Characterization of a {beta}-lactamase from Clostridium clostridioforme (1994)
Appelbaum, P. C., Spangler, S. K., Pankuch, G. A., Philippon, A., Jacobs, M. R., Shiman, R., ...
A β-lactamase-producing strain of Clostridium clostridioforme isolated from human peritoneal fluid was examined by MIC testing and enzyme characterization. MICs of penicillins (64–512 mg/L)...
Barry, A. L., Fuchs, P. C., Citron, D. M., Allen, S. D., Wexler, H. M.
The susceptibility of anaerobic bacteria to two new fluoroquinolones, PD 131628 (the bioactive form of PD 131112 or CI-990) and clinafloxacin (CI-960 or PD 127391), was determined with the agar...
Hudspeth, M. K., Gerardo, S. Hunt, Maiden, M. F. J., Citron, D. M., Goldstein, E. J. C.
Bacteroides forsythus strains recovered from cat and dog bite wound infections in humans (n = 3), monkey oral strains (n = 3), and the human oral ATCC 43037 type strain were characterized by using...
Citron, D. M., Merriam, C. V., Tyrrell, K. L., Warren, Y. A., Fernandez, H., Goldstein, E. J. C.
By using an agar dilution method, the in vitro activities of ramoplanin, teicoplanin, vancomycin, linezolid, and five other agents were determined against 300 gram-positive and 54 gram-negative...
Goldstein, E J, Nesbit, C A, Citron, D M
The activities of sparfloxacin, levofloxacin, Bay y 3118, azithromycin, cefprozil, loracarbef, and nine other oral antimicrobial agents against 194 aerobic and anaerobic clinical bite wound isolates...
Hunt Gerardo, S, Citron, D M, Claros, M C, Goldstein, E J
When the Etest was compared to broth microdilution for susceptibility testing of Streptococcus pneumoniae, levofloxacin, erythromycin, and penicillin results correlated for both methods; azithromycin...
Goldstein, E J, Citron, D M, Hunt Gerardo, S, Hudspeth, M, Merriam, C V
The activities of DU-6859a, levofloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against bite wound isolates were determined by the agar dilution method. DU-6859a was the most active compound...
Goldstein, E J, Citron, D M, Hudspeth, M, Hunt Gerardo, S, Merriam, C V
The in vitro activity of Bay 12-8039, a new oral 8-methoxyquinolone, was compared to the activities of 11 other oral antimicrobial agents (ciprofloxacin, levofloxacin, ofloxacin, sparfloxacin,...
Four hundred thirty-eight bacteria cultured from specimens of patients with serious intra-abdominal infections were tested by agar dilution against trovafloxacin and other quinolones and...
Brazier, J S, Goldstein, E J, Citron, D M, Ostovari, M I
Fastidious anaerobe agar supported the growth of 82 strains of fusobacteria better than brain heart infusion agar, brucella agar, and Wilkins-Chalgren agar. Fastidious anaerobe agar showed less...
Goldstein, E J, Citron, D M, Richwald, G A
The in vitro susceptibility of human isolates of Pasteurella multocida to oral antimicrobial agents from our current study and from a review of the literature suggests that dicloxacillin (oxacillin),...
We studied the comparative in vitro activities of 10 oral antimicrobial agents against 147 aerobic and 61 anaerobic bacteria making up species in 13 genera (Staphylococcus aureus, streptococci,...
The activity of cefbuperazone against 266 strains of anaerobic bacteria was determined by the agar dilution method and compared with cefoxitin, moxalactam, piperacillin, and clindamycin. All strains...
With a macrotube dilution method, MICs and MBCs were determined for three aminothiazolyl cephalosporins, cefpirome (HR 810), ceftazidime, and cefotaxime, against Pseudomonas aeruginosa, enterococci,...
Susceptibility of Eikenella corrodens to newer and older quinolones.
Goldstein, E J, Citron, D M, Vagvolgyi, A E, Gombert, M E
The susceptibilities of 44 clinical strains and a reference strain (ATCC 23834) of Eikenella corrodens were determined by agar dilution. All isolates were very susceptible (MICs, less than 2...
Susceptibility of Eikenella corrodens to penicillin, apalcillin, and twelve new cephalosporins.
The susceptibility of 29 strains of Eikenella corrodens to penicillin, apalcillin, and 12 new cephalosporins was determined by the agar dilution method. Most strains were resistant to cefsulodin, and...
Comparative activity of the quinolones against anaerobic bacteria isolated at community hospitals.
The in vitro activity of five quinolone compounds, amoxicillin, and clindamycin against 118 strains of anaerobic bacteria isolated at community hospitals was determined by an agar dilution method....
The susceptibilities of recent clinical isolates of anaerobic bacteria from two community hospitals were determined. Thirty percent of pigmented Bacteroides species and bile-sensitive, nonpigmented...
Goldstein, E J, Citron, D M, Vagvolgyi, A E, Finegold, S M
The susceptibility of 93 aerobic and 59 anaerobic bacteria isolated from human and animal bite wounds was determined by agar dilution. No agent tested (penicillin, oxacillin, cephalexin,...
Impact of cefoperazone therapy on fecal flora.
Mulligan, M E, Citron, D M, McNamara, B T, Finegold, S M
To evaluate the effects of parenteral cefoperazone therapy upon human fecal flora, fecal specimens obtained from four patients before and during therapy (as well as after therapy for one patient)...
The in vitro activities of sparfloxacin, temafloxacin, ciprofloxacin, ofloxacin, clarithromycin, erythromycin, tetracycline, cephalothin, penicillin G, and amoxicillin-clavulanic acid against 173...
The in vitro activities of seven fluoroquinolones against 290 anaerobes were determined by agar dilution. CI-960 and WIN 57273 inhibited greater than 95% of the strains at less than or equal to 2...
Survival of anaerobic bacteria in various thioglycolate and chopped meat broth formulations.
Claros, M C, Citron, D M, Goldstein, E J
Three commercially available formulations of thioglycolate broth and of chopped meat broth were evaluated for their abilities to maintain the viabilities of 32 strains of anaerobic bacteria during a...
Alexander, C J, Citron, D M, Brazier, J S, Goldstein, E J
Clostridium ramosum, C. innocuum, and C. clostridioforme are frequently isolated from clinical specimens including blood. Because of Gram stain variability, a lack of spores, and atypical colonial...
Alexander, C J, Citron, D M, Hunt Gerardo, S, Claros, M C, Talan, D, Goldstein, E J
Saccharolytic, nonpigmented, anaerobic gram-negative rods isolated from infected dog and cat bite wounds in humans have been poorly characterized, and most are not included in the databases of kits...
Hudspeth, M K, Hunt Gerardo, S, Citron, D M, Goldstein, E J
Thirty-nine clinical isolates of Porphyromonas species recovered from infected cat and dog bite wounds in humans and eight American Type Culture Collection and National Collection of Type Cultures...
Goldstein, E J, Citron, D M, Cherubin, C E
We compared the inoculum effects of 105 recent clinical isolates of the family Enterobacteriaceae on cefoxitin, other cephalosporins, aztreonam, and three beta-lactamase inhibitors (clavulanic acid,...
Goldstein, E J, Citron, D M, Cherubin, C E
We compared the inoculum effects for 109 recent clinical isolates of the Bacteroides fragilis group of cefoxitin, cefotetan, ceftizoxime, ceftriaxone, and three beta-lactamase inhibitors (clavulanic...
The in vitro activities of ofloxacin alone and in combination with metronidazole against 177 anaerobic bacteria isolated from intra-abdominal infections, as determined by broth microdilution, showed...
Goldstein, E J, Citron, D M, Goldman, R J
The methods for performing anaerobic bacterial isolation and identification continue to change and improve. Anaerobic susceptibility testing has become controversial, and method-dependent variability...
Mulligan, M E, Citron, D M, Kwok, R Y, Wheelock, J P, Farrohi, F K, Hindler, J A, ...
Because strains of Staphylococcus aureus that are resistant to penicillinase-resistant penicillins may be difficult to detect in the clinical laboratory, a variety of changes in methodology have been...
The six species of the Bacteroides fragilis group are potent pathogens and commonly have different susceptibility patterns. We determined the relative annual isolation rate of anaerobic bacteria and...
Mulligan, M E, Kwok, R Y, Citron, D M, John, J F, Smith, P B
An immunoblotting system was developed for typing of oxacillin-resistant Staphylococcus aureus. Clinical isolates recovered during a 40-month period at a single institution were evaluated with this...
Goldstein, E J, Citron, D M, Merkin, T E, Pickett, M J
An unusual gram-negative rod (RMA 1571) was isolated from a hand infection following a pig bite. This unclassified isolate was characterized by growth requirements, microscopic examination,...
Citron, D M, Baron, E J, Finegold, S M, Goldstein, E J
The rapid identification of isolates of bile-resistant Bacteroides species has clinical and therapeutic relevance because of differences in their patterns of susceptibility and virulence. Five...
Failure of rapid agglutination methods to detect oxacillin-resistant Staphylococcus aureus.
Ruane, P J, Morgan, M A, Citron, D M, Mulligan, M E
Although a latex agglutination test (StaphAurex) and a hemagglutination test (Staphyloslide) correctly identified all strains of Staphylococcus aureus that were susceptible or had intermediate...
Evaluation of the E test for susceptibility testing of anaerobic bacteria.
Citron, D M, Ostovari, M I, Karlsson, A, Goldstein, E J
The susceptibilities of 105 clinical isolates of anaerobic bacteria were determined by a new method, the E test (AB Biodisk, Solna, Sweden), and were compared with the MICs for these organisms...
New medium selective for Fusobacterium species and differential for Fusobacterium necrophorum.
Morgenstein, A A, Citron, D M, Finegold, S M
Fusobacterium egg yolk agar is a new medium selective for Fusobacterium species and differential for Fusobacterium necrophorum. The medium is a Brucella Agar base (Difco Laboratories, Detroit, Mich.)...
Bacteriology of human and animal bite wounds.
Goldstein, E J, Citron, D M, Wield, B, Blachman, U, Sutter, V L, Miller, T A, ...
Seventy-three patients with bite wounds (16 patients with clenched-fist injuries, 18 with human bite wounds, and 39 with animal bites) were cultured aerobically and anaerobically. A total of 33 of 34...
Hudspeth, M. K., Gerardo, S. Hunt, Maiden, M. F. J., Citron, D. M., Goldstein, E. J. C.
Bacteroides forsythus strains recovered from cat and dog bite wound infections in humans (n = 3), monkey oral strains (n = 3), and the human oral ATCC 43037 type strain were characterized by using...
Citron, D. M., Merriam, C. V., Tyrrell, K. L., Warren, Y. A., Fernandez, H., Goldstein, E. J. C.
By using an agar dilution method, the in vitro activities of ramoplanin, teicoplanin, vancomycin, linezolid, and five other agents were determined against 300 gram-positive and 54 gram-negative...
Goldstein, E J, Nesbit, C A, Citron, D M
The activities of sparfloxacin, levofloxacin, Bay y 3118, azithromycin, cefprozil, loracarbef, and nine other oral antimicrobial agents against 194 aerobic and anaerobic clinical bite wound isolates...
Hunt Gerardo, S, Citron, D M, Claros, M C, Goldstein, E J
When the Etest was compared to broth microdilution for susceptibility testing of Streptococcus pneumoniae, levofloxacin, erythromycin, and penicillin results correlated for both methods; azithromycin...
Goldstein, E J, Citron, D M, Hunt Gerardo, S, Hudspeth, M, Merriam, C V
The activities of DU-6859a, levofloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against bite wound isolates were determined by the agar dilution method. DU-6859a was the most active compound...
Goldstein, E J, Citron, D M, Hudspeth, M, Hunt Gerardo, S, Merriam, C V
The in vitro activity of Bay 12-8039, a new oral 8-methoxyquinolone, was compared to the activities of 11 other oral antimicrobial agents (ciprofloxacin, levofloxacin, ofloxacin, sparfloxacin,...
Four hundred thirty-eight bacteria cultured from specimens of patients with serious intra-abdominal infections were tested by agar dilution against trovafloxacin and other quinolones and...
Brazier, J S, Goldstein, E J, Citron, D M, Ostovari, M I
Fastidious anaerobe agar supported the growth of 82 strains of fusobacteria better than brain heart infusion agar, brucella agar, and Wilkins-Chalgren agar. Fastidious anaerobe agar showed less...
Goldstein, E J, Citron, D M, Richwald, G A
The in vitro susceptibility of human isolates of Pasteurella multocida to oral antimicrobial agents from our current study and from a review of the literature suggests that dicloxacillin (oxacillin),...
We studied the comparative in vitro activities of 10 oral antimicrobial agents against 147 aerobic and 61 anaerobic bacteria making up species in 13 genera (Staphylococcus aureus, streptococci,...
The activity of cefbuperazone against 266 strains of anaerobic bacteria was determined by the agar dilution method and compared with cefoxitin, moxalactam, piperacillin, and clindamycin. All strains...
With a macrotube dilution method, MICs and MBCs were determined for three aminothiazolyl cephalosporins, cefpirome (HR 810), ceftazidime, and cefotaxime, against Pseudomonas aeruginosa, enterococci,...
Susceptibility of Eikenella corrodens to newer and older quinolones.
Goldstein, E J, Citron, D M, Vagvolgyi, A E, Gombert, M E
The susceptibilities of 44 clinical strains and a reference strain (ATCC 23834) of Eikenella corrodens were determined by agar dilution. All isolates were very susceptible (MICs, less than 2...
Susceptibility of Eikenella corrodens to penicillin, apalcillin, and twelve new cephalosporins.
The susceptibility of 29 strains of Eikenella corrodens to penicillin, apalcillin, and 12 new cephalosporins was determined by the agar dilution method. Most strains were resistant to cefsulodin, and...
Comparative activity of the quinolones against anaerobic bacteria isolated at community hospitals.
The in vitro activity of five quinolone compounds, amoxicillin, and clindamycin against 118 strains of anaerobic bacteria isolated at community hospitals was determined by an agar dilution method....
The susceptibilities of recent clinical isolates of anaerobic bacteria from two community hospitals were determined. Thirty percent of pigmented Bacteroides species and bile-sensitive, nonpigmented...
Goldstein, E J, Citron, D M, Vagvolgyi, A E, Finegold, S M
The susceptibility of 93 aerobic and 59 anaerobic bacteria isolated from human and animal bite wounds was determined by agar dilution. No agent tested (penicillin, oxacillin, cephalexin,...
Impact of cefoperazone therapy on fecal flora.
Mulligan, M E, Citron, D M, McNamara, B T, Finegold, S M
To evaluate the effects of parenteral cefoperazone therapy upon human fecal flora, fecal specimens obtained from four patients before and during therapy (as well as after therapy for one patient)...
The in vitro activities of sparfloxacin, temafloxacin, ciprofloxacin, ofloxacin, clarithromycin, erythromycin, tetracycline, cephalothin, penicillin G, and amoxicillin-clavulanic acid against 173...
The in vitro activities of seven fluoroquinolones against 290 anaerobes were determined by agar dilution. CI-960 and WIN 57273 inhibited greater than 95% of the strains at less than or equal to 2...
Survival of anaerobic bacteria in various thioglycolate and chopped meat broth formulations.
Claros, M C, Citron, D M, Goldstein, E J
Three commercially available formulations of thioglycolate broth and of chopped meat broth were evaluated for their abilities to maintain the viabilities of 32 strains of anaerobic bacteria during a...
Alexander, C J, Citron, D M, Brazier, J S, Goldstein, E J
Clostridium ramosum, C. innocuum, and C. clostridioforme are frequently isolated from clinical specimens including blood. Because of Gram stain variability, a lack of spores, and atypical colonial...
Alexander, C J, Citron, D M, Hunt Gerardo, S, Claros, M C, Talan, D, Goldstein, E J
Saccharolytic, nonpigmented, anaerobic gram-negative rods isolated from infected dog and cat bite wounds in humans have been poorly characterized, and most are not included in the databases of kits...
Hudspeth, M K, Hunt Gerardo, S, Citron, D M, Goldstein, E J
Thirty-nine clinical isolates of Porphyromonas species recovered from infected cat and dog bite wounds in humans and eight American Type Culture Collection and National Collection of Type Cultures...
Goldstein, E J, Citron, D M, Cherubin, C E
We compared the inoculum effects of 105 recent clinical isolates of the family Enterobacteriaceae on cefoxitin, other cephalosporins, aztreonam, and three beta-lactamase inhibitors (clavulanic acid,...
Goldstein, E J, Citron, D M, Cherubin, C E
We compared the inoculum effects for 109 recent clinical isolates of the Bacteroides fragilis group of cefoxitin, cefotetan, ceftizoxime, ceftriaxone, and three beta-lactamase inhibitors (clavulanic...
The in vitro activities of ofloxacin alone and in combination with metronidazole against 177 anaerobic bacteria isolated from intra-abdominal infections, as determined by broth microdilution, showed...
Goldstein, E J, Citron, D M, Goldman, R J
The methods for performing anaerobic bacterial isolation and identification continue to change and improve. Anaerobic susceptibility testing has become controversial, and method-dependent variability...
Mulligan, M E, Citron, D M, Kwok, R Y, Wheelock, J P, Farrohi, F K, Hindler, J A, ...
Because strains of Staphylococcus aureus that are resistant to penicillinase-resistant penicillins may be difficult to detect in the clinical laboratory, a variety of changes in methodology have been...
The six species of the Bacteroides fragilis group are potent pathogens and commonly have different susceptibility patterns. We determined the relative annual isolation rate of anaerobic bacteria and...
Mulligan, M E, Kwok, R Y, Citron, D M, John, J F, Smith, P B
An immunoblotting system was developed for typing of oxacillin-resistant Staphylococcus aureus. Clinical isolates recovered during a 40-month period at a single institution were evaluated with this...
Goldstein, E J, Citron, D M, Merkin, T E, Pickett, M J
An unusual gram-negative rod (RMA 1571) was isolated from a hand infection following a pig bite. This unclassified isolate was characterized by growth requirements, microscopic examination,...
Citron, D M, Baron, E J, Finegold, S M, Goldstein, E J
The rapid identification of isolates of bile-resistant Bacteroides species has clinical and therapeutic relevance because of differences in their patterns of susceptibility and virulence. Five...
Failure of rapid agglutination methods to detect oxacillin-resistant Staphylococcus aureus.
Ruane, P J, Morgan, M A, Citron, D M, Mulligan, M E
Although a latex agglutination test (StaphAurex) and a hemagglutination test (Staphyloslide) correctly identified all strains of Staphylococcus aureus that were susceptible or had intermediate...
Evaluation of the E test for susceptibility testing of anaerobic bacteria.
Citron, D M, Ostovari, M I, Karlsson, A, Goldstein, E J
The susceptibilities of 105 clinical isolates of anaerobic bacteria were determined by a new method, the E test (AB Biodisk, Solna, Sweden), and were compared with the MICs for these organisms...
New medium selective for Fusobacterium species and differential for Fusobacterium necrophorum.
Morgenstein, A A, Citron, D M, Finegold, S M
Fusobacterium egg yolk agar is a new medium selective for Fusobacterium species and differential for Fusobacterium necrophorum. The medium is a Brucella Agar base (Difco Laboratories, Detroit, Mich.)...
Bacteriology of human and animal bite wounds.
Goldstein, E J, Citron, D M, Wield, B, Blachman, U, Sutter, V L, Miller, T A, ...
Seventy-three patients with bite wounds (16 patients with clenched-fist injuries, 18 with human bite wounds, and 39 with animal bites) were cultured aerobically and anaerobically. A total of 33 of 34...