D. Laurent

Publication List Details

Period

1984 - 2008

Number

20

Co-Authors

Phase II, open-label study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate (2008)

Joensuu, H., De Braud, F., Coco, P., De Pas, T., Putzu, C., Spreafico, C., ...

Background: We evaluated safety and efficacy of PTK787/ZK222584 (PTK/ZK), a novel tyrosine kinase inhibitor of KIT, platelet-derived growth factor receptors and vascular endothelial cell growth...

Learning Query-Rules for Optimizing Databases with Update-Rules (2007)

C. Vrain, D. Laurent

In this paper, we consider an approach to updating Datalog neg databases containing two kinds of rules, namely query-rules and update-rules that can be seen as constraints. Update-rules are used to...

Optimization and Serializability of Update Transactions in Marked Databases (2007)

D. Laurent, Laurent Spyratos, G. Vossen, Cedex Orsay Cedex

Marked databases are a generalization of relational databases in which there are no fixed schemas, and in which tuples are never deleted, but eventually marked as invalid. The study of marked...

Update-Driven Rules in Datalog neg Databases (2007)

M. Halfeld, Ferrari Alves, D. Laurent, N. Spyratos

We present a model for deductive databases which contain query-driven and updatedriven rules. Our approach is based on the assumptions that (a) both inserted and deleted facts are explicitly stored...

1 (2007)

C. T. Diop, D. Laurent, N. Spyratos

Association rule mining often requires the repeated execution of some extraction algorithm for dierent values of the support and condence thresholds, as well as for dierent source datasets. This is...

A phase IB, open-label dose-escalating study of the oral angiogenesis inhibitor PTK787/ZK 222584 (PTK/ZK), in combination with FOLFOX4 chemotherapy in patients with advanced colorectal cancer (2007)

Thomas, AL, Trarbach, T, Bartel, C, Laurent, D, Henry, A, Poethig, M, ...

Background: This open-label, phase IB study was undertaken to determine the safety/toxicity profile and recommended dose of oral once-daily PTK787/ZK 222584 (PTK/ZK) combined with...

A phase IB, open-label dose-escalating study of the oral angiogenesis inhibitor PTK787/ZK 222584 (PTK/ZK), in combination with FOLFOX4 chemotherapy in patients with advanced colorectal cancer (2007)

Thomas, AL, Trarbach, T, Bartel, C, Laurent, D, Henry, A, Poethig, M, ...

Background: This open-label, phase IB study was undertaken to determine the safety/toxicity profile and recommended dose of oral once-daily PTK787/ZK 222584 (PTK/ZK) combined with...

A phase IB, open-label dose-escalating study of the oral angiogenesis inhibitor PTK787/ZK 222584 (PTK/ZK), in combination with FOLFOX4 chemotherapy in patients with advanced colorectal cancer (2007)

Thomas, AL, Trarbach, T, Bartel, C, Laurent, D, Henry, A, Poethig, M, ...

Background: This open-label, phase IB study was undertaken to determine the safety/toxicity profile and recommended dose of oral once-daily PTK787/ZK 222584 (PTK/ZK) combined with...

Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators (2005)

Garrec, R. B. L., Benoit, E., Sauviat, M. P., Lewis, R. J., Molgo, J., Laurent, D

The effects of 31 plant extracts, which most are traditionally used to treat ciguatera fish poisoning in the Pacific area, were Studied on the cytotoxicity of mouse neuroblastoma cells produced by...

Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators (2005)

Garrec, R. B. L., Benoit, E., Sauviat, M. P., Lewis, R. J., Molgo, J., Laurent, D

The effects of 31 plant extracts, which most are traditionally used to treat ciguatera fish poisoning in the Pacific area, were Studied on the cytotoxicity of mouse neuroblastoma cells produced by...

Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials (2005)

Drevs, J., Zirrgiebel, U., Mross, K., Medinger, M., Lee, L., ...

Background: Plasma and serum biomarkers of angiogenesis and activated endothelial cells were evaluated to assess biological activity of PTK787/ZK 222584 (PTK/ZK), a novel oral angiogenesis inhibitor...

Soluble markers for the assessment of biological activity with PTK787/ZK 222584 (PTK/ZK), a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor in patients with advanced colorectal cancer from two phase I trials (2005)

Drevs, J., Zirrgiebel, U., Mross, K., Medinger, M., Lee, L., ...

Background: Plasma and serum biomarkers of angiogenesis and activated endothelial cells were evaluated to assess biological activity of PTK787/ZK 222584 (PTK/ZK), a novel oral angiogenesis inhibitor...

Extending tree automata to model XML validation under element and attribute constraints (2003)

B. Bouchou, D. Duarte, M. Halfeld, Ferrari Alves, D. Laurent

Abstract: Algorithms for validation play a crucial role in the use of XML. Although much effort has been made for formalizing the treatment of elements, attributes have been neglected. This paper...

Left ventricular wall stress and sarcoplasmic reticulum Ca2+-ATPase gene expression in renal hypertensive rats: dose-dependent effects of ACE inhibition and AT1-receptor blockade (1996)

Zierhut, W., Studer, R., Laurent, D., Kästner, S., Allegrini, P., Whitebread, S., ...

BackgroundCardiac hypertrophy is associated with altered Ca2+ handling and may predispose to the development of LV dysfunction and cardiac failure. At the cellular level, the re-expression of ANF...

Une nouvelle approche des mises à jour des bases de données (1994)

Laurent, D., Phan Luang, V., Spyratos, N.

Nous présentons une nouvelle approche des mises à jour des bases de données dont le point essentiel est que toute insertion et toute suppression est déterministe, i.e. toute information peut...

Overall myocardial energetics in physiological conditions and in acute volume overloading (1984)

Jarry, G., Maarek, J. M., Laurent, D.

Left ventricular heat production (PH.lv) was compared with myocardial O2 consumption (PmerO2) and mechanical parameters in intact anaesthetized dogs before and after acute volume overload induced by...

Mathematical Modeling of Ventilatory Mechanics during Spontaneous Breathing

Lorino, H., Lorino, A.M., Harf, A., Atlan, G., Laurent, D.

The overall mechanical behavior of the ventilatory system during spontaneous breathing can be described using linear models such as the first order equation P = V/C + R.V, where V̊ is the...

Updates, Induction and Abduction in Deductive Databases

Ch. Vrain, D. Laurent

this paper, we consider an application of Inductive Logic Programming to a recently introduced model of Datalog