Scientific Commons: D. Baeten

Objective: A genetic variant of the toll-like receptor (TLR) 2/4 adaptor protein TIRAP (single nucleotide polymorphism (SNP) C539T) was identified in a UK and in several African populations. The...

A functional variant of TIR-domain-containing adaptor protein (TIRAP) is not associated with spondyloarthritis (2008)

Cantaert, T., Stone, M., Ter Borg, M., De Vries, N., Wilson, A., Tak, P., ...

Citrullination in extra-articular manifestations of rheumatoid arthritis (2007)

Bongartz, T., Cantaert, T., Atkins, S. R., Harle, P., Myers, J. L., Turesson, C., ...

Background. Anti-citrullinated protein antibodies have been detected with high specificity in serum of patients with rheumatoid arthritis (RA), and citrullination of proteins may play a key role in...

Standardisation of synovial tissue infiltrate analysis: how far have we come? how much further do we need to go? (2006)

Smith , M.D., Baeten, D., Ulfgren , A.K., McInnes , I.B., Fitzgerald, O., Bresnihan , B., ...

Synovial inflammation does not change in the absence of effective treatment: implications for the use of synovial histopathology as biomarker in early phase clinical trials in rheumatoid arthritis (2006)

Baeten , D., Houbiers, J., Kruithof, E., Vandooren, B., Bosch, F. Van Den, Boots, A.M., ...

Myelin oligodendrocyte glycoprote in-specific T and B cells cooperate to induce a Devic-like disease in mice (2006)

Bettelli, E., Baeten, D., Jager, A., Sobel, R.A., Kuchroo, V.K.

Myelin oligodendrocyte glycoprote in-specific T and B cells cooperate to induce a Devic-like disease in mice (2006)

Bettelli, E., Baeten, D., Jager, A., Sobel, R.A., Kuchroo, V.K.

Distinct synovial immunopathologic characteristics of juvenile-onset spondylarthritis and other forms of juvenile idiopathic arthritis (2006)

Kruithof, E., Bossche, V. Van Den, Rycke, L. De, Vandooren, B., Joos, R., Canete, J.D., ...

Objective. To characterize the synovial immunopathologic features of juvenile-onset spondylarthritis (SpA) in relation to adult SpA and other forms of juvenile idiopathic arthritis (JIA). Methods....

Identification of synovial biomarkers of response to experimental treatment in early-phase clinical trials in spondylarthritis (2006)

Kruithof, E., Rycke, L. De, Vandooren, B., Keyser, F. De, FitzGerald, O., McInnes, I., ...

Objective. To identify biomarkers for effective treatment in early-phase clinical trials of spondyl-arthritis (SpA), by analyzing which synovial features can be reliably identified in patients with...

A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis (2006)

Haringman, J.J., Gerlag, D.M., Smeets, T.J.M., Baeten, D., Bosch, F. V.d., Bresnihan, B., ...

Objective. Chemokines such as CCL2/monocyte chemotactic protein 1 (MCP-1) play a key role in leukocyte migration and are potential targets in the treatment of chronic inflammatory disorders. The...

Citrullinated proteins in rheumatoid arthritis - Crucial ... but not sufficient! (2006)

Cantaert, T., Rycke, L. De, Bongartz, T., Matteson, E.L., Tak, P.P., Nicholas, A.P., ...

Ankylosing spondylitis and bowel disease (2006)

Rudwaleit, M., Baeten, D.

Between 5 and 10% of cases of ankylosing spondylitis (AS) are associated with inflammatory bowel disease (IBD), either Crohn's disease or ulcerative colitis. A much larger percentage of AS patients...

Phenotypically and functionally distinct CD8(+) lymphocyte populations in long-term drug-free tolerance and chronic rejection in human kidney graft recipients (2006)

Baeten, D., Louis, S., Braud, C., Braudeau, C., Ballet, C., Moizant, F., ...

A substantial proportion of long-term kidney graft recipients, including those with a stable renal function in the absence of immunosuppressive therapy, present a skewed T cell receptor (TCR) V beta...

Standardisation of synovial tissue infiltrate analysis: how far have we come? how much further do we need to go? (2006)

Smith, M.D., Baeten, D., Ulfgren, A.K., McInnes, I.B., FitzGerald, O., Bresnihan, B., ...

Changes in cellular infiltrate and expression of cytokines, chemokines, and cell adhesion molecules as a result of therapeutic interventions in rheumatoid arthritis can be demonstrated in the...

Citrullination in extra-articular manifestations of rheumatoid arthritis (2006)

Bongartz, T., Cantaert, T., Atkins, S. R., Harle, P., Myers, J. L., Turesson, C., ...

Background. Anti-citrullinated protein antibodies have been detected with high specificity in serum of patients with rheumatoid arthritis (RA), and citrullination of proteins may play a key role in...

Citrullination in extra-articular manifestations of rheumatoid arthritis (2006)

Bongartz, T., Cantaert, T., Atkins, S. R., Harle, P., Myers, J. L., Turesson, C., ...

Background. Anti-citrullinated protein antibodies have been detected with high specificity in serum of patients with rheumatoid arthritis (RA), and citrullination of proteins may play a key role in...

Synovial histopathology of psoriatic arthritis, both oligo- and polyarticular, resembles spondyloarthropathy more than it does rheumatoid arthritis (2005)

Kruithof, E, Baeten, D, De Rycke, L, Vandooren, B, Foell, D, Roth, J, ...

At present only few biological data are available to indicate whether psoriatic arthritis (PsA) is part of the spondyloarthropathy (SpA) concept, whether it is a separate disease entity or a...

Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy (2005)

Baeten, D, Kruithof, E, De Rycke, L, Boots, A, Mielants, H, Veys, E, ...

Considering the relation between synovial inflammation and global disease activity in rheumatoid arthritis (RA) and the distinct but heterogeneous histology of spondyloarthropathy (SpA) synovitis,...

Synovial tissue analysis in clinical trials (2005)

Bresnihan, B., Baeten, D., Firestein, G.S., FitzGerald, O.M., Gerlag, D.M., Haringman, J.J., ...

Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis (2005)

Haringman, J.J., Gerlag, D., Zwinderman, A.H., Smeets, T.J.M., Kraan, M.C., Baeten, D., ...

Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis (2005)

Haringman, J.J., Gerlag, D., Zwinderman, A.H., Smeets, T.J.M., Kraan, M.C., Baeten, D., ...

The presence of deiminated fibrin in the synovial membrane is not specific for rheumatoid arthritis (2004)

Chapuy-Regaud, S, Sebbag, M, Baeten, D, Clavel, C, De Keyser, F, Serre, G

No abstract available.

Differential expression and response to infliximab treatment of specific macrophage subsets in inflammatory synovitis (2004)

De Rycke, L, Baeten, D, Foell, D, Kruithof, E, Veys, EM, Roth, J, ...

No abstract available.

The effect of infliximab on skin lesions in a patient with scleroderma (CREST) (2004)

De Rycke, L, Baeten, D, Mielants, H, De Keyser, F, Veys, EM

No abstract available.

Serum MRP8/MRP14 as a biomarker for inflammation in autoimmune arthritis (2004)

De Rycke, L, Baeten, D, Foell, D, Kruithof, E, Veys, EM, Roth, J, ...

No abstract available.

De Rycke, L, Baeten, D, Foell, D, Veys, EM, De Keyser, F, Roth, J

No abstract available.

Local production of soluble CD163 in the spondyloarthropathic joint (2003)

Baeten, D, Møller, HJ, Delanghe, J, Veys, EM, Moestrup, SK, De Keyser, F

No abstract available.

The diagnostic value of synovial histopathology in undifferentiated inflammatory arthritis: a prospective study in 154 consecutive patients (2003)

Baeten, D, Kruithof, E, Hoffman, IEA, De Rycke, L, Vandooren, B, Veys, EM, ...

No abstract available.

Localisation of MHC Class II/HC gp-39 complexes in synovia of rheumatoid arthritis patients using complex-specific monoclonal antibodies (2003)

Baeten, D, Steenbakkers, PGA, Rovers, E, Veys, EM, Rijnders, AMW, Meijerink, J, ...

No abstract available.

The presentation of the immunodominant epitope of HC gp-39 in the context of the RA-associated HLA class II molecules is specific for RA synovium (2003)

Baeten, D, Steenbakkers, P, Boots, A, Veys, EM, De Keyser, F

No abstract available.

Peptidylarginine deiminase isoforms expressed in the synovial membrane of rheumatoid arthritis patients (2003)

Chapuy-Regaud, S, Sebbag, M, Nachat, R, Baeten, D, Foulquier, V, Simon, M, ...

No abstract available.

The use of neural network algorithms for the classification of undifferentiated arthritis by synovial histopathology (2003)

Baeten, D, Wyns, B, Hoffman, I, Sette, S, Boullart, L, De Keyser, F

No abstract available.

Dynamic T cell receptor clonotype changes in synovial tissue of patients with early rheumatoid arthritis: Effects of treatment with cyclosporin A (Neoral (R)) (2002)

Vanderborght, A, De Keyser, F, De Backer, M, Malaise, M, Baeten, D, ...

Objective. To study T cell receptor (TCR) repertoire changes in synovial membrane over a 16 week period in patients with early rheumatoid arthritis (RA); and to study the influence of cyclosporin A...

Dynamic T cell receptor clonotype changes in synovial tissue of patients with early rheumatoid arthritis: Effects of treatment with cyclosporin A (Neoral (R)) (2002)

Vanderborght, A, De Keyser, F, De Backer, M, Malaise, M, Baeten, D, ...

Objective. To study T cell receptor (TCR) repertoire changes in synovial membrane over a 16 week period in patients with early rheumatoid arthritis (RA); and to study the influence of cyclosporin A...

Dynamic T cell receptor clonotype changes in synovial tissue of patients with early rheumatoid arthritis: Effects of treatment with cyclosporin A (Neoral (R)) (2002)

De Keyser, F, Geusens, P, De Backer, Manu; U0039058, Malaise, M, Baeten, D, ...

Objective. To study T cell receptor (TCR) repertoire changes in synovial membrane over a 16 week period in patients with early rheumatoid arthritis (RA); and to study the influence of cyclosporin A...

A 588-gene microarray analysis of the peripheral blood mononuclear cells of spondyloarthropathy patients (2002)

Gu, J., Märker-Hermann, E., Baeten, D., Tsai, W. C., Gladman, D., Xiong, M., ...

Objectives. To identify genes which are more highly expressed in the peripheral blood mononuclear cells (PBMC) of patients with spondyloarthropathy (SpA), rheumatoid arthritis...

Macrophages expressing the scavenger receptor CD163: a link between immune alterations of the gut and synovial inflammation in spondyloarthropathy (2001)

Baeten, D, Demetter, P, Cuvelier, C, Kruithof, E, Van Damme, N, De Vos, M, ...

No abstract available.

Increased number of macrophages in non-inflamed colon of patients with spondyloarthropathy a human model of early Crohn's disease (2000)

De Vos, M, De Keyser, F, Baeten, D, Van Damme, N, ...

Crohn's disease and ulcerative colitis show different distribution patterns of CD83 positive dendritic cells. (1999)

Demetter, Pieter, DE VOS, M, VAN DAMME, N, BAETEN, D, MIELANTS, H, LELIE, B, ...

Inflammatory bowel disease and subclinical gut inflammation in spondyloarthropathy patients are associated with increased expression of the E-cadherin/catenin complex. (1999)

Demetter, Pieter, DE VOS, M, BAETEN, D, VAN DAMME, N, DE KEYSER, F, ELEWAUT, D, ...

Inflammatory bowel disease and subclinical gut inflammation in spondyloarthropathy patients are associated with increased expression of the E-cadherin/catenin complex. (1999)

Demetter, Pieter, DE VOS, M, BAETEN, D, VAN DAMME, N, DE KEYSER, F, ELEWAUT, D, ...

Intestinal mucosa of patients with spondyloarthropathy is enriched with T cells carrying alpha E beta 7 integrin, even in the absence of histologically defined inflammation. (1999)

ELEWAUT, D, VAN DAMME, N, BAETEN, D, Demetter, Pieter, SAS, S, DE VOS, M, ...

Effects of chemical agents and enzymes on lymphocyte surface markers. (1999)

VAN DAMME, N, BAETEN, D, DE VOS, M, Demetter, Pieter, ELEWAUT, D, MIELANTS, H, ...

T cell cytokines in gut mucosa of patients with spondyloarthropathy reflect immune alterations in Crohn's disease. (1999)

VAN DAMME, N, DE VOS, M, BAETEN, D, Demetter, Pieter, ELEWAUT, D, Cuvelier, Claude, ...

Altered expression of alpha E beta 7 integrin on intra-epithelial and lamina propria lymphocytes in patients with Crohn's disease. (1998)

Elewaut, Dirk, Van Damme, Nancy, De Keyser, Filip, BAETEN, D, De Paepe, Pascale, Van Vlierberghe, Hans, ...

In-reactor digestion of solid wastes (1993)

BAETEN, D, Verstraete, Willy

In-reactor anaerobic digestion of MSW-organics (1993)

BAETEN, D, Verstraete, Willy

In-reactor digestion of solid wastes (1992)

BAETEN, D, Verstraete, Willy

A comparative phenotypical analysis of rheumatoid nodules and rheumatoid synovium with special reference to adhesion molecules and activation markers

Elewaut, D., De Keyser, F., De Wever, N., Baeten, D., Van Damme, N., Verbruggen, G., ...

OBJECTIVES—(1)To analyse the in situ expression of adhesion molecules in rheumatoid nodules. (2) To compare the endothelial expression of adhesion molecules in synovial tissue and subcutaneous...

Comparative study of the synovial histology in rheumatoid arthritis, spondyloarthropathy, and osteoarthritis: influence of disease duration and activity

Baeten, D, Demetter, P, Cuvelier, C, Kruithof, E, Van Damme, N, ...

OBJECTIVES—To compare the macroscopic and microscopic characteristics of synovial tissue in rheumatoid arthritis (RA), spondyloarthropathy (SpA), and osteoarthritis (OA) after exclusion of possible...

Subclinical gut inflammation in spondyloarthropathy patients is associated with upregulation of the E-cadherin/catenin complex

Demetter, P, Baeten, D, De Keyser, F, De Vos, M, Van Damme, N, Verbruggen, G, ...

OBJECTIVE—Previously an upregulation of E-cadherin and its associated molecules α-catenin, β-catenin and plakoglobin has been demonstrated in clinically overt inflammatory bowel disease (IBD)....

Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor α (infliximab) in spondyloarthropathy: an open pilot study

Kruithof, E., Baeten, D., De Keyser, F., Mielants, H., Veys, E.

OBJECTIVE—To evaluate the efficacy and safety of a loading dose regimen of three intravenous infusions with infliximab in patients with active spondyloarthropathy. METHODS—A monocentre,...

Flow cytometric analysis of gut mucosal lymphocytes supports an impaired Th1 cytokine profile in spondyloarthropathy

Van Damme, N, De Vos, M, Baeten, D, Demetter, P, Mielants, H, Verbruggen, G, ...

OBJECTIVE—To quantify the fraction of gut mucosal lymphocytes expressing the T helper type 1 (Th1) cytokines, interferon γ (IFNγ) and interleukin (IL)2, and the Th2 cytokines, IL4 and IL10, at...

Impaired Th1 cytokine production in spondyloarthropathy is restored by anti-TNFα

Baeten, D, Van Damme, N, Kruithof, E, De Vos, M, Mielants, H, ...

OBJECTIVES—To evaluate the effect of anti-TNFα on the Th1 and Th2 cytokines in patients with spondyloarthropathy (SpA). METHODS—Peripheral blood mononuclear cells (PBMC) were obtained from...

Culture of chondrocytes in alginate surrounded by fibrin gel: characteristics of the cells over a period of eight weeks

Almqvist, K, Wang, L, Wang, J, Baeten, D, Cornelissen, M, Verdonk, R, ...

OBJECTIVE—To produce tissue engineered cartilage by human articular chondrocytes in vitro for further use in in vivo manipulations for the treatment of cartilage defects. METHODS—Human...

Repeated infusions of infliximab, a chimeric anti-TNFα monoclonal antibody, in patients with active spondyloarthropathy: one year follow up

Kruithof, E, Baeten, D, Herssens, A, De Keyser, F, Mielants, H, ...

Background: In a pilot study, the anti-tumour necrosis factor α monoclonal antibody, infliximab, induced a rapid and significant improvement in global, peripheral, and axial disease manifestations...

Tenosynovitis with acute onset: unexpected giant cell tumour of the tendon sheath

Kruithof, E, Baeten, D, Dierckxsens, P, Veys, E, De Keyser, F

Systematic safety follow up in a cohort of 107 patients with spondyloarthropathy treated with infliximab: a new perspective on the role of host defence in the pathogenesis of the disease?

Baeten, D, Kruithof, E, Herssens, A, Mielants, H, ...

Background: Recent studies with infliximab indicate the therapeutic potential of tumour necrosis factor α blockade in spondyloarthropathy (SpA). Because defective host defence is implicated in the...

Case Number 29: Ochronosis: synovial histopathological characteristics

Kruithof, E, Baeten, D, Veys, E, De Keyser, F, Suykens, S, De Wilde, L, ...

Treatment of active spondyloarthropathy with infliximab, the chimeric monoclonal antibody to tumour necrosis factor α

Baeten, D, Kruithof, E, De Keyser, F, Mielants, H, Veys, E

Tumour necrosis factor α independent disease mechanisms in rheumatoid arthritis: a histopathological study on the effect of infliximab on rheumatoid nodules

Baeten, D, De Keyser, F, Veys, E, Theate, Y, Houssiau, F, Durez, P

Background: It has been suggested that the immunopathology of rheumatoid nodules parallels that of inflamed synovium in rheumatoid arthritis (RA).

Technical validation of cDNA based microarray as screening technique to identify candidate genes in synovial tissue biopsy specimens from patients with spondyloarthropathy

Rihl, M, Baeten, D, Seta, N, Gu, J, De Keyser, F, Veys, E, ...

Objectives: To validate the use of cDNA based microarray on synovial biopsies by analysing the experimental variability due to amplification of RNA, reproducibility of the assay, heterogeneity of the...

The proportion of Th1 cells, which prevail in gut mucosa, is decreased in inflammatory bowel syndrome

Van Damme, N, De Keyser, F, Demetter, P, Baeten, D, Mielants, H, Verbruggen, G, ...

T lymphocytes and their cytokines have an important role in the regulation of immune responses in the gut and in the pathogenesis of intestinal inflammation such as in Crohn's disease. The aim of...

Alpha beta but not gamma delta T cell clones in synovial fluids of patients with reactive arthritis show active transcription of tumour necrosis factor α and interferon γ

Rihl, M, Gu, J, Baeten, D, Marker-Hermann, E, Goodall, J, Gaston, J, ...

Methods: Complementary DNA based microarrays containing the specific sequence of 56 cytokine transcripts were used for screening. Selected genes were confirmed by reverse transcriptase-polymerase...

Colon mucosa of patients both with spondyloarthritis and Crohn's disease is enriched with macrophages expressing the scavenger receptor CD163

Demetter, P, De Vos, M, Van Huysse, J A, Baeten, D, Ferdinande, L, Peeters, H, ...

Objective: To investigate macrophages and other antigen presenting cells in gut mucosa from patients with SpA and Crohn's disease, given the relationship between both entities.

Histological evidence that infliximab treatment leads to downregulation of inflammation and tissue remodelling of the synovial membrane in spondyloarthropathy

Kruithof, E, Baeten, D, Mielants, H, Veys, E, De Keyser, F

Objective: To confirm and extend the immunopathological evidence of effects of infliximab on the synovium in active spondyloarthropathy.

Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis

Haringman, J, Gerlag, D, Zwinderman, A, Smeets, T, Kraan, M, Baeten, D, ...

Background: Previous work identified synovial sublining macrophage numbers as a potential biomarker for clinical efficacy in rheumatoid arthritis.

Anti-citrullinated peptide antibodies may occur in patients with psoriatic arthritis

Vander, C, Hoffman, I, Zmierczak, H, Kruithof, E, De Rycke, L, ...

Background: Anti-cyclic citrullinated peptide (anti-CCP) antibodies are considered highly specific markers of rheumatoid arthritis. Despite the high specificity of the test, anti-CCP antibodies have...

Functional haplotypes of PADI4: relevance for rheumatoid arthritis specific synovial intracellular citrullinated proteins and anticitrullinated protein antibodies

Cantaert, T, Coucke, P, De Rycke, L, Veys, E, De Keyser, F, Baeten, D

Background: Haplotypes of PADI4, encoding for a citrullinating enzyme, were associated with rheumatoid arthritis in a Japanese population. It was suggested they were related to the presence of...

Involvement of neurotrophins and their receptors in spondyloarthritis synovitis: relation to inflammation and response to treatment

Rihl, M, Kruithof, E, Barthel, C, De Keyser, F, Veys, E, Zeidler, H, ...

Objective: To investigate whether expression of the four members of the neurotrophin (NT) family and their four corresponding receptors is related to synovial inflammation in patients with...

Standardisation of synovial tissue infiltrate analysis: how far have we come? how much further do we need to go?

Smith, M D, Baeten, D, Ulfgren, A‐K, McInnes, I B, Fitzgerald, O, Bresnihan, B, ...

Changes in cellular infiltrate and expression of cytokines, chemokines, and cell adhesion molecules as a result of therapeutic interventions in rheumatoid arthritis can be demonstrated in the...

Altered expression of ocE-ß7 integrin on intra-epithelial and lamina propria lymphocytes in patients with Crohn's disease. Acta Gastroenterol,61,1998,288-294.

ELEWAUT, D, VAN DAMME, N, DE KEYSER, F, BAETEN, D, DE PAEPE, P, Van Vlierberghe, Hans, ...

Synovial inflammation does not change in the absence of effective treatment: implications for the use of synovial histopathology as biomarker in early phase clinical trials in rheumatoid arthritis

Baeten, D, Houbiers, J, Kruithof, E, Vandooren, B, Boots, A M, ...

D. Baeten

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