An essential regulatory role for macrophage migration inhibitory factor in T-cell activation.
Bacher, M, Metz, C N, Calandra, T, Mayer, K, Chesney, J, Lohoff, M, ...
The protein known as macrophage migration inhibitory factor (MIF) was one of the first cytokines to be discovered and was described 30 years ago to be a T-cell-derived factor that inhibited the...
Kaufmann, A., Mühlradt, P. F., Gemsa, D., Sprenger, H.
Bacterial infections are characterized by strong inflammatory reactions. The responsible mediators are often bacterially derived cell wall molecules, such as lipopolysaccharide or lipoteichoic acids,...
Borrelia burgdorferi induces chemokines in human monocytes.
Sprenger, H, Krause, A, Kaufmann, A, Priem, S, Fabian, D, Burmester, G R, ...
Lyme disease is clinically and histologically characterized by strong inflammatory reactions that contrast the paucity of spirochetes at lesional sites, indicating that borreliae induce mechanisms...
Renz, H, Gentz, U, Schmidt, A, Dapper, T, Nain, M, Gemsa, D
Infection of Lewis rats with Erysipelothrix rhusiopathiae represents an experimental model system of acute and chronic arthritis. We studied here the acute inflammatory phase with respect to...
Stimulation of heme oxygenase in macrophages and liver by endotoxin.
Gemsa, D, Woo, C H, Fudenberg, H H, Schmid, R
In rat peritoneal macrophages, engaged in erythrophagocytosis in vitro, endotoxin stimulated heme oxygenase (HO) activity, which was additive to the substrate-mediated enzyme induction produced by...
Menzel, J, Jungfer, H, Gemsa, D
The effect of immunoglobulins and complement (C) on phagocytosis and intracellular killing of Escherichia coli was studied in vitro. The incubation system consisted of monolayers of human...
Regulation of prostaglandin synthesis by protein kinase C in mouse peritoneal macrophages.
Pfannkuche, H J, Kaever, V, Gemsa, D, Resch, K
Resident mouse peritoneal macrophages synthesized and released prostaglandins (PGs) when challenged with 12-O-tetradecanoylphorbol 13-acetate (TPA) or 1,2-dioctanoyl-sn-glycerol (DiC8). Both stimuli...
Goppelt-Strübe, M, Pfannkuche, H J, Gemsa, D, Resch, K
Prostanoids are synthesized by resident macrophages upon stimulation with diacylglycerols. Oleoylacetylglycerol and dioctanoylglycerol induced prostaglandin E and thromboxane synthesis in a time- and...
Microbial Transformation of 2,4,6-Trinitrotoluene in Aerobic Soil Columns
Bruns-Nagel, D., Breitung, J., Von Low, E., Steinbach, K., Gorontzy, T., Kahl, M., ...
2,4,6-Trinitrotoluene (TNT)-contaminated soil material of a former TNT production plant was percolated aerobically in soil columns. Nineteen days of percolation with a potassium phosphate buffer...
An essential regulatory role for macrophage migration inhibitory factor in T-cell activation.
Bacher, M, Metz, C N, Calandra, T, Mayer, K, Chesney, J, Lohoff, M, ...
The protein known as macrophage migration inhibitory factor (MIF) was one of the first cytokines to be discovered and was described 30 years ago to be a T-cell-derived factor that inhibited the...
Kaufmann, A., Mühlradt, P. F., Gemsa, D., Sprenger, H.
Bacterial infections are characterized by strong inflammatory reactions. The responsible mediators are often bacterially derived cell wall molecules, such as lipopolysaccharide or lipoteichoic acids,...
Borrelia burgdorferi induces chemokines in human monocytes.
Sprenger, H, Krause, A, Kaufmann, A, Priem, S, Fabian, D, Burmester, G R, ...
Lyme disease is clinically and histologically characterized by strong inflammatory reactions that contrast the paucity of spirochetes at lesional sites, indicating that borreliae induce mechanisms...
Renz, H, Gentz, U, Schmidt, A, Dapper, T, Nain, M, Gemsa, D
Infection of Lewis rats with Erysipelothrix rhusiopathiae represents an experimental model system of acute and chronic arthritis. We studied here the acute inflammatory phase with respect to...
Stimulation of heme oxygenase in macrophages and liver by endotoxin.
Gemsa, D, Woo, C H, Fudenberg, H H, Schmid, R
In rat peritoneal macrophages, engaged in erythrophagocytosis in vitro, endotoxin stimulated heme oxygenase (HO) activity, which was additive to the substrate-mediated enzyme induction produced by...
Menzel, J, Jungfer, H, Gemsa, D
The effect of immunoglobulins and complement (C) on phagocytosis and intracellular killing of Escherichia coli was studied in vitro. The incubation system consisted of monolayers of human...
Regulation of prostaglandin synthesis by protein kinase C in mouse peritoneal macrophages.
Pfannkuche, H J, Kaever, V, Gemsa, D, Resch, K
Resident mouse peritoneal macrophages synthesized and released prostaglandins (PGs) when challenged with 12-O-tetradecanoylphorbol 13-acetate (TPA) or 1,2-dioctanoyl-sn-glycerol (DiC8). Both stimuli...
Goppelt-Strübe, M, Pfannkuche, H J, Gemsa, D, Resch, K
Prostanoids are synthesized by resident macrophages upon stimulation with diacylglycerols. Oleoylacetylglycerol and dioctanoylglycerol induced prostaglandin E and thromboxane synthesis in a time- and...
Microbial Transformation of 2,4,6-Trinitrotoluene in Aerobic Soil Columns
Bruns-Nagel, D., Breitung, J., Von Low, E., Steinbach, K., Gorontzy, T., Kahl, M., ...
2,4,6-Trinitrotoluene (TNT)-contaminated soil material of a former TNT production plant was percolated aerobically in soil columns. Nineteen days of percolation with a potassium phosphate buffer...
Migration inhibitory factor expression in experimentally induced endotoxemia.
Bacher, M., Meinhardt, A., Lan, H. Y., Mu, W., Metz, C. N., Chesney, J. A., ...
Macrophage migration inhibitory factor (MIF) is an important constituent of the host response to stress and infection and is the first mediator that has been identified to be released from immune...
Activation of glomerular mesangial cells by gram-negative bacterial cell wall components.
Lovett, D. H., Bursten, S. L., Gemsa, D., Bessler, W., Resch, K., Ryan, J. L.
The cell walls of gram-negative bacteria contain several biologically active components, including lipopolysaccharide (LPS), lipoprotein, and protein 1. The effects of these individual components and...
Lovett, D. H., Resch, K., Gemsa, D.
Monocytic (MC) infiltration is a prominent feature of many forms of immune-mediated glomerulonephritis. Through the release of interleukin-1, (IL-1), monocyte/macrophages have been shown to induce...
Release of prostaglandin E and thromboxane from macrophages by stimulation with factor H.
Hartung, H P, Hadding, U, Bitter-Suermann, D, Gemsa, D
Recently novel actions of factor H of complement other than regulation of alternative pathway activation have been described. We examined the influence of H on the arachidonic acid (AA) metabolism of...
MIF expression in the rat brain: implications for neuronal function.
Bacher, M., Meinhardt, A., Lan, H. Y., Dhabhar, F. S., Mu, W., Metz, C. N., ...
BACKGROUND: The mediator known historically as macrophage migration inhibitory factor (MIF) has been identified recently as being released into the circulation by the anterior pituitary gland as a...