D. G. Souza

Effects of the PAF receptor antagonist UK74505 on local and remote reperfusion injuries following ischaemia of the superior mesenteric artery in the rat

Souza, D G, Cara, D C, Cassali, G D, Coutinho, S F, Silveira, M R, Andrade, S P, ...

The effects of the long lasting and potent PAF receptor antagonist UK74505 were assessed on the local and remote injuries following ischaemia and reperfusion (I/R) of the superior mesenteric artery...

Role of the platelet-activating factor (PAF) receptor during pulmonary infection with gram negative bacteria

Soares, A C, Pinho, V S, Souza, D G, Shimizu, T, Ishii, S, Nicoli, J R, ...

The lipid mediator PAF plays an important role in the phagocytosis of particles, including bacteria, and consequent production of pro-inflammatory cytokines, such as TNF-α and IL-8.Using a PAF...

Impaired host defense to Klebsiella pneumoniae infection in mice treated with the PDE4 inhibitor rolipram

Soares, A C, Souza, D G, Pinho, V, Vieira, A T, Barsante, M M, Nicoli, J R, ...

The increase in levels of cAMP in leukocytes by selective inhibitors of PDE4 may result in reduction of inflammation, and may be useful in the treatment of pulmonary inflammatory disorders in humans....

Apoptotic mimicry: phosphatidylserine liposomes reduce inflammation through activation of peroxisome proliferator-activated receptors (PPARs) in vivo

Ramos, G C, Fernandes, D, Charão, C T, Souza, D G, Teixeira, M M, Assreuy, J

Commensal microbiota is fundamental for the development of inflammatory pain

Amaral, F. A., Sachs, D., Costa, V. V., Fagundes, C. T., Cisalpino, D., Cunha, T. M., ...

The ability of an individual to sense pain is fundamental for its capacity to adapt to its environment and to avoid damage. The sensation of pain can be enhanced by acute or chronic inflammation. In...