Inactivation of {beta}-lactamases from Enterobacter cloacae by monophosphams (1988)
Bush, Karen, Smith, S. A., Tanaka, S. K., Bonner, D. P.
Amongst the monocyclic β-lactam antibiotics, selected monophosphams were potent mechanism-based inactivators of the P99 and E2 cephalosporinases of Enterobacter cloacae. Inhibition of these enzymes...
In vitro antifungal and fungicidal spectra of a new pradimicin derivative, BMS-181184.
Fung-Tomc, J C, Minassian, B, Huczko, E, Kolek, B, Bonner, D P, Kessler, R E
A new pradimicin derivative, BMS-181184, was compared with amphotericin B and fluconazole against 249 strains from 35 fungal species to determine its antifungal spectrum. Antifungal testing was...
In vitro activity of BMS-181139, a new carbapenem with potent antipseudomonal activity.
Kessler, R E, Fung-Tomc, J, Kolek, B, Minassian, B, Huczko, E, Gradelski, E, ...
The in vitro activities of the carbapenem BMS-181139 were determined in comparison with those of imipenem, meropenem, ciprofloxacin, ceftriaxone, and vancomycin. BMS-181139 was the most active...
Fung-Tomc, J C, Gradelski, E, Kolek, B, Minassian, B, Pucci, M, Kessler, R E, ...
The broad antipseudomonal spectrum of the carbapenem BMS-181139 includes clinical strains and laboratory mutants of Pseudomonas aeruginosa that are resistant to imipenem. Unlike other known...
Fung-Tomc, J C, Huczko, E, Banville, J, Ménard, M, Kolek, B, Gradelski, E, ...
A number of carbapenem derivatives were examined to determine the structure-activity relationships required for dependence on porin protein D2 for activity against Pseudomonas aeruginosa. As...
Fung-Tomc, J C, Gradelski, E, Huczko, E, Dougherty, T J, Kessler, R E, Bonner, D P
The rates of development of resistance to ceftriaxone, ceftazidime, cefepime, and cefpirome in 10 strains of Enterobacter cloacae were determined by daily transfer for 7 days to fresh medium...
In vitro evaluation of tigemonam, a novel oral monobactam.
Tanaka, S K, Summerill, R A, Minassian, B F, Bush, K, Visnic, D A, Bonner, D P, ...
Tigemonam, a novel, orally administered monobactam, exhibited potent and specific activity in vitro against members of the family Enterobacteriaceae, Haemophilus influenzae, and Neisseria...
In vivo evaluation of tigemonam, a novel oral monobactam.
Clark, J M, Olsen, S J, Weinberg, D S, Dalvi, M, Whitney, R R, Bonner, D P, ...
Tigemonam, a new monobactam with excellent activity against gram-negative bacteria, was evaluated for in vivo efficacy and absorption after oral administration to laboratory animals. Tigemonam is...
Bush, K, Smith, S A, Ohringer, S, Tanaka, S K, Bonner, D P
Tigemonam and temocillin, but not aztreonam, bound to penicillin-binding proteins (PBPs) 1a and 3 of Escherichia coli with apparent improved affinity when challenged with benzylpenicillin at lowered...
Resistance caused by decreased penetration of beta-lactam antibiotics into Enterobacter cloacae.
Bush, K, Tanaka, S K, Bonner, D P, Sykes, R B
Strains of Enterobacter cloacae were selected on the basis of resistance to aztreonam, ceftazidime, moxalactam, or imipenem. All strains produced the same E2 beta-lactamase, with an isoelectric point...
Sykes, R B, Bonner, D P, Bush, K, Georgopapadakou, N H
Azthreonam (SQ 26,776) is a synthetic monocyclic beta-lactam antimicrobial agent belonging to the monobactam family (Sykes et al., Nature [London] 291:489-491, 1981), members of which are...
Georgopapadakou, N H, Smith, S A, Bonner, D P
The penicillin-binding proteins (PBPs) of a clinical isolate of Staphylococcus aureus specifically resistant to oral cephalosporins were compared with those of a susceptible strain. In the resistant...
Mamber, S W, Kolek, B, Brookshire, K W, Bonner, D P, Fung-Tomc, J
Eight quinolones were examined for their bacterial mutagenicity in the Ames Salmonella TA102 assay and for their effects in other bacterial genotoxicity assays. In the quantitative Ames plate...
Fung-Tomc, J, Kolek, B, Bonner, D P
The effects of ciprofloxacin on the rates of development of low-level resistance to other antibiotics were determined in vitro. Three methicillin-resistant Staphylococcus aureus and two Pseudomonas...
Amphotericin B lipid complex therapy of experimental fungal infections in mice.
Clark, J M, Whitney, R R, Olsen, S J, George, R J, Swerdel, M R, Kunselman, L, ...
The amphotericin B lipid complex (ABLC), which is composed of amphotericin B and the phospholipids dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol, was evaluated for its acute...
Braitman, A, Swerdel, M R, Olsen, S J, Tuomari, A V, Lynch, J S, Blue, B, ...
The new antiviral nucleoside SQ 34,514 [(1R-1 alpha, 2 beta, 3 alpha)-2-amino-9- [2,3-bis(hydroxymethyl)cyclobutyl]-6H-purin-6-one], the active R isomer of racemic SQ 33,054 (cyclobut-G), was...
Bush, K, Flamm, R K, Ohringer, S, Singer, S B, Summerill, R, Bonner, D P
An isolate of Serratia marcescens that produced both an inducible chromosomal and a plasmid-mediated TEM-1 beta-lactamase was resistant to ampicillin and amoxicillin and also demonstrated decreased...
Emergence of homogeneously methicillin-resistant Staphylococcus aureus.
Fung-Tomc, J, Huczko, E, Gradelski, E, Denbleyker, K, Bonner, D P, Kessler, R E
Forty-seven clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), collected between 1986 and 1990 from 29 institutions, were analyzed for susceptibility to various antibiotics....
In vitro antifungal and fungicidal spectra of a new pradimicin derivative, BMS-181184.
Fung-Tomc, J C, Minassian, B, Huczko, E, Kolek, B, Bonner, D P, Kessler, R E
A new pradimicin derivative, BMS-181184, was compared with amphotericin B and fluconazole against 249 strains from 35 fungal species to determine its antifungal spectrum. Antifungal testing was...
In vitro activity of BMS-181139, a new carbapenem with potent antipseudomonal activity.
Kessler, R E, Fung-Tomc, J, Kolek, B, Minassian, B, Huczko, E, Gradelski, E, ...
The in vitro activities of the carbapenem BMS-181139 were determined in comparison with those of imipenem, meropenem, ciprofloxacin, ceftriaxone, and vancomycin. BMS-181139 was the most active...
Fung-Tomc, J C, Gradelski, E, Kolek, B, Minassian, B, Pucci, M, Kessler, R E, ...
The broad antipseudomonal spectrum of the carbapenem BMS-181139 includes clinical strains and laboratory mutants of Pseudomonas aeruginosa that are resistant to imipenem. Unlike other known...
Fung-Tomc, J C, Huczko, E, Banville, J, Ménard, M, Kolek, B, Gradelski, E, ...
A number of carbapenem derivatives were examined to determine the structure-activity relationships required for dependence on porin protein D2 for activity against Pseudomonas aeruginosa. As...
Fung-Tomc, J C, Gradelski, E, Huczko, E, Dougherty, T J, Kessler, R E, Bonner, D P
The rates of development of resistance to ceftriaxone, ceftazidime, cefepime, and cefpirome in 10 strains of Enterobacter cloacae were determined by daily transfer for 7 days to fresh medium...
In vitro evaluation of tigemonam, a novel oral monobactam.
Tanaka, S K, Summerill, R A, Minassian, B F, Bush, K, Visnic, D A, Bonner, D P, ...
Tigemonam, a novel, orally administered monobactam, exhibited potent and specific activity in vitro against members of the family Enterobacteriaceae, Haemophilus influenzae, and Neisseria...
In vivo evaluation of tigemonam, a novel oral monobactam.
Clark, J M, Olsen, S J, Weinberg, D S, Dalvi, M, Whitney, R R, Bonner, D P, ...
Tigemonam, a new monobactam with excellent activity against gram-negative bacteria, was evaluated for in vivo efficacy and absorption after oral administration to laboratory animals. Tigemonam is...
Bush, K, Smith, S A, Ohringer, S, Tanaka, S K, Bonner, D P
Tigemonam and temocillin, but not aztreonam, bound to penicillin-binding proteins (PBPs) 1a and 3 of Escherichia coli with apparent improved affinity when challenged with benzylpenicillin at lowered...
Resistance caused by decreased penetration of beta-lactam antibiotics into Enterobacter cloacae.
Bush, K, Tanaka, S K, Bonner, D P, Sykes, R B
Strains of Enterobacter cloacae were selected on the basis of resistance to aztreonam, ceftazidime, moxalactam, or imipenem. All strains produced the same E2 beta-lactamase, with an isoelectric point...
Sykes, R B, Bonner, D P, Bush, K, Georgopapadakou, N H
Azthreonam (SQ 26,776) is a synthetic monocyclic beta-lactam antimicrobial agent belonging to the monobactam family (Sykes et al., Nature [London] 291:489-491, 1981), members of which are...
Georgopapadakou, N H, Smith, S A, Bonner, D P
The penicillin-binding proteins (PBPs) of a clinical isolate of Staphylococcus aureus specifically resistant to oral cephalosporins were compared with those of a susceptible strain. In the resistant...
Mamber, S W, Kolek, B, Brookshire, K W, Bonner, D P, Fung-Tomc, J
Eight quinolones were examined for their bacterial mutagenicity in the Ames Salmonella TA102 assay and for their effects in other bacterial genotoxicity assays. In the quantitative Ames plate...
Fung-Tomc, J, Kolek, B, Bonner, D P
The effects of ciprofloxacin on the rates of development of low-level resistance to other antibiotics were determined in vitro. Three methicillin-resistant Staphylococcus aureus and two Pseudomonas...
Amphotericin B lipid complex therapy of experimental fungal infections in mice.
Clark, J M, Whitney, R R, Olsen, S J, George, R J, Swerdel, M R, Kunselman, L, ...
The amphotericin B lipid complex (ABLC), which is composed of amphotericin B and the phospholipids dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol, was evaluated for its acute...
Braitman, A, Swerdel, M R, Olsen, S J, Tuomari, A V, Lynch, J S, Blue, B, ...
The new antiviral nucleoside SQ 34,514 [(1R-1 alpha, 2 beta, 3 alpha)-2-amino-9- [2,3-bis(hydroxymethyl)cyclobutyl]-6H-purin-6-one], the active R isomer of racemic SQ 33,054 (cyclobut-G), was...
Bush, K, Flamm, R K, Ohringer, S, Singer, S B, Summerill, R, Bonner, D P
An isolate of Serratia marcescens that produced both an inducible chromosomal and a plasmid-mediated TEM-1 beta-lactamase was resistant to ampicillin and amoxicillin and also demonstrated decreased...
Emergence of homogeneously methicillin-resistant Staphylococcus aureus.
Fung-Tomc, J, Huczko, E, Gradelski, E, Denbleyker, K, Bonner, D P, Kessler, R E
Forty-seven clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), collected between 1986 and 1990 from 29 institutions, were analyzed for susceptibility to various antibiotics....