Rectal biopsy in the diagnosis of systemic vasculitis.
Tribe, C R, Scott, D G, Bacon, P A
Vasculitis has been seen in rectal biopsies from 22 patients over a six year period. The most common finding was a necrotising vasculitis of small arteries, indistinguishable from that seen in...
The rattled CSM should think again.
Struthers, G, Smith, D, Scott, D G, Farr, M, Symmons, D P, Coppock, J, ...
"Normal" acute phase response in systemic sclerosis.
Chellingsworth, M, Scott, D G, Crockson, P A, Bacon, P A
An Italian woman with classic active progressive systemic sclerosis had a normal serum concentration of C reactive protein (less than 6 mg/1). During an infection with Staphylococcus aureus, however,...
Retinal vasculitis in rheumatoid arthritis.
Martin, M F, Scott, D G, Gilbert, C, Dieppe, P A, Easty, D L
A woman with exacerbation of severe rheumatoid arthritis developed lesions compatible with retinal vasculitis. Laboratory studies confirmed the diagnosis, and the rapid clinical improvement that...
Rectal biopsy in the diagnosis of systemic vasculitis.
Tribe, C R, Scott, D G, Bacon, P A
Vasculitis has been seen in rectal biopsies from 22 patients over a six year period. The most common finding was a necrotising vasculitis of small arteries, indistinguishable from that seen in...
The rattled CSM should think again.
Struthers, G, Smith, D, Scott, D G, Farr, M, Symmons, D P, Coppock, J, ...
"Normal" acute phase response in systemic sclerosis.
Chellingsworth, M, Scott, D G, Crockson, P A, Bacon, P A
An Italian woman with classic active progressive systemic sclerosis had a normal serum concentration of C reactive protein (less than 6 mg/1). During an infection with Staphylococcus aureus, however,...
Retinal vasculitis in rheumatoid arthritis.
Martin, M F, Scott, D G, Gilbert, C, Dieppe, P A, Easty, D L
A woman with exacerbation of severe rheumatoid arthritis developed lesions compatible with retinal vasculitis. Laboratory studies confirmed the diagnosis, and the rapid clinical improvement that...
Two fluorochromes of contrasting colour, fluorescein and lissamine rhodamine B200 have been used in an application of Coons's immuno-histochemical technique to a comparison of the reactions with...
Immunofluorescence of the skin in gold rashes - with particular reference to IgE.
Iveson, J M, Scott, D G, Perera, W D, Cunliffe, W J, Wright, V
Immunofluorescence studies have been carried out on rashes from 36 patients with rheumatoid arthritis receiving gold therapy. 24 of the rashes were clinically attributed to gold and 12 were diagnosed...
Chronic sarcoid synovitis in the Caucasian: an arthroscopic and histological study.
Scott, D G, Porto, L O, Lovell, C R, Thomas, G O
Chronic synovitis is a rare complication of sarcoidosis, virtually confined to the black population. Synovial histology may be nonspecific or show typical sarcoid granulomata. We report 2 cases of...
Allen, C, Elson, C J, Scott, D G, Bacon, P A, Bucknall, R C
A radioimmunoassay has been developed for measuring IgG antiglobulins using baboon IgG as antigen. Raised levels were virtually confined to the sera of patients with rheumatoid arthritis (RA) and not...
Pyrophosphate arthropathy: a clinical and radiological study of 105 cases.
Dieppe, P A, Alexander, G J, Jones, H E, Doherty, M, Scott, D G, Manhire, A, ...
105 consecutive patients who presented to a rheumatologist because of joint disease and who also had evidence of deposition of calcium pyrophosphate dihydrate (CPD) were studied clinically and...
Pyrophosphate arthropathy: a study of metabolic associations and laboratory data.
Alexander, G M, Dieppe, P A, Doherty, M, Scott, D G
105 consecutive patients with pyrophosphate arthropathy have been studied. Disease associations and metabolic abnormalities were compared with those of an age and sex matched group of 105 acute...
Complement-activating rheumatoid-factor-containing complexes in patients with rheumatoid vasculitis.
Elson, C J, Scott, D G, Blake, D R, Bacon, P A, Holt, P D
The role of complement and rheumatoid factor in immune complexes was examined in patients with a variety of rheumatic diseases. This was done by assessing the amount of rheumatoid factor (RF) bound...
We reported the case of a 40-year-old female with acute onset of systemic lupus erythematosus, followed rapidly by the development of fatal pneumonitis and disseminated intravascular coagulation. The...
Blake, D R, Winyard, P, Scott, D G, Brailsford, S, Blann, A, Lunec, J
One of the proposed mechanisms of vascular damage in connective tissue disease is the direct action of a cytotoxic serum factor inducing endothelial cell damage. The nature of this serum factor is...
Factor VIII related antigen in the assessment of vasculitis.
Woolf, A D, Wakerley, G, Wallington, T B, Scott, D G, Dieppe, P A
Factor VIII related antigen, an endothelial cell product, was markedly raised in systemic necrotising arteritis, reflecting disease activity, but was not raised in active cutaneous vasculitis. In...
Gaston, J S, Scott, D G, Bacon, P A
An acute confusional state, which developed in a patient with polyarteritis nodosa (PAN), proved to be secondary to inappropriate secretion of antidiuretic hormone and consequent hyponatraemia. This...
What proteins are present in polyethylene glycol precipitates from rheumatic sera?
Robinson, M W, Scott, D G, Bacon, P A, Walton, K W, Coppock, J S, Scott, D L
The proteins present in 4% polyethylene glycol (PEG) precipitates of 10 normal sera and 60 samples from patients with rheumatic diseases were studied. A variety of immunochemical methods were used,...
Churg-Strauss vasculitis and ascaris infection.
Chauhan, A, Scott, D G, Neuberger, J, Gaston, J S, Bacon, P A
A patient with Churg-Strauss vasculitis presenting with mononeuritis multiplex, who developed obstructive jaundice, is described. On investigation the jaundice proved to be due to ascaris...
Mycotic aneurysm of the aortic arch masquerading as systemic lupus erythematosus.
The case is described of a patient with mycotic aneurysm of the aortic arch whose clinical and serological features were indistinguishable from those of systemic lupus erythematosus. Surgical...
Isolated nail fold vasculitis in rheumatoid arthritis.
Watts, R A, Carruthers, D M, Scott, D G
OBJECTIVES--To establish the clinical significance of isolated nail fold vasculitis in patients with rheumatoid arthritis (RA). METHODS--Patients attending hospital with established RA were assessed...
Precipitating antibodies to nuclear antigens in systemic vasculitis.
Scott, D G, Skinner, R P, Bacon, P A, Maddison, P J
We have examined sera from 61 patients with systemic vasculitis for precipitating antibodies to components of saline tissue extracts. Precipitins were rare in patients with polyarteritis nodosa (PAN)...
Scott, D G, Bacon, P A, Allen, C, Elson, C J, Wallington, T
IgG and IgM rheumatoid factors (IgG-RF and IgM-RF), complement and three assays for immune complexes were measured in 22 patients with rheumatoid arthritis (RA) complicated by either chronic active...
Fellows, G, Gittoes, N, Scott, D G, Coppock, J S, Wainwright, A, Goodall, M, ...
Using a solid-phase radioimmunoassay we have measured levels of anti-histone autoantibodies of the IgG, IgA and IgM heavy chain classes in 40 patients with systemic lupus erythematosus. Twenty-two...
Elson, C J, Carter, S D, Cottrell, B J, Scott, D G, Bacon, P A, Wallington, T B
The relationship between complexes containing rheumatoid factor and complexes activating complement was examined in synovial fluids and sera from patients with rheumatoid arthritis (RA). In each case...
Anthony, H M, Mearns, A J, Mason, M K, Scott, D G, Moghissi, K, Deverall, P B, ...
Life table analysis of early entry to this randomised blind trial of 318 patients has shown a significantly poorer survival for resected lung cancer patients treated with levamisole for three days...
Response to methotrexate in fibrosing alveolitis associated with connective tissue disease.
Methotrexate by intermittent intramuscular injection was used to treat three patients with fibrosing alveolitis complicating connective tissue diseases. All three patients had improvement of...
Steroid-responsive nephrotic syndrome and allergy: immunological studies.
Meadow, S R, Sarsfield, J K, Scott, D G, Rajah, S M
Immunological studies were performed on 84 children with steroid-sensitive nephrotic syndrome as part of an investigation of the relationship between steroid-responsive nephrotic syndrome and...
Erythromelalgia--the role of hypnotherapy.
Chakravarty, K., Pharoah, P. D., Scott, D. G., Barker, S.
Erythromelalgia is an unusual condition characterized by attacks of burning pain in the hands and feet with local congestion and increased skin temperature. We report a case of erythromelalgia, with...
Cervical spondylotic myelopathy with occult foramen magnum meningioma--a case for MRI?
Chakravarty, K., Scott, D. G., Dick, D., Visick, J.
A fatal case of occult foramen magnum meningioma is described which presented with features of cervical myelopathy confirmed by cervical myelogram. Surgical decompression led to initial improvement...
Myocardial infiltration with immature cells in hypereosinophilic syndrome.
Scott, D. G., Leatherdale, B. A.
A case of hypereosinophilic syndrome is reported. Investigation failed to reveal any precipitating cause or evidence of leukaemia. Death was due to intractable cardiac failure, and post-mortem...
Erosive arthritis in relapsing polychondritis.
Jawad, A. S., Burrel, M., Lim, K. L., Scott, D. G.
We report the case history of a 57 year old man who has suffered from typical deforming, relapsing polychondritis for 13 years. He has also developed erosive destructive seronegative polyarthritis...
Granulomatous mastitis--a rare cause of erythema nodosum.
Adams, D. H., Hubscher, S. G., Scott, D. G.
Granulomatous mastitis is a recently described, rare condition of unknown aetiology. It occurs in young, parous women as a tender extra-areolar breast lump and therefore needs to be differentiated...