S. G. Priori, J. Barhanin, W. Haverkamp, H. J. Jongsma, A. G. Kleber, ...
Clinical cardiologists who manage arrhythmias are increasingly faced with new complexities in management decisions. The once obscure science and jargon of medical genetics is assuming a much more...
Unmasking of brugada syndrome by lithium (2005)
Darbar, D., Yang, T., Churchwell, K., Wilde, A.A.M., Roden, D.M.
Atrial fibrillation in KCNE1-null mice (2005)
Temple, J., Frias, P., Rottman, J., Yang, T., Wu, Y., Verheijck, E.E., ...
A calcium sensor in the sodium channel modulates cardiac excitability (2002)
Tan, H.L., Kupershmidt, S., Zhang, R., Stepanovic, S., Roden, D.M., Wilde, A.A.M., ...
A calcium sensor in the sodium channel modulates cardiac excitability (2002)
Tan, H.L., Kupershmidt, S., Zhang, R., Stepanovic, S., Roden, D.M., Wilde, A.A.M., ...
A calcium sensor in the sodium channel modulates cardiac excitability (2002)
Tan, H.L., Kupershmidt, S., Zhang, R., Stepanovic, S., Roden, D.M., Wilde, A.A.M., ...
Differential expression of KvLQT1 and its regulator IsK in mouse epithelia (2001)
Demolombe, S., Franco, D., Kuperschmidt, S., Roden, D.M., Pereon, Y., ...
Differential expression of KvLQT1 and its regulator IsK in mouse epithelia (2001)
Demolombe, S., Franco, D., Kuperschmidt, S., Roden, D.M., Pereon, Y., ...
Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhytmia syndromes (2001)
Viswanathan, P.C., Bezzina, C.R., George Jr, A.L., Roden, D.M., Wilde, A.A.M., Balser, J.R.
Differential expression of KvLQT1 and its regulator IsK in mouse epithelia (2001)
Demolombe, S., Franco, D., Kuperschmidt, S., Roden, D.M., Pereon, Y., ...
Gating-dependent mechanisms for flecainide intolerance in SCN5A-linked arrhythmia syndromes (2001)
Viswanathan, P.C., Bezzina, C.R., Roden, D.M., Wilde, A.A.M., Balser, J.C.
Congenital and acquired long QT syndrome (2000)
Camm, A.J., Janse, M.J., Roden, D.M., Rosen, M.R., Cinca, J., Cobbe, S.M.
Congenital and acquired long QT syndrome (2000)
Camm, A.J., Janse, M.J., Roden, D.M., Rosen, M.R., Cinca, J., Cobbe, S.M.
Genetic and molecular basis of cardiac arrhythmias: impact on clinical management (1999)
Priori, S.G., Barhanin, J., Hauer, R.N.W., Haverkamp, W., Jongsma, H.J., Kleber, A.G., ...
Wei, J., Wang, D.W., Alings, A.M.W., Fish, F., Wathen, M., Roden, D.M., ...
Drug-induced J point evaluation: a marker for genetic risk of sudden death or ECG curiosity ? (1999)
Genetic molecular basis of cardiac arrhythmias: impact on clinical management part III (1999)
Priori, S.G., Barhanin, J., Hauer, R.N.W., Haverkamp, W., Jongsma, H.J., Kleber, A.G., ...
Genetic and molecular basis of cardiac arrhythmias: Impact on clinical management (1999)
Priori, S.G., Barhanin, J., Hauer, R.N.W., Haverkamp, W., Jongsma, H.J., Kleber, A.G., ...
Common clinical features in drug-induced torsade de pointes include hypokalemia and cycle-length prolongation just prior to initiation of the arrhythmia. In canine Purkinje fibres, drugs known to be...
Murray, K T, Reilly, C, Koshakji, R P, Roden, D M, Lineberry, M D, Wood, A J, ...
To investigate the mechanisms of ventricular arrhythmia suppression by propranolol, we determined the antiarrhythmic efficacy of d-propranolol in 10 patients with frequent ventricular ectopic...
Carey, E L, Duff, H J, Roden, D M, Primm, R K, Wilkinson, G R, Wang, T, ...
To assess the relative contributions of encainide and its putatively active metabolites, O-demethyl encainide (ODE) and 3 methoxy-O-demethyl encainide (3MODE), to the drug's pharmacologic effects, we...
Kim, R B, Fromm, M F, Wandel, C, Leake, B, Wood, A J, Roden, D M, ...
Currently available HIV-1 protease inhibitors are potent agents in the therapy of HIV-1 infection. However, limited oral absorption and variable tissue distribution, both of which are largely...
Global parameter optimization for cardiac potassium channel gating models.
Balser, J R, Roden, D M, Bennett, P B
Quantitative ion channel model evaluation requires the estimation of voltage dependent rate constants. We have tested whether a unique set of rate constants can be reliably extracted from...
Single inward rectifier potassium channels in guinea pig ventricular myocytes. Effects of quinidine.
Balser, J R, Roden, D M, Bennett, P B
The effects of quinidine on single inward rectifier K channels were investigated in cell-attached patches with 4.5 mM pipette potassium concentrations. Under these conditions, the single-channel...
Indications for different modes of surgical therapy in medically refractory ventricular arrhythmias.
Hammon, J W, Echt, D S, Merrill, W H, Primm, K R, Woosley, R L, Smith, R F, ...
Fifty-one adult patients were referred for surgical treatment during the time period from July 1980 to November 1985. The average age was 59 +/- 6 years (19-70 years). All patients had symptomatic...
Murray, K T, Reilly, C, Koshakji, R P, Roden, D M, Lineberry, M D, Wood, A J, ...
To investigate the mechanisms of ventricular arrhythmia suppression by propranolol, we determined the antiarrhythmic efficacy of d-propranolol in 10 patients with frequent ventricular ectopic...
Carey, E L, Duff, H J, Roden, D M, Primm, R K, Wilkinson, G R, Wang, T, ...
To assess the relative contributions of encainide and its putatively active metabolites, O-demethyl encainide (ODE) and 3 methoxy-O-demethyl encainide (3MODE), to the drug's pharmacologic effects, we...
Kim, R B, Fromm, M F, Wandel, C, Leake, B, Wood, A J, Roden, D M, ...
Currently available HIV-1 protease inhibitors are potent agents in the therapy of HIV-1 infection. However, limited oral absorption and variable tissue distribution, both of which are largely...
Indications for different modes of surgical therapy in medically refractory ventricular arrhythmias.
Hammon, J W, Echt, D S, Merrill, W H, Primm, K R, Woosley, R L, Smith, R F, ...
Fifty-one adult patients were referred for surgical treatment during the time period from July 1980 to November 1985. The average age was 59 +/- 6 years (19-70 years). All patients had symptomatic...
Global parameter optimization for cardiac potassium channel gating models.
Balser, J R, Roden, D M, Bennett, P B
Quantitative ion channel model evaluation requires the estimation of voltage dependent rate constants. We have tested whether a unique set of rate constants can be reliably extracted from...
Single inward rectifier potassium channels in guinea pig ventricular myocytes. Effects of quinidine.
Balser, J R, Roden, D M, Bennett, P B
The effects of quinidine on single inward rectifier K channels were investigated in cell-attached patches with 4.5 mM pipette potassium concentrations. Under these conditions, the single-channel...
A mechanism of D-(+)-sotalol effects on heart rate not related to beta-adrenoceptor antagonism.
Funck-Brentano, C, Silberstein, D J, Roden, D M, Wood, A J, Woosley, R L
1. In order to determine whether the effects of d- or (+)-sotalol on heart rate are mediated by beta-adrenoceptor antagonism or might be due to other actions, we administered (+)-sotalol (400 mg...
Turgeon, J, Evans, W E, Relling, M V, Wilkinson, G R, Roden, D M
1. The major pathway for 4-hydroxylation of debrisoquine in man is polymorphic and under genetic control. More than 90% of subjects (extensive metabolizers, EMs) have active debrisoquine...
Funck-Brentano, C, Kroemer, H K, Pavlou, H, Woosley, R L, Roden, D M
1. Quinidine is a potent inhibitor of the genetically-determined debrisoquine 4-hydroxylation. Oxidation reactions of several other drugs, including the 5-hydroxylation of the new antiarrhythmic drug...
Birgersdotter, U M, Wong, W, Turgeon, J, Roden, D M
1. Recent reports have indicated a role for the P450IID6 polymorphism in the stereoselective disposition of single doses of the antiarrhythmic flecainide. 2. In this study, we evaluated the effects...
Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers.
Yang, T., Prakash, C., Roden, D. M., Snyders, D. J.
1. The cardiac toxicity of racemic terfenadine (marked QT prolongation and polymorphic ventricular arrhythmias) is probably due to potassium channel blockade. To test whether one of its enantiomers...
Cellular basis of drug-induced torsades de pointes
Striking QT prolongation and the morphologically distinctive ventricular tachycardia torsades de pointes can occur in up to 5% of patients treated with certain antiarrhythmic drugs. This adverse drug...