Hoffman, IEA, Lauwerys, BR, De Keyser, Filip, Huizinga, TWJ, Isenberg, D, Cebecauer, L, ...
Objective: To investigate differences in clinical signs and symptoms, and in antinuclear antibodies ( ANA), between patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE)....
Chambers, S. A., Raine, R., Rahman, A., Isenberg, D.
Objective. It has been suggested that low adherence may contribute to poor clinical outcomes in patients with SLE. In this study, we explored the reasons why patients with lupus did or did not take...
Hanly, J G, Urowitz, M B, Su, L, Sanchez-Guerrero, J, Bae, S C, Gordon, C, ...
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Hanly, J G, Urowitz, M B, Siannis, F, Farewell, V, Gordon, C, Bae, S C, ...
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Urowitz, M B, Gladman, D, Ibañez, D, Fortin, P, Sanchez-Guerrero, J, Bae, S, ...
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Urowitz, M B, Gladman, D, Ibañez, D, Fortin, P, Sanchez-Guerrero, J, Bae, S, ...
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Hodgkin's lymphoma in systemic lupus erythematosus (2007)
Bernatsky, S., Ramsey-Goldman, R., Isenberg, D., Rahman, A., Dooley, M. A., Sibley, J., ...
Objective. In systemic lupus erythematosus (SLE), there is a well-documented increased risk of non-Hodgkin's lymphoma (NHL), but little is known about the risk of Hodgkin's lymphoma (HL). The purpose...
Hanly, J G, Urowitz, M B, Sanchez-Guerrero, J, Bae, S C, Gordon, C, Wallace, D J, ...
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Urowitz, M B, Gladman, D, Ibañez, D, Fortin, P, Sanchez-Guerrero, J, Bae, S, ...
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Hodgkin's lymphoma in systemic lupus erythematosus (2007)
Bernatsky, S., Ramsey-Goldman, R., Isenberg, D., Rahman, A., Dooley, M. A., Sibley, J., ...
Objective. In systemic lupus erythematosus (SLE), there is a well-documented increased risk of non-Hodgkin's lymphoma (NHL), but little is known about the risk of Hodgkin's lymphoma (HL). The purpose...
Hodgkin's lymphoma in systemic lupus erythematosus (2007)
Bernatsky, S., Ramsey-Goldman, R., Isenberg, D., Rahman, A., Dooley, M. A., Sibley, J., ...
Objective. In systemic lupus erythematosus (SLE), there is a well-documented increased risk of non-Hodgkin's lymphoma (NHL), but little is known about the risk of Hodgkin's lymphoma (HL). The purpose...
Giles, I., Lambrianides, N., Pattni, N., Faulkes, D., Latchman, D., Chen, P., ...
In the antiphospholipid syndrome (APS), antiphospholipid Abs (aPL) bind to anionic phospholipids (PL) and various associated proteins, especially beta2-glycoprotein I (beta2GPI) and prothrombin. In...
Mortality in systemic lupus erythematosus (2006)
Bernatsky, S, Boivin, J-F, Joseph, L, Manzi, S, Ginzler, E, Gladman, D D, ...
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Adler, M., Chambers, S., Edwards, C., Neild, G., Isenberg, D.
Objectives. Although the prognosis for patients with renal lupus has improved, a small number still progress to renal failure. Studies from the USA have found it difficult to distinguish whether the...
Adler, M., Chambers, S., Edwards, C., Neild, G., Isenberg, D.
Objectives. Although the prognosis for patients with renal lupus has improved, a small number still progress to renal failure. Studies from the USA have found it difficult to distinguish whether the...
Adler, M., Chambers, S., Edwards, C., Neild, G., Isenberg, D.
Objectives. Although the prognosis for patients with renal lupus has improved, a small number still progress to renal failure. Studies from the USA have found it difficult to distinguish whether the...
Giles, I., Lambrianides, N., Latchman, D., Chen, P., Chukwuocha, R., Isenberg, D., ...
Previously we reported that the variable heavy chain region (VH) of a human beta2 glycoprotein I-dependent monoclonal antiphospholipid antibody (IS4) was dominant in conferring the ability to bind...
Race/ethnicity and cancer occurrence in systemic lupus erythematosus (2005)
Bernatsky, S, Boivin, J F, Joseph, L, Manzi, S, Ginzler, E, Urowitz, M, ...
An international cohort study of cancer in systemic lupus erythematosus (2005)
Bernatsky, S, Boivin, J F, Joseph, L, Rajan, R, Zoma, A, Manzi, S, ...
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Hoffman, IEA, Peene, I, Union, A, Meheus, L, Huizinga, T, Cebecauer, L, ...
No abstract available.
Hoffman, I, Peene, I, Meheus, L, Bosschere, K De, Hulstaert, F, Huizinga, TWJ, ...
No abstract available.
Sharma, A., Isenberg, D., Diamond, B.
Background. Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease serologically characterized by production of a variety of autoantibodies. Antibodies to...
Sharma, A., Isenberg, D., Diamond, B.
Background. Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease serologically characterized by production of a variety of autoantibodies. Antibodies to double-stranded (ds) DNA are...
Sharma, A., Isenberg, D., Diamond, B.
Background. Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease serologically characterized by production of a variety of autoantibodies. Antibodies to double-stranded (ds) DNA are...
Lupus patients with fatigue--is there a link with fibromyalgia syndrome? (2000)
Taylor, J., Skan, J., Erb, N., Carruthers, D., Bowman, S., Gordon, C., ...
Objective. To determine whether fibromyalgia syndrome (FMS) was more common in patients with lupus who were complaining of fatigue. Methods. We interviewed 216 patients attending two...
GENETIC ANALYSIS OF TAP2 IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS FROM TWO ETHNIC GROUPS (1996)
ÖCAL, L., RUSSELL, K., BEYNON, H., CRUICKSHANK, K., LANCHBURY, J. S., WALPORT, M., ...
The aim of this study was to determine whether the TAP2 (Transporter associated with Antigen Processing 2) locus is involved in susceptibility to systemic lupus erythematosus (SLE). We adopted the...
PREVALENCE OF SELF-REPORTED DEPRESSION IN PATIENTS WITH RHEUMATOID ARTHRITIS (1996)
PINCUS, T., GRIFFITH, J., PEARCE, S., ISENBERG, D.
The prevalence of self-reported depressive symptoms was investigated in a case-control study of patients with rheumatoid arthritis (RA) attending an out-patient clinic at the Middlesex Hospital....
BODMAN-SMITH, K., SUMAR, N., SINCLAIR, H., ROITT, I., ISENBERG, D., YOUNG, A.
This long-term prospective study of patients with newly diagnosed RA assesses the relative value of certain clinical and laboratory measures at first consultation in order to determine factors that...
FAULDS, G., CONROY, S., MADAIO, M., ISENBERG, D., LATCHMAN, D.
Approximately 30% of human patients with systemic lupus erythematosus (SLE) develop IgG autoantibodies to the highly conserved 90 kDa heat shock protein (hsp90). The development of anti-hsp90...
IDENTIFICATION OF THE 9G4 IDIOTOPE IN SYSTEMIC LUPUS ERYTHEMATOSUS (1993)
ISENBERG, D., SPELLERBERG, M., WILLIAMS, W., GRIFFITHS, M., STEVENSON, F.
An idiotope designated 9G4 (9G4Id) is known to be a marker for immunoglobulins which utilize a particular VH gene, VH4–21. The idiotope has been found to be present on anti-DNA antibodies, and have...
THE DIFFERENTIAL EXPRESSION OF HEAT SHOCK PROTEINS IN RHEUMATIC DISEASE (1993)
DHILLON, V., MCCALLUM, S., WILKS, D., TWOMEY, B., LATCHMAN, D., ISENBERG, D.
The concept of overexpression of endogenous heat shock proteins (hsps) is central to hypotheses in which hsps are implicated in the pathogenesis of autoimmune rheumatic disease. Hsps were quantitated...
BENCIVELLI, W, VITALI, C, ISENBERG, D, SMOLEN, J, SNAITH, M, SCIUTO, M, ...
VITALI, C, BENCIVELLI, W, ISENBERG, D, SMOLEN, J, SNAITH, M, SCIUTO, M, ...
VITALI, C, BENCIVELLI, W, ISENBERG, D, SMOLEN, J, SNAITH, M, SCIUTO, M, ...
LEAKER, B., MCGREGOR, A., GRIFFITHS, M., SNAITH, M., NEILD, G. H., ISENBERG, D.
Circulating anticardiolipin antibodies are associated with recurrent thrombosis, fetal loss and thrombocytopenia. We have identified four patients with SLE or lupus-like disease who have high...
SJOGREN'S SYNDROME: A STUDY OF ITS NEUROLOGICAL COMPLICATIONS (1988)
BINDER, A., SNAITH, M. L., ISENBERG, D.
A detailed retrospective study of 105 patients with Sjoögren's syndrome (50 primary and 55 secondary cases), showed that 31 had vasculitis and 18 had neurological abnormalities which after full...
Production of human monoclonal antibodies to myeloperoxidase.
Ehrenstein, M R, Leaker, B, Isenberg, D, Cambridge, G
Two mouse-human heterohybridomas secreting human antibodies to myeloperoxidase (MPO) were derived from the peripheral blood of a patient who developed microscopic polyarteritis as the result of...
Efthimiou, J, D'Cruz, D, Kaplan, P, Isenberg, D
We describe a patient with myasthenia gravis, systemic lupus erythematosus, and angioedema associated with heterozygous complement factor 2 (C2) deficiency. The significance of this association is...
Acute pancreatitis in systemic lupus erythematosus: report of a case unrelated to drug therapy.
Wolman, R, De Gara, C, Isenberg, D
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease that can affect most organs or systems. It most frequently involves the joints, skin, and the kidneys. It less commonly involves...
Autoantibody and idiotype profile of lung involvement in autoimmune rheumatic disease.
Turner-Stokes, L, Haslam, P, Jones, M, Dudeney, C, Le Page, S, Isenberg, D
Several reports have linked the presence of certain serum autoantibodies with particular clinical manifestations of autoimmune disease. For example, the Jo-1 antibody is now established as a marker...
T cell receptor expression in Sjögren's syndrome.
Zumla, A, Mathur, M, Stewart, J, Wilkinson, L, Isenberg, D
T lymphocytes expressing the gamma/delta T cell receptor and B lymphocytes expressing CD5 are known to occur in expanded numbers in the peripheral blood of patients with primary Sjögren's syndrome....
Correlation of 9G4 idiotope with disease activity in patients with systemic lupus erythematosus
Isenberg, D, McClure, C, Farewell, V, Spellerberg, M, Williams, W, Cambridge, G, ...
OBJECTIVE—To compare the levels of the 9G4 idiotope (9G4 Id) in systemic lupus erythematosus (SLE) patients with a detailed disease activity index, the British Isles Lupus Assessment Group (BILAG)...
Pourmand, N., Wahren-Herlenius, M., Gunnarsson, I., Svenungsson, E., Lofstrom, B., Ioannou, Y., ...
OBJECTIVE—To investigate the occurrence of IgA autoantibodies to Ro 52 kDa, Ro 60 kDa and La antigen in serum of patients with primary Sjögren's syndrome (pSS) and systemic lupus erythematosus...
Stoll, T., Sutcliffe, N., Klaghofer, R., Isenberg, D.
OBJECTIVE—To study whether either initial damage, disease activity, disease duration, age, a drug score, or health status would predict an increase in damage in patients with systemic lupus...
Fatigue in primary Sjögren's syndrome: Is there a link with the fibromyalgia syndrome?
OBJECTIVE—To determine whether fibromyalgia (FM) is more common in patients with primary Sjögren's syndrome (pSS) who complain of fatigue. The association and prevalence of fatigue and FM was...
OBJECTIVE—In view of the recognised clustering of autoimmune diseases (AID), the chronology of development of other autoimmune diseases in systemic lupus erythematosus (SLE) patients was...
Mok, M, Farewell, V, Isenberg, D
BACKGROUND—Avascular necrosis of bone (AVN) is a well known complication in patients with systemic lupus erythematosus (SLE). OBJECTIVE—To investigate the role of antiphospholipid antibody...
Mediwake, R, Isenberg, D, Schellekens, G, Van Venrooij, W J
OBJECTIVES—Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) can both present with an erosive arthritis with the small joints of the hands affected. Therefore a serological marker...
Autoantibody profiles in the sera of European patients with myositis
Brouwer, R, Hengstman, G, Egberts, W, Ehrfeld, H, Bozic, B, Ghirardello, A, ...
OBJECTIVE—To determine the prevalence of myositis specific autoantibodies (MSAs) and several myositis associated autoantibodies (MAAs) in a large group of patients with myositis. METHODS—A...
Autoimmune thyroid disease in systemic lupus erythematosus
Objective: To report the prevalence of autoimmune thyroid disease and thyroid antibodies in 300 patients with SLE, followed up at our centre between 1978 and 2000, by a retrospective analysis of case...
Moss, K, Ioannou, Y, Sultan, S, Haq, I, Isenberg, D
Objective: To examine the mortality rate and causes of death in a cohort of 300 patients with systemic lupus erythematosus (SLE).
Tzioufas, A, Wassmuth, R, Dafni, U, Guialis, A, Haga, H, Isenberg, D, ...
Objectives: To investigate the clinical and immunogenetic aspects of antibody formation against Ro/SSA and La/SSB as well as their linear B cell epitopes in patients with primary Sjögren's syndrome...
Suicide attempts in patients with systemic lupus erythematosus
Karassa, F, Magliano, M, Isenberg, D
Objective: To obtain a better understanding of the reasons for suicidal behaviour in patients with SLE.
Yee, C, Gordon, C, Dostal, C, Petera, P, Dadoniene, J, Griffiths, B, ...
Objective: To compare the efficacy and side effects of intermittent pulse cyclophosphamide plus methylprednisolone with continuous oral cyclophosphamide plus prednisolone, followed by azathioprine,...
Expression of a common idiotype PR4 in the sera of patients with leprosy.
Zumla, A, Williams, W, Mudd, D, Locniskar, M, Behrens, R, Isenberg, D, ...
The sera of 187 patients from across the leprosy spectrum were screened for the expression of the PR4 idiotype, which was first identified on a human hybridoma-derived monoclonal antibody from a...
Expression of an interspecies idiotype in sera of SLE patients and their first-degree relatives.
Dang, H, Takei, M, Isenberg, D, Shoenfeld, Y, Backimer, R, Rauch, J, ...
Sera from 29 SLE patients and 81 first-degree healthy family members were tested for quantitative expression of a cross-reactive idiotype present on a murine monoclonal anti-Sm autoantibody (Y2)....
Batchelor, J. R., Fielder, A. H. L., Walport, M. J., David, J., Lord, D. K., Davey, N., ...
Susceptibility to systemic lupus erythematosus (SLE) is known to be governed by genes in the HLA region of the 6th chromosome. From previous studies it has not been possible to distinguish between...
A cross-reactive idiotype on anti-DNA and lymphocytotoxic antibodies.
Lydyard, P M, Isenberg, D, De Sousa, B, Mackenzie, L, Cooke, A
The possibility that shared idiotypes may be present on antibodies of different specificities was explored using sera from 13 patients with systemic lupus erythematosus. Eleven sera had anti-DNA and...
El-Roeiy, A, Gleicher, N, Isenberg, D, Kennedy, R C, Shoenfeld, Y
Since the immune response in fetuses of mothers with systemic lupus erythematosus (SLE) is unknown, we investigated sera from six mothers and their paired offspring by enzyme-linked immunosorbent...
Hoffman, I, Peene, I, Meheus, L, Huizinga, T, Cebecauer, L, Isenberg, D, ...
Methods: A consecutive cohort of 289 patients with SLE was included; 235 fulfilled ACR criteria for SLE and were further analysed. ANA profiles were determined by line immunoassay and by indirect...
Hoffman, I, Peene, I, Cebecauer, L, Isenberg, D, Huizinga, T, Union, A, ...
Raised levels of interleukin 6 in systemic lupus erythematosus correlate with anaemia
Ripley, B, Goncalves, B, Isenberg, D, Latchman, D, Rahman, A
Objectives: Raised levels of the cytokines interleukin (IL) 6 and IL10 have been reported in patients with systemic lupus erythematosus (SLE).
Methods: A retrospective case note review was carried out on 114 patients in whom a diagnosis of pSS had been made in a department of rheumatology from 1979 onwards. The year of diagnosis of pSS was...
Serum metalloproteinases and their inhibitors: markers for malignant potential.
Baker, T., Tickle, S., Wasan, H., Docherty, A., Isenberg, D., Waxman, J.
Death from cancer results from the development of metastases or local progression of tumour. Metastasis and local progression may result from the inappropriate activity of metalloproteinases released...