Donnelly, S. C., Haslett, C., Strieter, Robert M., Kunkel, Steven L., Walz, Alfred, Robertson, C. R., ...
Neutrophils have been implicated in the pathogenesis of the adult respiratory distress syndrome (ARDS). We have measured concentrations of the neutrophil attractant interleukin-8 in blood and...
Tectonic evolution of Northern Anglesey. (1988)
2 vols.; vol. 2 of this thesis has not been filmed; Please apply direct to the issuing university.
He, X M, Rüker, F, Casale, E, Carter, D C
The three-dimensional structure of a human monoclonal antibody (Fab), which binds specifically to a major epitope of the transmembrane protein gp41 of the human immunodeficiency virus type 1, has...
O'Riordain, M G, Fearon, K C, Ross, J A, Rogers, P, Falconer, J S, Bartolo, D C, ...
OBJECTIVE: The authors determined the effect of glutamine-supplementation of TPN on postoperative peripheral blood T-cell response and proinflammatory cytokine production in patients undergoing...
John, T G, Greig, J D, Carter, D C, Garden, O J
OBJECTIVE: The authors performed a prospective evaluation of staging laparoscopy with laparoscopic ultrasonography in predicting surgical resectability in patients with carcinomas of the pancreatic...
Falconer, J S, Fearon, K C, Plester, C E, Ross, J A, Carter, D C
OBJECTIVE: To determine whether resting energy expenditure (REE) is increased in cachectic patients with pancreatic cancer and to define the relation of tumor necrosis factor (TNF) and interleukin-6...
Blamey, S L, Osborne, D H, Gilmour, W H, O'Neill, J, Carter, D C, Imrie, C W
Early differentiation of gallstone from nongallstone associated acute pancreatitis by imaging methods is often difficult. Timing of surgery in gallstone pancreatitis is controversial, but early...
Despite recent advances in the delivery of nutritional support, cachexia continues to contribute to the morbidity and mortality of cancer patients. This impasse has called for a review of the many...
MacLeod, I A, Mills, P R, MacKenzie, J F, Joffe, S N, Russell, R I, Carter, D C
A prospective single blind controlled trial was performed to assess the efficacy of the neodymium yttrium aluminium garnet laser in the management of patients bleeding from peptic ulcers and single...
Crystals of cadmium, zinc metallothionein.
Melis, K A, Carter, D C, Stout, C D, Winge, D R
Single crystals have been grown of Cd,Zn metallothionein isoform II from rat liver. The space group is P41212(P43212) with unit cell dimensions a = b = 31.0 A and c = 120.0 A, and one molecule in the...
Effect of Orally Administered Prostaglandin E2 and its 15-Methyl Analogues on Gastric Secretion
Karim, S. M. M., Carter, D. C., Bhana, D., Ganesan, P. Adaikan
The effect of orally administered prostaglandin E2 and its synthetic 15-methyl analogues on gastric secretion in man was studied. The parent E2 compound did not inhibit basal secretion, whereas both...
Effect of Histamine H2-Receptor Blockade on Vagally Induced Gastric Secretion in Man
Carter, D. C., Forrest, J. A. H., Werner, M., Heading, R. C., Park, J., Shearman, D. J. C.
Metiamide, an antagonist of histamine H2 receptors, was administered intravenously to normal subjects and to patients with a peptic ulcer during vagal stimulation with a constant infusion of insulin....
He, X M, Rüker, F, Casale, E, Carter, D C
The three-dimensional structure of a human monoclonal antibody (Fab), which binds specifically to a major epitope of the transmembrane protein gp41 of the human immunodeficiency virus type 1, has...
O'Riordain, M G, Fearon, K C, Ross, J A, Rogers, P, Falconer, J S, Bartolo, D C, ...
OBJECTIVE: The authors determined the effect of glutamine-supplementation of TPN on postoperative peripheral blood T-cell response and proinflammatory cytokine production in patients undergoing...
John, T G, Greig, J D, Carter, D C, Garden, O J
OBJECTIVE: The authors performed a prospective evaluation of staging laparoscopy with laparoscopic ultrasonography in predicting surgical resectability in patients with carcinomas of the pancreatic...
Falconer, J S, Fearon, K C, Plester, C E, Ross, J A, Carter, D C
OBJECTIVE: To determine whether resting energy expenditure (REE) is increased in cachectic patients with pancreatic cancer and to define the relation of tumor necrosis factor (TNF) and interleukin-6...
Blamey, S L, Osborne, D H, Gilmour, W H, O'Neill, J, Carter, D C, Imrie, C W
Early differentiation of gallstone from nongallstone associated acute pancreatitis by imaging methods is often difficult. Timing of surgery in gallstone pancreatitis is controversial, but early...
Despite recent advances in the delivery of nutritional support, cachexia continues to contribute to the morbidity and mortality of cancer patients. This impasse has called for a review of the many...
MacLeod, I A, Mills, P R, MacKenzie, J F, Joffe, S N, Russell, R I, Carter, D C
A prospective single blind controlled trial was performed to assess the efficacy of the neodymium yttrium aluminium garnet laser in the management of patients bleeding from peptic ulcers and single...
Crystals of cadmium, zinc metallothionein.
Melis, K A, Carter, D C, Stout, C D, Winge, D R
Single crystals have been grown of Cd,Zn metallothionein isoform II from rat liver. The space group is P41212(P43212) with unit cell dimensions a = b = 31.0 A and c = 120.0 A, and one molecule in the...
Effect of Orally Administered Prostaglandin E2 and its 15-Methyl Analogues on Gastric Secretion
Karim, S. M. M., Carter, D. C., Bhana, D., Ganesan, P. Adaikan
The effect of orally administered prostaglandin E2 and its synthetic 15-methyl analogues on gastric secretion in man was studied. The parent E2 compound did not inhibit basal secretion, whereas both...
Effect of Histamine H2-Receptor Blockade on Vagally Induced Gastric Secretion in Man
Carter, D. C., Forrest, J. A. H., Werner, M., Heading, R. C., Park, J., Shearman, D. J. C.
Metiamide, an antagonist of histamine H2 receptors, was administered intravenously to normal subjects and to patients with a peptic ulcer during vagal stimulation with a constant infusion of insulin....
Insulin Infusion Test of Gastric Acid Secretion
Carter, D. C., Dozois, R. R., Kirkpatrick, J. R.
In view of the disadvantages of the standard insulin test for completeness of vagotomy a continuous insulin infusion test has been developed. Twenty-six tests were carried out on 12 healthy male...
Taurocholate induced gastric mucosal injuries in experimental portal hypertension.
Angerson, W J, Geraghty, J G, Carter, D C
The susceptibility of the gastric mucosa to injury by topical sodium taurocholate (40 mmol/l) in hydrochloric acid (150 mmol/l) was studied in prehepatic and cirrhotic rat models of portal...
Plasma concentrations of endogenous heparinoids in portal hypertension.
McKee, R F, Hodson, S, Dawes, J, Garden, O J, Carter, D C
Bleeding as a complication of liver disease can occur in the absence of recognised haemostatic defects. It is now possible to measure the concentration of endogenous heparinoid substances in the...
Triger, D R, Johnson, A G, Brazier, J E, Johnston, G W, Spencer, E F, McKee, R, ...
In a prospective three centre study oesophageal transection and gastric devascularisation have been compared with endoscopic sclerotherapy in the long term management of bleeding oesophageal varices....
Factors influencing morbidity and mortality in acute pancreatitis; an analysis of 279 cases.
De Beaux, A C, Palmer, K R, Carter, D C
Of 279 patients admitted to a specialist unit with acute pancreatitis, 210 were admitted directly and 69 were transferred for treatment of local or systemic complications. Outcome was assessed in...
Effect of gastric secretory inhibitors on the gastric mucosal barrier.
The effects of the synthetic prostaglandin 16, 16 dimethyl-E2 methyl ester (16-diMe-PGE2) and the histamine H2-receptor antagonist metiamide on the gastric mucosal barrier have been studied using the...
Effect of cimetidine on the human lower oesophageal sphincter.
Osborne, D H, Lennon, J, Henderson, M, Lidgard, G, Creel, R, Carter, D C
Lower oesophageal sphincter pressures in healthy volunteers were measured by a rapid pull-through technique during intravenous infusion of the histamine H2-receptor antagonist, cimetidine. No...
Cimetidine and the gastric mucosal barrier.
Kenyon, G S, Ansell, I F, Carter, D C
The histamine H2-receptor antagonist, cimetidine, when given topically or parenterally, did not affect net luminal Na+ gain or net luminal H+ loss in vagally-denervated pouches of antrectomised dogs....
Lower oesophageal sphincter response to gastrin--pharmacological or physiological?
Henderson, J M, Lidgard, G, Osborne, D H, Carter, D C, Heading, R C
The response of the lower oesophageal sphincter (LOS) to intragastric instillation of protein was assessed in 10 healthy volunteers. Sphincter pressures were measured by a rapid pull-through...
The effect of vagotomy on gastric adaptation
Carter, D. C., Whitfield, H. N., Macleod, I. B.
Gastric adaptation was impaired immediately after the performance of complete vagotomy in a series of 20 acute experiments in the dog. Preliminary isolation of the intact vagi in 10 of these animals...
Reappraisal of the secretory potency and disappearance rate of pure human minigastrin.
Carter, D C, Taylor, I L, Elashoff, J, Grossman, M I
The secretory potency and disappearance rates of pure synthetic human non-sulphated minigastrin (HG-14-I) and pure natural human non-sulphated heptadecapeptide (HG-17-I) were compared in five dogs...
The gastric secretory response to a continuous insulin infusion in the dog
Dozois, R. R., Carter, D. C., Kirkpatrick, J. R.
The gastric acid response to graded doses of insulin given by continuous infusion was studied in four dogs, each surgically provided with a gastric fistula. All doses of insulin resulted in a...
Bile salt-induced gastric mucosal damage and histamine receptor antagonists.
The effects of both an H1 receptor antagonist and an H2 receptor antagonist on changes in monovalent ion flux induced by topical sodium taurocholate were studied in antrectomised dogs fashioned with...
Prognostic factors in acute pancreatitis.
Blamey, S L, Imrie, C W, O'Neill, J, Gilmour, W H, Carter, D C
Prognostic factor scoring systems provide one method of predicting severity of acute pancreatitis. This paper reports the prospective assessment of a system using nine factors available within 48...
Mills, P R, Rae, A P, Farah, D A, Russell, R I, Lorimer, A R, Carter, D C
The effects of different types of adrenoreceptor blocking agents on portal venous pressure were studied in patients with cirrhosis and portal hypertension. Oral atenolol (selective beta 1 blocker),...
Utley, R J, Salim, A S, Carter, D C
The effect of varying doses of cimetidine and omeprazole, on acute gastric mucosal lesions produced by topical aspirin (200 mg/kg; 1 ml/100 g) in 0.175 M HCl or topical sodium taurocholate (40 mM; 1...
Wilson, C, Imrie, C W, Carter, D C
Review of all deaths from acute pancreatitis recorded at Glasgow Royal Infirmary between 1974 and 1984 identified 126 patients, 53 (42%) of whom had pancreatitis first diagnosed at necropsy....
Hepatobiliary complications in chronic pancreatitis.
Wilson, C, Auld, C D, Schlinkert, R, Hasan, A H, Imrie, C W, MacSween, R N, ...
Thirty nine patients undergoing surgery for chronic pancreatitis were investigated for evidence of hepatobiliary disease. In addition to pre-operative assessment by liver function tests, ultrasound,...
Lim, K., Ho, J. X., Keeling, K., Gilliland, G. L., Ji, X., Rüker, F., ...
The 3-dimensional crystal structure of glutathione S-transferase (GST) of Schistosoma japonicum (Sj) fused with a conserved neutralizing epitope on gp41 (glycoprotein, 41 kDa) of human...
Dockal, M., Chang, M., Carter, D. C., Rüker, F.
Human serum albumin (HSA) interacts with a vast array of chemically diverse ligands at specific binding sites. To pinpoint the essential structural elements for the formation of the warfarin binding...
GOUGH, D B, FEARON, K C H, CARTER, D C
Increased TNF production and impaired lymphocyte function have been individually linked with metabolic disturbance, endotoxaemia and mortality in humans. The inter-relationship between these...
Splanchnic Haemodynamics and Vasoactive Agents in Experimental Cirrhosis
Geraghty, J. G., Angerson, W. J., Carter, D. C.
It is well known that portal hypertension is associated with a hyperdynamic systemic circulatory state. This study measures systemic and splanchnic haemodynamics in an experimental rat model of...
Fibronectin as a Prognostic Indicator in Portal Hypertension
Mckee, Ruth F., Maharaj, D. P., Garden, O. J., Carter, D. C.
Plasma fibronectin levels were measured in 33 patients with portal hypertension and c6mpared with modified Child’s grading and a previously described prognostic index. Outcome at one year from...
A Comparison of Sms 201-995 and Oesophageal Tamponade in the Control of Acute Variceal Haemorrhage
Mckee, Ruth F., Garden, O. J., Anderson, J. R., Carter, D. C.
Forty endoscopically proven active variceal bleeds were entered in a prospective trial comparing oesophageal tamponade with SMS 201-995 infusion.
Erosive Gastritis and Portal Hypertension
Geraghty, J. G., Angerson, W. J., Carter, D. C.
There is conflicting evidence concerning the effects of portal hypertension on the gastric mucosa. This paper summarises the histological and haemodynamic alterations which are present in both human...
Second laparotomy following 'curative' resection for colorectal cancer.
Lewi, H. J., Carter, D. C., Ratcliffe, J. G., McArdle, C. S.
Second laparotomy was undertaken in 63 patients with suspected local recurrence following 'curative' resection for colorectal cancer. Nine patients proved to have benign disease and 4 a new cancer....