Design and synthesis of ferrocene probe molecules for detection by electrochemical methods (2006)
Tranchant, I., Carlisle, S., Lowe, K.J., Slevin, C.J., Forssten, C., ...
A series of ferrocenyl conjugates to fatty acids have been designed and synthesized to establish the key properties required for use in biomolecular binding studies. Amperometric detection of the...
Patchen, M. L., Fischer, R., MacVittie, T. J., Seiler, F. R., Williams, D. E.
In the presence of hemopoietic cytokines such as granulocyte- macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3), mast cell growth factor (MGF; also known as steel factor, stem...
Patchen, M. L., Fischer, R., Schmauder-Chock, E. A., Williams, D. E.
Based on in vitro studies, mast cell growth factor (MGF; also known as steel factor, stem cell factor, and c-kit ligand) has been implicated as an important hematopoietic regulator, especially in the...
Patchen, M. L., Fischer, R., Macvittie, T. J., Seiler, F., Williams, D. E.
One of the most recent cytokines implicated in hematopoietic regulation is c-kit ligand, also known as mast cell growth factor (MGF), steel factor (SLF), and stem cell factor (SCF) (1-3). The c-kit...
Synthesis of Pelorol and analogues: activators of the Inositol 5-Phosphatase SHIP (2005)
Yang, L., Williams, D.E., Mui, A., Ong, C., Krystal, G., Andersen, R.J., ...
Air Revitalization Unit for Sealed Survival Shelters (2005)
An air revitalization unit for use with sealed survival shelters without an external power supply was developed. The unit is capable of supplying oxygen to and removing carbon dioxide and odors from...
Polytoroidal Tunneling Thruster for Specialized Navy Applications. (2005)
Williams,D. E., Gaberson,H. A.
The report introduced an application of vermiculating or worm-like motion, a motion in which a longitudinal wave traverse one of the contacting surfaces in the direction of motion. The high force...
Scott, R.W.J., Yang, S.M., Coombs, N., Ozin, G.A., Williams, D.E.
Structure-property relationships in tin dioxide materials have been studied utilizing a reverse templating strategy to synthesize opaline structures with controlled neck dimensions between spheres....
Meso-SiO2–C12EO10OH–CF3SO3H — a novel proton-conducting solid electrolyte (2003)
Halla, J.D., Mamak, M., Williams, D.E., Ozin, G.A.
This paper describes the synthesis and characterization of a novel mesostructured solid electrolyte composite material, denoted meso-SiO2-C12EO10OH-CF3SO3H. A lyotropic non-ionic surfactant-triflic...
Crystal structure prediction of small organic molecules: a second blind test. (2002)
Motherwell, W.D.S., Ammon, H.L., Dunitz, J.D., Dzyabchenko, A., Erk, P., Gavezzotti, A., ...
New Disinfection Agents for Water. (2002)
Worley,S. D., Swango,L. J., Aull,J. L., Kohl,H. H., Williams,D. E.
Further comparisons of 3-chloro-4,4-dimethyl-2-oxazolidinone (Compound I) with calcium hypochlorite (HTH) as field water disinfectants have been made. A mixture of 10 parts Compound I and 1 part HTH...
Wöllenstein, J., Plescher, G., Kühner, G., Böttner, H., Niemeyer, D., Williams, D.E.
The effect of humidity on chromium titanium oxide (Cr/sub 2-x/Ti/sub x/O/sub 3+z/, CTO), on both baseline resistance and sensitivity, is small compared to SnO/sub 2/. This has been the key to...
Crystal structure prediction of small organic molecules: A second blind test (2002)
Motherwell, W.D.S., Ammon, H.L., Dunitz, J.D., Dzyabchenko, A., Erk, P., Gavezzotti, A., ...
The first collaborative workshop on crystal structure prediction (CSP1999) has been followed by a second workshop (CSP2001) held at the Cambridge Crystallographic Data Centre. The 17 participants...
Tin dioxide opals and inverted opals: near-ideal microstructures for gas sensors (2001)
Scott, R.W.J., Yang, S.M., Chabanis, G., Coombs, N., Williams, D.E., Ozin, G.A.
HIGH-EXPLOSIVE FIELD TEST OF HIGH-CAPACITY BLAST VALVE. (1998)
The Naval Civil Engineering Laboratory has developed and tested a series of experimental valves varying in capacity from 700 cfm to 10,000 cfm, with 1 inch of water-flow resistance. A 2,500-cfm valve...
Stewart, J., Wells, D. B., Scott, P. M., Williams, D. E.
High-purity oxygenated water at 288C (BWR conditions) was used to detect corrosion current pulses for intergranular stress corrosion cracking (IGSCC) of sensitized 304 stainless steel; these...
Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.
Brannan, C I, Lyman, S D, Williams, D E, Eisenman, J, Anderson, D M, Cosman, D, ...
Mice homozygous for the viable Sl allele steel-Dickie (Sld) are sterile, severely anemic, and black-eyed white. The nature of the Sld mutation was investigated at the molecular level and was found to...
Curtis, B M, Williams, D E, Broxmeyer, H E, Dunn, J, Farrah, T, Jeffery, E, ...
Granulocyte/macrophage colony-stimulating factor-interleukin 3 (GM-CSF-IL-3) fusion proteins were generated by construction of a plasmid in which the coding regions of human GM-CSF and IL-3 cDNAs...
Efficacy of DL-alpha-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia.
Clarkson, A B, Williams, D E, Rosenberg, C
Pneumocystis carinii pneumonia is often the terminal event for patients with the acquired immunodeficiency syndrome. Eflornithine (DL-alpha-difluoromethylornithine [DFMO]; Ornidyl; Merrell Dow...
Effect of organic N-halamines on selected membrane functions in intact Staphylococcus aureus cells.
Williams, D E, Swango, L J, Wilt, G R, Worley, S D
Two N-halamine compounds, 3-chloro-4,4-dimethyl-2-oxazolidinone and 1,3-dichloro-4,4,5,5-tetramethyl-2-imidazolidinone, were compared with free chlorine as to their effects on selected membrane...
Efficacies of Novel N-Halamine Disinfectants against Salmonella and Pseudomonas Species
Lauten, S. D., Sarvis, H., Wheatley, W. B., Williams, D. E., Mora, E. C., Worley, S. D.
Six novel N-halamine compounds of potential importance as disinfectants to the food-processing industry were tested against Salmonella enteritidis, Salmonella gallinarum, Salmonella typhimurium, and...
Bactericidal activities of selected organic N-halamines.
Williams, D E, Worley, S D, Barnela, S B, Swango, L J
The bactericidal efficacies of three organic N,N'-dihalamine disinfectants in the class of compounds termed imidazolidinones were determined for combinations of pH, temperature, and water quality...
Inactivation of Legionella pneumophila by hypochlorite and an organic chloramine.
Swango, L J, Wilt, G R, Killen, A D, Williams, D E, Worley, S D
The susceptibility of a strain of Legionella pneumophila to disinfection by an organic halamine, free chlorine, and a mixture of the organic halamine and free chlorine was assessed. The organic...
Inactivation of Giardia lamblia and Giardia canis cysts by combined and free chlorine.
Kong, L I, Swango, L J, Blagburn, B L, Hendrix, C M, Williams, D E, Worley, S D
Free chlorine and a combined organic N-chloramine (3-chloro-4,4-dimethyl-2-oxazolidinone, compound 1) were compared for efficacy as disinfectants against an admixture of cysts of Giardia lamblia and...
Is free halogen necessary for disinfection?
Williams, D E, Elder, E D, Worley, S D
The principle of Le Chatelier was used in demonstrating that 3-chloro-4,4-dimethyl-2-oxazolidinone (compound 1) itself kills Staphylococcus aureus rather than the very small amount of free chlorine...
Williams, D E, Jackson, J M, Chaney, S G
Previous experiments with Escherichia coli strain 2S142 have shown that the synthesis of stable RNA is preferentially blocked at the restrictive temperature. In this paper, we have examined the...
Funasaka, Y, Boulton, T, Cobb, M, Yarden, Y, Fan, B, Lyman, S D, ...
The proto-oncogene c-Kit, a transmembrane receptor tyrosine kinase, is an important regulator of cell growth whose constitutively active oncogenic counterpart, v-kit, induces sarcomas in cats....
Williams, D E, Bicknell, D C, Park, L S, Straneva, J E, Cooper, S, Broxmeyer, H E
Purified recombinant murine granulocyte/macrophage colony-stimulating factor (GM-CSF) was labeled with 125I and used to examine the GM-CSF receptor on unfractionated normal murine bone marrow cells,...
Muerhoff, A S, Williams, D E, Leithauser, M T, Jackson, V E, Waterman, M R, Masters, B S
The mechanism of induction of an adult rabbit cytochrome P-450, prostaglandin (PG) omega-hydroxylase (P-450PG-omega), during pregnancy has been investigated. This P-450 isozyme regiospecifically...
Broxmeyer, H E, Williams, D E, Hangoc, G, Cooper, S, Gillis, S, Shadduck, R K, ...
Combinations of low dosages of purified murine hematopoietic colony-stimulating factors (CSFs)--L-cell CSF type 1 (CSF-1), recombinant interleukin 3 (IL-3), and recombinant granulocyte/macrophage CSF...
Rottapel, R, Reedijk, M, Williams, D E, Lyman, S D, Anderson, D M, Pawson, T, ...
The W/c-kit and Steel loci respectively encode a receptor tyrosine kinase (Kit) and its extracellular ligand, Steel factor, which are essential for the development of hematopoietic, melanocyte, and...
Bactericidal properties of a new water disinfectant.
Williams, D E, Worley, S D, Wheatley, W B, Swango, L J
The N-chloramine compound 3-chloro-4,4-dimethyl-2-oxazolidinone (agent I) has been compared with calcium hypochlorite as to its efficacy as a bactericide for the treatment of water. The study...
Broxmeyer, H E, Williams, D E, Cooper, S, Shadduck, R K, Gillis, S, Waheed, A, ...
Purified murine colony-stimulating factors (CSF) recombinant interleukin 3 (IL-3), natural CSF-1, and recombinant granulocyte-macrophage (GM) CSF were assessed in vivo for their effects on BDF1 mouse...
Passive transfer of diabetes from BB/W to Wistar-Furth rats.
Koevary, S B, Williams, D E, Williams, R M, Chick, W L
Autoimmune diabetes can be transferred to young, diabetes prone BB/W rats by injecting them intravenously with concanavalin A (Con A)-treated spleen cells from acute diabetic BB/W donors. This study...
Keshet, E, Lyman, S D, Williams, D E, Anderson, D M, Jenkins, N A, Copeland, N G, ...
Mutations at the dominant white spotting (W) and Steel (Sl) loci in mouse exert deleterious effects on three migratory cell lineages (primordial germ cells, melanocytes and hematopoietic stem cells)...
Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase.
Reith, A D, Ellis, C, Lyman, S D, Anderson, D M, Williams, D E, Bernstein, A, ...
Germline mutations at the Dominant White Spotting (W) and Steel (Sl) loci have provided conclusive genetic evidence that c-kit mediated signal transduction pathways are essential for normal mouse...
Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis.
Riley, R T, Enongene, E, Voss, K A, Norred, W P, Meredith, F I, Sharma, R P, ...
There is a great deal of evidence that altered sphingolipid metabolism is associated with fumonisin-induced animal diseases including increased apoptotic and oncotic necrosis, and carcinogenesis in...
Utilizing increased response effort to reduce chronic hand mouthing.
Irvin, D S, Thompson, T J, Turner, W D, Williams, D E
The effects of increased response effort on levels of hand mouthing, leisure engagement, and adaptive elbow flexion were investigated with 2 individuals who had been diagnosed with profound...
Temporal distributions of problem behavior based on scatter plot analysis.
Kahng, S, Iwata, B A, Fischer, S M, Page, T J, Treadwell, K R, Williams, D E, ...
The scatter plot is a commonly used assessment tool for identifying temporal patterns in the occurrence of behavior problems. However, the extent to which such patterns are frequently observed is...
Clinical evaluation of the self-injurious behavior inhibiting system (SIBIS).
Linscheid, T R, Iwata, B A, Ricketts, R W, Williams, D E, Griffin, J C
Five cases involving the treatment of longstanding, severe, and previously unmanageable self-injurious behavior are presented. In each case, the behavior was forceful contact with the head or face,...
Fish models for environmental carcinogenesis: the rainbow trout.
Bailey, G S, Williams, D E, Hendricks, J D
Progress over the past 30 years has revealed many strengths of the rainbow trout as an alternative model for environmental carcinogenesis research. These include low rearing costs, an early...
Carlson, D B, Curtis, L R, Williams, D E
Fish sexual development is sensitive to exogenous hormone manipulation, and salmonids have been used extensively as environmental sentinels and models for biomedical research. We simulated maternal...
Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.
Brannan, C I, Lyman, S D, Williams, D E, Eisenman, J, Anderson, D M, Cosman, D, ...
Mice homozygous for the viable Sl allele steel-Dickie (Sld) are sterile, severely anemic, and black-eyed white. The nature of the Sld mutation was investigated at the molecular level and was found to...
Curtis, B M, Williams, D E, Broxmeyer, H E, Dunn, J, Farrah, T, Jeffery, E, ...
Granulocyte/macrophage colony-stimulating factor-interleukin 3 (GM-CSF-IL-3) fusion proteins were generated by construction of a plasmid in which the coding regions of human GM-CSF and IL-3 cDNAs...
Efficacy of DL-alpha-difluoromethylornithine in a rat model of Pneumocystis carinii pneumonia.
Clarkson, A B, Williams, D E, Rosenberg, C
Pneumocystis carinii pneumonia is often the terminal event for patients with the acquired immunodeficiency syndrome. Eflornithine (DL-alpha-difluoromethylornithine [DFMO]; Ornidyl; Merrell Dow...
Effect of organic N-halamines on selected membrane functions in intact Staphylococcus aureus cells.
Williams, D E, Swango, L J, Wilt, G R, Worley, S D
Two N-halamine compounds, 3-chloro-4,4-dimethyl-2-oxazolidinone and 1,3-dichloro-4,4,5,5-tetramethyl-2-imidazolidinone, were compared with free chlorine as to their effects on selected membrane...
Efficacies of Novel N-Halamine Disinfectants against Salmonella and Pseudomonas Species
Lauten, S. D., Sarvis, H., Wheatley, W. B., Williams, D. E., Mora, E. C., Worley, S. D.
Six novel N-halamine compounds of potential importance as disinfectants to the food-processing industry were tested against Salmonella enteritidis, Salmonella gallinarum, Salmonella typhimurium, and...
Bactericidal activities of selected organic N-halamines.
Williams, D E, Worley, S D, Barnela, S B, Swango, L J
The bactericidal efficacies of three organic N,N'-dihalamine disinfectants in the class of compounds termed imidazolidinones were determined for combinations of pH, temperature, and water quality...
Inactivation of Legionella pneumophila by hypochlorite and an organic chloramine.
Swango, L J, Wilt, G R, Killen, A D, Williams, D E, Worley, S D
The susceptibility of a strain of Legionella pneumophila to disinfection by an organic halamine, free chlorine, and a mixture of the organic halamine and free chlorine was assessed. The organic...
Inactivation of Giardia lamblia and Giardia canis cysts by combined and free chlorine.
Kong, L I, Swango, L J, Blagburn, B L, Hendrix, C M, Williams, D E, Worley, S D
Free chlorine and a combined organic N-chloramine (3-chloro-4,4-dimethyl-2-oxazolidinone, compound 1) were compared for efficacy as disinfectants against an admixture of cysts of Giardia lamblia and...
Is free halogen necessary for disinfection?
Williams, D E, Elder, E D, Worley, S D
The principle of Le Chatelier was used in demonstrating that 3-chloro-4,4-dimethyl-2-oxazolidinone (compound 1) itself kills Staphylococcus aureus rather than the very small amount of free chlorine...
Williams, D E, Jackson, J M, Chaney, S G
Previous experiments with Escherichia coli strain 2S142 have shown that the synthesis of stable RNA is preferentially blocked at the restrictive temperature. In this paper, we have examined the...
Funasaka, Y, Boulton, T, Cobb, M, Yarden, Y, Fan, B, Lyman, S D, ...
The proto-oncogene c-Kit, a transmembrane receptor tyrosine kinase, is an important regulator of cell growth whose constitutively active oncogenic counterpart, v-kit, induces sarcomas in cats....
Williams, D E, Bicknell, D C, Park, L S, Straneva, J E, Cooper, S, Broxmeyer, H E
Purified recombinant murine granulocyte/macrophage colony-stimulating factor (GM-CSF) was labeled with 125I and used to examine the GM-CSF receptor on unfractionated normal murine bone marrow cells,...