D. B. Lubahn

Publication List Details

Period

1991 - 2009

Number

24

Co-Authors

The Androgen Receptor Gene Is Located on a Highly Conserved Region of the X Chromosomes of Marsupial and Monotreme as well as Eutherian Mammals (1991)

Spencer, J. A., Watson, J. M., Lubahn, D. B., Joseph, D. R., French, F. S., Wilson, E. M., ...

The androgen receptor gene (AR), which is located on the long arm of the human X chromosome, was mapped by somatic cell analysis and in situ hybridization in marsupial and monotreme species. Both...

Increased adipose tissue in male and female estrogen receptor-α knockout mice

Heine, P. A., Taylor, J. A., Iwamoto, G. A., Lubahn, D. B., Cooke, P. S.

Estrogen regulates the amount of white adipose tissue (WAT) in females, but its role in males and whether WAT effects involve estrogen receptor-α (ERα) or ERβ were unclear. We analyzed the role of...

Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium

Cooke, P. S., Buchanan, D. L., Young, P., Setiawan, T., Brody, J., Korach, K. S., ...

Estradiol-17β (E2) acts through the estrogen receptor (ER) to regulate uterine growth and functional differentiation. To determine whether E2 elicits epithelial mitogenesis through epithelial ER...

Estrogen receptor-dependent sexual differentiation of dopaminergic neurons in the preoptic region of the mouse

Simerly, R. B., Zee, M. C., Pendleton, J. W., Lubahn, D. B., Korach, K. S.

Although it has been known for some time that estrogen exerts a profound influence on brain development a definitive demonstration of the role of the classical estrogen receptor (ERα) in sexual...

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

Lubahn, D B, Moyer, J S, Golding, T S, Couse, J F, Korach, K S, Smithies, O

Estrogen receptor and its ligand, estradiol, have long been thought to be essential for survival, fertility, and female sexual differentiation and development. Consistent with this proposed crucial...

Deletion of the steroid-binding domain of the human androgen receptor gene in one family with complete androgen insensitivity syndrome: evidence for further genetic heterogeneity in this syndrome.

Brown, T R, Lubahn, D B, Wilson, E M, Joseph, D R, French, F S, Migeon, C J

The cloning of a cDNA for the human androgen receptor gene has resulted in the availability of cDNA probes that span various parts of the gene, including the entire steroid-binding domain and part of...

Identification of androgen receptors in normal human osteoblast-like cells.

Colvard, D S, Eriksen, E F, Keeting, P E, Wilson, E M, Lubahn, D B, French, F S, ...

The sex steroids, androgens and estrogens, are major regulators of bone metabolism. However, whether these hormones act on bone cells through direct or indirect mechanisms has remained unclear. A...

Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity.

Lubahn, D B, Brown, T R, Simental, J A, Higgs, H N, Migeon, C J, Wilson, E M, ...

Androgens act through a receptor protein (AR) to mediate sex differentiation and development of the male phenotype. We have isolated the eight exons in the amino acid coding region of the AR gene...

A steroid/thyroid hormone receptor superfamily member in Drosophila melanogaster that shares extensive sequence similarity with a mammalian homologue.

Henrich, V C, Sliter, T J, Lubahn, D B, MacIntyre, A, Gilbert, L I

A gene in Drosophila melanogaster that maps cytologically to 2C1-3 on the distal portion of the X-chromosome encodes a member of the steroid/thyroid hormone receptor superfamily. The gene was...

Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. Gender difference and effect of estrogen receptor gene disruption.

Rubanyi, G M, Freay, A D, Kauser, K, Sukovich, D, Burton, G, Lubahn, D B, ...

The present study was designed to test the hypothesis that estrogen receptors (ER) in the blood vessel wall play a role in the modulation of the release of endothelium-derived nitric oxide (EDNO)....

Population genetics of coagulant factor IX: frequencies of two DNA polymorphisms in five ethnic groups.

Lubahn, D B, Lord, S T, Bosco, J, Kirshtein, J, Jeffries, O J, Parker, N, ...

Two frequently used restriction-enzyme polymorphisms (RFLPs) of coagulant F.IX, TaqI and XmnI, have been examined in five ethnic groups: white Americans, black Americans, East Indians, Chinese, and...

Increased adipose tissue in male and female estrogen receptor-α knockout mice

Heine, P. A., Taylor, J. A., Iwamoto, G. A., Lubahn, D. B., Cooke, P. S.

Estrogen regulates the amount of white adipose tissue (WAT) in females, but its role in males and whether WAT effects involve estrogen receptor-α (ERα) or ERβ were unclear. We analyzed the role of...

Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium

Cooke, P. S., Buchanan, D. L., Young, P., Setiawan, T., Brody, J., Korach, K. S., ...

Estradiol-17β (E2) acts through the estrogen receptor (ER) to regulate uterine growth and functional differentiation. To determine whether E2 elicits epithelial mitogenesis through epithelial ER...

Estrogen receptor-dependent sexual differentiation of dopaminergic neurons in the preoptic region of the mouse

Simerly, R. B., Zee, M. C., Pendleton, J. W., Lubahn, D. B., Korach, K. S.

Although it has been known for some time that estrogen exerts a profound influence on brain development a definitive demonstration of the role of the classical estrogen receptor (ERα) in sexual...

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

Lubahn, D B, Moyer, J S, Golding, T S, Couse, J F, Korach, K S, Smithies, O

Estrogen receptor and its ligand, estradiol, have long been thought to be essential for survival, fertility, and female sexual differentiation and development. Consistent with this proposed crucial...

Deletion of the steroid-binding domain of the human androgen receptor gene in one family with complete androgen insensitivity syndrome: evidence for further genetic heterogeneity in this syndrome.

Brown, T R, Lubahn, D B, Wilson, E M, Joseph, D R, French, F S, Migeon, C J

The cloning of a cDNA for the human androgen receptor gene has resulted in the availability of cDNA probes that span various parts of the gene, including the entire steroid-binding domain and part of...

Identification of androgen receptors in normal human osteoblast-like cells.

Colvard, D S, Eriksen, E F, Keeting, P E, Wilson, E M, Lubahn, D B, French, F S, ...

The sex steroids, androgens and estrogens, are major regulators of bone metabolism. However, whether these hormones act on bone cells through direct or indirect mechanisms has remained unclear. A...

Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity.

Lubahn, D B, Brown, T R, Simental, J A, Higgs, H N, Migeon, C J, Wilson, E M, ...

Androgens act through a receptor protein (AR) to mediate sex differentiation and development of the male phenotype. We have isolated the eight exons in the amino acid coding region of the AR gene...

A steroid/thyroid hormone receptor superfamily member in Drosophila melanogaster that shares extensive sequence similarity with a mammalian homologue.

Henrich, V C, Sliter, T J, Lubahn, D B, MacIntyre, A, Gilbert, L I

A gene in Drosophila melanogaster that maps cytologically to 2C1-3 on the distal portion of the X-chromosome encodes a member of the steroid/thyroid hormone receptor superfamily. The gene was...

Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. Gender difference and effect of estrogen receptor gene disruption.

Rubanyi, G M, Freay, A D, Kauser, K, Sukovich, D, Burton, G, Lubahn, D B, ...

The present study was designed to test the hypothesis that estrogen receptors (ER) in the blood vessel wall play a role in the modulation of the release of endothelium-derived nitric oxide (EDNO)....

Population genetics of coagulant factor IX: frequencies of two DNA polymorphisms in five ethnic groups.

Lubahn, D B, Lord, S T, Bosco, J, Kirshtein, J, Jeffries, O J, Parker, N, ...

Two frequently used restriction-enzyme polymorphisms (RFLPs) of coagulant F.IX, TaqI and XmnI, have been examined in five ethnic groups: white Americans, black Americans, East Indians, Chinese, and...

Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism.

Brown, C J, Goss, S J, Lubahn, D B, Joseph, D R, Wilson, E M, French, F S, ...

The gene for the androgen receptor, mutations at which cause the X-linked androgen insensitivity syndrome, has been localized to the q11----q12 region of the human X chromosome by analysis, using a...

Dietary soy phytoestrogens and ERα signalling modulate interferon gamma production in response to bacterial infection

CURRAN, E M, JUDY, B M, NEWTON, L G, LUBAHN, D B, ROTTINGHAUS, G E, MACDONALD, R S, ...

Diets rich in soy phytoestrogens have many potential health benefits but isoflavones such as genistein may suppress cell mediated immune function. The effect of dietary phytoestrogens on the host...