, FcγRIIa-HR (FcγRIIa-R131), has been shown in vitroto reduce the capacity of phagocytic cells to bind and internalize IgG-containing immune complexes. Our aim was...
RAVIRAJAN, C T, SARRAF, C E, ANILKUMAR, T V, GOLDING, M C H, ALISON, M R, ISENBERG, D A
Apoptosis is a programmed cell death process that helps to regulate both T cell and B cell development. In this study, we have investigated the levels of apoptotic death in cells of the thymuses and...
Neurological involvement in the epidermal naevus syndrome.
McAuley, D L, Isenberg, D A, Gooddy, W
The case of a left handed girl aged 18 years suffering from the "epidermal maevus syndrome" is described. She presented with dysphasia, transient left hemiparesis, and sensory symptoms due to an...
Interleukin-10 activates heat-shock protein 90β gene expression
Ripley, B J M, Stephanou, A, Isenberg, D A, Latchman, D S
Elevated levels of the cytokine interleukin-10 (IL-10) have been reported in patients with active systemic lupus erythematosus (SLE). Any role for IL-10 in the pathogenesis of SLE is likely to...
Familial late onset oculopharyngeal muscular dystrophy.
An English family is described several members of which have suffered from oculopharyngeal muscular dystrophy. No symptoms were noticed in any affected members of the family until aged at least 50...
Osteosarcoma complicating familial Paget's disease.
Brenton, D. P., Isenberg, D. A., Bertram, J.
A most unusual family with aggressive Paget's disease is reported. Three brothers out of 10 siblings developed the disease at a relatively early age. Two of these brothers developed an osteosarcoma...
The distal form of spinal muscular atrophy: an unusual case demonstrating the intermediate variety
Isenberg, D. A., Kahn, Pauline A.
A 14-year-old boy with a long history of distal muscle weakness affecting primarily and predominantly the upper limbs is described. There is a family history of pes cavus and congenital dislocation...
Repeated B cell depletion in treatment of refractory systemic lupus erythematosus
Ng, K P, Leandro, M J, Edwards, J C, Ehrenstein, M R, Cambridge, G, Isenberg, D A
Treatment of inflammatory myopathies
Idiopathic inflammatory myopathies, notably polymyositis and dermatomyositis are comparatively uncommon diseases and few randomised, double blind placebo controlled trials have been done. Final...