Meltzer, E O, Hampel, F C, Ratner, P H, Bernstein, D I, Larsen, L V, Berger, W E, ...
Background: A nasal spray containing the antiallergy agent olopatadine hydrochloride is being developed for the treatment of seasonal allergic rhinitis (SAR). Objective: To evaluate the safety and...
Civamide (cis-Capsaicin) for Treatment of Primary or Recurrent Experimental Genital Herpes
Bourne, N., Bernstein, D. I., Stanberry, L. R.
Neuropharmacologic agents able to disrupt normal virus-neuron interactions may provide an alternative strategy for the treatment of herpes simplex virus (HSV) infections. We have previously shown...
Bourne, N., Stanberry, L. R., Kern, E. R., Holan, G., Matthews, B., Bernstein, D. I.
Dendrimers are large highly branched macromolecules synthesized from a polyfunctional core. They have shown a variety of biological properties, including, in some instances, antiviral activity. In...
Evans, T. G., Bernstein, D. I., Raborn, G. W., Harmenberg, J., Kowalski, J., Spruance, S. L.
Immunopathology is recognized as an important component of infectious disease manifestations, and corticosteroids have been used as an adjunct to antimicrobial therapy for a variety of conditions....
Effect of foscarnet cream on experimental UV radiation-induced herpes labialis.
Bernstein, D I, Schleupner, C J, Evans, T G, Blumberg, D A, Bryson, Y, Grafford, K, ...
A topical 3% foscarnet cream formulation was evaluated for its ability to treat experimental UV radiation (UVR)-induced herpes labialis in a double-blind study. Healthy adult volunteers with a...
Ribavirin small-particle-aerosol treatment of influenza B virus infection.
Bernstein, D I, Reuman, P D, Sherwood, J R, Young, E C, Schiff, G M
In a randomized double-blind trial of aerosolized ribavirin for the treatment of influenza B virus infection, no significant difference was found in the febrile course or symptom score of the...
R837 is an immune modulator with no in vitro activity against herpes simplex virus (HSV). We evaluated topical R837 as therapy for genital HSV type 2 infection using the guinea pig model of this...
Oral ribavirin treatment of influenza A and B.
Stein, D S, Creticos, C M, Jackson, G G, Bernstein, J M, Hayden, F G, Schiff, G M, ...
A loading dose and short-term administration of oral ribavirin significantly improved symptoms and signs of influenza type A or B infection in 25 patients. The antiviral effect was not significant....
Ward, R L, Mason, B B, Bernstein, D I, Sander, D S, Smith, V E, Zandle, G A, ...
The NSP4 protein of a simian rotavirus was reported to induce diarrhea following inoculation of mice. If NSP4 is responsible for rotavirus diarrhea in humans, attenuation of a human rotavirus may be...
Ward, R L, McNeal, M M, Sander, D S, Greenberg, H B, Bernstein, D I
Natural infection by very similar strains of rotavirus during the 1988-1989 rotavirus season in Cincinnati, Ohio, provided complete protection of young children against subsequent rotavirus illnesses...
Ward, R L, Knowlton, D R, Greenberg, H B, Schiff, G M, Bernstein, D I
Serum specimens from infants 2 to 12 months old vaccinated with the WC3 bovine rotavirus were analyzed to determine the relative concentrations of neutralizing antibody to the VP4 and VP7 proteins of...
Bernstein, D I, Ashley, R L, Stanberry, L R, Myers, M G
The evaluation of herpes simplex virus (HSV) vaccine efficacy will require methods to detect asymptomatic acquisition of HSV infection and to assess the risk of recurrences in these patients....
Prevention of surface-to-human transmission of rotaviruses by treatment with disinfectant spray.
Ward, R L, Bernstein, D I, Knowlton, D R, Sherwood, J R, Young, E C, Cusack, T M, ...
A model was developed to examine the effects of disinfectants on the transmission of infectious rotavirus from a dried surface to humans. The initial experiments were designed to find a method of...
Harrison, C J, Miller, R L, Bernstein, D I
Imiquimod, an immunomodulator with no direct in vitro antiviral activity, has in vivo anti-herpesvirus activity by inducing interferon and enhancing other only partially defined immune responses....
Bernstein, D. I., Stanberry, L. R., Sacks, S., Ayisi, N. K., Gong, Y. H., Ireland, J., ...
Prevention of sexually transmitted infections is a priority in developed and developing countries. One approach to prevention is the use of topical microbicides, and one promising approach is the use...
Evaluation of a possible association of urban air toxics and asthma.
Leikauf, G D, Kline, S, Albert, R E, Baxter, C S, Bernstein, D I, Buncher, C R
The prevalence of asthma, measured either as the frequency of hospital admissions or number of deaths attributed to asthma, has increased over the last 15 to 20 years. Rapid increases in disease...
Immune responses in farm workers after exposure to Bacillus thuringiensis pesticides.
Bernstein, I L, Bernstein, J A, Miller, M, Tierzieva, S, Bernstein, D I, Lummus, Z, ...
Although health risks to pesticides containing Bacillus thuringiensis (Bt) have been minimal, the potential allergenicity of these organisms has not been evaluated. Therefore, a health survey was...
Civamide (cis-Capsaicin) for Treatment of Primary or Recurrent Experimental Genital Herpes
Bourne, N., Bernstein, D. I., Stanberry, L. R.
Neuropharmacologic agents able to disrupt normal virus-neuron interactions may provide an alternative strategy for the treatment of herpes simplex virus (HSV) infections. We have previously shown...
Bourne, N., Stanberry, L. R., Kern, E. R., Holan, G., Matthews, B., Bernstein, D. I.
Dendrimers are large highly branched macromolecules synthesized from a polyfunctional core. They have shown a variety of biological properties, including, in some instances, antiviral activity. In...
Evans, T. G., Bernstein, D. I., Raborn, G. W., Harmenberg, J., Kowalski, J., Spruance, S. L.
Immunopathology is recognized as an important component of infectious disease manifestations, and corticosteroids have been used as an adjunct to antimicrobial therapy for a variety of conditions....
Effect of foscarnet cream on experimental UV radiation-induced herpes labialis.
Bernstein, D I, Schleupner, C J, Evans, T G, Blumberg, D A, Bryson, Y, Grafford, K, ...
A topical 3% foscarnet cream formulation was evaluated for its ability to treat experimental UV radiation (UVR)-induced herpes labialis in a double-blind study. Healthy adult volunteers with a...
Ribavirin small-particle-aerosol treatment of influenza B virus infection.
Bernstein, D I, Reuman, P D, Sherwood, J R, Young, E C, Schiff, G M
In a randomized double-blind trial of aerosolized ribavirin for the treatment of influenza B virus infection, no significant difference was found in the febrile course or symptom score of the...
R837 is an immune modulator with no in vitro activity against herpes simplex virus (HSV). We evaluated topical R837 as therapy for genital HSV type 2 infection using the guinea pig model of this...
Oral ribavirin treatment of influenza A and B.
Stein, D S, Creticos, C M, Jackson, G G, Bernstein, J M, Hayden, F G, Schiff, G M, ...
A loading dose and short-term administration of oral ribavirin significantly improved symptoms and signs of influenza type A or B infection in 25 patients. The antiviral effect was not significant....
Ward, R L, Mason, B B, Bernstein, D I, Sander, D S, Smith, V E, Zandle, G A, ...
The NSP4 protein of a simian rotavirus was reported to induce diarrhea following inoculation of mice. If NSP4 is responsible for rotavirus diarrhea in humans, attenuation of a human rotavirus may be...
Ward, R L, McNeal, M M, Sander, D S, Greenberg, H B, Bernstein, D I
Natural infection by very similar strains of rotavirus during the 1988-1989 rotavirus season in Cincinnati, Ohio, provided complete protection of young children against subsequent rotavirus illnesses...
Ward, R L, Knowlton, D R, Greenberg, H B, Schiff, G M, Bernstein, D I
Serum specimens from infants 2 to 12 months old vaccinated with the WC3 bovine rotavirus were analyzed to determine the relative concentrations of neutralizing antibody to the VP4 and VP7 proteins of...
Bernstein, D I, Ashley, R L, Stanberry, L R, Myers, M G
The evaluation of herpes simplex virus (HSV) vaccine efficacy will require methods to detect asymptomatic acquisition of HSV infection and to assess the risk of recurrences in these patients....
Prevention of surface-to-human transmission of rotaviruses by treatment with disinfectant spray.
Ward, R L, Bernstein, D I, Knowlton, D R, Sherwood, J R, Young, E C, Cusack, T M, ...
A model was developed to examine the effects of disinfectants on the transmission of infectious rotavirus from a dried surface to humans. The initial experiments were designed to find a method of...
Harrison, C J, Miller, R L, Bernstein, D I
Imiquimod, an immunomodulator with no direct in vitro antiviral activity, has in vivo anti-herpesvirus activity by inducing interferon and enhancing other only partially defined immune responses....
Bernstein, D. I., Stanberry, L. R., Sacks, S., Ayisi, N. K., Gong, Y. H., Ireland, J., ...
Prevention of sexually transmitted infections is a priority in developed and developing countries. One approach to prevention is the use of topical microbicides, and one promising approach is the use...
Evaluation of a possible association of urban air toxics and asthma.
Leikauf, G D, Kline, S, Albert, R E, Baxter, C S, Bernstein, D I, Buncher, C R
The prevalence of asthma, measured either as the frequency of hospital admissions or number of deaths attributed to asthma, has increased over the last 15 to 20 years. Rapid increases in disease...
Immune responses in farm workers after exposure to Bacillus thuringiensis pesticides.
Bernstein, I L, Bernstein, J A, Miller, M, Tierzieva, S, Bernstein, D I, Lummus, Z, ...
Although health risks to pesticides containing Bacillus thuringiensis (Bt) have been minimal, the potential allergenicity of these organisms has not been evaluated. Therefore, a health survey was...