Carboxylesterases, a key factor in evaluating potential genotoxicity of Trinem antibiotics (2000)
Oliver, J., Naidoo, A., Vandin, L., Pugnaghi, F., Gatehouse, D., Comelli, R.
Sanfetrinem cilexetil, a hexetil ester of a Trinem antibiotic, does not induce micronuclei in rat bone marrow cells or induce DNA repair synthesis in rat hepatocytes following oral dosing. However,...
Wilcox, P., Wedd, D.J., Gatehouse, D.
A collaborative trial was carried out to determine the intra/interlaboratory variability of Salmonella typhimurium strains TA102 and TA97a with regard to spontaneous revertant frequency and in...
Stemp, G., Pascoe, S., Gatehouse, D.
The in vitro and in vivo clastogenic potential of three β-lactam antibiotics, ampicillin, carbenicillin and penicillin VK, was investigated using cultured human lymphocytes and the rat micronucleus...
Albanese, R., Mirkova, E., Gatehouse, D., Ashby, J.
1, 2-Dimethylhydrazine is confirmed as active in the mouse bone-marrow micronucleus assay when administered as an aqueous solution via oral gavage to three different strains of mice. It is also shown...
Gatehouse, D., Wedd, D.J., Paes, D., Delow, G., Burlinson, B., Pascoe, S., ...
Loxtidine, a potent, non-competitive histamine H2-receptor antagonist was evaluated for genotoxic potential using a range of short-term mutagenicity assays. Unequivocally negative results were...
Critical features of bacterial mutation assays (1987)
This review discusses features of the standard protocols currently used in bacterial mutation assays which can have a critical effect upon the test outcome. Such features if not strictly controlled...
The differential mutagenicity of isoniazid in fluctuation assays and Salmonella plate tests (1984)
The anti-tuberculostatic drug, isoniazid (INH) was evaluated for its mutagenic potential using Salmonella plate tests and fluctuation assays with various strains of bacteria, and different metabolic...