Rothwell, D. G., Hang, B., Gorman, M. A., Freemont, P. S., Singer, B., Hickson, I. D.
HAP1, also known as APE/Ref-1, is the major apurinic/apyrimidinic (AP) endonuclease in human cells. Previous structural studies have suggested a possible role for the Asp-210 residue of HAP1 in the...
Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1.
HAP1 is a divalent cation-dependent endonuclease from human cells with specificity for apurinic/apyrimidinic (AP) sites in DNA. Extraction of the essential metal ion from purified HAP1 stabilized its...
Gorman, M A, Morera, S, Rothwell, D G, De La Fortelle, E, Mol, C D, Tainer, J A, ...
The structure of the major human apurinic/ apyrimidinic endonuclease (HAP1) has been solved at 2.2 A resolution. The enzyme consists of two symmetrically related domains of similar topology and has...
Rothwell, D. G., Hang, B., Gorman, M. A., Freemont, P. S., Singer, B., Hickson, I. D.
HAP1, also known as APE/Ref-1, is the major apurinic/apyrimidinic (AP) endonuclease in human cells. Previous structural studies have suggested a possible role for the Asp-210 residue of HAP1 in the...
Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1.
HAP1 is a divalent cation-dependent endonuclease from human cells with specificity for apurinic/apyrimidinic (AP) sites in DNA. Extraction of the essential metal ion from purified HAP1 stabilized its...
Gorman, M A, Morera, S, Rothwell, D G, De La Fortelle, E, Mol, C D, Tainer, J A, ...
The structure of the major human apurinic/ apyrimidinic endonuclease (HAP1) has been solved at 2.2 A resolution. The enzyme consists of two symmetrically related domains of similar topology and has...