Antoniou, A.C., Hardy, R., Walker, L., Evans, D.G., Shenton, A., Eeles, R., ...
Objectives: Genetic testing for the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 has important implications for the clinical management of people found to carry a mutation. However,...
DTD 5 ARTICLE IN PRESS Personalising web page presentation for older people Abstract (2008)
S. H. Kurniawan, A. King, D. G. Evans, P. L. Blenkhorn
This paper looks at different ways of personalising web page presentation to alleviate functional impairments in older people. The paper considers how impairments may be addressed by web design and...
Antoniou, A. C., Cunningham, A. P., Peto, J.l., Evans, D. G., Lalloo, F., Narod, S. A., ...
British Journal of Cancer Vol.98, 1457 - 1466
Antoniou, A.C., Spurdle, A.B., Sinilnikova, O.M., Healey, S., Pooley, K.A., Schmutzler, R.K., ...
Germline mutations in BRCA1 and BRCA2 confer high risks of breast cancer. However, evidence suggests that these risks are modified by other genetic or environmental factors that cluster in families....
Draffan, E.A., Evans, D.G., Blenkhorn, P.
Purpose. To identify the types and mix of technology (hardware and software) provided to post-secondary students with dyslexia under the UK's Disabled Student Allowance (DSA), and to determine the...
Draffan, E.A., Evans, D.G., Blenkhorn, P.
Purpose. To identify the types and mix of technology (hardware and software) provided to post-secondary students with dyslexia under the UK's Disabled Student Allowance (DSA), and to determine the...
Draffan, E.A., Evans, D.G., Blenkhorn, P.
Purpose. To identify the types and mix of technology (hardware and software) provided to post-secondary students with dyslexia under the UK's Disabled Student Allowance (DSA), and to determine the...
Innovative Practices in AT Training for LD (Dyslexic) Students (2007)
Draffan, E.A., Evans, D.G., Blenkhorn, P.
Between September and December 2005, we conducted a telephone survey of 455 dyslexic students who had received support under the DSA to identify the equipment supplied, the students’ experiences of...
Innovative Practices in AT Training for LD (Dyslexic) Students (2007)
Draffan, E.A., Evans, D.G., Blenkhorn, P.
Between September and December 2005, we conducted a telephone survey of 455 dyslexic students who had received support under the DSA to identify the equipment supplied, the students’ experiences of...
Innovative Practices in AT Training for LD (Dyslexic) Students (2007)
Draffan, E.A., Evans, D.G., Blenkhorn, P.
Between September and December 2005, we conducted a telephone survey of 455 dyslexic students who had received support under the DSA to identify the equipment supplied, the students’ experiences of...
Upadyaya, M., Huson, S M., Davies, M., Thomas, N., Chuzhanova, N., Giovannini, S., ...
Copyright © 2007 The American Society of Human Genetics
Upadyaya, M., Huson, S M., Davies, M., Thomas, N., Chuzhanova, N., Giovannini, S., ...
Copyright © 2007 The American Society of Human Genetics
Upadhyaya, M., Huson, S.M., Davies, M., Thomas, N., Chuzhanova, N., Giovannini, S., ...
Neurofibromatosis type 1 (NF1) is characterized by cafe-au-lait spots, skinfold freckling, and cutaneous neurofibromas. No obvious relationships between small mutations (ACG change of codon 990....
Do Text-to-Speech Synthesisers Pronounce Correctly? A Preliminary Study (2006)
Evans, D.G., Draffan, E.A., James, A., Blenkhorn, P.
This paper evaluates 4 commercial text-to-speech synthesisers used by dyslexic people to listen to and proof read text. Two evaluators listened to 704 common English words and determined whether the...
Do Text-to-Speech Synthesisers Pronounce Correctly? A Preliminary Study (2006)
Evans, D.G., Draffan, E.A., James, A., Blenkhorn, P.
This paper evaluates 4 commercial text-to-speech synthesisers used by dyslexic people to listen to and proof read text. Two evaluators listened to 704 common English words and determined whether the...
Do Text-to-Speech Synthesisers Pronounce Correctly? A Preliminary Study (2006)
Evans, D.G., Draffan, E.A., James, A., Blenkhorn, P.
This paper evaluates 4 commercial text-to-speech synthesisers used by dyslexic people to listen to and proof read text. Two evaluators listened to 704 common English words and determined whether the...
Griebsch, I., Brown, J., Boggis, C., Dixon, A., Dixon, M., Easton, D., ...
Contrast enhanced magnetic resonance imaging (CE MRI) is the most sensitive tool for screening women who are at high familial risk of breast cancer. Our aim in this study was to assess the...
Griebsch, I., Brown, J., Boggis, C., Dixon, A., Dixon, M., Easton, D., ...
Contrast enhanced magnetic resonance imaging (CE MRI) is the most sensitive tool for screening women who are at high familial risk of breast cancer. Our aim in this study was to assess the...
Evaluation of RAD50 in familial breast cancer predisposition (2005)
Tommiska, J., Seal, S., Renwick, A., Barfoot, R., Baskcomb, L., Jayatilake, H., ...
The genes predisposing to familial breast cancer are largely unknown, but 5 of the 6 known genes are involved in DNA damage repair. RAD50 is part of a highly conserved complex important in...
Leach, M. O., Boggis, C. R., Dixon, A. K., Easton, D. F., Eeles, R. A., Evans, D. G., ...
Background: Women genetically predisposed to breast cancer often develop the disease at a young age when dense breast tissue reduces the sensitivity of X-ray mammography. Our aim was, therefore, to...
Antoniou, A.C., Pharoah, P.D., Narod, S., Risch, H.A., Eyfjord, J.E., Hopper, J.L., ...
A recent report estimated the breast cancer risks in carriers of the three Ashkenazi founder mutations to be higher than previously published estimates derived from population based studies. In an...
Leach, M.O., Boggis, C.R., Dixon, A.K., Easton, D.F., Eeles, R.A., Evans, D.G., ...
Background Women genetically predisposed to breast cancer often develop the disease at a young age when dense breast tissue reduces the sensitivity of X-ray mammography. Our aim was, therefore, to...
Foster, C., Evans, D. G., Eeles, R., Eccles, D., Ashley, S., Brooks, L., ...
BRCA1/2 test decliners/deferrers have received almost no attention in the literature and this is the first study of this population in the United Kingdom. The aim of this multicenter study is to...
Antoniou, A., Pharoah, P.D.P., Narod, S., Risch, H.A., Eyfjord, J.E., Hopper, J.L., ...
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on the context. Estimates based on...
Schutte, M., Meijers-Heijboer, H., Easton, D.F., Wasielewski, M., Evans, D.G., Eccles, D., ...
We recently reported that a sequence variant in the cell-cycle-checkpoint kinase CHEK2 (CHEK2 1100delC) is a low-penetrance breast cancer-susceptibility allele in noncarriers of BRCA1 or BRCA2...
Panayiotis Zaphiris, Sri H. Kurniawan, R. Darin Ellis, Sri Hastuti Kurniawan, D. G. Evans, P. Blenkhorn
S Engelborghs, B Dermaut, J Goeman, J Saerens, P Mariën, Ba Pickut, ...
To order reprints of this article go to:
Leach, M.O., Eeles, R.A., Turnbull, L.W., Dixon, A.K., Brown, J., Hoff, R.J., ...
The UK national study of magnetic resonance imaging as a method of screening for breast cancer (MARIBS) is in progress. The study design, accrual to date, and related research projects are described....
Meijers-Heijboer H, Klijn J, Wasielewski M, De Snoo A, Oldenburg R, ...
Mutations in BRCA1 and BRCA2 confer a high risk of breast and ovarian cancer, but account for only a small fraction of breast cancer susceptibility. To find additional genes conferring susceptibility...
Simulating the Behaviour of Computer Systems: Co-simulation of Hardware/Software (1997)
Morris, D., Evans, D. G., Schofield, S.
This paper discusses the validation, by simulation, of Behavioural Models of computer systems that are developed as part of a whole lifecycle approach to product development (model-based object...
Towards the utilization of Victorian brown coal (1986)
Spine title: Utilization of Victorian brown coal. Collected papers. Includes bibliographical references.
Theoretical and experimental studies on transition metal clusters. (1984)
Thesis (Ph. D.)--University of Oxford, 1984.
Antimicrobial susceptibility of enterotoxigenic Escherichia coli (1978)
DUPONT, H. L., WEST, H., EVANS, D. G., OLARTE, J., EVANS, D. J.
LOCATION OF FOOD CONSUMPTION AND TRAVELERS' DIARRHEA (1977)
TJOA, W. S., DUPONT, H. L., SULLIVAN, P., PICKERING, L. K., HOLGUIN, A. H., OLARTE, J, ...
Tjoa, W. S., H. L. DuPont (U. of Texas Medical School, Houston, TX 77030), P. Sullivan, L. K. Pickering, A. H. Holguln, J. Olarte, D. G. Evans and D. J. Evans, Jr. Location of food consumption and...
The gasification of Victorian brown coal by the Lurgi process (1955)
Typescript (carbon copy). Includes bibliographical references (leaves 190-194).
Characterization of a Helicobacter pylori neutrophil-activating protein.
Evans, D J, Evans, D G, Takemura, T, Nakano, H, Lampert, H C, Graham, D Y, ...
Helicobacter pylori-associated gastritis is mainly an inflammatory cell response. In earlier work we showed that activation of human neutrophils by a cell-free water extract of H. pylori is...
Evans, D G, Karjalainen, T K, Evans, D J, Graham, D Y, Lee, C H
Gene hpaA, which codes for the receptor-binding subunit of the N-acetylneuraminyllactose-binding fibrillar hemagglutinin (NLBH) of Helicobacter pylori, was cloned and sequenced. The protein expressed...
Murray, B E, Evans, D J, Penãranda, M E, Evans, D G
Colonization factor antigen I (CFA/I) plays an important role in the pathogenesis of diarrhea due to enterotoxigenic Escherichia coli. In this study, we examined 11 CFA/I+ enterotoxigenic E. coli...
Peñaranda, M E, Evans, D G, Murray, B E, Evans, D J
Colonization factor antigen II-producing enterotoxigenic Escherichia coli serotypes possessed at least one large plasmid. Loss of colonization factor antigen II correlated with either complete or...
Urease-associated heat shock protein of Helicobacter pylori.
Evans, D J, Evans, D G, Engstrand, L, Graham, D Y
Helicobacter pylori urease is an extracellular, cell-bound enzyme with a molecular weight of approximately 600,000 (600K enzyme) comprising six 66K and six 31K subunits. A 62K protein is closely...
Evans, D G, Evans, D J, Moulds, J J, Graham, D Y
Campylobacter pylori is the causative agent of gastritis and possibly of peptic and duodenal ulcers in adults. Histological observations show C. pylori attached to gastric epithelium as well as in...
Evans, D J, Evans, D G, Diaz, S R, Graham, D Y
The human erythrocyte receptor which mediates mannose-resistant hemagglutination by enterotoxigenic Escherichia coli possessing colonization factor antigen II is not universally distributed among...
Evans, D G, Evans, D J, Clegg, S
An enzyme-linked immunosorbent assay (ELISA) was employed to detect and quantitate the fimbrial colonization factor antigen (CFA/I) of enterotoxigenic Escherichia coli in stool specimens obtained...
Evans, D J, Evans, D G, Höhne, C, Noble, M A, Haldane, E V, Lior, H, ...
Escherichia coli isolated from cases of bacteremia and from a variety of urinary tract infections were characterized according to serotype (O:H antigenicity), K type (possession of K1, K2, K3, K12,...
Sheep erythrocytes sensitized by incubation with the heat-labile enterotoxin (LT) of Escherichia coli are hemolyzed in the presence of anti-LT antiserum and complement. The Microtiter (Cooke...
Evans, D J, Evans, D G, Smith, K E, Graham, D Y
We recently reported that Campylobacter pylori possesses a surface-associated fibrillar hemagglutinin which has an affinity for N-acetylneuraminyllactose; this hemagglutinin may function as a...
Karjalainen, T K, Evans, D G, So, M, Lee, C H
The colonization factor antigen I (CFA/I) gene has been isolated and sequenced. The amino acid sequence of CFA/I deduced from the nucleotide sequence is composed of 170 amino acids. The first 23...
Receptor-mediated adherence of Campylobacter pylori to mouse Y-1 adrenal cell monolayers.
Evans, D G, Evans, D J, Graham, D Y
An in vitro adherence assay was developed to study the adherence of Campylobacter pylori to mammalian cells. Strains of C. pylori were isolated from individuals with gastritis. These strains...
Evans, D G, Evans, D J, Tjoa, W S, DuPont, H L
The fimbriate colonization factor antigen (CEA) of Escherichia coli strain H-1047 was isolated and used to prepare anti-CFA antiserum. Enterotoxigenic E. coli (ETEC) isolated from 29 adults with...
Evans, D J, Evans, D G, DuPont, H L
A hemagglutination (HA)-typing system has been developed for the presumptive identification of enterotoxigenic Escherichia coli (ETEC) possessing the colonization factor antigens (CFA) CFA/I or...
Purification and characterization of the CFA/I antigen of enterotoxigenic Escherichia coli.
Evans, D G, Evans, D J, Clegg, S, Pauley, J A
The fimbral colonization factor antigen CFA/I of enterotoxigenic Escherichia coli was purified and characterized. The initial purification step was release of these fimbriae from the bacterial cells...
Evans, D G, Silver, R P, Evans, D J, Chase, D G, Gorbach, S L
An enterotoxin-producing strain of Escherichia coli isolated from a case of cholera-like diarrhea (E. coli strain H-10407) was found to possess a surface-associated colonization factor. Colonization...
Sheep erythrocytes sensitized with the heat-labile enterotoxin (LT) of Escherichia coli exhibited passive immune hemolysis (PIH) when exposed to specific antitoxin and complement. Thus, PIH serves as...
Evans, D J, Evans, D G, DuPont, H L, Orskov, F, Orskov, I
Enterotoxigenic Escherichia coli isolates obtained in Mexico from adult subjects with diarrhea and from healthy controls were examined for the production of heat-stable enterotoxin (ST) and...
Evans, D G, Satterwhite, T K, Evans, D J, DuPont, H L
Double-blind studies were performed to compare the virulence of enterotoxigenic Escherichia coli with and without the fimbriate colonization factor antigen (CFA), using young healthy adults (mean...
Production of heat-stable, methanol-soluble enterotoxin by Yersinia enterocolitica.
Boyce, J M, Evans, E J, Evans, D G, DuPont, H L
Seven isolates of Yersinia enterocolitica serotype 0:8, recovered during an outbreak of gastrointestinal illness, were examined for enterotoxin production. All seven strains were enterotoxigenic in...
Comparison of agar based media for primary isolation of Helicobacter pylori.
Hachem, C Y, Clarridge, J E, Evans, D G, Graham, D Y
AIMS--To determine the best medium for the primary isolation of Helicobacter pylori. METHODS--Sixty six gastric mucosal biopsy specimens frozen in 1 ml Cysteine Albimi media with 20% glycerol from 22...
Evans, D G, Wallace, A J, Wu, C L, Trueman, L, Ramsden, R T, Strachan, T
Blood samples from 125 families with classic type 2 neurofibromatosis with bilateral vestibular schwannomas were analyzed for mutations in the NF2 gene. Causative mutations were identified in 52...
Roberts, S A, Spreadborough, A R, Bulman, B, Barber, J B, Evans, D G, Scott, D
Many inherited cancer-prone conditions show an elevated sensitivity to the induction of chromosome damage in cells exposed to ionizing radiation, indicative of defects in the processing of DNA...
Rypins, E B, Evans, D G, Hinrichs, W, Kipper, S L
OBJECTIVE: The authors' goal was to evaluate the accuracy of Technetium 99m-HMPAO-labeled leukocyte imaging for screening patients with atypically presenting appendicitis and to determine how...
Prevention of tetanus in the wounded.
Smith, J W, Laurence, D R, Evans, D G
Recommendations for the prevention of tetanus in the wounded have been revised to incorporate the use of human tetanus immunoglobulin, which is now available in the United Kingdom. Surgical toilet is...
A linkage study in seven breast cancer families.
Teare, M D, Santibáñez-Koref, M F, Wallace, S A, White, G R, Evans, D G, Burnell, L D, ...
Seven breast cancer families are examined for evidence of linkage to a site in the region of 17q12-q21, by using five markers. The families constitute a subset of a larger series of familial breast...
Characterization of a Helicobacter pylori neutrophil-activating protein.
Evans, D J, Evans, D G, Takemura, T, Nakano, H, Lampert, H C, Graham, D Y, ...
Helicobacter pylori-associated gastritis is mainly an inflammatory cell response. In earlier work we showed that activation of human neutrophils by a cell-free water extract of H. pylori is...
Evans, D G, Karjalainen, T K, Evans, D J, Graham, D Y, Lee, C H
Gene hpaA, which codes for the receptor-binding subunit of the N-acetylneuraminyllactose-binding fibrillar hemagglutinin (NLBH) of Helicobacter pylori, was cloned and sequenced. The protein expressed...
Murray, B E, Evans, D J, Penãranda, M E, Evans, D G
Colonization factor antigen I (CFA/I) plays an important role in the pathogenesis of diarrhea due to enterotoxigenic Escherichia coli. In this study, we examined 11 CFA/I+ enterotoxigenic E. coli...
Peñaranda, M E, Evans, D G, Murray, B E, Evans, D J
Colonization factor antigen II-producing enterotoxigenic Escherichia coli serotypes possessed at least one large plasmid. Loss of colonization factor antigen II correlated with either complete or...
Urease-associated heat shock protein of Helicobacter pylori.
Evans, D J, Evans, D G, Engstrand, L, Graham, D Y
Helicobacter pylori urease is an extracellular, cell-bound enzyme with a molecular weight of approximately 600,000 (600K enzyme) comprising six 66K and six 31K subunits. A 62K protein is closely...
Evans, D G, Evans, D J, Moulds, J J, Graham, D Y
Campylobacter pylori is the causative agent of gastritis and possibly of peptic and duodenal ulcers in adults. Histological observations show C. pylori attached to gastric epithelium as well as in...
Evans, D J, Evans, D G, Diaz, S R, Graham, D Y
The human erythrocyte receptor which mediates mannose-resistant hemagglutination by enterotoxigenic Escherichia coli possessing colonization factor antigen II is not universally distributed among...
Evans, D G, Evans, D J, Clegg, S
An enzyme-linked immunosorbent assay (ELISA) was employed to detect and quantitate the fimbrial colonization factor antigen (CFA/I) of enterotoxigenic Escherichia coli in stool specimens obtained...
Evans, D J, Evans, D G, Höhne, C, Noble, M A, Haldane, E V, Lior, H, ...
Escherichia coli isolated from cases of bacteremia and from a variety of urinary tract infections were characterized according to serotype (O:H antigenicity), K type (possession of K1, K2, K3, K12,...
Sheep erythrocytes sensitized by incubation with the heat-labile enterotoxin (LT) of Escherichia coli are hemolyzed in the presence of anti-LT antiserum and complement. The Microtiter (Cooke...
Evans, D J, Evans, D G, Smith, K E, Graham, D Y
We recently reported that Campylobacter pylori possesses a surface-associated fibrillar hemagglutinin which has an affinity for N-acetylneuraminyllactose; this hemagglutinin may function as a...
Karjalainen, T K, Evans, D G, So, M, Lee, C H
The colonization factor antigen I (CFA/I) gene has been isolated and sequenced. The amino acid sequence of CFA/I deduced from the nucleotide sequence is composed of 170 amino acids. The first 23...
Receptor-mediated adherence of Campylobacter pylori to mouse Y-1 adrenal cell monolayers.
Evans, D G, Evans, D J, Graham, D Y
An in vitro adherence assay was developed to study the adherence of Campylobacter pylori to mammalian cells. Strains of C. pylori were isolated from individuals with gastritis. These strains...
Evans, D G, Evans, D J, Tjoa, W S, DuPont, H L
The fimbriate colonization factor antigen (CEA) of Escherichia coli strain H-1047 was isolated and used to prepare anti-CFA antiserum. Enterotoxigenic E. coli (ETEC) isolated from 29 adults with...
Evans, D J, Evans, D G, DuPont, H L
A hemagglutination (HA)-typing system has been developed for the presumptive identification of enterotoxigenic Escherichia coli (ETEC) possessing the colonization factor antigens (CFA) CFA/I or...
Purification and characterization of the CFA/I antigen of enterotoxigenic Escherichia coli.
Evans, D G, Evans, D J, Clegg, S, Pauley, J A
The fimbral colonization factor antigen CFA/I of enterotoxigenic Escherichia coli was purified and characterized. The initial purification step was release of these fimbriae from the bacterial cells...
Evans, D G, Silver, R P, Evans, D J, Chase, D G, Gorbach, S L
An enterotoxin-producing strain of Escherichia coli isolated from a case of cholera-like diarrhea (E. coli strain H-10407) was found to possess a surface-associated colonization factor. Colonization...
Sheep erythrocytes sensitized with the heat-labile enterotoxin (LT) of Escherichia coli exhibited passive immune hemolysis (PIH) when exposed to specific antitoxin and complement. Thus, PIH serves as...
Evans, D J, Evans, D G, DuPont, H L, Orskov, F, Orskov, I
Enterotoxigenic Escherichia coli isolates obtained in Mexico from adult subjects with diarrhea and from healthy controls were examined for the production of heat-stable enterotoxin (ST) and...
Evans, D G, Satterwhite, T K, Evans, D J, DuPont, H L
Double-blind studies were performed to compare the virulence of enterotoxigenic Escherichia coli with and without the fimbriate colonization factor antigen (CFA), using young healthy adults (mean...
Production of heat-stable, methanol-soluble enterotoxin by Yersinia enterocolitica.
Boyce, J M, Evans, E J, Evans, D G, DuPont, H L
Seven isolates of Yersinia enterocolitica serotype 0:8, recovered during an outbreak of gastrointestinal illness, were examined for enterotoxin production. All seven strains were enterotoxigenic in...
Comparison of agar based media for primary isolation of Helicobacter pylori.
Hachem, C Y, Clarridge, J E, Evans, D G, Graham, D Y
AIMS--To determine the best medium for the primary isolation of Helicobacter pylori. METHODS--Sixty six gastric mucosal biopsy specimens frozen in 1 ml Cysteine Albimi media with 20% glycerol from 22...
Antoniou, A., Pharoah, P. D. P., Narod, S., Risch, H. A., Eyfjord, J. E., Hopper, J. L., ...
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on the context. Estimates based on...
Rypins, E B, Evans, D G, Hinrichs, W, Kipper, S L
OBJECTIVE: The authors' goal was to evaluate the accuracy of Technetium 99m-HMPAO-labeled leukocyte imaging for screening patients with atypically presenting appendicitis and to determine how...
Evans, D G, Wallace, A J, Wu, C L, Trueman, L, Ramsden, R T, Strachan, T
Blood samples from 125 families with classic type 2 neurofibromatosis with bilateral vestibular schwannomas were analyzed for mutations in the NF2 gene. Causative mutations were identified in 52...
Roberts, S A, Spreadborough, A R, Bulman, B, Barber, J B, Evans, D G, Scott, D
Many inherited cancer-prone conditions show an elevated sensitivity to the induction of chromosome damage in cells exposed to ionizing radiation, indicative of defects in the processing of DNA...
Prevention of tetanus in the wounded.
Smith, J W, Laurence, D R, Evans, D G
Recommendations for the prevention of tetanus in the wounded have been revised to incorporate the use of human tetanus immunoglobulin, which is now available in the United Kingdom. Surgical toilet is...
A linkage study in seven breast cancer families.
Teare, M D, Santibáñez-Koref, M F, Wallace, S A, White, G R, Evans, D G, Burnell, L D, ...
Seven breast cancer families are examined for evidence of linkage to a site in the region of 17q12-q21, by using five markers. The families constitute a subset of a larger series of familial breast...
Non-penetrance and late appearance of polyps in families with familial adenomatous polyposis.
Evans, D G, Guy, S P, Thakker, N, Armstrong, J G, Dodd, C, Davies, D R, ...
One case of non-penetrance of the familial adenomatous polyposis (FAP) gene at 59 years of age and late onset of polyps on endoscopy and biopsy in this and two other families is described. Screening...
Inappropriate hypergastrinaemia in asymptomatic healthy subjects infected with Helicobacter pylori.
Smith, J T, Pounder, R E, Nwokolo, C U, Lanzon-Miller, S, Evans, D G, Graham, D Y, ...
An ELISA test determined serologically that eight of 95 apparently healthy men (aged 19-26 years) had an asymptomatic infection with Helicobacter pylori at the time of simultaneous measurement of 24...
Burton, P., Evans, D. G., Harper, A. A., Howat, Henry T., Oleesky, S., Scott, J. E., ...
Pancreozymin in man as in animals appears to act as a specific enzyme stimulant. The preparations of pancreozymin used in these experiments also contain cholecystokinin, which causes the gall bladder...
Upadhyaya, M., Huson, S. M., Davies, M., Thomas, N., Chuzhanova, N., Giovannini, S., ...
Neurofibromatosis type 1 (NF1) is characterized by café-au-lait spots, skinfold freckling, and cutaneous neurofibromas. No obvious relationships between small mutations (
Bourn, D., Carter, S. A., Evans, D. G., Goodship, J., Coakham, H., Strachan, T.
We have sought mutations in the recently identified neurofibromatosis type 2 (NF2) tumor-suppressor gene in a large panel of NF2 patients, using PCR-based SSCP and heteroduplex analysis, followed by...
Ovarian cancer family and prophylactic choices.
Evans, D G, Ribiero, G, Warrell, D, Donnai, D
A subject from a family with ovarian cancer who has developed bilateral medullary carcinoma of the breast at the age of 40 is presented. The family is consistent with dominant inheritance of ovarian...
Evans, D G, Huson, S M, Donnai, D, Neary, W, Blair, V, Teare, D, ...
A clinical and genetic study of type 2 neurofibromatosis (NF2) has been carried out in the United Kingdom. Virtually complete ascertainment of cases in the north-west of England was achieved and...
Evans, D G, Huson, S M, Donnai, D, Neary, W, Blair, V, Newton, V, ...
The major defining features, age at onset of symptoms, and survival in 150 patients with type 2 neurofibromatosis (NF2) have been studied. The mean age at onset was 21.57 years (n = 110) and no cases...
Complications of the naevoid basal cell carcinoma syndrome: results of a population based study.
Evans, D G, Ladusans, E J, Rimmer, S, Burnell, L D, Thakker, N, Farndon, P A
There are many potential complications which have been reported in association with the naevoid basal cell carcinoma syndrome. We have been able to show the relative frequencies of these problems in...
Ankyloblepharon filiforme adnatum in trisomy 18 Edwards syndrome.
Evans, D G, Evans, I D, Donnai, D, Lindenbaum, R H
Three cases of ankyloblepharon filiforme adnatum (AFA) in infants with Edwards syndrome are described. The case for a fifth subgroup of AFA is reinforced.
Genetic linkage analysis in hereditary non-polyposis colon cancer syndrome.
Froggatt, N J, Koch, J, Davies, R, Evans, D G, Clamp, A, Quarrell, O W, ...
Hereditary Non-polyposis Colon Cancer Syndrome (HNPCC) is the most common cause of familial colorectal cancer. Molecular genetic studies of HNPCC have shown evidence of locus heterogeneity, and...
Diagnostic issues in a family with late onset type 2 neurofibromatosis.
Evans, D G, Bourn, D, Wallace, A, Ramsden, R T, Mitchell, J D, Strachan, T
We report a family with type 2 neurofibromatosis and late onset tumours. Five members of this family have developed hearing loss late in life, two of whom have only been shown to have the diagnosis...
Mutation screening of MSH2 and MLH1 mRNA in hereditary non-polyposis colon cancer syndrome.
Froggatt, N J, Brassett, C, Koch, D J, Evans, D G, Hodgson, S V, Ponder, B A, ...
Germline mutations in four human mismatch repair genes (MSH2, MLH1, PMS1, and PMS2) have been reported to cause hereditary non-polyposis colon cancer syndrome (HNPCC). The identification of germline...
Microsatellite instability in early onset and familial colorectal cancer.
Brassett, C, Joyce, J A, Froggatt, N J, Williams, G, Furniss, D, Walsh, S, ...
Hereditary non-polyposis colorectal cancer syndrome (HNPCC) is often considered to be the most common form of inherited colorectal cancer, although its precise incidence is unknown. The clinical...
Hoban, P R, Cowen, R L, Mitchell, E L, Evans, D G, Kelly, M, Howard, P J, ...
A 6 month old boy presented with bilateral Wilms' tumour. Cytogenetic analysis of the lymphocytes from the patient showed a de novo balanced translocation t(5;6)(q21;q21), which was also present in...
Uptake of genetic testing for cancer predisposition.
Evans, D G, Maher, E R, Macleod, R, Davies, D R, Craufurd, D
Although there has been much debate about the uptake and effects of predictive testing for common cancers, such as breast and colon cancer, little has been published on the more classical tumour...
Misleading linkage results in an NF2 presymptomatic test owing to mosaicism.
Bijlsma, E K, Wallace, A J, Evans, D G
A two generation family with neurofibromatosis type 2 (NF2) is presented in which a family member requested presymptomatic molecular diagnosis. Since the consultand's mother had clinically well...
An evaluation of common breast cancer gene mutations in a population of Ashkenazi Jews.
Lalloo, F, Cochrane, S, Bulman, B, Varley, J, Elles, R, Howell, A, ...
OBJECTIVES: In view of the recent reports of recurrent mutations in BRCA1 and BRCA2 in the Ashkenazi Jewish population, we have undertaken to assess the frequency of these mutations in this...
Evans, D G, Trueman, L, Wallace, A, Collins, S, Strachan, T
Blood samples from 125 unrelated families with classical type 2 neurofibromatosis (NF2) with bilateral vestibular schwannomas have been analysed for mutations in the NF2 gene. A further 17 families...
Men in breast cancer families: a preliminary qualitative study of awareness and experience.
McAllister, M F, Evans, D G, Ormiston, W, Daly, P
In inherited forms of breast cancer, attention in clinical genetics services has focused on women because they are most at risk of developing cancer. Men at risk of transmitting a predisposing gene...
Wu, C L, Thakker, N, Neary, W, Black, G, Lye, R, Ramsden, R T, ...
Patients who present with unilateral vestibular schwannomas either at a young age or with additional features of type 2 neurofibromatosis (NF2) are at risk of developing bilateral disease and...
An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53.
Varley, J M, McGown, G, Thorncroft, M, Tricker, K J, Teare, M D, Santibanez-Koref, M F, ...
We present an extended family with Li-Fraumeni syndrome characterised by gastric and breast carcinoma, glioma, sarcoma, and leukaemia. This family showed strong evidence of linkage to TP53, and three...
A genetic register for von Hippel-Lindau disease.
Maddock, I R, Moran, A, Maher, E R, Teare, M D, Norman, A, Payne, S J, ...
A genetic register for von Hippel-Lindau disease was set up in the north west of England in 1990. Population statistics, clinical features, age at onset, and survival of 83 people affected with von...
Evans, D G, Mason, S, Huson, S M, Ponder, M, Harding, A E, Strachan, T
OBJECTIVE: To delineate the clinical phenotype, molecular basis, and implications for screening in patients and families with multiple schwannomas not generally involving the cranium. METHODS: As...
Family implications of neonatal Gorlin's syndrome.
Evans, D G, Sims, D G, Donnai, D
Two very preterm infants (born at 29 and 25 weeks, respectively) were found to have abnormal ribs. Though this was thought unimportant at the time, it was subsequently shown to indicate that some...
Scenario planning for electricity supply
Soontornrangson, W., Evans, D. G., Fuller, R. J., Stewart, D. F.
The Fifth International Standard Gas-Gangrene Antitoxin (Perfringens) (Clostridium welchii Type A Antitoxin) was prepared from serum from immunized horses. It was freeze-dried in ampoules each...
An international collaborative study of the assay of the potency of poliomyelitis sera
Bentzon, M. Weis, Evans, D. G., Maaløe, O., Perkins, F. T., Spaun, J.
As a first step towards the standardization of poliomyelitis vaccine, the neutralizing antibody titres of ten test antipoliomyelitis sera were measured in nine laboratories in different countries in...
Perception of risk in women with a family history of breast cancer.
Evans, D. G., Burnell, L. D., Hopwood, P., Howell, A.
We present the findings of a pilot study to assess the perception of risk in 155 women with a family history of breast cancer by questionnaire. Only 11% of women were able to identify the correct...
The incidence of Gorlin syndrome in 173 consecutive cases of medulloblastoma.
Evans, D. G., Farndon, P. A., Burnell, L. D., Gattamaneni, H. R., Birch, J. M.
We have investigated the incidence of Gorlin syndrome (GS) in patients with the childhood brain tumour, medulloblastoma. One hundred and seventy-three consecutive cases of medulloblastoma in the...
Evans, D. G., Blair, V., Greenhalgh, R., Hopwood, P., Howell, A.
Women with a family history of breast cancer generally self-refer because they have a feeling that their risk is high. However, they have, in general, only a hazy notion of the population risk of...
Varley, J. M., McGown, G., Thorncroft, M., White, G. R., Tricker, K. J., Kelsey, A. M., ...
We report a Li-Fraumeni syndrome family in which we have detected a splice acceptor mutation in intron 3 of TP53. The mutation affects one of the invariant residues at the splice acceptor site, as a...
Cowan, R., Hoban, P., Kelsey, A., Birch, J. M., Gattamaneni, R., Evans, D. G.
Individuals with naevoid basal cell carcinoma (Gorlin) syndrome are at increased risk of developing medulloblastoma in childhood. We have shown that approximately 5% of patients with Gorlin syndrome...
Risk of subsequent primary cancers in patients with carcinoma of the Ampulla of Vater.
Moran, A., Collins, S., Evans, D. G., Davies, R.
Data were collected on subsequent primary cancers occurring in 194 individuals diagnosed with ampullary carcinoma during 1979-92 in the north western region of England, UK. Four cancers were...
Griebsch, I, Brown, J, Boggis, C, Dixon, A, Dixon, M, Easton, D, ...
Contrast enhanced magnetic resonance imaging (CE MRI) is the most sensitive tool for screening women who are at high familial risk of breast cancer. Our aim in this study was to assess the...
The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
Antoniou, A C, Cunningham, A P, Peto, J, Evans, D G, Lalloo, F, Narod, S A, ...
Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in...