Datta, R., Endo, K., Oki, E., Biedermann, V., Kojima, H., Yoshida, K., ...
The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.
Kharbanda, S, Bharti, A, Pei, D, Wang, J, Pandey, P, Ren, R, ...
c-Abl is a nonreceptor tyrosine kinase that is activated by certain DNA-damaging agents. The present studies demonstrate that nuclear c-Abl binds constitutively to the protein tyrosine phosphatase...
Kharbanda, S, Saleem, A, Yuan, Z, Emoto, Y, Prasad, K V, Kufe, D
Macrophage colony-stimulating factor (M-CSF) is required for the growth and differentiation of mononuclear phagocytes. In the present studies using human monocytes, we show that M-CSF induces...
Kharbanda, S, Saleem, A, Shafman, T, Emoto, Y, Weichselbaum, R, Kufe, D
The cellular response to ionizing radiation (IR) includes induction of the c-jun and EGR1 early response genes. The present work has examined potential cytoplasmic signaling cascades that transduce...
The present studies have examined the sequences responsible for regulating transcription of the human DF3 breast carcinoma-associated antigen (MUC1) gene. A region 1656 base pairs upstream to the DF3...
Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN.
Hallahan, D E, Sukhatme, V P, Sherman, M L, Virudachalam, S, Kufe, D, Weichselbaum, R R
The cellular response to ionizing radiation includes growth arrest and DNA repair followed by proliferation. Induction of immediate early response genes may participate in signal transduction...
Pantazis, P, Kharbanda, S, Goustin, A S, Galanopoulos, T, Kufe, D
Receptors for platelet-derived growth factor (PDGF) have not been identified previously to our knowledge in human myeloid cells that also produce PDGF. Here we report that phorbol ester-treated...
Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen.
Siddiqui, J, Abe, M, Hayes, D, Shani, E, Yunis, E, Kufe, D
The murine monoclonal antibody (mAb) DF3 reacts with a high molecular weight glycoprotein detectable in human breast carcinomas. DF3 antigen expression correlates with human breast tumor...
Kharbanda, S, Nakamura, T, Stone, R, Hass, R, Bernstein, S, Datta, R, ...
Members of the early growth response (EGR) gene family are rapidly induced after mitogenic stimulation of diverse cell types. The present work has examined EGR gene expression during differentiation...
Ionizing radiation induces expression and binding activity of the nuclear factor kappa B.
Brach, M A, Hass, R, Sherman, M L, Gunji, H, Weichselbaum, R, Kufe, D
Recent studies have demonstrated that treatment of mammalian cells with ionizing radiation is associated with activation of gene expression. Although the signal transduction pathways stimulated by...
Rambaldi, A, Wakamiya, N, Vellenga, E, Horiguchi, J, Warren, M K, Kufe, D, ...
Macrophage colony-stimulating factor (CSF-1; M-CSF) is a growth factor required for growth and differentiation of mononuclear phagocytes. The effects of CSF-1 are mediated through binding to...
Horiguchi, J, Spriggs, D, Imamura, K, Stone, R, Luebbers, R, Kufe, D
The treatment of human HL-60 promyelocytic leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with induction of tumor necrosis factor (TNF) transcript. The study reported...
Weber, B, Horiguchi, J, Luebbers, R, Sherman, M, Kufe, D
The c-fms proto-oncogene encodes a transmembrane glycoprotein that is closely related or identical to the receptor for the monocyte colony-stimulating factor CSF-1. The present studies examined the...
Effects of botulinum toxin type D on secretion of tumor necrosis factor from human monocytes.
Imamura, K, Spriggs, D, Ohno, T, Kufe, D
Botulinum toxins are potent neurotoxins which block the release of neurotransmitters. The effects of these toxins on hematopoietic cells, however, are unknown. Monocytes secrete a variety of...
Transcriptional and posttranscriptional regulation of CSF-1 gene expression in human monocytes.
Horiguchi, J, Sariban, E, Kufe, D
Regulation of CSF-1 gene expression was investigated in human monocytes. CSF-1 transcripts were at low or undetectable levels in resting monocytes. However, in monocytes treated with...
Pantazis, P, Sariban, E, Kufe, D, Antoniades, H N
Phorbol esters induce the differentiation of human myeloid leukemia cells HL-60 and U-937 along the monocytic-macrophage lineage. This process has been associated with the induction of several...
Cannistra, S A, Rambaldi, A, Spriggs, D R, Herrmann, F, Kufe, D, Griffin, J D
Human granulocyte-macrophage colony-stimulating factor (GM-CSF) exerts profound effects on the proliferation, differentiation, and effector function of myeloid lineage cells. In contrast to its...
RNA in Human Leukemic Cells Related to the RNA of a Mouse Leukemia Virus
Hehlmann, R., Kufe, D., Spiegelman, S.
Molecular hybridization with radioactively labeled DNA complementary to the RNA of the Rauscher leukemia virus was used to probe for homologous RNA in the polysome fraction of human leukemic cells....
Viral-Related RNA in Hodgkins' Disease and Other Human Lymphomas
Hehlmann, R., Kufe, D., Spiegelman, S.
Molecular hybridization with radioactively labeled DNA complementary to the RNA of the Rauscher leukemia virus was used to probe for homologous RNA in human lymphomas. 22 of 32 specimens contained...
Peters, W. P., Kufe, D., Schlom, J., Frankel, J. W., Prickett, C. O., Groupé, V., ...
The DNA-containing Epstein-Barr herpesvirus has been implicated in the etiology of Burkitt's lymphoma, a malignant tumor of children in Africa. Recently, however, particles possessing four...
Multiple antigenic determinants on the major surface glycoprotein of murine mammary tumor viruses.
Teramoto, Y A, Kufe, D, Schlom, J
The major external protein of murine mammary tumor viruses (MMTVs) is a glycoprotein of molecular weight 52,000 (gp52). We report here that the gp52s of MMTVs from different mouse strains contain...
RNA Related to That of a Murine Leukemia Virus in Burkitt's Tumors and Nasopharyngeal Carcinomas
Kufe, D., Hehlmann, R., Spiegelman, S.
RNA homologous to that of the Rauscher leukemia virus has been detected in Burkitt's lymphomas and nasopharyngeal carcinomas. Earlier excellent experimental evidence has linked these two human tumors...
Kufe, D., Magrath, I. T., Ziegler, J. L., Spiegelman, S.
Burkitt's lymphomas, linked by previous studies with the DNA-containing Epstein-Barr virus, contain an RNA related in sequence to that of Rauscher leukemia virus. The present study establishes that...
Sariban, E, Imamura, K, Luebbers, R, Kufe, D
Regulation of tumor necrosis factor (TNF) gene expression was investigated in resting human monocytes and in 12-O-tetradecanoylphorbol-13-acetate (TPA) activated monocytes. TNF transcripts were...
The treatment of human myeloid leukemia cell lines with phorbol esters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), is associated with loss of proliferative capacity and induction of...
Transcriptional and posttranscriptional control of c-fos gene expression in human monocytes.
Sariban, E, Luebbers, R, Kufe, D
We examined the mechanisms that are responsible for the regulation of c-fos gene expression in human monocytes. Levels of c-fos mRNA were low or undetectable in resting monocytes. Results of run-on...
Teramoto, Y A, Kufe, D, Schlom, J
We recently showed that the 52,000-dalton external glycoprotein (gp52) of the highly oncogenic mouse mammary tumor viruses (MMTVs) of RIII, GR, and C3H mice contains both type- and group-specific...
Colony-stimulating factor 1 activates protein kinase C in human monocytes.
Imamura, K, Dianoux, A, Nakamura, T, Kufe, D
Colony-stimulating factor 1 (CSF-1) is required for the survival, proliferation and differentiation of monocytes. We previously demonstrated that the CSF-1 receptor is linked to a pertussis...
Nakamura, T, Lin, L L, Kharbanda, S, Knopf, J, Kufe, D
The macrophage colony stimulating factor (M-CSF) is required for the proliferation and differentiation of monocytes. Previous studies have demonstrated that M-CSF stimulation is associated with...
The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.
Kharbanda, S, Bharti, A, Pei, D, Wang, J, Pandey, P, Ren, R, ...
c-Abl is a nonreceptor tyrosine kinase that is activated by certain DNA-damaging agents. The present studies demonstrate that nuclear c-Abl binds constitutively to the protein tyrosine phosphatase...
Kharbanda, S, Saleem, A, Yuan, Z, Emoto, Y, Prasad, K V, Kufe, D
Macrophage colony-stimulating factor (M-CSF) is required for the growth and differentiation of mononuclear phagocytes. In the present studies using human monocytes, we show that M-CSF induces...
Kharbanda, S, Saleem, A, Shafman, T, Emoto, Y, Weichselbaum, R, Kufe, D
The cellular response to ionizing radiation (IR) includes induction of the c-jun and EGR1 early response genes. The present work has examined potential cytoplasmic signaling cascades that transduce...
The present studies have examined the sequences responsible for regulating transcription of the human DF3 breast carcinoma-associated antigen (MUC1) gene. A region 1656 base pairs upstream to the DF3...
Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN.
Hallahan, D E, Sukhatme, V P, Sherman, M L, Virudachalam, S, Kufe, D, Weichselbaum, R R
The cellular response to ionizing radiation includes growth arrest and DNA repair followed by proliferation. Induction of immediate early response genes may participate in signal transduction...
Pantazis, P, Kharbanda, S, Goustin, A S, Galanopoulos, T, Kufe, D
Receptors for platelet-derived growth factor (PDGF) have not been identified previously to our knowledge in human myeloid cells that also produce PDGF. Here we report that phorbol ester-treated...
Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen.
Siddiqui, J, Abe, M, Hayes, D, Shani, E, Yunis, E, Kufe, D
The murine monoclonal antibody (mAb) DF3 reacts with a high molecular weight glycoprotein detectable in human breast carcinomas. DF3 antigen expression correlates with human breast tumor...
Kharbanda, S, Nakamura, T, Stone, R, Hass, R, Bernstein, S, Datta, R, ...
Members of the early growth response (EGR) gene family are rapidly induced after mitogenic stimulation of diverse cell types. The present work has examined EGR gene expression during differentiation...
Ionizing radiation induces expression and binding activity of the nuclear factor kappa B.
Brach, M A, Hass, R, Sherman, M L, Gunji, H, Weichselbaum, R, Kufe, D
Recent studies have demonstrated that treatment of mammalian cells with ionizing radiation is associated with activation of gene expression. Although the signal transduction pathways stimulated by...
Rambaldi, A, Wakamiya, N, Vellenga, E, Horiguchi, J, Warren, M K, Kufe, D, ...
Macrophage colony-stimulating factor (CSF-1; M-CSF) is a growth factor required for growth and differentiation of mononuclear phagocytes. The effects of CSF-1 are mediated through binding to...
Horiguchi, J, Spriggs, D, Imamura, K, Stone, R, Luebbers, R, Kufe, D
The treatment of human HL-60 promyelocytic leukemia cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with induction of tumor necrosis factor (TNF) transcript. The study reported...
Weber, B, Horiguchi, J, Luebbers, R, Sherman, M, Kufe, D
The c-fms proto-oncogene encodes a transmembrane glycoprotein that is closely related or identical to the receptor for the monocyte colony-stimulating factor CSF-1. The present studies examined the...
Effects of botulinum toxin type D on secretion of tumor necrosis factor from human monocytes.
Imamura, K, Spriggs, D, Ohno, T, Kufe, D
Botulinum toxins are potent neurotoxins which block the release of neurotransmitters. The effects of these toxins on hematopoietic cells, however, are unknown. Monocytes secrete a variety of...
Transcriptional and posttranscriptional regulation of CSF-1 gene expression in human monocytes.
Horiguchi, J, Sariban, E, Kufe, D
Regulation of CSF-1 gene expression was investigated in human monocytes. CSF-1 transcripts were at low or undetectable levels in resting monocytes. However, in monocytes treated with...
Pantazis, P, Sariban, E, Kufe, D, Antoniades, H N
Phorbol esters induce the differentiation of human myeloid leukemia cells HL-60 and U-937 along the monocytic-macrophage lineage. This process has been associated with the induction of several...
Cannistra, S A, Rambaldi, A, Spriggs, D R, Herrmann, F, Kufe, D, Griffin, J D
Human granulocyte-macrophage colony-stimulating factor (GM-CSF) exerts profound effects on the proliferation, differentiation, and effector function of myeloid lineage cells. In contrast to its...
RNA in Human Leukemic Cells Related to the RNA of a Mouse Leukemia Virus
Hehlmann, R., Kufe, D., Spiegelman, S.
Molecular hybridization with radioactively labeled DNA complementary to the RNA of the Rauscher leukemia virus was used to probe for homologous RNA in the polysome fraction of human leukemic cells....
Viral-Related RNA in Hodgkins' Disease and Other Human Lymphomas
Hehlmann, R., Kufe, D., Spiegelman, S.
Molecular hybridization with radioactively labeled DNA complementary to the RNA of the Rauscher leukemia virus was used to probe for homologous RNA in human lymphomas. 22 of 32 specimens contained...
Peters, W. P., Kufe, D., Schlom, J., Frankel, J. W., Prickett, C. O., Groupé, V., ...
The DNA-containing Epstein-Barr herpesvirus has been implicated in the etiology of Burkitt's lymphoma, a malignant tumor of children in Africa. Recently, however, particles possessing four...
Multiple antigenic determinants on the major surface glycoprotein of murine mammary tumor viruses.
Teramoto, Y A, Kufe, D, Schlom, J
The major external protein of murine mammary tumor viruses (MMTVs) is a glycoprotein of molecular weight 52,000 (gp52). We report here that the gp52s of MMTVs from different mouse strains contain...
RNA Related to That of a Murine Leukemia Virus in Burkitt's Tumors and Nasopharyngeal Carcinomas
Kufe, D., Hehlmann, R., Spiegelman, S.
RNA homologous to that of the Rauscher leukemia virus has been detected in Burkitt's lymphomas and nasopharyngeal carcinomas. Earlier excellent experimental evidence has linked these two human tumors...
Kufe, D., Magrath, I. T., Ziegler, J. L., Spiegelman, S.
Burkitt's lymphomas, linked by previous studies with the DNA-containing Epstein-Barr virus, contain an RNA related in sequence to that of Rauscher leukemia virus. The present study establishes that...
Sariban, E, Imamura, K, Luebbers, R, Kufe, D
Regulation of tumor necrosis factor (TNF) gene expression was investigated in resting human monocytes and in 12-O-tetradecanoylphorbol-13-acetate (TPA) activated monocytes. TNF transcripts were...
The treatment of human myeloid leukemia cell lines with phorbol esters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), is associated with loss of proliferative capacity and induction of...
Transcriptional and posttranscriptional control of c-fos gene expression in human monocytes.
Sariban, E, Luebbers, R, Kufe, D
We examined the mechanisms that are responsible for the regulation of c-fos gene expression in human monocytes. Levels of c-fos mRNA were low or undetectable in resting monocytes. Results of run-on...
Teramoto, Y A, Kufe, D, Schlom, J
We recently showed that the 52,000-dalton external glycoprotein (gp52) of the highly oncogenic mouse mammary tumor viruses (MMTVs) of RIII, GR, and C3H mice contains both type- and group-specific...
Colony-stimulating factor 1 activates protein kinase C in human monocytes.
Imamura, K, Dianoux, A, Nakamura, T, Kufe, D
Colony-stimulating factor 1 (CSF-1) is required for the survival, proliferation and differentiation of monocytes. We previously demonstrated that the CSF-1 receptor is linked to a pertussis...
Nakamura, T, Lin, L L, Kharbanda, S, Knopf, J, Kufe, D
The macrophage colony stimulating factor (M-CSF) is required for the proliferation and differentiation of monocytes. Previous studies have demonstrated that M-CSF stimulation is associated with...
Gong, J, Apostolopoulos, V, Chen, D, Chen, H, Koido, S, Gendler, S J, ...
Mice transgenic for the human MUC1 carcinoma-associated antigen (MUC1.Tg) are tolerant to immunization with MUC1 antigen. Recent studies, however, have demonstrated that immunization of MUC1.Tg mice...