Lowis, S., Lewis, I., Elsworth, A., Weston, C., Doz, F., Vassal, G., ...
Stupp, R., Lacombe, D., Desir, J.P., Lesimple, T., Dittrich, C., ...
BACKGROUND: Glufosfamide is a new alkylating agent in which the active metabolite of isophosphoramide mustard is covalently linked to beta-D-glucose to target the glucose transporter system and...
Van Den Bent, M. J., Grisold, W., Frappaz, D., Stupp, R., Desir, J. P., Lesimple, T., ...
Background: Glufosfamide is a new alkylating agent in which the active metabolite of isophosphoramide mustard is covalently linked to &bgr;-d-glucose to target the glucose transporter system and...
Favrot, M. C., Ambros, P., Schilling, F., Frappaz, D., Combaret, V., Berthold, F., ...
Background: The prognosis of pediatric neuroblastoma depends both on clinical presentation and on certain cellular and molecular characteristics. Screening programs have been initiated in infants of...
Once daily antibiotic regimen in paediatric oncology.
Bouffet, E, Fuhrmann, C, Frappaz, D, Couillioud, D, Artiges, V, Charra, C, ...
The feasibility and efficacy of a once daily antibiotic regimen were assessed in children with malignant tumours. Over a 44 month period, 296 febrile episodes were treated with a regimen of once...
Philip, T., Ladenstein, R., Zucker, J. M., Pinkerton, R., Bouffet, E., Louis, D., ...
In the LMCE1 study using a single course of megatherapy most of the relapses occurred during the first 2 years after autologous bone marrow transplantation. A second pilot study (LMCE2) was therefore...
Favrot, M. C., Frappaz, D., Maritaz, O., Philip, I., Fontaniere, B., Gentilhomme, O., ...
On 80 occasions 4 iliac biopsy trephines and 4 iliac aspirations were performed in 37 children with neuroblastoma at various stages of the disease. In 38 of these procedures, tumour cells were...
Is neuroblastoma screening evaluation needed and feasible?
Estève, J., Parker, L., Roy, P., Herrmann, F., Duffy, S., Frappaz, D., ...
Despite the five million children who have been screened for neuroblastoma in Japan through detection of catecholamine metabolites, it is still uncertain whether screening for this disease is...
Rubie, H., Michon, J., Plantaz, D., Peyroulet, M. C., Coze, C., Frappaz, D., ...
Neuroblastomas (NBs) were assessed according to INSS recommendations including MIBG scan and extensive bone marrow staging to eliminate metastatic spread. Patients with unresectable tumour received...
Combaret, V., Gross, N., Lasset, C., Balmas, K., Bouvier, R., Frappaz, D., ...
TRKA expression was evaluated on 122 untreated neuroblastomas by immunohistochemistry using an antibody with predetermined specificity. This procedure is simple and reliable for protein detection at...
Lowis, S, Lewis, I, Elsworth, A, Weston, C, Doz, F, Vassal, G, ...
Anthracyclines are widely used in paediatric oncology, but their use is limited by the risk of cumulative cardiac toxicity. Encapsulating anthracyclines in liposomes may reduce cardiac toxicity and...
Geoerger, B, Vassal, G, Doz, F, O'Quigley, J, Wartelle, M, Watson, A J, ...
Cisplatin may have additive activity with temozolomide due to ablation of the DNA repair protein O6-alkylguanine-DNA alkyltransferase (MGMT). This phase I/II study determined recommended combination...
Doz, F, Gentet, J C, Pein, F, Frappaz, D, Chastagner, P, Moretti, S, ...
The maximum tolerated dose of paclitaxel administered by 24-hour continuous infusion in children is known. Short infusion might offer equivalent antitumour efficacy and reduced haematological...
Frappaz, D, Perol, D, Michon, J, Berger, C, Coze, C, Bernard, J L, ...
The Lyon-Marseille-Curie-Est (LMCE) of France cooperative group has previously reported successive series of unselected stage four children older than 1 year at diagnosis with metastatic...