D. M.

Increased endogenous angiogenic response and hypoxia-inducible factor-1 alpha in human critical limb ischemia (2006)

  • Ho,
  • T.K.,
  • Rajkumar,
  • V.,
  • Ponticos,
  • M.,
  • ...

Objective: The potent physiologic endogenous angiogenic response to ischemic stimuli is often suboptimal, and therefore, a better understanding of the basic mechanisms is essential for the use in...

Donas-de-casa: suas apropriações e reelaborações na recepção da narrativa radiofônica popular.1 (2005)

  • POSSATTI,
  • D.M

Trabalho apresentado no Intercom Júnior, evento componente do XXVIII Congresso Brasileiro de Ciências da Comunicação, Rio de Janeiro, RJ, 05-09,setembro,2005  Daniele...

Mídias, identidades culturais e cidadania: sobre cenários e políticas de visibilidade midiática dos movimentos sociais (2005)

Trabalho apresentado no NP 12 - Comunicação para a Cidadania no XXVII Congresso Brasileiro de Ciências da Comunicação, Porto Alegre RS, 2004.  Esse texto busca...

Comunicação, mídia e cidadania: um percurso pelas interfaces de um Núcleo de Pesquisa da Intercom (2005)

Trabalho apresentado no NP12 - Comunicação para a Cidadania durante o XXVIII Congresso Brasileiro de Ciências da Comunicação, Rio de Janeiro, RJ,...

Disorders of body schema (2005)

  • Haggard,
  • P.,
  • Wolpert,
  • D.M.

Application of soft tissue modelling to image-guided surgery (2005)

  • Carter,
  • T.J.,
  • Sermesant,
  • M.,
  • Cash,
  • D.M.,
  • ...

The deformation of soft tissue compromises the accuracy of image-guided surgery based on preoperative images, and restricts its applicability to surgery on or near bony structures. One way to...

Representational difference analysis of cDNA identifies novel genes expressed following preconditioning of the heart (2005)

Preconditioning of the myocardium rapidly induces a number of transcription factors, which are likely to be responsible for a cascade of transcriptional changes underlying the development of delayed...

Use of total lymphocyte count for informing when to start antiretroviral therapy in HIV-infected children: a meta-analysis of longitudinal data (2005)

  • Dunn,
  • D.T.,
  • Gibb,
  • D.M.,
  • Duong,
  • T.,
  • ...

Background Total lymphocyte count has been proposed as an alternative to the percentage of CD4+ T-cells to indicate when antiretroviral therapy should be started in children with HIV in resource-poor...

The use of the Montgomery T-tube in difficult paediatric airways (2005)

  • Phillips,
  • P.S.,
  • Kubba,
  • H.,
  • Hartley,
  • B.E.,
  • ...

OBJECTIVE:: We report our experience of using Montgomery T-tubes in children. METHOD:: A retrospective review of medical records was performed. Data collected included particular clinical...

Relationship between changes in thymic emigrants and cell-associated HIV-1 DNA in HIV-1-infected children initiating antiretroviral therapy (2005)

Objectives and methods: To investigate the relationship between cell-associated HIV-1 dynamics and recent thymic T-cell emigrants, HIV-1 DNA and T-cell receptor rearrangement excision circles (TREC,...

Altered expression of IGFs and IGF-binding proteins during intrauterine growth restriction in guinea pigs (2005)

The IGF system is one of the most important endocrine and paracrine growth factor systems that regulate fetal and placental growth. We hypothesized that intrauterine growth restriction (IUGR) in...

Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy (2005)

  • Charakida,
  • M.,
  • Donald,
  • A.E.,
  • Green,
  • H.,
  • ...

BACKGROUND: Premature cardiovascular disease is increasingly recognized in HIV-infected patients, but the mechanisms involved are unclear. The purpose of this study was to determine the impact of HIV...

The prevalence of the cysteine1584 variant of von Willebrand factor is increased in type 1 von Willebrand disease: co- segregation with increased susceptibility to ADAMTS13 proteolysis but not clinical phenotype (2005)

  • Bowen,
  • D.J.,
  • Collins,
  • P.W.,
  • Lester,
  • W.,
  • ...

The molecular pathogenesis of type 1 von Willebrand disease (VWD) is uncertain in most patients. We examined 30 type 1 VWD families in the UK Haemophilia Centre Doctors' Organization study....

How we do it: BAHA positioning in patients with microtia requiring auricular reconstruction (2005)

  • Bajaj,
  • Y.,
  • Wyatt,
  • M.E.,
  • Gault,
  • D.,
  • ...

Bilateral microtia is a challenging problem as these patients require both reconstruction of the auricle and rehabilitation of hearing. Our aim was to find the optimal position for bone-anchored...

A detailed phenotypic study of "cone dystrophy with supernormal rod ERG" (2005)

  • Michaelides,
  • M.,
  • Holder,
  • G.E.,
  • Webster,
  • A.R.,
  • ...

AIMS: To characterise the detailed phenotype of "cone dystrophy with supernormal rod ERG" in a case series of 10 patients. METHODS: 10 affected patients were examined clinically and underwent colour...

A detailed study of the phenotype of an autosomal dominant cone-rod dystrophy (CORD7) associated with mutation in the gene for RIM1 (2005)

  • Michaelides,
  • M.,
  • Holder,
  • G.E.,
  • Hunt,
  • D.M.,
  • ...

AIM: To characterise the phenotype of an autosomal dominant cone-rod dystrophy (CORD7) associated with the Arg844His mutation in RIM1. METHODS: Eight members of a four generation, non-consanguineous...

Blue cone monochromatism: a phenotype and genotype assessment with evidence of progressive loss of cone function in older individuals (2005)

  • Michaelides,
  • M.,
  • Johnson,
  • S.,
  • Simunovic,
  • M.P.,
  • ...

AIM: To perform a detailed clinical and psychophysical assessment of the members of three British families affected with blue cone monochromatism (BCM), and to determine the molecular basis of...

Cone topography and spectral sensitivity in two potentially trichromatic marsupials, the quokka (Setonix brachyurus) and quenda (Isoodon obesulus) (2005)

The potential for trichromacy in mammals, thought to be unique to primates, was recently discovered in two Australian marsupials. Whether the presence of three cone types, sensitive to short- (SWS),...

Cone-rod dystrophy, intrafamilial variability, and incomplete penetrance associated with the R172W mutation in the peripherin/RDS gene (2005)

  • Michaelides,
  • M.,
  • Holder,
  • G.E.,
  • Bradshaw,
  • K.,
  • ...

PURPOSE: To determine the underlying molecular genetic basis of a retinal dystrophy identified in a 5-generation family, and to examine the phenotype and degree of intrafamilial variability. DESIGN:...

Isolation and characterization of murine Cds (CDP-diacylglycerol synthase) 1 and 2 (2005)

  • Inglis-Broadgate,
  • S.L.,
  • Ocaka,
  • L.,
  • Banerjee,
  • R.,
  • ...

Phototransduction in Drosophila is a phosphoinositide-mediated signalling pathway. Phosphatidylinositol 4,5-bisphosphate (PIP2) plays a central role in this process, and its levels are tightly...

Mutation in the gene GUCA1A, encoding guanylate cyclase-activating protein 1, causes cone, cone-rod, and macular dystrophy (2005)

  • Michaelides,
  • M.,
  • Wilkie,
  • S.E.,
  • Jenkins,
  • S.,
  • ...

PURPOSE: To determine the underlying molecular genetic basis of a retinal dystrophy identified in a 4-generation family and to examine the phenotype and the degree of intrafamilial variability....

X-linked cone dysfunction syndrome with myopia and protanopia (2005)

  • Michaelides,
  • M.,
  • Johnson,
  • S.,
  • Bradshaw,
  • K.,
  • ...

PURPOSE: To perform a detailed clinical, psychophysical, and molecular assessment of members of 4 families with an unusual X-linked cone dysfunction syndrome associated with myopia. PARTICIPANTS:...

North Pacific seasonality and the glaciation of North America 2.7 million years ago (2005)

  • Haug,
  • G.H.,
  • Ganopolski,
  • A.,
  • Sigman,
  • D.M.,
  • ...

In the context of gradual Cenozoic cooling, the timing of the onset of significant Northern Hemisphere glaciation 2.7 million years ago is consistent with Milankovitch's orbital theory, which posited...

Pulmonary thromboembolism in Klippel-Trenaunay-Weber syndrome - should all cases be anticoagulated? (2005)

  • Bagul,
  • N.B.,
  • Pathak,
  • R.,
  • Garg,
  • N.K.,
  • ...

Klippel-Trenaunay-Weber syndrome (KTWS) is a congenital disorder characterized by a triad of varicose veins and venous malformation involving one or more extremities, cutaneous haemangioma, and...

Response to highly active antiretroviral therapy varies with age: the UK and Ireland Collaborative HIV Paediatric Study (2004)

  • Walker,
  • A.S.,
  • Doerholt,
  • K.,
  • Sharland,
  • M.,
  • ...

OBJECTIVE: To evaluate the effect of age, CD4 percentage (CD4%) and plasma HIV-1 RNA on response to highly active antiretroviral therapy (HAART) in previously untreated children. DESIGN: Cohort...

The body scheme. (2004)

  • Haggard,
  • P.,
  • Wolpert,
  • D.M.

Natural organic matter in sedimentary basins and its relation to arsenic in anoxic ground water: the example of West Bengal and its worldwide implications (2004)

In order to investigate the mechanism of As release to anoxic ground water in alluvial aquifers, the authors sampled ground waters from 3 piezometer nests, 79 shallow (80 m) wells, in an area 750 m...

Decline in mortality, AIDS, and hospital admissions in perinatally HIV-1 infected children in the United Kingdom and Ireland (2003)

  • Gibb,
  • D.M.,
  • Duong,
  • T.,
  • Tookey,
  • P.A.,
  • ...

OBJECTIVE: To describe changes in demographic factors, disease progression, hospital admissions, and use of antiretroviral therapy in children with HIV. DESIGN: Active surveillance through the...

p53 down-regulation: a new molecular mechanism involved in ischaemic preconditioning. (2003)

Ischaemic preconditioning is associated with the activation of prosurvival mechanisms. Here we demonstrate that following a preconditioning protocol, the proapoptotic p53 is inactivated possibly via...

Urinary outflow obstruction increases apoptosis and deregulates Bcl-2 and Bax expression in the fetal ovine bladder (2003)

  • Thiruchelvam,
  • N.,
  • Nyirady,
  • P.,
  • Peebles,
  • D.M.,
  • ...

During organogenesis, net growth of tissues is determined by a balance between proliferation, hypertrophy, and apoptotic death. Human fetal bladder outflow obstruction is a major cause of end-stage...

Nevirapine use in HIV-1-infected children (2003)

  • Verweel,
  • G.,
  • Sharland,
  • M.,
  • Lyall,
  • H.,
  • ...

OBJECTIVES: To evaluate the safety, efficacy, and clinical, virological, and immunological responses in HIV-1-infected children receiving nevirapine as part of combination antiretroviral therapy...

Risk factors for Kaposi's sarcoma: A case-control study of HIV- seronegative people in Uganda (2003)

  • Ziegler,
  • J.,
  • Newton,
  • R.,
  • Bourboulia,
  • D.,
  • ...

As part of a larger investigation of cancer in Uganda, we conducted a case-control study of Kaposi's sarcoma in human immunodeficiency virus-I (HIV)-seronegative adults presenting at hospitals in...

The genetics of inherited macular dystrophies (2003)

  • Michaelides,
  • M.,
  • Hunt,
  • D.M.,
  • Moore,
  • A.T.

The inherited macular dystrophies comprise a heterogeneous group of disorders characterised by central visual loss and atrophy of the macula and underlying retinal pigment epithelium (RPE). The...

The rod opsin pigments from two marsupial species, the South American bare-tailed woolly opossum and the Australian fat-tailed dunnart (2003)

Rod visual pigment genes have been studied in a wide range of vertebrates including a number of mammalian species. However, no marsupials have yet been examined. To correct this omission, we have...

Transgenesis and neuroendocrine physiology: a transgenic rat model expressing growth hormone in vasopressin neurones (2003)

Human growth hormone (hGH) and bovine neurophysin (bNP) DNA reporter fragments were inserted into the rat vasopressin (VP) and oxytocin (OT) genes in a 44 kb cosmid construct used to generate two...

Effects of in utero bladder outflow obstruction on fetal sheep detrusor contractility, compliance and innervation (2002)

  • Nyirady,
  • P.,
  • Thiruchelvam,
  • N.,
  • Fry,
  • C.H.,
  • ...

PURPOSE: Congenital bladder outflow obstruction caused by posterior urethral valves is a common cause of end stage renal failure in boys. We hypothesized that fetal bladder outflow obstruction...

Cerebral carbon copies (2002)

  • Baradue,
  • P.,
  • Hamilton,
  • A.F.de C.,
  • Wolpert,
  • D.M.

The effect of preconditioning (ischemic and pharmacological) on myocardial necrosis following coronary artery bypass graft surgery (2002)

  • Teoh,
  • L.K.,
  • Grant,
  • R.,
  • Hulf,
  • J.A.,
  • ...

OBJECTIVES: Ischemic preconditioning is known to protect the human heart from ischemic injury during coronary artery bypass graft (CABG) surgery but is not practised routinely. Adenosine A1 receptor...

Haplotype analysis of the PPAR? Pro12Ala and C1431T variants reveals opposing associations with body weight (2002)

  • Doney,
  • A.,
  • Fischer,
  • B.,
  • Frew,
  • D.,
  • ...

Background: Variation at the PPARG locus may influence susceptibility to type 2 diabetes andrelated traits. The Pro12Ala polymorphism may modulate receptor activity and is associated withprotection...

Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide (2001)

BACKGROUND: The sulfonylurea glibenclamide (Glib) abolishes the cardioprotective effect of ischemic preconditioning (IP), presumably by inhibiting mitochondrial K(ATP) channel opening in myocytes....

Cardioprotective effects of transforming growth factor-β1 during early reoxygenation or reperfusion are mediated by p42/p44 MAPK (2001)

Apoptosis contributes to myocardial cell death during ischemia and reperfusion, especially during reperfusion. Growth factor "survival" signaling attenuates apoptosis. We therefore examined the...

Angiotensin-converting enzyme inhibition enhances a subthreshold stimulus to elicit delayed preconditioning in pig myocardium (2001)

OBJECTIVES: We assessed the effect of angiotensin-converting enzyme (ACE) inhibition in combination with a subthreshold preconditioning (PC) stimulus to elicit delayed preconditioning against...

Backtable heat-enhanced preconditioning: a simple and effective means of improving function of heart transplants (2001)

  • Kevelaitis,
  • E.,
  • Patel,
  • A.P.,
  • Oubenaissa,
  • A.,
  • ...

BACKGROUND: Cardiac harvest teams are usually committed to immediately transfer the explanted donor heart into its cold storage solution. We tested the opposite hypothesis that a brief prestorage...

Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury (2001)

  • Schulman,
  • D.,
  • Latchman,
  • D.S.,
  • Yellon,
  • D.M.

Ischemic preconditioning (IP) reduces infarct size in young animals; however, its impact on aging is underinvestigated. The effect of variations in IP stimuli was studied in young, middle-aged, and...

Exercise directly enhances myocardial tolerance to ischaemia-reperfusion injury in the rat through a protein kinase C mediated mechanism (2001)

  • Yamashita,
  • N.,
  • Baxter,
  • G.F.,
  • Yellon,
  • D.M.

OBJECTIVE: To determine whether exercise is capable of protecting the myocardium from experimental infarction and to explore the involvement of protein kinase C, a key signalling protein, in the...

Ischemic and pharmacological preconditioning in Girardi cells and C2C12 myotubes induce mitochondrial uncoupling (2001)

  • Minners,
  • J.,
  • Lacerda,
  • L.,
  • McCarthy,
  • J.,
  • ...

Pharmacological uncoupling of mitochondrial oxidation from phosphorylation promotes preconditioning-like cardioprotection in the isolated rat heart. We hypothesized that modest mitochondrial...

Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling (2001)

The "metabolic cocktail" comprising glucose-insulin-potassium administrated at reperfusion reduces infarct size in the in vivo rat heart. We propose that insulin is the major component mediating this...

MUC1 in Heliobacter gastritis (2001)

  • King,
  • M.,
  • Vinall,
  • L.E.,
  • Novelli,
  • M.,
  • ...

An immunodominant MHC class II-restricted tumor antigen is conformation dependent and binds to the endoplasmic reticulum chaperone, calreticulin (2001)

  • Golgher,
  • D.,
  • Korangy,
  • F.,
  • Gao,
  • B.,
  • ...

There is accumulating evidence that CD4(+) T cell responses are important in antitumor immunity. Accordingly, we generated CD4(+) T cells against the murine CT26 colon cancer. Three of three...

The origins of utilisation behaviour (1989)

  • Shallice,
  • T.,
  • Burgess,
  • P.W.,
  • Schon,
  • F.,
  • ...
 
Additional Information

Publishing period:

1979 - 2006 (202)

Co-authors: