Cellular Mechanisms Of Calcium Elevation Involved In Long Term Memory (1999)
K. T. Blackwell, T. P. Vogl, D. L. Alkon
Hermissenda crassicornis is a shell-less marine snail that can be classically conditioned to associate light (the conditioned stimulus) with turbulence (the unconditioned stimulus). Acquisition of...
K. T. Blackwell, T. P. Vogl, D. L. Alkon
Pattern matching is the ability to produce a stronger response to a previously learned pattern than to a novel pattern. Is it possible that the ability of mammals to recognize patterns is due to...
Collin, C, Devane, W A, Dahl, D, Lee, C J, Axelrod, J, Alkon, D L
Evidence is presented for a distinctive type of hippocampal synaptic modification [previously described for a molluscan gamma-aminobutyric acid (GABA) synapse after paired pre- and postsynaptic...
Kim, C S, Han, Y F, Etcheberrigaray, R, Nelson, T J, Olds, J L, Yoshioka, T, ...
The two proteins most consistently identified in the brains of patients with Alzheimer disease (AD) have been beta-amyloid and tau, whose roles in the physiology or pathophysiology of brain cells are...
Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.
Ito, E, Oka, K, Etcheberrigaray, R, Nelson, T J, McPhie, D L, Tofel-Grehl, B, ...
The recent demonstration of K+ channel dysfunction in fibroblasts from Alzheimer disease (AD) patients and past observations of Ca(2+)-mediated K+ channel modulation during memory storage suggested...
Nelson, T J, Yoshioka, T, Toyoshima, S, Han, Y F, Alkon, D L
The phosphorylation state of cp20, a low molecular weight GTP-binding protein that is a high-affinity substrate for protein kinase C, was previously shown to change after associative conditioning of...
Sunayashiki-Kusuzaki, K, Lester, D S, Schreurs, B G, Alkon, D L
Using electrophysiological, biochemical, and autoradiographic techniques, changes in protein kinase C (PKC) activity in specific regions of the hippocampus have been previously implicated in...
Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease.
Etcheberrigaray, R, Ito, E, Oka, K, Tofel-Grehl, B, Gibson, G E, Alkon, D L
Since memory loss is characteristic of Alzheimer disease (AD), and since K+ channels change during acquisition of memory in both molluscs and mammals, we investigated K+ channel function as a...
Etcheberrigaray, R, Matzel, L D, Lederhendler, I I, Alkon, D L
The patch-clamp technique was used to study the effects of classical conditioning and protein kinase C (PKC) activation on K+ channels of identified neurons in the snail Hermissenda crassicornis....
Long-term transformation of an inhibitory into an excitatory GABAergic synaptic response.
Alkon, D L, Sánchez-Andrés, J V, Ito, E, Oka, K, Yoshioka, T, Collin, C
For a constant membrane potential, a predominantly inhibitory GABAergic synaptic response is shown to undergo long-term transformation into an excitatory response after pairing of exogenous...
Scharenberg, A M, Olds, J L, Schreurs, B G, Craig, A M, Alkon, D L
This manuscript describes experiments designed to investigate protein kinase C redistribution occurring during acquisition of the rabbit nictitating membrane (NM) conditioned response (CR). The first...
Specific high molecular weight mRNAs induced by associative learning in Hermissenda.
Associative conditioning of Hermissenda crassicornis has been demonstrated to result in long-term changes in the potassium currents IA and ICa2(+)-K+ in photoreceptor neurons in the eye and to...
Contraction of neuronal branching volume: an anatomic correlate of Pavlovian conditioning.
Alkon, D L, Ikeno, H, Dworkin, J, McPhie, D L, Olds, J L, Lederhendler, I, ...
Associative memory of the mollusc Hermissenda crassicornis, previously correlated with changes of specific K+ currents, protein phosphorylation, and increased synthesis of mRNA and specific proteins,...
Enhancement of synaptic potentials in rabbit CA1 pyramidal neurons following classical conditioning.
LoTurco, J L, Coulter, D A, Alkon, D L
A synaptic potential elicited by high-frequency stimulation of the Schaffer collaterals was enhanced in hippocampal CA1 pyramidal cells from rabbits that were classically conditioned relative to...
Bank, B, DeWeer, A, Kuzirian, A M, Rasmussen, H, Alkon, D L
The role of the Ca2+/phospholipid-dependent, diacylglycerol-activated enzyme protein kinase C (PKC) in rabbit eyelid conditioning was examined. PKC was partially purified from the CA1 region of...
Prolonged RNA changes in the Hermissenda eye induced by classical conditioning.
The incorporation of 32P into mRNA and the total amount of mRNA were increased 3- to 4-fold in eyes isolated from Hermissenda crassicornis trained to associate light with rotation on a turntable...
Alkon, D L, Bank, B, Naito, S, Chen, C, Ram, J
Elevated intracellular Ca2+ concentration within the Hermissenda type B cell has previously been shown to cause transient reduction of both the early K+ current IA and the delayed, Ca2+-dependent K+...
Conditioning-specific membrane changes of rabbit hippocampal neurons measured in vitro.
Disterhoft, J F, Coulter, D A, Alkon, D L
Intracellular recordings were made from hippocampal CA1 pyramidal neurons within brain slices of nictitating membrane conditioned, pseudoconditioned, and naive adult male albino rabbits. All neurons...
Calexcitin interaction with neuronal ryanodine receptors.
Nelson, T J, Zhao, W Q, Yuan, S, Favit, A, Pozzo-Miller, L, Alkon, D L
Calexcitin (CE), a Ca2+- and GTP-binding protein, which is phosphorylated during memory consolidation, is shown here to co-purify with ryanodine receptors (RyRs) and bind to RyRs in a...
Reconstruction of ionic currents in a molluscan photoreceptor.
Sakakibara, M, Ikeno, H, Usui, S, Collin, C, Alkon, D L
Two-microelectrode voltage-clamp measurements were made to determine the kinetics and voltage dependence of ionic currents across the soma membrane of the Hermissenda type B photoreceptor. The...
Early regulation of membrane excitability by ras oncogene proteins.
Collin, C, Papageorge, A G, Sakakibara, M, Huddie, P L, Lowy, D R, Alkon, D L
Two electrode voltage clamp conditions were used to study the early effects on ionic membrane channels of the intracellularly injected proto-oncogenic form of c-Ha-ras (c-ras) and its oncogenic...
Thermal imaging of receptor-activated heat production in single cells.
Zohar, O, Ikeda, M, Shinagawa, H, Inoue, H, Nakamura, H, Elbaum, D, ...
Changes in enthalpy (i.e., heat content) occur during the diverse intracellular chemical and biophysical interactions that take place in the life cycle of biological cells. Such changes have...
In quantum theory, nothing that is observable, be it physical, chemical, or biological, is separable from the observer. Furthermore, ". all possible knowledge concerning that object is given by its...
Calcium-mediated decrease of a voltage-dependent potassium current.
Alkon, D L, Shoukimas, J J, Heldman, E
Elevated intracellular Ca++ concentration reduces the amplitude of an early, voltage-dependent K+ current (IA) in the Type B photoreceptor of Hermissenda crassicornis. Internal Ca++ is increased by...
Calcium activates and inactivates a photoreceptor soma potassium current.
Light-induced currents were measured with a two-microelectrode voltage clamp of type B photoreceptor somata, which had been isolated by axotomy from all synaptic interactions as well as from all...
Sakakibara, M, Alkon, D L, DeLorenzo, R, Goldenring, J R, Neary, J T, Heldman, E
Iontophoretic injection of Ca2+ causes reduction of I0A (an early rapidly activating and inactivating K+ current) and I0C (a late Ca2+-dependent K+ current) measured across the isolated type B soma...
Inositol trisphosphate regulation of photoreceptor membrane currents.
Sakakibara, M, Alkon, D L, Neary, J T, Heldman, E, Gould, R
In previous studies elevation of intracellular Ca2+ was shown to cause prolonged reduction of two voltage-dependent K+ currents (IA and ICa2+-K+) across the membrane of the isolated Hermissenda...
Sequential modification of membrane currents with classical conditioning.
Collin, C, Ikeno, H, Harrigan, J F, Lederhendler, I, Alkon, D L
Pavlovian conditioning of the nudibranch mollusc Hermissenda crassicornis was previously shown to produce long-lasting reduction of two K+ currents measured across the Type B photoreceptor soma...
Voltage-dependent calcium and calcium-activated potassium currents of a molluscan photoreceptor.
Alkon, D L, Farley, J, Sakakibara, M, Hay, B
Two-microelectrode voltage clamp studies were performed on the somata of Hermissenda Type B photoreceptors that had been isolated by axotomy from all synaptic interaction as well as any...
Collin, C, Devane, W A, Dahl, D, Lee, C J, Axelrod, J, Alkon, D L
Evidence is presented for a distinctive type of hippocampal synaptic modification [previously described for a molluscan gamma-aminobutyric acid (GABA) synapse after paired pre- and postsynaptic...
Kim, C S, Han, Y F, Etcheberrigaray, R, Nelson, T J, Olds, J L, Yoshioka, T, ...
The two proteins most consistently identified in the brains of patients with Alzheimer disease (AD) have been beta-amyloid and tau, whose roles in the physiology or pathophysiology of brain cells are...
Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.
Ito, E, Oka, K, Etcheberrigaray, R, Nelson, T J, McPhie, D L, Tofel-Grehl, B, ...
The recent demonstration of K+ channel dysfunction in fibroblasts from Alzheimer disease (AD) patients and past observations of Ca(2+)-mediated K+ channel modulation during memory storage suggested...
Nelson, T J, Yoshioka, T, Toyoshima, S, Han, Y F, Alkon, D L
The phosphorylation state of cp20, a low molecular weight GTP-binding protein that is a high-affinity substrate for protein kinase C, was previously shown to change after associative conditioning of...
Sunayashiki-Kusuzaki, K, Lester, D S, Schreurs, B G, Alkon, D L
Using electrophysiological, biochemical, and autoradiographic techniques, changes in protein kinase C (PKC) activity in specific regions of the hippocampus have been previously implicated in...
Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease.
Etcheberrigaray, R, Ito, E, Oka, K, Tofel-Grehl, B, Gibson, G E, Alkon, D L
Since memory loss is characteristic of Alzheimer disease (AD), and since K+ channels change during acquisition of memory in both molluscs and mammals, we investigated K+ channel function as a...
Etcheberrigaray, R, Matzel, L D, Lederhendler, I I, Alkon, D L
The patch-clamp technique was used to study the effects of classical conditioning and protein kinase C (PKC) activation on K+ channels of identified neurons in the snail Hermissenda crassicornis....
Long-term transformation of an inhibitory into an excitatory GABAergic synaptic response.
Alkon, D L, Sánchez-Andrés, J V, Ito, E, Oka, K, Yoshioka, T, Collin, C
For a constant membrane potential, a predominantly inhibitory GABAergic synaptic response is shown to undergo long-term transformation into an excitatory response after pairing of exogenous...
Scharenberg, A M, Olds, J L, Schreurs, B G, Craig, A M, Alkon, D L
This manuscript describes experiments designed to investigate protein kinase C redistribution occurring during acquisition of the rabbit nictitating membrane (NM) conditioned response (CR). The first...
Specific high molecular weight mRNAs induced by associative learning in Hermissenda.
Associative conditioning of Hermissenda crassicornis has been demonstrated to result in long-term changes in the potassium currents IA and ICa2(+)-K+ in photoreceptor neurons in the eye and to...
Contraction of neuronal branching volume: an anatomic correlate of Pavlovian conditioning.
Alkon, D L, Ikeno, H, Dworkin, J, McPhie, D L, Olds, J L, Lederhendler, I, ...
Associative memory of the mollusc Hermissenda crassicornis, previously correlated with changes of specific K+ currents, protein phosphorylation, and increased synthesis of mRNA and specific proteins,...
Enhancement of synaptic potentials in rabbit CA1 pyramidal neurons following classical conditioning.
LoTurco, J L, Coulter, D A, Alkon, D L
A synaptic potential elicited by high-frequency stimulation of the Schaffer collaterals was enhanced in hippocampal CA1 pyramidal cells from rabbits that were classically conditioned relative to...
Bank, B, DeWeer, A, Kuzirian, A M, Rasmussen, H, Alkon, D L
The role of the Ca2+/phospholipid-dependent, diacylglycerol-activated enzyme protein kinase C (PKC) in rabbit eyelid conditioning was examined. PKC was partially purified from the CA1 region of...
Prolonged RNA changes in the Hermissenda eye induced by classical conditioning.
The incorporation of 32P into mRNA and the total amount of mRNA were increased 3- to 4-fold in eyes isolated from Hermissenda crassicornis trained to associate light with rotation on a turntable...
Alkon, D L, Bank, B, Naito, S, Chen, C, Ram, J
Elevated intracellular Ca2+ concentration within the Hermissenda type B cell has previously been shown to cause transient reduction of both the early K+ current IA and the delayed, Ca2+-dependent K+...
Conditioning-specific membrane changes of rabbit hippocampal neurons measured in vitro.
Disterhoft, J F, Coulter, D A, Alkon, D L
Intracellular recordings were made from hippocampal CA1 pyramidal neurons within brain slices of nictitating membrane conditioned, pseudoconditioned, and naive adult male albino rabbits. All neurons...
Calexcitin interaction with neuronal ryanodine receptors.
Nelson, T J, Zhao, W Q, Yuan, S, Favit, A, Pozzo-Miller, L, Alkon, D L
Calexcitin (CE), a Ca2+- and GTP-binding protein, which is phosphorylated during memory consolidation, is shown here to co-purify with ryanodine receptors (RyRs) and bind to RyRs in a...
Reconstruction of ionic currents in a molluscan photoreceptor.
Sakakibara, M, Ikeno, H, Usui, S, Collin, C, Alkon, D L
Two-microelectrode voltage-clamp measurements were made to determine the kinetics and voltage dependence of ionic currents across the soma membrane of the Hermissenda type B photoreceptor. The...
Early regulation of membrane excitability by ras oncogene proteins.
Collin, C, Papageorge, A G, Sakakibara, M, Huddie, P L, Lowy, D R, Alkon, D L
Two electrode voltage clamp conditions were used to study the early effects on ionic membrane channels of the intracellularly injected proto-oncogenic form of c-Ha-ras (c-ras) and its oncogenic...
Thermal imaging of receptor-activated heat production in single cells.
Zohar, O, Ikeda, M, Shinagawa, H, Inoue, H, Nakamura, H, Elbaum, D, ...
Changes in enthalpy (i.e., heat content) occur during the diverse intracellular chemical and biophysical interactions that take place in the life cycle of biological cells. Such changes have...
In quantum theory, nothing that is observable, be it physical, chemical, or biological, is separable from the observer. Furthermore, ". all possible knowledge concerning that object is given by its...
Calcium-mediated decrease of a voltage-dependent potassium current.
Alkon, D L, Shoukimas, J J, Heldman, E
Elevated intracellular Ca++ concentration reduces the amplitude of an early, voltage-dependent K+ current (IA) in the Type B photoreceptor of Hermissenda crassicornis. Internal Ca++ is increased by...
Calcium activates and inactivates a photoreceptor soma potassium current.
Light-induced currents were measured with a two-microelectrode voltage clamp of type B photoreceptor somata, which had been isolated by axotomy from all synaptic interactions as well as from all...
Sakakibara, M, Alkon, D L, DeLorenzo, R, Goldenring, J R, Neary, J T, Heldman, E
Iontophoretic injection of Ca2+ causes reduction of I0A (an early rapidly activating and inactivating K+ current) and I0C (a late Ca2+-dependent K+ current) measured across the isolated type B soma...
Inositol trisphosphate regulation of photoreceptor membrane currents.
Sakakibara, M, Alkon, D L, Neary, J T, Heldman, E, Gould, R
In previous studies elevation of intracellular Ca2+ was shown to cause prolonged reduction of two voltage-dependent K+ currents (IA and ICa2+-K+) across the membrane of the isolated Hermissenda...
Sequential modification of membrane currents with classical conditioning.
Collin, C, Ikeno, H, Harrigan, J F, Lederhendler, I, Alkon, D L
Pavlovian conditioning of the nudibranch mollusc Hermissenda crassicornis was previously shown to produce long-lasting reduction of two K+ currents measured across the Type B photoreceptor soma...
Voltage-dependent calcium and calcium-activated potassium currents of a molluscan photoreceptor.
Alkon, D L, Farley, J, Sakakibara, M, Hay, B
Two-microelectrode voltage clamp studies were performed on the somata of Hermissenda Type B photoreceptors that had been isolated by axotomy from all synaptic interaction as well as any...