D. M. Slater

Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour (2007)

Astle, S., Newton, R., Thornton, S., Vatish, M., Slater, D.M.

Since the controversies regarding the use of non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclo-oxygenase (COX)-2 antagonists for the treatment of preterm labour (PTL), more emphasis...

Molecular identification and localization of Trp homologues, putative calcium channels, in pregnant human uterus (2002)

Dalrymple, A., Slater, D.M., Beech, D., Poston, L., Tribe, R.M.

The mechanisms underlying the switch from uterine quiescence to contractile activity in labour are not clearly understood. Increasing evidence suggests that pathways of myometrial calcium...

Human labour is associated with nuclear factor-{{kappa}}B activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal' (2001)

Allport, V.C., Pieber, D., Slater, D.M., Newton, R., White, J.O., Bennett, P.R.

Human labour is associated with the up-regulation of prostaglandins within the uterus, synthesized via the type-2 cyclo-oxygenase enzyme (COX-2). These lead to remodelling of the fetal membranes and...

NF-{kappa}B and AP-1 are required for cyclo-oxygenase 2 gene expression in amnion epithelial cell line (WISH) (2000)

Allport, V.C., Slater, D.M., Newton, R., Bennett, P.R.

Prostaglandins are known to play an important role in human labour and are used clinically to induce labour onset. Cytokines, e.g. interleukin 1 β (IL-1β), are up-regulated in the amniotic fluid...

Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein in human fetal membranes throughout pregnancy and at term (1999)

Brown, N.L., Slater, D.M., Alvi, S.A., Elder, M.G., Sullivan, M.H.F., Bennett, P.R.

Lipoxygenase metabolites may be involved in human parturition. 5-lipoxygenase (5-LOX) catalyses the first steps in the synthesis of leukotrienes from arachidonic acid, and its activity is dependent...