Carney, D N, Bunn, P A, Gazdar, A F, Pagan, J A, Minna, J D
Fifteen tumor-containing specimens were obtained directly from patients with small cell carcinoma of the lung and tested for their ability to grow in serum-supplemented medium and in serum-free...
Human small-cell lung cancers show amplification and expression of the N-myc gene.
Nau, M M, Brooks, B J, Carney, D N, Gazdar, A F, Battey, J F, Sausville, E A, ...
We have found that 6 of 31 independently derived human small-cell lung cancer (SCLC) cell lines have 5- to 170-fold amplified N-myc gene sequences. The amplification is seen with probes from two...
Broers, J L, Carney, D N, De Ley, L, Vooijs, G P, Ramaekers, F C
The expression of intermediate filament proteins in classic and variant-type small-cell lung carcinoma (SCLC) cell lines was studied using immunocytochemical techniques, two-dimensional gel...
Carney, D N, Ahluwalia, G S, Jayaram, H N, Cooney, D A, Johns, D G
The antitumor activity of the antineoplastic agent, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), has previously been shown to require intracellular anabolism of the drug to a...
Johnson, B E, Battey, J, Linnoila, I, Becker, K L, Makuch, R W, Snider, R H, ...
Small cell lung cancer growing in cell culture possesses biologic properties that allow classification into two categories: classic and variant. Compared with classic small cell lung cancer cell...
Determinants of the sensitivity of human small-cell lung cancer cell lines to methotrexate.
Curt, G A, Jolivet, J, Carney, D N, Bailey, B D, Drake, J C, Clendeninn, N J, ...
We have characterized the determinants of methotrexate (MTX) responsiveness in eight patient-derived cell lines of small-cell lung cancer (SCLC). Clonogenic survival was correlated with factors known...
Johnson, B E, Ihde, D C, Makuch, R W, Gazdar, A F, Carney, D N, Oie, H, ...
44 small cell lung cancer cell lines established from 227 patients were studied for myc family DNA amplification (c-myc, N-myc, and L-myc). Two of 19 lines (11%) established from untreated patients'...
Extrarenal malignancy and the nephrotic syndrome.
Heaton, J M, Menzin, M A, Carney, D N
The clinical and histological findings are described of a patient who presented with the nephrotic syndrome and was found at necropsy to have a bronchial carcinoma. Amyloidosis, renal vein...
Carney, D N, Bunn, P A, Gazdar, A F, Pagan, J A, Minna, J D
Fifteen tumor-containing specimens were obtained directly from patients with small cell carcinoma of the lung and tested for their ability to grow in serum-supplemented medium and in serum-free...
Human small-cell lung cancers show amplification and expression of the N-myc gene.
Nau, M M, Brooks, B J, Carney, D N, Gazdar, A F, Battey, J F, Sausville, E A, ...
We have found that 6 of 31 independently derived human small-cell lung cancer (SCLC) cell lines have 5- to 170-fold amplified N-myc gene sequences. The amplification is seen with probes from two...
Broers, J L, Carney, D N, De Ley, L, Vooijs, G P, Ramaekers, F C
The expression of intermediate filament proteins in classic and variant-type small-cell lung carcinoma (SCLC) cell lines was studied using immunocytochemical techniques, two-dimensional gel...
Carney, D N, Ahluwalia, G S, Jayaram, H N, Cooney, D A, Johns, D G
The antitumor activity of the antineoplastic agent, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide), has previously been shown to require intracellular anabolism of the drug to a...
Johnson, B E, Battey, J, Linnoila, I, Becker, K L, Makuch, R W, Snider, R H, ...
Small cell lung cancer growing in cell culture possesses biologic properties that allow classification into two categories: classic and variant. Compared with classic small cell lung cancer cell...
Determinants of the sensitivity of human small-cell lung cancer cell lines to methotrexate.
Curt, G A, Jolivet, J, Carney, D N, Bailey, B D, Drake, J C, Clendeninn, N J, ...
We have characterized the determinants of methotrexate (MTX) responsiveness in eight patient-derived cell lines of small-cell lung cancer (SCLC). Clonogenic survival was correlated with factors known...
Johnson, B E, Ihde, D C, Makuch, R W, Gazdar, A F, Carney, D N, Oie, H, ...
44 small cell lung cancer cell lines established from 227 patients were studied for myc family DNA amplification (c-myc, N-myc, and L-myc). Two of 19 lines (11%) established from untreated patients'...
Extrarenal malignancy and the nephrotic syndrome.
Heaton, J M, Menzin, M A, Carney, D N
The clinical and histological findings are described of a patient who presented with the nephrotic syndrome and was found at necropsy to have a bronchial carcinoma. Amyloidosis, renal vein...
A phase II study of oral etoposide in elderly patients with small cell lung cancer.
Smit, E F, Carney, D N, Harford, P, Sleijfer, D T, Postmus, P E
Thirty five previously untreated patients with small cell lung cancer older than 70 years were treated with oral etoposide (800 mg/m2 over five consecutive days) every four weeks. Twenty two patients...
Imaging of bronchial carcinoid tumours with indium-111 pentetreotide.
O'Byrne, K J, O'Hare, N J, Freyne, P J, Luke, D A, Clancy, L J, Prichard, J S, ...
Neuroendocrine tumours are characterised by the expression of high affinity binding sites for somatostatin. The detection of bronchial carcinoid tumours through scintigraphic imaging is described in...