Detecting the Glint of Starlight on the Oceans of Distant Planets (2008)
We propose that astronomers will be eventually be able to discriminate between extrasolar Earth-like planets with surface oceans and those without using the shape of phase light curves in the visible...
(a set of scales, accompanying ""Keepsakes for the Treasure Chest of Life"")
Treweek, T. M., Ecroyd, H., Williams, D. M., Meehan, S., Carver, J. A., Walker, M. J.
Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease are associated with inappropriate protein deposition and ordered amyloid fibril assembly. Molecular chaperones, including αBcrystallin, play a...
Treweek, T. M., Ecroyd, H., Williams, D. M., Meehan, S., Carver, J. A., Walker, M. J.
Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease are associated with inappropriate protein deposition and ordered amyloid fibril assembly. Molecular chaperones, including αBcrystallin, play a...
Treweek, T. M., Ecroyd, H., Williams, D. M., Meehan, S., Carver, J. A., Walker, M. J.
Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease are associated with inappropriate protein deposition and ordered amyloid fibril assembly. Molecular chaperones, including αBcrystallin, play a...
Treweek, T. M., Ecroyd, H., Williams, D. M., Meehan, S., Carver, J. A., Walker, M. J.
Alzheimer's, Parkinson's and Creutzfeldt-Jakob disease are associated with inappropriate protein deposition and ordered amyloid fibril assembly. Molecular chaperones, including αBcrystallin,...
Thermal Emission and Dust Properties of Comet Hale-Bopp (2004)
Hanner, M. S., Gehrz, R. D., Hayward, T. L., Lynch, D. K., Mason, C. G., Williams, D. M., ...
Hanner, M. S., Gehrz, R. D., Harker, D. E., Hayward, T. L., Lynch, D. K., Mason, C. C., ...
The dust coma of comet Hale-Bopp was observed in the themal infrared over a wide range in solar heating (R=4.9-0.9 AU) and over the full wavelength range from 3 mu to 160 mu.
Nuclear targeting of Porphyromonas gingivalis W50 protease in epithelial cells (2002)
Scragg, M.A., Alsam, A., Rangarajan, M., Slaney, J.M., Shepherd, P., Williams, D.M., ...
Porphyromonas gingivalis is an important pathogen associated with destructive periodontal disease and is able to invade the epithelial cell barrier. Its cysteine proteases are recognized as major...
Short-term exposure to alcohol increases the permeability of human oral mucosa (2001)
Howie, N.M., Trigkas, T.K., Cruchley, A.T., Wertz, P.W., Squier, C.A., Williams, D.M.
OBJECTIVES: The aim of this study was to evaluate the effect of short-term exposure to ethanol on the permeability barrier properties of human oral mucosa. MATERIALS AND METHODS: Permeability...
A polymeric system for the intra-oral delivery of an anti-fungal agent (2001)
Patel, M.P., Cruchley, A.T., Coleman, D.C., Swai, H., Braden, M., Williams, D.M.
Oral candidal infections are often persistent and intractable and thus the aim of this study was to develop a polymeric sustained release device to improve the topical treatment of these infections....
The development of real-time substructure testing (2001)
Blakeborough, A, Williams, M. S., Darby, A., Williams, D. M.
Full-scale dynamic testing of civil engineering structures is extremely costly and difficult to perform. Most test methods therefore involve either a reduction in the physical scale or an extension...
Selvaratnam, L., Cruchley, A.T., Navsaria, H., Wertz, P.W., Hagi-Pavli, E.P., Leigh, I.M., ...
OBJECTIVES: The aim of this study was to establish whether an in vitro model of human oral mucosa had similar permeability characteristics to normal oral mucosa. Such a model would have considerable...
Selection of novel ligands from a whole-molecule randomly mutated C5a library (2001)
Cain, S.A., Williams, D.M., Harris, V., Monk, P.N.
Novel antagonists of the proinflammatory leukocyte chemoattractant C5a have been produced from a phage display library of whole-molecule random mutants. The cDNA for the inflammatory polypeptide...
STOTT, W. T., YANO, B. L., WILLIAMS, D. M., BARNARD, S. D., HANNAH, M. A., CIESZLAK, F. S., ...
The potential of haloxyfop [2-(-4-((3-chloro-5-(trifluoromethyl)-2pyridinyl)oxy)phenoxy)propanoic acid; HAL] to induce the proliferation of hepatocellular peroxisomes (PP) was examined in rats, mice,...
Batch, J. A., Williams, D. M., Davies, H. R., Brown, B. D., Evans, B. A. J., Hughes, I. A., ...
The androgen insensitivity syndrome (AIS) is a disorder of male sexual development resulting in a wide range of clinical phenotypes. AIS is classified into two phenotypic forms: complete (CAIS) and...
The development of a computer model for the chemical speciation of metals in lung fluids. (1989)
Davies, E.S., Duffield, J.R., Taylor, D.M., Williams, D.M., Yule, L.
2nd Karlsruhe Internat.Conf.on Analytical Chemistry in Nuclear Technology, Karlsruhe, June 5-9, 1989
An approach to the stereoselective synthesis of Sp- dinucleoside phosphorothioates has been investigated which utilizes phosphotriester chemistry. The stereoselectivity of internucleotide bond...
Abstracts of scientific presentations (1986)
Clark, J., Munitz, H. A., Benjamin, S. B., Frager, J., Janower, M. L., Wolf, E. L., ...
Peer Reviewed
Agnostic behaviour and mate selection in the mallard (Anas Platyrhynchos). (1982)
Thesis (Ph. D.)--University of Leicester, 1982.
West African Marketing Boards (1953)
This article represents the main parts of a lecture delivered on the 30th October, with Lord Milverton in the chair. Mr. Williams is editor of West Africa and the West African Review. He served with...
Williams, D M, Pieken, W A, Eckstein, F
The importance of the 2'-hydroxyl group of several guanosine residues for the catalytic efficiency of a hammerhead ribozyme has been investigated. Five ribozymes in which single guanosine residues...
Scragg, M. A., Cannon, S. J., Rangarajan, M., Williams, D. M., Curtis, M. A.
Cell surface integrins mediate interactions between cells and their extracellular matrix and are frequently exploited by a range of bacterial pathogens to facilitate adherence and/or invasion. In...
Negishi, K, Williams, D M, Inoue, Y, Moriyama, K, Brown, D M, Hayatsu, H
The triphosphate of the nucleoside deoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one (dP) is known to be incorporated into DNA efficiently by Taq polymerase and is a useful tool for...
Hill, F, Williams, D M, Loakes, D, Brown, D M
The structure of the deoxyribonucleoside derived from N 6-methoxy-2, 6-diaminopurine (dK) was examined by NMR. The methoxyamino residue was found predominantly in the imino rather than the amino...
Pharmacokinetics of vancomycin in adult cystic fibrosis patients.
Pleasants, R A, Michalets, E L, Williams, D M, Samuelson, W M, Rehm, J R, Knowles, M R
Although the depositions of many antibiotics are altered in cystic fibrosis patients, that of vancomycin has not been studied. To assess vancomycin pharmacokinetics, 10 adult cystic fibrosis patients...
Role of CD8 T cells in primary Chlamydia infection.
Magee, D M, Williams, D M, Smith, J G, Bleicker, C A, Grubbs, B G, Schachter, J, ...
The role of CD4 and CD8 T cells in primary Chlamydia trachomatis pneumonia was investigated by using in vivo depletion techniques to eliminate T-cell populations. Reduction of either CD4 T cells or...
Role of gamma-delta T cells in murine Chlamydia trachomatis infection.
Williams, D M, Grubbs, B G, Kelly, K, Pack, E, Rank, R G
The role of gamma-delta T cells in host resistance to Chlamydia trachomatis was characterized by using a murine model of pneumonia caused by the mouse pneumonitis agent (MoPn), murine C. trachomatis....
Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis.
Williams, D M, Grubbs, B G, Pack, E, Kelly, K, Rank, R G
A murine model of pneumonia due to the mouse pneumonitis agent (MoPn [murine Chlamydia trachomatis]) in mice deficient in CD4+ T-cell function (major histocompatibility complex [MHC] class II...
Duvall, E J, Williams, D M, Mongkolsuk, S, Lovett, P S
Plasmid pPL603 is a promoter cloning vector for Bacillus subtilis and consists of a 1.1-kilobase fragment of Bacillus pumilus DNA inserted between the EcoRI and BamHI sites of pUB110. The gene...
Cloning restriction fragments that promote expression of a gene in Bacillus subtilis.
Williams, D M, Duvall, E J, Lovett, P S
Plasmid pPL603 (3.1 megadaltons) specifies neomycin resistance in Bacillus subtilis and contains a structural gene for chloramphenicol acetyltransferase. Cells harboring the plasmid cannot grow on...
Effect of gamma interferon on resolution of murine chlamydial genital infection.
Rank, R G, Ramsey, K H, Pack, E A, Williams, D M
Mice infected in the genital tract with the Chlamydia trachomatis agent of mouse pneumonitis were treated with monoclonal rat anti-gamma interferon (anti-IFN-gamma) antibody to determine whether...
Chlamydia trachomatis pneumonia induces in vivo production of interleukin-1 and -6.
Magee, D M, Smith, J G, Bleicker, C A, Carter, C J, Bonewald, L F, Schachter, J, ...
Cytokine induction during Chlamydia trachomatis pneumonia may alter the pathogenesis or course of disease. We examined interleukin-1 (IL-1) and IL-6 production by measuring mRNA and bioactivity in...
Production of colony-stimulating factors during pneumonia caused by Chlamydia trachomatis.
Magee, D M, Williams, D M, Wing, E J, Bleicker, C A, Schachter, J
The colony-stimulating factors (CSFs) are cytokines involved in the production, differentiation, and activation of host phagocytes. During murine infection with Chlamydia trachomatis (MoPn), plasma...
A role in vivo for tumor necrosis factor alpha in host defense against Chlamydia trachomatis.
Williams, D M, Magee, D M, Bonewald, L F, Smith, J G, Bleicker, C A, Byrne, G I, ...
In a mouse model of pneumonia caused by murine Chlamydia trachomatis (mouse pneumonitis agent [MoPn]), tumor necrosis factor alpha (TNF-alpha) antigen and bioactivity were demonstrated in vivo in the...
Gamma interferon-mediated cytotoxicity related to murine Chlamydia trachomatis infection.
Byrne, G I, Grubbs, B, Marshall, T J, Schachter, J, Williams, D M
After infection with the mouse pneumonitis agent (MoPn; murine Chlamydia trachomatis), heterozygous (nu/+) but not nude athymic (nu/nu) mice produced enhanced amounts of gamma interferon (IFN-gamma)...
Role in vivo for gamma interferon in control of pneumonia caused by Chlamydia trachomatis in mice.
Williams, D M, Byrne, G I, Grubbs, B, Marshal, T J, Schachter, J
In a model of pneumonia caused by murine Chlamydia trachomatis, depletion experiments with monoclonal antibody to gamma interferon (IFN-gamma) made mice more susceptible. Repletion experiments giving...
Williams, D M, Schachter, J, Grubbs, B
Natural killer (NK) activity is increased in both spleen and lung early in pulmonary infection by murine Chlamydia trachomatis in both susceptible nude and resistant heterozygous (nu/+) mice....
Primary murine Chlamydia trachomatis pneumonia in B-cell-deficient mice.
Williams, D M, Grubbs, B, Schachter, J
Mice were rendered deficient in B-cell activity by treatment with anti-mu antibody from birth. These animals were then infected intranasally with murine Chlamydia trachomatis (murine pneumonitis...
Antibody in host defense against mouse pneumonitis agent (murine Chlamydia trachomatis).
Williams, D M, Schachter, J, Weiner, M H, Grubbs, B
In a murine model of chlamydial pneumonia employing murine Chlamydia trachomatis, immune serum given intranasally delayed death in nude (nu/nu) mice and prevented death in nu/+ mice. Serum-derived...
Gamma interferon levels during Chlamydia trachomatis pneumonia in mice.
Williams, D M, Grubbs, B G, Schachter, J, Magee, D M
Host defense against murine Chlamydia trachomatis (mouse pneumonitis agent [MoPn]) in a murine model was investigated. Gamma interferon (IFN-gamma) was produced in the lungs by both MoPn-susceptible...
The role of superoxide anion radical in the reduction of ferritin iron by xanthine oxidase.
Williams, D M, Lee, G R, Cartwright, G E
Superoxide dismutase exerted a pronounced inhibitory effect upon xanthine oxidase-mediated reduction of iron in ferritin, ferric chloride, or ferric ADP. Maximal inhibition was observed when the...
Role for CD8+ T cells in antichlamydial immunity defined by Chlamydia-specific T-lymphocyte clones.
Igietseme, J U, Magee, D M, Williams, D M, Rank, R G
The role of CD8+ T cells in antichlamydial immunity was investigated in a murine model of chlamydial genital infection by using T-cell clones generated against the Chlamydia trachomatis agent of...
An approach to the stereoselective synthesis of Sp- dinucleoside phosphorothioates has been investigated which utilizes phosphotriester chemistry. The stereoselectivity of internucleotide bond...
Characterization of gamma interferon-mediated cytotoxicity to chlamydia-infected fibroblasts.
Byrne, G I, Schobert, C S, Williams, D M, Krueger, D A
Addition of murine recombinant gamma interferon (IFN-gamma) to mouse fibroblast cultures infected with Chlamydia psittaci was found to induce a cytotoxic response that was dependent on the...
Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection.
Williams, D M, Bonewald, L F, Roodman, G D, Byrne, G I, Magee, D M, Schachter, J
A mouse model of pneumonia caused by murine Chlamydia trachomatis (mouse pneumonitis agent) was used to demonstrate that whole spleen cells from both nude athymic mice (nu/nu) and heterozygous mice...
Cosstick, R, Li, X, Tuli, D K, Williams, D M, Connolly, B A, Newman, P C
An improved procedure for the preparation of 3-deaza-2'-deoxyadenosine (d3CA) is described which is suitable for the synthesis of gram quantities of this analogue. Using phosphoramidite chemistry...
A common protein binds to two silencers 5' to the human beta-globin gene.
Berg, P E, Williams, D M, Qian, R L, Cohen, R B, Cao, S X, Mittelman, M, ...
The temporal sequence of expression of human globin genes during development suggests precise regulation of these genes. Recent studies have characterized a number of DNA sequences within or flanking...
Genetic control of murine resistance to Toxoplasma gondii.
Williams, D M, Grumet, F C, Remington, J S
The genetics of murine susceptibility to Toxoplasma gondii was investigated in inbred mice and their F1 and F2 offspring. Among four strains of congenic mice of the B10 background, those with H-2a/a...
Strain-dependent differences in murine susceptibility to toxoplasma.
Araujo, F G, Williams, D M, Grumet, F C, Remington, J S
Susceptibility of seven inbred and outbred strains of mice to infection with trophozoites of Toxoplasma gondii at two different doses was determined. Stroking strain differences in susceptibility and...
Histoplasma capsulatum infection in nude mice.
Williams, D M, Graybill, J R, Drutz, D J
Congenitally athymic nude (nu/nu) mice, when injected intraperitoneally with Histoplasma capsulatum, developed a rapidly fatal disseminated infection characterized by heavy parasitization of...
Changes in the level of neutrophil alkaline phosphatase (NAP) in a population of peripheral blood neutrophils were determined in healthy subjects dosed with either aetiocholanolone (Aetio, 4 mg/m2...
Expression of the matrix metalloproteinase 9 in Hodgkin's disease is independent of EBV status
Flavell, J R, Baumforth, K R N, Williams, D M, Lukesova, M, Madarova, J, Noskova, V, ...
Background—In vitro the Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP-1) has been shown to upregulate expression of matrix metalloproteinase 9 (MMP-9), a member of a family of...
Tinkler, S M, Linder, J E, Williams, D M, Johnson, N W
In order to investigate a monocyte origin for osteoclasts, tritiated thymidine labelled blood monocytes, harvested from the blood of donor mice, were injected intravenously into syngeneic recipient...
Tinkler, S M, Williams, D M, Johnson, N W
In order to assess osteoclast formation in response to 1 alpha-hydroxycholecalciferol, osteoclast counts per cm of bone surface were performed on paraffin sections of femurs of male CBA mice killed...
Tinkler, S M, Williams, D M, Linder, J E, Johnson, N W
The significance of blood monocytes as a source of osteoclast precursors was investigated during 1 alpha-hydroxycholecalciferol-stimulated bone resorption in mice. Animals were given three injections...
Williams, D M, Pieken, W A, Eckstein, F
The importance of the 2'-hydroxyl group of several guanosine residues for the catalytic efficiency of a hammerhead ribozyme has been investigated. Five ribozymes in which single guanosine residues...
Scragg, M. A., Cannon, S. J., Rangarajan, M., Williams, D. M., Curtis, M. A.
Cell surface integrins mediate interactions between cells and their extracellular matrix and are frequently exploited by a range of bacterial pathogens to facilitate adherence and/or invasion. In...
Negishi, K, Williams, D M, Inoue, Y, Moriyama, K, Brown, D M, Hayatsu, H
The triphosphate of the nucleoside deoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one (dP) is known to be incorporated into DNA efficiently by Taq polymerase and is a useful tool for...
Hill, F, Williams, D M, Loakes, D, Brown, D M
The structure of the deoxyribonucleoside derived from N 6-methoxy-2, 6-diaminopurine (dK) was examined by NMR. The methoxyamino residue was found predominantly in the imino rather than the amino...
Pharmacokinetics of vancomycin in adult cystic fibrosis patients.
Pleasants, R A, Michalets, E L, Williams, D M, Samuelson, W M, Rehm, J R, Knowles, M R
Although the depositions of many antibiotics are altered in cystic fibrosis patients, that of vancomycin has not been studied. To assess vancomycin pharmacokinetics, 10 adult cystic fibrosis patients...
Role of CD8 T cells in primary Chlamydia infection.
Magee, D M, Williams, D M, Smith, J G, Bleicker, C A, Grubbs, B G, Schachter, J, ...
The role of CD4 and CD8 T cells in primary Chlamydia trachomatis pneumonia was investigated by using in vivo depletion techniques to eliminate T-cell populations. Reduction of either CD4 T cells or...
Role of gamma-delta T cells in murine Chlamydia trachomatis infection.
Williams, D M, Grubbs, B G, Kelly, K, Pack, E, Rank, R G
The role of gamma-delta T cells in host resistance to Chlamydia trachomatis was characterized by using a murine model of pneumonia caused by the mouse pneumonitis agent (MoPn), murine C. trachomatis....
Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis.
Williams, D M, Grubbs, B G, Pack, E, Kelly, K, Rank, R G
A murine model of pneumonia due to the mouse pneumonitis agent (MoPn [murine Chlamydia trachomatis]) in mice deficient in CD4+ T-cell function (major histocompatibility complex [MHC] class II...
Duvall, E J, Williams, D M, Mongkolsuk, S, Lovett, P S
Plasmid pPL603 is a promoter cloning vector for Bacillus subtilis and consists of a 1.1-kilobase fragment of Bacillus pumilus DNA inserted between the EcoRI and BamHI sites of pUB110. The gene...
Cloning restriction fragments that promote expression of a gene in Bacillus subtilis.
Williams, D M, Duvall, E J, Lovett, P S
Plasmid pPL603 (3.1 megadaltons) specifies neomycin resistance in Bacillus subtilis and contains a structural gene for chloramphenicol acetyltransferase. Cells harboring the plasmid cannot grow on...
Effect of gamma interferon on resolution of murine chlamydial genital infection.
Rank, R G, Ramsey, K H, Pack, E A, Williams, D M
Mice infected in the genital tract with the Chlamydia trachomatis agent of mouse pneumonitis were treated with monoclonal rat anti-gamma interferon (anti-IFN-gamma) antibody to determine whether...
Chlamydia trachomatis pneumonia induces in vivo production of interleukin-1 and -6.
Magee, D M, Smith, J G, Bleicker, C A, Carter, C J, Bonewald, L F, Schachter, J, ...
Cytokine induction during Chlamydia trachomatis pneumonia may alter the pathogenesis or course of disease. We examined interleukin-1 (IL-1) and IL-6 production by measuring mRNA and bioactivity in...
Production of colony-stimulating factors during pneumonia caused by Chlamydia trachomatis.
Magee, D M, Williams, D M, Wing, E J, Bleicker, C A, Schachter, J
The colony-stimulating factors (CSFs) are cytokines involved in the production, differentiation, and activation of host phagocytes. During murine infection with Chlamydia trachomatis (MoPn), plasma...
A role in vivo for tumor necrosis factor alpha in host defense against Chlamydia trachomatis.
Williams, D M, Magee, D M, Bonewald, L F, Smith, J G, Bleicker, C A, Byrne, G I, ...
In a mouse model of pneumonia caused by murine Chlamydia trachomatis (mouse pneumonitis agent [MoPn]), tumor necrosis factor alpha (TNF-alpha) antigen and bioactivity were demonstrated in vivo in the...
Gamma interferon-mediated cytotoxicity related to murine Chlamydia trachomatis infection.
Byrne, G I, Grubbs, B, Marshall, T J, Schachter, J, Williams, D M
After infection with the mouse pneumonitis agent (MoPn; murine Chlamydia trachomatis), heterozygous (nu/+) but not nude athymic (nu/nu) mice produced enhanced amounts of gamma interferon (IFN-gamma)...
Role in vivo for gamma interferon in control of pneumonia caused by Chlamydia trachomatis in mice.
Williams, D M, Byrne, G I, Grubbs, B, Marshal, T J, Schachter, J
In a model of pneumonia caused by murine Chlamydia trachomatis, depletion experiments with monoclonal antibody to gamma interferon (IFN-gamma) made mice more susceptible. Repletion experiments giving...
Williams, D M, Schachter, J, Grubbs, B
Natural killer (NK) activity is increased in both spleen and lung early in pulmonary infection by murine Chlamydia trachomatis in both susceptible nude and resistant heterozygous (nu/+) mice....
Primary murine Chlamydia trachomatis pneumonia in B-cell-deficient mice.
Williams, D M, Grubbs, B, Schachter, J
Mice were rendered deficient in B-cell activity by treatment with anti-mu antibody from birth. These animals were then infected intranasally with murine Chlamydia trachomatis (murine pneumonitis...
Antibody in host defense against mouse pneumonitis agent (murine Chlamydia trachomatis).
Williams, D M, Schachter, J, Weiner, M H, Grubbs, B
In a murine model of chlamydial pneumonia employing murine Chlamydia trachomatis, immune serum given intranasally delayed death in nude (nu/nu) mice and prevented death in nu/+ mice. Serum-derived...
Gamma interferon levels during Chlamydia trachomatis pneumonia in mice.
Williams, D M, Grubbs, B G, Schachter, J, Magee, D M
Host defense against murine Chlamydia trachomatis (mouse pneumonitis agent [MoPn]) in a murine model was investigated. Gamma interferon (IFN-gamma) was produced in the lungs by both MoPn-susceptible...
The role of superoxide anion radical in the reduction of ferritin iron by xanthine oxidase.
Williams, D M, Lee, G R, Cartwright, G E
Superoxide dismutase exerted a pronounced inhibitory effect upon xanthine oxidase-mediated reduction of iron in ferritin, ferric chloride, or ferric ADP. Maximal inhibition was observed when the...
Role for CD8+ T cells in antichlamydial immunity defined by Chlamydia-specific T-lymphocyte clones.
Igietseme, J U, Magee, D M, Williams, D M, Rank, R G
The role of CD8+ T cells in antichlamydial immunity was investigated in a murine model of chlamydial genital infection by using T-cell clones generated against the Chlamydia trachomatis agent of...
An approach to the stereoselective synthesis of Sp- dinucleoside phosphorothioates has been investigated which utilizes phosphotriester chemistry. The stereoselectivity of internucleotide bond...
Characterization of gamma interferon-mediated cytotoxicity to chlamydia-infected fibroblasts.
Byrne, G I, Schobert, C S, Williams, D M, Krueger, D A
Addition of murine recombinant gamma interferon (IFN-gamma) to mouse fibroblast cultures infected with Chlamydia psittaci was found to induce a cytotoxic response that was dependent on the...
Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection.
Williams, D M, Bonewald, L F, Roodman, G D, Byrne, G I, Magee, D M, Schachter, J
A mouse model of pneumonia caused by murine Chlamydia trachomatis (mouse pneumonitis agent) was used to demonstrate that whole spleen cells from both nude athymic mice (nu/nu) and heterozygous mice...
Cosstick, R, Li, X, Tuli, D K, Williams, D M, Connolly, B A, Newman, P C
An improved procedure for the preparation of 3-deaza-2'-deoxyadenosine (d3CA) is described which is suitable for the synthesis of gram quantities of this analogue. Using phosphoramidite chemistry...
A common protein binds to two silencers 5' to the human beta-globin gene.
Berg, P E, Williams, D M, Qian, R L, Cohen, R B, Cao, S X, Mittelman, M, ...
The temporal sequence of expression of human globin genes during development suggests precise regulation of these genes. Recent studies have characterized a number of DNA sequences within or flanking...
Genetic control of murine resistance to Toxoplasma gondii.
Williams, D M, Grumet, F C, Remington, J S
The genetics of murine susceptibility to Toxoplasma gondii was investigated in inbred mice and their F1 and F2 offspring. Among four strains of congenic mice of the B10 background, those with H-2a/a...
Strain-dependent differences in murine susceptibility to toxoplasma.
Araujo, F G, Williams, D M, Grumet, F C, Remington, J S
Susceptibility of seven inbred and outbred strains of mice to infection with trophozoites of Toxoplasma gondii at two different doses was determined. Stroking strain differences in susceptibility and...
Histoplasma capsulatum infection in nude mice.
Williams, D M, Graybill, J R, Drutz, D J
Congenitally athymic nude (nu/nu) mice, when injected intraperitoneally with Histoplasma capsulatum, developed a rapidly fatal disseminated infection characterized by heavy parasitization of...
Changes in the level of neutrophil alkaline phosphatase (NAP) in a population of peripheral blood neutrophils were determined in healthy subjects dosed with either aetiocholanolone (Aetio, 4 mg/m2...
Tinkler, S M, Linder, J E, Williams, D M, Johnson, N W
In order to investigate a monocyte origin for osteoclasts, tritiated thymidine labelled blood monocytes, harvested from the blood of donor mice, were injected intravenously into syngeneic recipient...
Tinkler, S M, Williams, D M, Johnson, N W
In order to assess osteoclast formation in response to 1 alpha-hydroxycholecalciferol, osteoclast counts per cm of bone surface were performed on paraffin sections of femurs of male CBA mice killed...
Tinkler, S M, Williams, D M, Linder, J E, Johnson, N W
The significance of blood monocytes as a source of osteoclast precursors was investigated during 1 alpha-hydroxycholecalciferol-stimulated bone resorption in mice. Animals were given three injections...
Expression of the matrix metalloproteinase 9 in Hodgkin's disease is independent of EBV status
Flavell, J R, Baumforth, K R N, Williams, D M, Lukesova, M, Madarova, J, Noskova, V, ...
Background—In vitro the Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP-1) has been shown to upregulate expression of matrix metalloproteinase 9 (MMP-9), a member of a family of...
Effect of human monocytes and macrophages on Trypanosoma cruzi.
Studies were undertaken to determine whether Trypanosoma cruzi can invade and multiply within human monocytes and macrophages cultured in vitro and, if so, whether macrophages can be activated to...
Reid, P A, Gardner, S D, Williams, D M, Harnett, M M
Phosphatidylcholine-phospholipase D has been proposed to play a key role in the transduction of the proliferative responses of a wide range of mitogens and growth factors. We now report that the...
Occupationally related angiosarcoma of the liver in the United Kingdom 1972-1994.
Lee, F I, Smith, P M, Bennett, B, Williams, D M
BACKGROUND: Angiosarcoma of the liver (ASL) has been described in vinyl chloride workers worldwide. AIM: To describe the UK experience of occupationally related ASL. PATIENTS: Twenty patients who...
Monitoring liver disorders in vinyl chloride monomer workers using greyscale ultrasonography.
Williams, D M, Smith, P M, Taylor, K J, Crossley, I R, Duck, B W
Recognition that vinyl chloride could be hepatotoxic led to a survey of workers to determine whether changes had been induced by past exposure, and to evaluate standard liver function tests as...
Mutational screening of the Wilms's tumour gene, WT1, in males with genital abnormalities.
Clarkson, P A, Davies, H R, Williams, D M, Chaudhary, R, Hughes, I A, Patterson, M N
Several lines of evidence suggest that the Wilms's tumour susceptibility gene, WT1, has an important role in genital as well as kidney development. WT1 is expressed in developing kidney and genital...
Hyperinsulinaemic hypoglycaemia in small for dates babies.
Collins, J E, Leonard, J V, Teale, D, Marks, V, Williams, D M, Kennedy, C R, ...
Blood glucose concentrations were measured prospectively in 27 small for dates infants in the first 48 hours after birth: 10 infants became hypoglycaemic. Of these, five had inappropriately raised...
Normal postnatal androgen production and action in isolated micropenis and isolated hypospadias.
Evans, B A, Williams, D M, Hughes, I A
To try and find out if a defect in androgen biosynthesis or action could be responsible for the incomplete virilisation seen in boys with isolated hypospadias and isolated micropenis, androgen...
Rapid diagnosis of malignancy using flow cytometry.
Williams, D M, O'Connor, S, Grant, J W, Marcus, R E, Broadbent, V
The rapid and accurate diagnosis of childhood malignancy is important both in the planning of appropriate treatment and in relieving the inevitable family anxiety. The use of flow cytometry to...