Natarajan, K, Singh, S, Burke, T R, Grunberger, D, Aggarwal, B B
Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory properties. The...
Carothers, A M, Zhen, W, Mucha, J, Zhang, Y J, Santella, R M, Grunberger, D, ...
We evaluated the formation and removal of (+-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4- tetrahydrobenzo[c]phenanthrene (BcPHDE)-DNA adducts in two Chinese hamster ovary (CHO) cell...
Carothers, A M, Mucha, J, Grunberger, D
We previously showed that the preferred mutation induced by (+/-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy- 1,2,3,4-tetrahydrobenzo[c]phenanthrene (BcPHDE) in the dihydrofolate reductase gene...
Carothers, A M, Urlaub, G, Mucha, J, Harvey, R G, Chasin, L A, Grunberger, D
Cultured Chinese hamster ovary (CHO) cells were treated with the polycyclic aromatic hydrocarbon racemic 3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4- tetrahydrobenzo[c]phenanthrene....
Novel Pseudomonas product stimulates interleukin-8 production in airway epithelial cells in vitro.
Massion, P P, Inoue, H, Richman-Eisenstat, J, Grunberger, D, Jorens, P G, Housset, B, ...
Because high concentrations of IL-8 are found in the sputum of cystic fibrosis patients, we hypothesized that Pseudomonas aeruginosa (PA) induces the production of IL-8 in airway epithelial cells and...
Abuaf, P A, Kadlubar, F F, Grunberger, D
Poly(dG-dC) was modified to different extents by the carcinogens 4-aminobiphenyl (ABP) or N-methyl-4-aminoazobenzene (MAB). HPLC analysis of the enzymatically hydrolyzed modified polymers indicates...
Santella, R M, Grunberger, D, Weinstein, I B, Rich, A
Poly(dG-dC).poly(dG-dC) and poly(dG).poly(dC) were modified by treatment with N-acetoxy-N-2-acetylaminofluorene, and their conformations were examined by circular dichroism and susceptibility to...
Ushay, H M, Santella, R M, Caradonna, J P, Grunberger, D, Lippard, S J
Chlorodiethylenetriamineplatinum(II) chloride, [(dien)PtCl]Cl, bound to less than or equal to 10% of the nucleotide bases of poly(dG-dC) . poly(dG-dC) reduces the amount of ethanol necessary to bring...
Banerjee, R, Carothers, A M, Grunberger, D
It has been demonstrated that certain alternating purine and pyrimidine sequences may assume a left-handed Z-DNA conformation. In order to evaluate the possibility that Z-DNA is involved in the...
Recent studies have demonstrated that the left-handed, Z-DNA conformation is favored in polymers containing alternating purine/pyrimidine sequences that can exist in vivo and may play a role in gene...
Singer, B, Pulkrabek, P, Weinstein, I B, Grunberger, D
TMV RNA was modified by two bulky carcinogens, N-acetoxy-2-acetylamino-fluorene (AAAF) and (+/-)-7beta, 8alpha- dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo[alpha]pyrene (BPDE), and the...
Molecular cloning, sequence analysis and in vitro expression of a rat tRNA gene cluster.
Makowski, D R, Haas, R A, Dolan, K P, Grunberger, D
A rat genomic DNA fragment containing a tRNA gene cluster was isolated from a lambda phage library. Hybridization and nucleotide sequence analysis revealed the presence of a 83 bp tRNALeuCUG gene and...
Changes of post-transcriptional modification of wye base in tumor-specific tRNAPhe.
Kuchino, Y, Borek, E, Grunberger, D, Mushinski, J F, Nishimura, S
Nucleotide sequences of normal mouse liver tRNAPhe and tumor-specific tRNAPhes isolated from Ehrlich ascites tumor and neuroblastoma cells were examined by post-labeling techniques. The results...
Santella, R M, Grunberger, D, Broyde, S, Hingerty, B E
The conformation of poly(dG-dC).poly(dG-dC), poly(dG).poly(dC), and calf thymus DNA modified with N-acetoxy-N-2-acetylaminofluorene (N-acetoxy-AAF) was examined by extent of reaction with anti...
Singer, B, Pergolizzi, R G, Grunberger, D
Dinucleoside diphosphates of the general type pGpN have been prepared enzymatically using ribonuclease N1. Alkylated uridines or cytidines, which are products of carcinogens acting on nucleic acids,...
Incorporation of lysine into Y base of phenylalanine tRNA in Vero cells.
Pergolizzi, R G, Engelhardt, D L, Grunberger, D
Vero cells, a line derived from African green monkey kidney, contains a hypermodified base, called Y, adjacent to the 3' end of the anticodon of tRNAPhe. Two types of evidence are presented...
Reconstitution of rods from tobacco mosaic virus protein and RNA modified with bulky carcinogens.
Fraenkel-Conrat, H, Singer, B, Takanami, Y, Santella, R M, Grunberger, D
Tobacco mosaic virus (TMV) RNA was treated with radioactive N-acetoxy-2-acetylaminofluorene (N-acetoxy-AAF) and (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10...
Poirier, M C, Lippard, S J, Zwelling, L A, Ushay, H M, Kerrigan, D, Thill, C C, ...
Rabbit antiserum elicited against calf thymus DNA modified to 4.4% (Pt drug/nucleotide ratio = 0.044) with the antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP) contains antibodies specific...
Carothers, A M, Urlaub, G, Grunberger, D, Chasin, L A
Point mutants induced with a variety of mutagens at the dihydrofolate reductase (dhfr) locus in Chinese hamster ovary (CHO) cells were screened for aberrantly spliced dhfr mRNA by RNase protection...
Carothers, A M, Urlaub, G, Steigerwalt, R W, Chasin, L A, Grunberger, D
To determine the types of alterations in gene structure that are induced by the carcinogen 2-(N-acetoxy-N-acetyl)aminofluorene, we used this compound to generate mutations at the dihydrofolate...
Natarajan, K, Singh, S, Burke, T R, Grunberger, D, Aggarwal, B B
Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory properties. The...
Carothers, A M, Zhen, W, Mucha, J, Zhang, Y J, Santella, R M, Grunberger, D, ...
We evaluated the formation and removal of (+-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4- tetrahydrobenzo[c]phenanthrene (BcPHDE)-DNA adducts in two Chinese hamster ovary (CHO) cell...
Carothers, A M, Mucha, J, Grunberger, D
We previously showed that the preferred mutation induced by (+/-)-3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy- 1,2,3,4-tetrahydrobenzo[c]phenanthrene (BcPHDE) in the dihydrofolate reductase gene...
Carothers, A M, Urlaub, G, Mucha, J, Harvey, R G, Chasin, L A, Grunberger, D
Cultured Chinese hamster ovary (CHO) cells were treated with the polycyclic aromatic hydrocarbon racemic 3 alpha,4 beta-dihydroxy-1 alpha,2 alpha-epoxy-1,2,3,4- tetrahydrobenzo[c]phenanthrene....
Novel Pseudomonas product stimulates interleukin-8 production in airway epithelial cells in vitro.
Massion, P P, Inoue, H, Richman-Eisenstat, J, Grunberger, D, Jorens, P G, Housset, B, ...
Because high concentrations of IL-8 are found in the sputum of cystic fibrosis patients, we hypothesized that Pseudomonas aeruginosa (PA) induces the production of IL-8 in airway epithelial cells and...
Abuaf, P A, Kadlubar, F F, Grunberger, D
Poly(dG-dC) was modified to different extents by the carcinogens 4-aminobiphenyl (ABP) or N-methyl-4-aminoazobenzene (MAB). HPLC analysis of the enzymatically hydrolyzed modified polymers indicates...
Santella, R M, Grunberger, D, Weinstein, I B, Rich, A
Poly(dG-dC).poly(dG-dC) and poly(dG).poly(dC) were modified by treatment with N-acetoxy-N-2-acetylaminofluorene, and their conformations were examined by circular dichroism and susceptibility to...
Ushay, H M, Santella, R M, Caradonna, J P, Grunberger, D, Lippard, S J
Chlorodiethylenetriamineplatinum(II) chloride, [(dien)PtCl]Cl, bound to less than or equal to 10% of the nucleotide bases of poly(dG-dC) . poly(dG-dC) reduces the amount of ethanol necessary to bring...
Banerjee, R, Carothers, A M, Grunberger, D
It has been demonstrated that certain alternating purine and pyrimidine sequences may assume a left-handed Z-DNA conformation. In order to evaluate the possibility that Z-DNA is involved in the...
Recent studies have demonstrated that the left-handed, Z-DNA conformation is favored in polymers containing alternating purine/pyrimidine sequences that can exist in vivo and may play a role in gene...
Singer, B, Pulkrabek, P, Weinstein, I B, Grunberger, D
TMV RNA was modified by two bulky carcinogens, N-acetoxy-2-acetylamino-fluorene (AAAF) and (+/-)-7beta, 8alpha- dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo[alpha]pyrene (BPDE), and the...
Molecular cloning, sequence analysis and in vitro expression of a rat tRNA gene cluster.
Makowski, D R, Haas, R A, Dolan, K P, Grunberger, D
A rat genomic DNA fragment containing a tRNA gene cluster was isolated from a lambda phage library. Hybridization and nucleotide sequence analysis revealed the presence of a 83 bp tRNALeuCUG gene and...
Changes of post-transcriptional modification of wye base in tumor-specific tRNAPhe.
Kuchino, Y, Borek, E, Grunberger, D, Mushinski, J F, Nishimura, S
Nucleotide sequences of normal mouse liver tRNAPhe and tumor-specific tRNAPhes isolated from Ehrlich ascites tumor and neuroblastoma cells were examined by post-labeling techniques. The results...
Santella, R M, Grunberger, D, Broyde, S, Hingerty, B E
The conformation of poly(dG-dC).poly(dG-dC), poly(dG).poly(dC), and calf thymus DNA modified with N-acetoxy-N-2-acetylaminofluorene (N-acetoxy-AAF) was examined by extent of reaction with anti...
Singer, B, Pergolizzi, R G, Grunberger, D
Dinucleoside diphosphates of the general type pGpN have been prepared enzymatically using ribonuclease N1. Alkylated uridines or cytidines, which are products of carcinogens acting on nucleic acids,...
Incorporation of lysine into Y base of phenylalanine tRNA in Vero cells.
Pergolizzi, R G, Engelhardt, D L, Grunberger, D
Vero cells, a line derived from African green monkey kidney, contains a hypermodified base, called Y, adjacent to the 3' end of the anticodon of tRNAPhe. Two types of evidence are presented...
Reconstitution of rods from tobacco mosaic virus protein and RNA modified with bulky carcinogens.
Fraenkel-Conrat, H, Singer, B, Takanami, Y, Santella, R M, Grunberger, D
Tobacco mosaic virus (TMV) RNA was treated with radioactive N-acetoxy-2-acetylaminofluorene (N-acetoxy-AAF) and (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10...
Poirier, M C, Lippard, S J, Zwelling, L A, Ushay, H M, Kerrigan, D, Thill, C C, ...
Rabbit antiserum elicited against calf thymus DNA modified to 4.4% (Pt drug/nucleotide ratio = 0.044) with the antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP) contains antibodies specific...
Carothers, A M, Urlaub, G, Grunberger, D, Chasin, L A
Point mutants induced with a variety of mutagens at the dihydrofolate reductase (dhfr) locus in Chinese hamster ovary (CHO) cells were screened for aberrantly spliced dhfr mRNA by RNase protection...
Carothers, A M, Urlaub, G, Steigerwalt, R W, Chasin, L A, Grunberger, D
To determine the types of alterations in gene structure that are induced by the carcinogen 2-(N-acetoxy-N-acetyl)aminofluorene, we used this compound to generate mutations at the dihydrofolate...