SYSTEMIC EFFICACY OF NODULISPORAMIDES AGAINST FLEAS ON DOGS (2001)
W. L. Shoop, M. Zakson-Aiken, L. M. Gregory, B. F. Michael, J. Pivnichny, P. T. Meinke, ...
Nodulisporic acid A (NSA) has been shown previously to be safe in dogs and to deliver >90% flea control for 4 days following a single oral administration. Three newly prepared nodulisporamide...
SYSTEMIC EFFICACY OF NODULISPORIC ACID AGAINST FLEAS ON DOGS (2001)
W. L. Shoop, L. M. Gregory, M. Zakson-Aiken, B. F. Michael, H. W. Haines, J. G. Ondeyka, ...
Nodulisporic acid A (NSA) is a novel natural product from a new structural class that was shown previously to have insecticidal activity against blowfly larvae. To determine if there was useful...
Selective labeling of intracellular parasite proteins by using ricin.
Gurnett, A M, Dulski, P M, Darkin-Rattray, S J, Carrington, M J, Schmatz, D M
Studies focused on the synthesis by intracellular parasites of developmentally regulated proteins have been limited due to the lack of a simple method for selectively labeling proteins produced by...
Treatment of Pneumocystis carinii pneumonia with 1,3-beta-glucan synthesis inhibitors.
Schmatz, D M, Romancheck, M A, Pittarelli, L A, Schwartz, R E, Fromtling, R A, Nollstadt, K H, ...
Pneumocystis carinii pneumonia is a major cause of death in AIDS patients in the United States. The presently available treatments have limited use due to a high incidence of adverse reactions....
Bowman, J. C., Abruzzo, G. K., Anderson, J. W., Flattery, A. M., Gill, C. J., Pikounis, V. B., ...
Caspofungin acetate (MK-0991) is an antifungal antibiotic that inhibits the synthesis of 1,3-β-d-glucan, an essential component of the cell wall of several pathogenic fungi. Caspofungin acetate was...
Novel Enzyme-Linked Immunoassay To Determine Nanogram Levels of Pneumocandins in Human Plasma
Karkhanis, Y. D., Schmatz, D. M.
A binding enzyme-linked immunosorbent assay (ELISA) has been developed for measuring nanogram concentrations of semisynthetic pneumocandin antifungal agents in human plasma. Semisynthetic...
Bowman, J. C., Hicks, P. Scott, Kurtz, M. B., Rosen, H., Schmatz, D. M., Liberator, P. A., ...
Caspofungin acetate is an antifungal antibiotic that inhibits synthesis of 1,3-β-d-glucan, an essential component of the fungal cell wall. While caspofungin causes cell death in yeasts and dimorphic...
New semisynthetic pneumocandins with improved efficacies against Pneumocystis carinii in the rat.
Schmatz, D M, Powles, M A, McFadden, D, Nollstadt, K, Bouffard, F A, Dropinski, J F, ...
A new series of semisynthetic, water-soluble pneumocandin analogs has been found to be extremely potent against Pneumocystis carinii in an immunocompromised-rat model. These compounds are 5 to 10...
Aerosolized L-693,989 for Pneumocystis carinii prophylaxis in rats.
Powles, M A, McFadden, D C, Liberator, P A, Anderson, J W, Vadas, E B, Meisner, D, ...
Water-soluble pneumocandin L-693,989, a potent antipneumocystis agent in the rat model for Pneumocystis carinii pneumonia (PCP), inhibits P. carinii cyst development and effectively prevents the...
Antipneumocystis activity of water-soluble lipopeptide L-693,989 in rats.
Schmatz, D M, Powles, M A, McFadden, D C, Pittarelli, L, Balkovec, J, Hammond, M, ...
Water-soluble lipopeptide L-693,989 was evaluated for its antipneumocystis activity in rats. Rats from colonies with latent Pneumocystis carinii infections were immunosuppressed with dexamethasone...
Mouse model for Pneumocystis carinii pneumonia that uses natural transmission to initiate infection.
Powles, M A, McFadden, D C, Pittarelli, L A, Schmatz, D M
Animal models for Pneumocystis carinii, for the most part, have been limited to immunosuppressed rats and ferrets, while a dependable mouse model has been more difficult to develop. A P. carinii...
Bhogal, B S, Nollstadt, K H, Karkhanis, Y D, Schmatz, D M, Jacobson, E B
Anti-idiotypic antibodies were raised in rabbits against four monoclonal antibodies with specificity for the surface antigenic determinants of Eimeria tenella sporozoites, the infective stage of the...
Liberator, P A, Anderson, J W, Powles, M, Pittarelli, L A, Worley, M, Becker-Hapak, M, ...
A repetitive genomic DNA clone (B12-2) that specifically hybridizes to Pneumocystis carinii DNA has been identified. No cross-hybridization to genomic DNA prepared from bacteria, other fungi,...
Nollstadt, K H, Powles, M A, Fujioka, H, Aikawa, M, Schmatz, D M
A new class of promising antipneumocystis agents, cyclic lipopeptide pneumocandin analogs, has been shown to effectively prevent Pneumocystis carinii cyst development in murine models. These...
Use of anti-CD4+ hybridoma cells to induce Pneumocystis carinii in mice.
McFadden, D C, Powles, M A, Smith, J G, Flattery, A M, Bartizal, K, Schmatz, D M
A reduction of peripheral CD4+ cell levels has been correlated with the onset of Pneumocystis carinii pneumonia in AIDS patients. Most in vivo drug discovery and development for P. carinii have been...
Bhogal, B S, Jacobson, E B, Tse, H Y, Schmatz, D M, Ravino, O J
Polyclonal anti-idiotype 1073 (anti-Id 1073), raised against a monoclonal antibody specific for the protective epitope(s) of Eimeria tenella sporozoites, induced cell-mediated immune (CMI) responses...
Anthrax lethal factor inhibition
Shoop, W. L., Xiong, Y., Wiltsie, J., Woods, A., Guo, J., Pivnichny, J. V., ...
The primary virulence factor of Bacillus anthracis is a secreted zinc-dependent metalloprotease toxin known as lethal factor (LF) that is lethal to the host through disruption of signaling pathways,...
Selective labeling of intracellular parasite proteins by using ricin.
Gurnett, A M, Dulski, P M, Darkin-Rattray, S J, Carrington, M J, Schmatz, D M
Studies focused on the synthesis by intracellular parasites of developmentally regulated proteins have been limited due to the lack of a simple method for selectively labeling proteins produced by...
Treatment of Pneumocystis carinii pneumonia with 1,3-beta-glucan synthesis inhibitors.
Schmatz, D M, Romancheck, M A, Pittarelli, L A, Schwartz, R E, Fromtling, R A, Nollstadt, K H, ...
Pneumocystis carinii pneumonia is a major cause of death in AIDS patients in the United States. The presently available treatments have limited use due to a high incidence of adverse reactions....
Bowman, J. C., Abruzzo, G. K., Anderson, J. W., Flattery, A. M., Gill, C. J., Pikounis, V. B., ...
Caspofungin acetate (MK-0991) is an antifungal antibiotic that inhibits the synthesis of 1,3-β-d-glucan, an essential component of the cell wall of several pathogenic fungi. Caspofungin acetate was...
Novel Enzyme-Linked Immunoassay To Determine Nanogram Levels of Pneumocandins in Human Plasma
Karkhanis, Y. D., Schmatz, D. M.
A binding enzyme-linked immunosorbent assay (ELISA) has been developed for measuring nanogram concentrations of semisynthetic pneumocandin antifungal agents in human plasma. Semisynthetic...
Bowman, J. C., Hicks, P. Scott, Kurtz, M. B., Rosen, H., Schmatz, D. M., Liberator, P. A., ...
Caspofungin acetate is an antifungal antibiotic that inhibits synthesis of 1,3-β-d-glucan, an essential component of the fungal cell wall. While caspofungin causes cell death in yeasts and dimorphic...
New semisynthetic pneumocandins with improved efficacies against Pneumocystis carinii in the rat.
Schmatz, D M, Powles, M A, McFadden, D, Nollstadt, K, Bouffard, F A, Dropinski, J F, ...
A new series of semisynthetic, water-soluble pneumocandin analogs has been found to be extremely potent against Pneumocystis carinii in an immunocompromised-rat model. These compounds are 5 to 10...
Aerosolized L-693,989 for Pneumocystis carinii prophylaxis in rats.
Powles, M A, McFadden, D C, Liberator, P A, Anderson, J W, Vadas, E B, Meisner, D, ...
Water-soluble pneumocandin L-693,989, a potent antipneumocystis agent in the rat model for Pneumocystis carinii pneumonia (PCP), inhibits P. carinii cyst development and effectively prevents the...
Antipneumocystis activity of water-soluble lipopeptide L-693,989 in rats.
Schmatz, D M, Powles, M A, McFadden, D C, Pittarelli, L, Balkovec, J, Hammond, M, ...
Water-soluble lipopeptide L-693,989 was evaluated for its antipneumocystis activity in rats. Rats from colonies with latent Pneumocystis carinii infections were immunosuppressed with dexamethasone...
Mouse model for Pneumocystis carinii pneumonia that uses natural transmission to initiate infection.
Powles, M A, McFadden, D C, Pittarelli, L A, Schmatz, D M
Animal models for Pneumocystis carinii, for the most part, have been limited to immunosuppressed rats and ferrets, while a dependable mouse model has been more difficult to develop. A P. carinii...
Bhogal, B S, Nollstadt, K H, Karkhanis, Y D, Schmatz, D M, Jacobson, E B
Anti-idiotypic antibodies were raised in rabbits against four monoclonal antibodies with specificity for the surface antigenic determinants of Eimeria tenella sporozoites, the infective stage of the...
Liberator, P A, Anderson, J W, Powles, M, Pittarelli, L A, Worley, M, Becker-Hapak, M, ...
A repetitive genomic DNA clone (B12-2) that specifically hybridizes to Pneumocystis carinii DNA has been identified. No cross-hybridization to genomic DNA prepared from bacteria, other fungi,...
Nollstadt, K H, Powles, M A, Fujioka, H, Aikawa, M, Schmatz, D M
A new class of promising antipneumocystis agents, cyclic lipopeptide pneumocandin analogs, has been shown to effectively prevent Pneumocystis carinii cyst development in murine models. These...
Use of anti-CD4+ hybridoma cells to induce Pneumocystis carinii in mice.
McFadden, D C, Powles, M A, Smith, J G, Flattery, A M, Bartizal, K, Schmatz, D M
A reduction of peripheral CD4+ cell levels has been correlated with the onset of Pneumocystis carinii pneumonia in AIDS patients. Most in vivo drug discovery and development for P. carinii have been...
Bhogal, B S, Jacobson, E B, Tse, H Y, Schmatz, D M, Ravino, O J
Polyclonal anti-idiotype 1073 (anti-Id 1073), raised against a monoclonal antibody specific for the protective epitope(s) of Eimeria tenella sporozoites, induced cell-mediated immune (CMI) responses...
Anthrax lethal factor inhibition
Shoop, W. L., Xiong, Y., Wiltsie, J., Woods, A., Guo, J., Pivnichny, J. V., ...
The primary virulence factor of Bacillus anthracis is a secreted zinc-dependent metalloprotease toxin known as lethal factor (LF) that is lethal to the host through disruption of signaling pathways,...