D. Kieran

A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice (2005)

Kieran, D., Hafezparast, M., Bohnert, S., Dick, J.R.T., Martin, J., Schiavo, G., ...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by motoneuron degeneration and muscle paralysis. Although the precise pathogenesis of ALS remains unclear,...

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice (2004)

Kieran, D., Kalmar, B., Dick, J.R.T., Riddoch-Contreras, J., Burnstock, G., Greensmith, L.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition in which motoneurons of the spinal cord and motor cortex die, resulting in progressive paralysis1, 2. This condition has no...