The many facets of Internet topology and traffic (2006)
D. Alderson, H. Chang, M. Roughan, S. Uhlig, W. Willinger
ABSTRACT. The Internet’s layered architecture and organizational structure give rise to a number of different topologies, with the lower layers defining more physical and the higher layers more...
Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome (2003)
Lim, W., Hearle, N., Shah, B., Murday, V., Hodgson, S.V., Lucassen, A., ...
Germline mutations in the LKB1/STK11 tumour suppressor gene cause Peutz-Jeghers syndrome (PJS), a rare dominant disorder. In addition to typical hamartomatous gastrointestinal polyps and pigmented...
Vickery, C.W., Blazeby, J.M., Conroy, T., Arraras, J., Sezer, O., Koller, M., ...
Quality of life (QL) is an important outcome in clinical trials in oncology. There is currently no valid international QL measure for gastric cancer. This paper describes the development of a QL...
SSCL Phase 1 Inner Cable Development Program at IGC Advanced Superconductors, Inc. (1998)
Valaris, P., Kanithi, H., Alderson, D., Krahula, F., Wiegert, W.
For the sscl main ring dipole magnets nearly 1500 tons of 800 filament superconductor is required. one of the three subcontractors in the present sscl development program, who are qualifying to...
Two phase III trials of tauromustine (TCNU) in advanced colorectal cancer (1995)
Smyth, J. F., Hardcastle, J. D., Denton, G., Alderson, D., Grace, R. H., Mansi, J. L., ...
Primary yolk sac tumour of the liver in adulthood.
Wong, N A, D'Costa, H, Barry, R E, Alderson, D, Moorghen, M
Primary yolk sac tumour of the liver is exceedingly rare. A 28 year old woman presented with a cystic liver mass and a markedly raised serum alpha-fetoprotein concentration. She underwent a partial...
c-erbB-2 overexpression in the dysplasia/carcinoma sequence of Barrett's oesophagus.
Hardwick, R H, Shepherd, N A, Moorghen, M, Newcomb, P V, Alderson, D
AIMS--To investigate overexpression of the oncoprotein c-erbB-2 in the dysplasia/carcinoma sequence of Barrett's columnar-lined oesophagus (CLO). METHODS--Immunohistochemical staining was performed...
Endoscopic sphincterotomy before pancreaticoduodenectomy for ampullary carcinoma.
Alderson, D, Lavelle, M I, Venables, C W
Pancreaticoduodenectomy remains the operation of choice for carcinoma of the ampulla of Vater, but the presence of severe jaundice in almost all patients with ampullary neoplasia is a major...
Primary yolk sac tumour of the liver in adulthood.
Wong, N A, D'Costa, H, Barry, R E, Alderson, D, Moorghen, M
Primary yolk sac tumour of the liver is exceedingly rare. A 28 year old woman presented with a cystic liver mass and a markedly raised serum alpha-fetoprotein concentration. She underwent a partial...
c-erbB-2 overexpression in the dysplasia/carcinoma sequence of Barrett's oesophagus.
Hardwick, R H, Shepherd, N A, Moorghen, M, Newcomb, P V, Alderson, D
AIMS--To investigate overexpression of the oncoprotein c-erbB-2 in the dysplasia/carcinoma sequence of Barrett's columnar-lined oesophagus (CLO). METHODS--Immunohistochemical staining was performed...
Endoscopic sphincterotomy before pancreaticoduodenectomy for ampullary carcinoma.
Alderson, D, Lavelle, M I, Venables, C W
Pancreaticoduodenectomy remains the operation of choice for carcinoma of the ampulla of Vater, but the presence of severe jaundice in almost all patients with ampullary neoplasia is a major...
Barham, C P, Gotley, D C, Miller, R, Mills, A, Alderson, D
Previous studies of the mechanisms that precipitate acid reflux episodes and acid clearance have used unphysiological, short term hospital based data. A new 24 hour pH and motility recording system...
Hardwick, R H, Shepherd, N A, Moorghen, M, Newcomb, P V, Alderson, D
Adenocarcinoma arising in Barrett's oesophagus is often preceded by mucosal dysplasia, but little is currently known about the aetiology or natural history of this dysplasia/carcinoma sequence. To...
Barham, C P, Gotley, D C, Mills, A, Alderson, D
Previous studies of the mechanisms that precipitate acid reflux episodes have used short term hospital based measurements. A 24 hour pH and motility recording system, incorporating a sphincter...
Quality of life measurement in patients with oesophageal cancer.
Blazeby, J M, Williams, M H, Brookes, S T, Alderson, D, Farndon, J R
Quality of life (QOL) measurement may aid decision making in the treatment of patients with oesophageal cancer but must be clinically valid to be useful. This study considered if the European...
Griffin, S M, Alderson, D, Farndon, J R
Conventional treatment of pancreatic steatorrhoea in man has been unsatisfactory because 90% of the lipase content of therapy is inactivated by acid in the stomach and large doses of replacement...
Arul, G, Moorghen, M, Myerscough, N, Alderson, D, Spicer, R, Corfield, A
BACKGROUND AND AIMS—Mucin genes are expressed in a site specific manner throughout the gastrointestinal tract. Little is known about the expression pattern in the oesophagus. In this study we have...
The prognostic value of quality of life scores during treatment for oesophageal cancer
Blazeby, J, Brookes, S, Alderson, D
BACKGROUND—Quality of life (QL) data are useful to evaluate the effectiveness of treatment. Accumulating evidence suggests that QL data may predict survival. AIMS—In this study we investigated...
Diffuse oesophageal spasm: diagnosis by ambulatory 24 hour manometry
Barham, C, Gotley, D, Fowler, A, Mills, A, Alderson, D
University Department of Surgery, Bristol Royal Infirmary, UK
King, P M, Blazeby, J M, Gupta, J, Alderson, D, Moorghen, M
Aims: Accurate pathological (pTNM) staging of oesophageal and gastric cancer provides important prognostic information. The aim of this study was to compare the standard of pathology reporting of...