D. H. Rich

Inhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin A.

Bartz, S R, Hohenwalter, E, Hu, M K, Rich, D H, Malkovsky, M

Analogs of the immunosuppressive cyclic undecapeptide cyclosporin A (CsA) with substitutions in positions 1, 4, 6, and/or 11 were rationally designed to possess substantially diminished or no...

X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor.

Swain, A L, Miller, M M, Green, J, Rich, D H, Schneider, J, Kent, S B, ...

The structure of a crystal complex of the chemically synthesized protease of human immunodeficiency virus 1 with a heptapeptide-derived inhibitor bound in the active site has been determined. The...

Deuterated oxytocins: the synthesis and biological properties of three crystalline analogs of deamino-oxytocin deuterated in the 1-beta-mercaptopropionic acid position.

Blomquist, A T, Rich, D H, Hruby, V J, Nangeroni, L L, Glose, P, Du Vigneaud, V

Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin.

James, M N, Sielecki, A, Salituro, F, Rich, D H, Hofmann, T

Crystals of the molecular complex between the esterified tripeptide fragment of pepstatin and the aspartyl proteinase penicillopepsin are isomorphous with crystals of native penicillopepsin. The...

Affinity purification of the novel cysteine proteinase papaya proteinase IV, and papain from papaya latex.

Buttle, D J, Kembhavi, A A, Sharp, S L, Shute, R E, Rich, D H, Barrett, A J

A procedure is described for the purification of a previously undetected cysteine proteinase, which we have called papaya proteinase IV, from spray-dried latex of the papaya (Carica papaya) plant....

Purification of cathepsin B by a new form of affinity chromatography.

Rich, D H, Brown, M A, Barrett, A J

Human cathepsin B was purified by affinity chromatography on the semicarbazone of Gly-Phe-glycinal linked to Sepharose 4B, with elution by 2,2'-dipyridyl disulphide at pH 4.0. The product obtained in...

Inhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin A.

Bartz, S R, Hohenwalter, E, Hu, M K, Rich, D H, Malkovsky, M

Analogs of the immunosuppressive cyclic undecapeptide cyclosporin A (CsA) with substitutions in positions 1, 4, 6, and/or 11 were rationally designed to possess substantially diminished or no...

X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor.

Swain, A L, Miller, M M, Green, J, Rich, D H, Schneider, J, Kent, S B, ...

The structure of a crystal complex of the chemically synthesized protease of human immunodeficiency virus 1 with a heptapeptide-derived inhibitor bound in the active site has been determined. The...

Deuterated oxytocins: the synthesis and biological properties of three crystalline analogs of deamino-oxytocin deuterated in the 1-beta-mercaptopropionic acid position.

Blomquist, A T, Rich, D H, Hruby, V J, Nangeroni, L L, Glose, P, Du Vigneaud, V

Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin.

James, M N, Sielecki, A, Salituro, F, Rich, D H, Hofmann, T

Crystals of the molecular complex between the esterified tripeptide fragment of pepstatin and the aspartyl proteinase penicillopepsin are isomorphous with crystals of native penicillopepsin. The...

Affinity purification of the novel cysteine proteinase papaya proteinase IV, and papain from papaya latex.

Buttle, D J, Kembhavi, A A, Sharp, S L, Shute, R E, Rich, D H, Barrett, A J

A procedure is described for the purification of a previously undetected cysteine proteinase, which we have called papaya proteinase IV, from spray-dried latex of the papaya (Carica papaya) plant....

Purification of cathepsin B by a new form of affinity chromatography.

Rich, D H, Brown, M A, Barrett, A J

Human cathepsin B was purified by affinity chromatography on the semicarbazone of Gly-Phe-glycinal linked to Sepharose 4B, with elution by 2,2'-dipyridyl disulphide at pH 4.0. The product obtained in...