Hawkins, M E, Mitsuya, H, McCully, C M, Godwin, K S, Murakami, K, Poplack, D G, ...
The pharmacokinetics of 2',3'-dideoxyadenosine (ddA), didanosine, 2',3'-dideoxyguanosine (ddG), and 6-halogenated prodrugs of ddG, 6-chloro-ddG and 6-iodo-ddG, in plasma and cerebrospinal fluid (CSF)...
Penetration of SCH-39304, a new antifungal triazole, into cerebrospinal fluid of primates.
Walsh, T J, Lester-McCully, C, Rinaldi, M G, Wallace, J E, Balis, F M, Lee, J W, ...
We characterized the cerebrospinal fluid (CSF) penetration and pharmacokinetics of SCH-39304 in adult rhesus monkeys receiving a single oral dose of SCH-39304 (2.0 mg/kg of body weight). The mean...
Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome.
Rogers, P, Allegra, C J, Murphy, R F, Drake, J C, Masur, H, Poplack, D G, ...
The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired...
Hockett, R D, De Villartay, J P, Pollock, K, Poplack, D G, Cohen, D I, Korsmeyer, S J
Individual T cells express the CD3 molecule in association with alternative gamma delta or alpha beta heterodimeric T-cell receptors (TCRs). T-cell precursors and occasional gamma delta-expressing T...
Pharmacokinetics of subcutaneous azidothymidine in rhesus monkeys.
Balis, F M, McCully, C, Gough, L, Pizzo, P A, Poplack, D G
The pharmacokinetics of subcutaneous bolus and continuous infusion azidothymidine (AZT) was studied in rhesus monkeys. Three animals received 100 mg/m2 as a bolus injection both intravenously and...
Expression of a multidrug-resistance gene in human tumors and tissues.
Fojo, A T, Ueda, K, Slamon, D J, Poplack, D G, Gottesman, M M, Pastan, I
The identification and cloning of a segment of a human multidrug resistance gene (mdr1) was reported recently. To examine the molecular basis of one type of multidrug resistance, we have prepared RNA...
Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells.
Korsmeyer, S J, Hieter, P A, Ravetch, J V, Poplack, D G, Waldmann, T A, Leder, P
We have used a special class of human acute lymphocytic leukemias, the common "non-T/non-B" cell type, to define a hierarchy of genetic rearrangements that occur during the earliest stages of B-cell...
Smyth, J F, Poplack, D G, Holiman, B J, Leventhal, B G, Yarbro, G
Adenosine deaminase (ADA) activity has been measured in the lymphoblasts of 23 untreated patients with acute lymphoblastic leukemia and related to the presence or absence of immunologic cell surface...
Lipid Peroxidation in the Killing of Phagocytized Pneumococci
Shohet, S. B., Pitt, J., Baehner, R. L., Poplack, D. G.
To directly examine the role of hydrogen peroxide in the killing of bacteria after ingestion by granulocytes, we have studied some of the events of phagocytosis of a mutant strain of pneumococci...
Korsmeyer, S J, Arnold, A, Bakhshi, A, Ravetch, J V, Siebenlist, U, Hieter, P A, ...
We have explored the relationship among immunoglobulin gene rearrangement, cytoplasmic immunoglobulin production, and cell surface antigen expression within 37 cases of acute lymphocytic leukemia....
Felix, C A, Wright, J J, Poplack, D G, Reaman, G H, Cole, D, Goldman, P, ...
We examined alpha-, beta-, and gamma-T cell receptor (TCR) gene activation within acute lymphoblastic leukemias (ALLs) that represent early stages of B and T cell development. We wished to determine...
Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.
Felix, C A, Nau, M M, Takahashi, T, Mitsudomi, T, Chiba, I, Poplack, D G, ...
The p53 gene was examined in primary lymphoblasts of 25 pediatric patients with acute lymphoblastic leukemia by the RNase protection assay and by single strand conformation polymorphism analysis in...
Hawkins, M E, Mitsuya, H, McCully, C M, Godwin, K S, Murakami, K, Poplack, D G, ...
The pharmacokinetics of 2',3'-dideoxyadenosine (ddA), didanosine, 2',3'-dideoxyguanosine (ddG), and 6-halogenated prodrugs of ddG, 6-chloro-ddG and 6-iodo-ddG, in plasma and cerebrospinal fluid (CSF)...
Penetration of SCH-39304, a new antifungal triazole, into cerebrospinal fluid of primates.
Walsh, T J, Lester-McCully, C, Rinaldi, M G, Wallace, J E, Balis, F M, Lee, J W, ...
We characterized the cerebrospinal fluid (CSF) penetration and pharmacokinetics of SCH-39304 in adult rhesus monkeys receiving a single oral dose of SCH-39304 (2.0 mg/kg of body weight). The mean...
Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome.
Rogers, P, Allegra, C J, Murphy, R F, Drake, J C, Masur, H, Poplack, D G, ...
The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired...
Hockett, R D, De Villartay, J P, Pollock, K, Poplack, D G, Cohen, D I, Korsmeyer, S J
Individual T cells express the CD3 molecule in association with alternative gamma delta or alpha beta heterodimeric T-cell receptors (TCRs). T-cell precursors and occasional gamma delta-expressing T...
Pharmacokinetics of subcutaneous azidothymidine in rhesus monkeys.
Balis, F M, McCully, C, Gough, L, Pizzo, P A, Poplack, D G
The pharmacokinetics of subcutaneous bolus and continuous infusion azidothymidine (AZT) was studied in rhesus monkeys. Three animals received 100 mg/m2 as a bolus injection both intravenously and...
Expression of a multidrug-resistance gene in human tumors and tissues.
Fojo, A T, Ueda, K, Slamon, D J, Poplack, D G, Gottesman, M M, Pastan, I
The identification and cloning of a segment of a human multidrug resistance gene (mdr1) was reported recently. To examine the molecular basis of one type of multidrug resistance, we have prepared RNA...
Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells.
Korsmeyer, S J, Hieter, P A, Ravetch, J V, Poplack, D G, Waldmann, T A, Leder, P
We have used a special class of human acute lymphocytic leukemias, the common "non-T/non-B" cell type, to define a hierarchy of genetic rearrangements that occur during the earliest stages of B-cell...
Smyth, J F, Poplack, D G, Holiman, B J, Leventhal, B G, Yarbro, G
Adenosine deaminase (ADA) activity has been measured in the lymphoblasts of 23 untreated patients with acute lymphoblastic leukemia and related to the presence or absence of immunologic cell surface...
Lipid Peroxidation in the Killing of Phagocytized Pneumococci
Shohet, S. B., Pitt, J., Baehner, R. L., Poplack, D. G.
To directly examine the role of hydrogen peroxide in the killing of bacteria after ingestion by granulocytes, we have studied some of the events of phagocytosis of a mutant strain of pneumococci...
Korsmeyer, S J, Arnold, A, Bakhshi, A, Ravetch, J V, Siebenlist, U, Hieter, P A, ...
We have explored the relationship among immunoglobulin gene rearrangement, cytoplasmic immunoglobulin production, and cell surface antigen expression within 37 cases of acute lymphocytic leukemia....
Felix, C A, Wright, J J, Poplack, D G, Reaman, G H, Cole, D, Goldman, P, ...
We examined alpha-, beta-, and gamma-T cell receptor (TCR) gene activation within acute lymphoblastic leukemias (ALLs) that represent early stages of B and T cell development. We wished to determine...
Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.
Felix, C A, Nau, M M, Takahashi, T, Mitsudomi, T, Chiba, I, Poplack, D G, ...
The p53 gene was examined in primary lymphoblasts of 25 pediatric patients with acute lymphoblastic leukemia by the RNase protection assay and by single strand conformation polymorphism analysis in...
Nelson, D L, Poplack, D G, Holiman, B J, Henkart, P A
Studies were undertaken to investigate the role of anti-target cell antibodies in determining whether lymphocytes can mediate antibody-dependent cellular cytotoxicity (ADCC) in vitro. Trinitrophenyl...