Rapid Preclinical Detection of Sheeppox Virus by a Real-Time PCR Assay (2008)
Balinsky, C. A., Delhon, Gustavo A., Smoliga, G., Prarat, M., French, R. A., Geary, S. J., ...
Sheeppox virus (SPPV) is a member of the Capripoxvirus (CaPV) genus of the Poxviridae family. Members of this genus, which also include goatpox and lumpy skin disease viruses, cause economically...
Sheeppox Virus Kelch-Like Gene SPPV-019 Affects Virus Virulence (2007)
Balinsky, C. A., Delhon, Gustavo A., Afonso, C. L., Risatti, G. R., Borca, M. V., French, R. A., ...
Sheeppox virus (SPPV), a member of the Capripoxvirus genus of the Poxviridae, is the etiologic agent of a significant disease of sheep in the developing world. Genomic analysis of pathogenic and...
Genome of Horsepox Virus (2006)
Delhon, Gustavo A., Afonso, C. L., Lu, Z., Zsak, L., Sandybaev, N. T., Kerembekova, U. M., ...
Here we present the genomic sequence of horsepox virus (HSPV) isolate MNR-76, an orthopoxvirus (OPV) isolated in 1976 from diseased Mongolian horses. The 212-kbp genome contained 7.5-kbp inverted...
Genome of Crocodilepox Virus (2006)
Afonso, C. L., Tulman, E. R., Delhon, Gustavo A., Lu, Z., Viljoen, G. J., Wallace, D. B., ...
Here, we present the genome sequence, with analysis, of a poxvirus infecting Nile crocodiles (Crocodylus niloticus) (crocodilepox virus; CRV). The genome is 190,054 bp (62% G+C) and predicted to...
Genome of Horsepox Virus (2006)
E. R. Tulman, G. Delhon, C. L. Afonso, Z. Lu, L. Zsak, U. Z. Kerembekova, ...
Here we present the genomic sequence of horsepox virus (HSPV) isolate MNR-76, an orthopoxvirus (OPV) isolated in 1976 from diseased Mongolian horses. The 212-kbp genome contained 7.5-kbp inverted...
Comparative Genomics of Foot-and-Mouth Disease Virus (2005)
Carrillo, C., Tuhlman, E. R., Delhon, Gustavo A., Lu, Z., Carreno, A., Vagnozzi, A., ...
Here we present complete genome sequences, including a comparative analysis, of 103 isolates of foot-and-mouth disease virus (FMDV) representing all seven serotypes and including the first complete...
Genome of Deerpox Virus (2005)
Afonso, C. L., Delhon, Gustavo A., Tuhlman, E. R., Lu, Z., Zsak, A., Becerra, V. M., ...
Deerpox virus (DPV), an uncharacterized and unclassified member of the Poxviridae, has been isolated from North American free-ranging mule deer (Odocoileus hemionus) exhibiting mucocutaneous disease....
Genomes of the Parapoxviruses Orf Virus and Bovine Papular Stomatitis Virus (2004)
Delhon, Gustavo A., Tuhlman, E. R., Afonso, C. L., Lu, Z., Lehmkuhl, H. D., ...
Bovine papular stomatitis virus (BPSV) and orf virus (ORFV), members of the genus Parapoxvirus of the Poxviridae, are etiologic agents of worldwide diseases affecting cattle and small ruminants,...
Comparative Genomics of Foot-and-Mouth Disease Virus† (2004)
C. Carrillo, E. R. Tulman, G. Delhon, Z. Lu, A. Carreno, A. Vagnozzi, ...
Here we present complete genome sequences, including a comparative analysis, of 103 isolates of foot-andmouth disease virus (FMDV) representing all seven serotypes and including the first complete...
Genome of Bovine Herpesvirus 5 (2003)
Delhon, Gustavo A., Moraes, M. P., Lu, Z., Afonso, C. L., Flores, E. F., Weiblen, R., ...
Here we present the complete genomic sequence of bovine herpesvirus 5 (BHV-5), an alphaherpesvirus responsible for fatal meningoencephalitis in cattle. The 138,390-bp genome encodes 70 putative...
The Genome of Swinepox Virus (2002)
Afonso, C. L., Tulman, E. R., Lu, Z., Zsak, L., Osorio, Fernando A., Balinsky, C., ...
Swinepox virus (SWPV), the sole member of the Suipoxvirus genus of the Poxviridae, is the etiologic agent of a worldwide disease specific for swine. Here we report the genomic sequence of SWPV. The...
The genome of turkey herpesvirus (2001)
C. L. Afonso, E. R. Tulman, Z. Lu, L. Zsak, D. L. Rock, G. F. Kutish
Here we present the first complete genomic sequence of Marek’s disease virus serotype 3 (MDV3), also known as turkey herpesvirus (HVT). The 159,160-bp genome encodes an estimated 99 putative...
The Genome of Melanoplus sanguinipes Entomopoxvirus
Afonso, C. L., Tulman, E. R., Lu, Z., Oma, E., Kutish, G. F., Rock, D. L.
The family Poxviridae contains two subfamilies: the Entomopoxvirinae (poxviruses of insects) and the Chordopoxvirinae (poxviruses of vertebrates). Here we present the first characterization of the...
African Swine Fever Virus Infection in the Argasid Host, Ornithodoros porcinus porcinus
Kleiboeker, S. B., Burrage, T. G., Scoles, G. A., Fish, D., Rock, D. L.
The pathogenesis of African swine fever virus (ASFV) infection in Ornithodoros porcinus porcinus was examined in nymphal ticks infected with the ASFV isolate Chiredzi/83/1. At times postinfection...
Borca, M. V., Carrillo, C., Zsak, L., Laegreid, W. W., Kutish, G. F., Neilan, J. G., ...
An African swine fever virus (ASFV) gene with similarity to the T-lymphocyte surface antigen CD2 has been found in the pathogenic African isolate Malawi Lil-20/1 (open reading frame [ORF] 8-DR) and a...
Moore, D. M., Zsak, L., Neilan, J. G., Lu, Z., Rock, D. L.
African swine fever virus (ASFV) replicates in the cytoplasm of infected cells and contains genes encoding a number of enzymes needed for DNA synthesis, including a thymidine kinase (TK) gene....
Lewis, T., Zsak, L., Burrage, T. G., Lu, Z., Kutish, G. F., Neilan, J. G., ...
The African swine fever virus (ASFV) genome contains a gene, 9GL, with similarity to yeast ERV1 and ALR genes. ERV1 has been shown to function in oxidative phosphorylation and in cell growth, while...
Afonso, C. L., Tulman, E. R., Lu, Z., Zsak, L., Kutish, G. F., Rock, D. L.
Here we present the genomic sequence, with analysis, of a pathogenic fowlpox virus (FPV). The 288-kbp FPV genome consists of a central coding region bounded by identical 9.5-kbp inverted terminal...
The Genome of a Very Virulent Marek's Disease Virus
Tulman, E. R., Afonso, C. L., Lu, Z., Zsak, L., Rock, D. L., Kutish, G. F.
Here we present the first complete genomic sequence, with analysis, of a very virulent strain of Marek's disease virus serotype 1 (MDV1), Md5. The genome is 177,874 bp and is predicted to encode 103...
The Genome of Turkey Herpesvirus
Afonso, C. L., Tulman, E. R., Lu, Z., Zsak, L., Rock, D. L., Kutish, G. F.
Here we present the first complete genomic sequence of Marek's disease virus serotype 3 (MDV3), also known as turkey herpesvirus (HVT). The 159,160-bp genome encodes an estimated 99 putative proteins...
Zsak, L., Lu, Z., Burrage, T. G., Neilan, J. G., Kutish, G. F., Moore, D. M., ...
Pathogenic African swine fever virus (ASFV) isolates primarily target cells of the mononuclear-phagocytic system in infected swine and replicate efficiently in primary macrophage cell cultures in...
Genome of Lumpy Skin Disease Virus
Tulman, E. R., Afonso, C. L., Lu, Z., Zsak, L., Kutish, G. F., Rock, D. L.
Lumpy skin disease virus (LSDV), a member of the capripoxvirus genus of the Poxviridae, is the etiologic agent of an important disease of cattle in Africa. Here we report the genomic sequence of...
Genome Sequence of a Baculovirus Pathogenic for Culex nigripalpus
Afonso, C. L., Tulman, E. R., Lu, Z., Balinsky, C. A., Moser, B. A., Becnel, J. J., ...
In this report we describe the complete genome sequence of a nucleopolyhedrovirus that infects larval stages of the mosquito Culex nigripalpus (CuniNPV). The CuniNPV genome is a circular...
Zsak, L., Caler, E., Lu, Z., Kutish, G. F., Neilan, J. G., Rock, D. L.
Sequence analysis of the right variable genomic region of the pathogenic African swine fever virus (ASFV) isolate E70 revealed a novel gene, UK, that is immediately upstream from the previously...
Neilan, J. G., Zsak, L., Lu, Z., Kutish, G. F., Afonso, C. L., Rock, D. L.
Previously we have shown that the African swine fever virus (ASFV) NL gene deletion mutant E70ΔNL is attenuated in pigs. Our recent observations that NL gene deletion mutants of two additional...
The Genomes of Sheeppox and Goatpox Viruses
Tulman, E. R., Afonso, C. L., Lu, Z., Zsak, L., Sandybaev, N. T., ...
Sheeppox virus (SPPV) and goatpox virus (GTPV), members of the Capripoxvirus genus of the Poxviridae, are etiologic agents of important diseases of sheep and goats in northern and central Africa,...
Afonso, C. L., Tulman, E. R., Lu, Z., Zsak, L., Osorio, F. A., Balinsky, C., ...
Swinepox virus (SWPV), the sole member of the Suipoxvirus genus of the Poxviridae, is the etiologic agent of a worldwide disease specific for swine. Here we report the genomic sequence of SWPV. The...
An African swine fever virus Bc1-2 homolog, 5-HL, suppresses apoptotic cell death.
Afonso, C L, Neilan, J G, Kutish, G F, Rock, D L
Here, we show that the African swine fever virus 5-HL gene is a highly conserved viral gene and contains all known protein domains associated with Bcl-2 activity, including those involved with...
Zsak, L, Lu, Z, Kutish, G F, Neilan, J G, Rock, D L
We described previously an African swine fever virus (ASFV) open reading frame, 23-NL, in the African isolate Malawi Lil 20/1 whose product shared significant similarity in a carboxyl-terminal domain...
Genome of Bovine Herpesvirus 5
Delhon, G., Moraes, M. P., Lu, Z., Afonso, C. L., Flores, E. F., Weiblen, R., ...
Here we present the complete genomic sequence of bovine herpesvirus 5 (BHV-5), an alphaherpesvirus responsible for fatal meningoencephalitis in cattle. The 138,390-bp genome encodes 70 putative...
Long-term persistent infection of swine monocytes/macrophages with African swine fever virus.
Carrillo, C, Borca, M V, Afonso, C L, Onisk, D V, Rock, D L
Long-term persistent infection was established in 100% of pigs (n = 19) experimentally infected with African swine fever virus (ASFV). Viral DNA was detected in peripheral blood mononuclear...
Neilan, J G, Lu, Z, Afonso, C L, Kutish, G F, Sussman, M D, Rock, D L
An open reading frame, LMW5-HL, in the African swine fever virus genome displays a high degree of similarity to the proto-oncogene bcl-2 and, to a lesser degree, the Epstein-Barr virus gene BHRF1. A...
Latent herpes simplex virus type 1 DNA contains two copies of the virion DNA joint region.
Southern blot analysis of latent herpes simplex virus DNA detected in mouse brain and digested with a restriction enzyme revealed two copies of the virion DNA joint fragment. Thus, the absence of...
Rock, D L, Nesburn, A B, Ghiasi, H, Ong, J, Lewis, T L, Lokensgard, J R, ...
Using a combination of in situ hybridization and Northern (RNA) blot analysis, we investigated herpes simplex virus type 1 (HSV-1) transcriptional activity in an ocular rabbit model of HSV-1 latency....
Rock, D L, Beam, S L, Mayfield, J E
Here we have used the bovine herpesvirus type 1 (BHV-1) rabbit model together with in situ nucleic acid hybridization to identify and map viral RNA present in latently infected neurons. Radioactively...
Sussman, M D, Lu, Z, Kutish, G, Afonso, C L, Roberts, P, Rock, D L
Here we describe an open reading frame (LMW23-NL) in the African swine fever virus genome that possesses striking similarity to a murine myeloid differentiation primary response gene (MyD116) and the...
Tulman, E. R., Afonso, C. L., Lu, Z., Zsak, L., Kutish, G. F., Rock, D. L.
Here we present the genomic sequence, with analysis, of a canarypox virus (CNPV). The 365-kbp CNPV genome contains 328 potential genes in a central region and in 6.5-kbp inverted terminal repeats....
Genomes of the Parapoxviruses Orf Virus and Bovine Papular Stomatitis Virus
Delhon, G., Tulman, E. R., Afonso, C. L., Lu, Z., Lehmkuhl, H. D., ...
Bovine papular stomatitis virus (BPSV) and orf virus (ORFV), members of the genus Parapoxvirus of the Poxviridae, are etiologic agents of worldwide diseases affecting cattle and small ruminants,...
Neilan, J G, Lu, Z, Kutish, G F, Sussman, M D, Roberts, P C, Yozawa, T, ...
Persistent infection with bovine herpesvirus type 1: rabbit model.
Persistent infection with bovine herpesvirus type 1 (BHV-1) was established in all rabbits after conjunctival inoculation of virus. Spontaneous reactivations of BHV-1 with and without the appearance...
Burrage, T. G., Lu, Z., Neilan, J. G., Rock, D. L., Zsak, L.
Recently, we reported that African swine fever virus (ASFV) multigene family (MGF) 360 and 530 genes are significant swine macrophage host range determinants that function by promoting infected-cell...
African Swine Fever Virus Multigene Family 360 and 530 Genes Affect Host Interferon Response
Afonso, C. L., Piccone, M. E., Zaffuto, K. M., Neilan, J., Kutish, G. F., Lu, Z., ...
African swine fever virus (ASFV) multigene family 360 and 530 (MGF360/530) genes affect viral growth in macrophage cell cultures and virulence in pigs (L. Zsak, Z. Lu, T. G. Burrage, J. G. Neilan, G....
Afonso, C. L., Delhon, G., Tulman, E. R., Lu, Z., Zsak, A., Becerra, V. M., ...
Deerpox virus (DPV), an uncharacterized and unclassified member of the Poxviridae, has been isolated from North American free-ranging mule deer (Odocoileus hemionus) exhibiting mucocutaneous disease....
Preclinical Diagnosis of African Swine Fever in Contact-Exposed Swine by a Real-Time PCR Assay
Zsak, L., Borca, M. V., Risatti, G. R., Zsak, A., French, R. A., Lu, Z., ...
A fluorogenic probe hydrolysis (TaqMan) PCR assay for African swine fever virus (ASFV) was developed and evaluated in experimentally infected swine. This sensitive and specific one-step single-tube...
The E2 Glycoprotein of Classical Swine Fever Virus Is a Virulence Determinant in Swine
Risatti, G. R., Borca, M. V., Kutish, G. F., Lu, Z., Holinka, L. G., French, R. A., ...
To identify genetic determinants of classical swine fever virus (CSFV) virulence and host range, chimeras of the highly pathogenic Brescia strain and the attenuated vaccine strain CS were constructed...
Comparative Genomics of Foot-and-Mouth Disease Virus†
Carrillo, C., Tulman, E. R., Delhon, G., Lu, Z., Carreno, A., Vagnozzi, A., ...
Here we present complete genome sequences, including a comparative analysis, of 103 isolates of foot-and-mouth disease virus (FMDV) representing all seven serotypes and including the first complete...
Afonso, C. L., Tulman, E. R., Delhon, G., Lu, Z., Viljoen, G. J., Wallace, D. B., ...
Here, we present the genome sequence, with analysis, of a poxvirus infecting Nile crocodiles (Crocodylus niloticus) (crocodilepox virus; CRV). The genome is 190,054 bp (62% G+C) and predicted to...
The Genome of Melanoplus sanguinipes Entomopoxvirus
Afonso, C. L., Tulman, E. R., Lu, Z., Oma, E., Kutish, G. F., Rock, D. L.
The family Poxviridae contains two subfamilies: the Entomopoxvirinae (poxviruses of insects) and the Chordopoxvirinae (poxviruses of vertebrates). Here we present the first characterization of the...
African Swine Fever Virus Infection in the Argasid Host, Ornithodoros porcinus porcinus
Kleiboeker, S. B., Burrage, T. G., Scoles, G. A., Fish, D., Rock, D. L.
The pathogenesis of African swine fever virus (ASFV) infection in Ornithodoros porcinus porcinus was examined in nymphal ticks infected with the ASFV isolate Chiredzi/83/1. At times postinfection...
Borca, M. V., Carrillo, C., Zsak, L., Laegreid, W. W., Kutish, G. F., Neilan, J. G., ...
An African swine fever virus (ASFV) gene with similarity to the T-lymphocyte surface antigen CD2 has been found in the pathogenic African isolate Malawi Lil-20/1 (open reading frame [ORF] 8-DR) and a...
Moore, D. M., Zsak, L., Neilan, J. G., Lu, Z., Rock, D. L.
African swine fever virus (ASFV) replicates in the cytoplasm of infected cells and contains genes encoding a number of enzymes needed for DNA synthesis, including a thymidine kinase (TK) gene....
Lewis, T., Zsak, L., Burrage, T. G., Lu, Z., Kutish, G. F., Neilan, J. G., ...
The African swine fever virus (ASFV) genome contains a gene, 9GL, with similarity to yeast ERV1 and ALR genes. ERV1 has been shown to function in oxidative phosphorylation and in cell growth, while...
Afonso, C. L., Tulman, E. R., Lu, Z., Zsak, L., Kutish, G. F., Rock, D. L.
Here we present the genomic sequence, with analysis, of a pathogenic fowlpox virus (FPV). The 288-kbp FPV genome consists of a central coding region bounded by identical 9.5-kbp inverted terminal...
The Genome of a Very Virulent Marek's Disease Virus
Tulman, E. R., Afonso, C. L., Lu, Z., Zsak, L., Rock, D. L., Kutish, G. F.
Here we present the first complete genomic sequence, with analysis, of a very virulent strain of Marek's disease virus serotype 1 (MDV1), Md5. The genome is 177,874 bp and is predicted to encode 103...
The Genome of Turkey Herpesvirus
Afonso, C. L., Tulman, E. R., Lu, Z., Zsak, L., Rock, D. L., Kutish, G. F.
Here we present the first complete genomic sequence of Marek's disease virus serotype 3 (MDV3), also known as turkey herpesvirus (HVT). The 159,160-bp genome encodes an estimated 99 putative proteins...
Zsak, L., Lu, Z., Burrage, T. G., Neilan, J. G., Kutish, G. F., Moore, D. M., ...
Pathogenic African swine fever virus (ASFV) isolates primarily target cells of the mononuclear-phagocytic system in infected swine and replicate efficiently in primary macrophage cell cultures in...
Genome of Lumpy Skin Disease Virus
Tulman, E. R., Afonso, C. L., Lu, Z., Zsak, L., Kutish, G. F., Rock, D. L.
Lumpy skin disease virus (LSDV), a member of the capripoxvirus genus of the Poxviridae, is the etiologic agent of an important disease of cattle in Africa. Here we report the genomic sequence of...
Genome Sequence of a Baculovirus Pathogenic for Culex nigripalpus
Afonso, C. L., Tulman, E. R., Lu, Z., Balinsky, C. A., Moser, B. A., Becnel, J. J., ...
In this report we describe the complete genome sequence of a nucleopolyhedrovirus that infects larval stages of the mosquito Culex nigripalpus (CuniNPV). The CuniNPV genome is a circular...
Zsak, L., Caler, E., Lu, Z., Kutish, G. F., Neilan, J. G., Rock, D. L.
Sequence analysis of the right variable genomic region of the pathogenic African swine fever virus (ASFV) isolate E70 revealed a novel gene, UK, that is immediately upstream from the previously...
Neilan, J. G., Zsak, L., Lu, Z., Kutish, G. F., Afonso, C. L., Rock, D. L.
Previously we have shown that the African swine fever virus (ASFV) NL gene deletion mutant E70ΔNL is attenuated in pigs. Our recent observations that NL gene deletion mutants of two additional...
The Genomes of Sheeppox and Goatpox Viruses
Tulman, E. R., Afonso, C. L., Lu, Z., Zsak, L., Sandybaev, N. T., ...
Sheeppox virus (SPPV) and goatpox virus (GTPV), members of the Capripoxvirus genus of the Poxviridae, are etiologic agents of important diseases of sheep and goats in northern and central Africa,...
Afonso, C. L., Tulman, E. R., Lu, Z., Zsak, L., Osorio, F. A., Balinsky, C., ...
Swinepox virus (SWPV), the sole member of the Suipoxvirus genus of the Poxviridae, is the etiologic agent of a worldwide disease specific for swine. Here we report the genomic sequence of SWPV. The...
An African swine fever virus Bc1-2 homolog, 5-HL, suppresses apoptotic cell death.
Afonso, C L, Neilan, J G, Kutish, G F, Rock, D L
Here, we show that the African swine fever virus 5-HL gene is a highly conserved viral gene and contains all known protein domains associated with Bcl-2 activity, including those involved with...
Zsak, L, Lu, Z, Kutish, G F, Neilan, J G, Rock, D L
We described previously an African swine fever virus (ASFV) open reading frame, 23-NL, in the African isolate Malawi Lil 20/1 whose product shared significant similarity in a carboxyl-terminal domain...
Genome of Bovine Herpesvirus 5
Delhon, G., Moraes, M. P., Lu, Z., Afonso, C. L., Flores, E. F., Weiblen, R., ...
Here we present the complete genomic sequence of bovine herpesvirus 5 (BHV-5), an alphaherpesvirus responsible for fatal meningoencephalitis in cattle. The 138,390-bp genome encodes 70 putative...
Long-term persistent infection of swine monocytes/macrophages with African swine fever virus.
Carrillo, C, Borca, M V, Afonso, C L, Onisk, D V, Rock, D L
Long-term persistent infection was established in 100% of pigs (n = 19) experimentally infected with African swine fever virus (ASFV). Viral DNA was detected in peripheral blood mononuclear...
Neilan, J G, Lu, Z, Afonso, C L, Kutish, G F, Sussman, M D, Rock, D L
An open reading frame, LMW5-HL, in the African swine fever virus genome displays a high degree of similarity to the proto-oncogene bcl-2 and, to a lesser degree, the Epstein-Barr virus gene BHRF1. A...
Latent herpes simplex virus type 1 DNA contains two copies of the virion DNA joint region.
Southern blot analysis of latent herpes simplex virus DNA detected in mouse brain and digested with a restriction enzyme revealed two copies of the virion DNA joint fragment. Thus, the absence of...
Rock, D L, Nesburn, A B, Ghiasi, H, Ong, J, Lewis, T L, Lokensgard, J R, ...
Using a combination of in situ hybridization and Northern (RNA) blot analysis, we investigated herpes simplex virus type 1 (HSV-1) transcriptional activity in an ocular rabbit model of HSV-1 latency....
Rock, D L, Beam, S L, Mayfield, J E
Here we have used the bovine herpesvirus type 1 (BHV-1) rabbit model together with in situ nucleic acid hybridization to identify and map viral RNA present in latently infected neurons. Radioactively...
Sussman, M D, Lu, Z, Kutish, G, Afonso, C L, Roberts, P, Rock, D L
Here we describe an open reading frame (LMW23-NL) in the African swine fever virus genome that possesses striking similarity to a murine myeloid differentiation primary response gene (MyD116) and the...
Tulman, E. R., Afonso, C. L., Lu, Z., Zsak, L., Kutish, G. F., Rock, D. L.
Here we present the genomic sequence, with analysis, of a canarypox virus (CNPV). The 365-kbp CNPV genome contains 328 potential genes in a central region and in 6.5-kbp inverted terminal repeats....
Genomes of the Parapoxviruses Orf Virus and Bovine Papular Stomatitis Virus
Delhon, G., Tulman, E. R., Afonso, C. L., Lu, Z., Lehmkuhl, H. D., ...
Bovine papular stomatitis virus (BPSV) and orf virus (ORFV), members of the genus Parapoxvirus of the Poxviridae, are etiologic agents of worldwide diseases affecting cattle and small ruminants,...
Neilan, J G, Lu, Z, Kutish, G F, Sussman, M D, Roberts, P C, Yozawa, T, ...
Persistent infection with bovine herpesvirus type 1: rabbit model.
Persistent infection with bovine herpesvirus type 1 (BHV-1) was established in all rabbits after conjunctival inoculation of virus. Spontaneous reactivations of BHV-1 with and without the appearance...
Burrage, T. G., Lu, Z., Neilan, J. G., Rock, D. L., Zsak, L.
Recently, we reported that African swine fever virus (ASFV) multigene family (MGF) 360 and 530 genes are significant swine macrophage host range determinants that function by promoting infected-cell...
African Swine Fever Virus Multigene Family 360 and 530 Genes Affect Host Interferon Response
Afonso, C. L., Piccone, M. E., Zaffuto, K. M., Neilan, J., Kutish, G. F., Lu, Z., ...
African swine fever virus (ASFV) multigene family 360 and 530 (MGF360/530) genes affect viral growth in macrophage cell cultures and virulence in pigs (L. Zsak, Z. Lu, T. G. Burrage, J. G. Neilan, G....
Afonso, C. L., Delhon, G., Tulman, E. R., Lu, Z., Zsak, A., Becerra, V. M., ...
Deerpox virus (DPV), an uncharacterized and unclassified member of the Poxviridae, has been isolated from North American free-ranging mule deer (Odocoileus hemionus) exhibiting mucocutaneous disease....
Preclinical Diagnosis of African Swine Fever in Contact-Exposed Swine by a Real-Time PCR Assay
Zsak, L., Borca, M. V., Risatti, G. R., Zsak, A., French, R. A., Lu, Z., ...
A fluorogenic probe hydrolysis (TaqMan) PCR assay for African swine fever virus (ASFV) was developed and evaluated in experimentally infected swine. This sensitive and specific one-step single-tube...
The E2 Glycoprotein of Classical Swine Fever Virus Is a Virulence Determinant in Swine
Risatti, G. R., Borca, M. V., Kutish, G. F., Lu, Z., Holinka, L. G., French, R. A., ...
To identify genetic determinants of classical swine fever virus (CSFV) virulence and host range, chimeras of the highly pathogenic Brescia strain and the attenuated vaccine strain CS were constructed...
Comparative Genomics of Foot-and-Mouth Disease Virus†
Carrillo, C., Tulman, E. R., Delhon, G., Lu, Z., Carreno, A., Vagnozzi, A., ...
Here we present complete genome sequences, including a comparative analysis, of 103 isolates of foot-and-mouth disease virus (FMDV) representing all seven serotypes and including the first complete...
Afonso, C. L., Tulman, E. R., Delhon, G., Lu, Z., Viljoen, G. J., Wallace, D. B., ...
Here, we present the genome sequence, with analysis, of a poxvirus infecting Nile crocodiles (Crocodylus niloticus) (crocodilepox virus; CRV). The genome is 190,054 bp (62% G+C) and predicted to...
Tulman, E. R., Delhon, G., Afonso, C. L., Lu, Z., Zsak, L., Sandybaev, N. T., ...
Here we present the genomic sequence of horsepox virus (HSPV) isolate MNR-76, an orthopoxvirus (OPV) isolated in 1976 from diseased Mongolian horses. The 212-kbp genome contained 7.5-kbp inverted...
Carrillo, C., Lu, Z., Borca, M. V., Vagnozzi, A., Kutish, G. F., Rock, D. L.
Foot-and-mouth disease virus (FMDV), like other RNA viruses, exhibits high mutation rates during replication that have been suggested to be of adaptive value. However, even though genetic variation...
Sheeppox Virus Kelch-Like Gene SPPV-019 Affects Virus Virulence▿
Balinsky, C. A., Delhon, G., Afonso, C. L., Risatti, G. R., Borca, M. V., French, R. A., ...
Sheeppox virus (SPPV), a member of the Capripoxvirus genus of the Poxviridae, is the etiologic agent of a significant disease of sheep in the developing world. Genomic analysis of pathogenic and...
Rapid Preclinical Detection of Sheeppox Virus by a Real-Time PCR Assay▿
Balinsky, C. A., Delhon, G., Smoliga, G., Prarat, M., French, R. A., Geary, S. J., ...
Sheeppox virus (SPPV) is a member of the Capripoxvirus (CaPV) genus of the Poxviridae family. Members of this genus, which also include goatpox and lumpy skin disease viruses, cause economically...