Fulminant Crohn's colitis after allogeneic stem cell transplantation (2003)
Sonwalkar, S.A., James, R.M., Ahmad, T., Zhang, L., Verbeke, C.S., Barnard, D.L., ...
We report a case of fulminant Crohn’s colitis that occurred following non-myeloablative allogeneic stem cell transplantation for Hodgkin’s lymphoma. Adoptive transfer of inflammatory bowel...
BLDSC reference no.: D222912.
Evidence for inflammatory bowel disease of a susceptibility locus on the X chromosome (2001)
Satsangi, J, Peeters, M, Parkes, M, Jewell, D P, ...
BACKGROUND & AIMS: The technique of genomewide scanning has been applied successfully in inflammatory bowel disease (IBD). A number of putative susceptibility loci have been identified through...
The aim of this study was to assess whether interleukin-10 (IL-10) and/or transforming growth factor β-1 (TGF β1) downregulate HLA-DR expression using the HT29 cell line as a model of colonic...
Altered expression of mucins throughout the colon in ulcerative colitis. (1997)
Smithson, J. E., Campbell, A., Andrews, J. M., Milton, J. D., Pigott, R., Jewell, D. P.
Altered expression of mucins throughout the colon in ulcerative colitis. (1997)
Smithson, J. E., Campbell, A., Andrews, J. M., Milton, J. D., Pigott, R., Jewell, D. P.
The Role of Cytokines in Inflammatory Bowel Disease (1994)
G. Radford-Smith, D. P. Jewell
Cytokines play an important role in the development and persistence of the inflammatory lesions seen in Crohn's disease and ulcerative colitis. This review discusses the current thinking of the role...
P. Hoang, H. R. Dalton, D. P. Jewell
Using an ELISA technique, concentrations of γ-interferon and interleukin-2 were assayed in the supernatants of colonic intraepithelial lymphocytes cultured with or without phytohaemagglutinin (PHA)....
The Association of Autoimmune Disorders with Inflammatory Bowel Disease (1989)
SNOOK, J. A., De SILVA, H. J., JEWELL, D. P.
Medical records of patients with ulcerative colitis (n= 858), Crohn's disease (n= 378) and coeliac disease (n = 148) were examined to determine the prevalence of associated...
Ulcerative Colitis and Persistent Liver Dysfunction (1983)
SHEPHERD, H. A., SELBY, W. S., CHAPMAN, R. W. G., NOLAN, D., BARBATIS, C., McGEE, J. O'D., ...
Six hundred and eighty-one patients with ulcerative colitis who attend the outpatient clinic in Oxford have been screened for the presence of persistently abnormal liver function tests. Of the 21...
Campbell, A P, Merrett, M N, Kettlewell, M, Mortensen, N J, Jewell, D P
AIMS--To investigate colonic metaplasia of goblet and columnar epithelial cells in ileal pouch mucosa; to correlate this with the degree of morphological and inflammatory change; and to assess...
Selby, W S, Poulter, L W, Hobbs, S, Jewell, D P, Janossy, G
HLA-DR-positive histiocytes in the lamina propria of the human intestine have been characterised using combined histochemical and immunohistological techniques. In the small intestine, 80-90% of the...
Assessment of fat malabsorption.
Teh, L B, Stopard, M, Anderson, S, Grant, A, Quantrill, D, Wilkinson, R H, ...
For the assessment of fat malabsorption, the standard method of measuring faecal fat excretion using a 5 day stool collection has been compared with the alternative methods: stool microscopy, a lipid...
Jejunal mucosal morphology in healthy north Indian subjects.
Bennett, M K, Sachdev, G K, Jewell, D P, Anand, B S
Morphometric measurements have been performed on small intestinal biopsy specimens obtained from 18 healthy adult Indian volunteers. The measurements were made using a computer aided measuring...
Histological features of sclerosing cholangitis in patients with chronic ulcerative colitis.
Barbatis, C, Grases, P, Shepherd, H A, Chapman, R W, Trowell, J, Jewell, D P, ...
Primary sclerosing cholangitis was diagnosed radiologically in 16 of 681 patients (2.2%) with chronic ulcerative colitis in a follow up study at the gastroenterology unit in Oxford. On the basis of...
Crypt cell proliferation and HLA-DR expression in pelvic ileal pouches.
De Silva, H J, Gatter, K C, Millard, P R, Kettlewell, M, Mortensen, N J, Jewell, D P
To investigate the nature of the morphological changes that occur in ileal pouches, 26 biopsy specimens from patients with functioning ileo-anal pouches (eight with pouchitis) were studied. Normal...
Eighty four colonic biopsy specimens were obtained from patients with ulcerative colitis, Crohn's disease, radiation colitis, infectious colitis, and from normal controls. Paired specimens were...
Immunoperoxidase staining of intermediate filaments in human small bowel.
Malik, A K, Rawcliffe, P, Morton, J A, Jewell, D P, McGee, J O
Gastric function and histology in chronic renal failure.
Mitchell, C J, Jewell, D P, Lewin, M R, McLaughlin, J E, Moorhead, J F
Gastric function and histology were investigated in 24 patients with untreated chronic renal failure. At endoscopy nine patients had oesophagitis, 12 patients were considered to have gastritis, and...
Monocytes in inflammatory bowel disease: absolute monocyte counts.
Mee, A S, Berney, J, Jewell, D P
Using a cytochemical staining technique, peripheral blood monocytes have been precisely identified and enumerated in patients with inflammatory bowel disease and compared with healthy and disease...
Monocytes in inflammatory bowel disease: phagocytosis and intracellular killing.
Mee, A S, Szawatakowski, M, Jewell, D P
The ability of peripheral blood monocytes from patients with ulcerative colitis and Crohn's disease to phagocytose and kill a standard strain of Staphyloccus aureus has been studied. Using...
Primary Sclerosing Cholangitis—An Immunologically Mediated Disease?
Chapman, R. W. G., Jewell, D. P.
Primary sclerosing cholangitis (PSC) is an uncommon, chronic disorder characterized by inflammatory fibrosis usually involving the entire biliary tree. The etiology has been unknown, but PSC is...
Olsalazine in active ulcerative colitis.
Selby, W S, Barr, G D, Ireland, A, Mason, C H, Jewell, D P
Olsalazine (azodisalicylate) is a new drug in which two molecules of 5-aminosalicylic acid are linked by an azo bond. Its role in the treatment of mildly active, distal ulcerative colitis was...
Azathioprine in Ulcerative Colitis: Final Report on Controlled Therapeutic Trial
Jewell, D. P., Truelove, S. C.
Eighty patients, all of whom were suffering from a frank clinical attack of ulcerative colitis, were admitted to the trial. The attack was treated with a standard course of corticosteroids and the...
Campbell, A P, Merrett, M N, Kettlewell, M, Mortensen, N J, Jewell, D P
AIMS--To investigate colonic metaplasia of goblet and columnar epithelial cells in ileal pouch mucosa; to correlate this with the degree of morphological and inflammatory change; and to assess...
Selby, W S, Poulter, L W, Hobbs, S, Jewell, D P, Janossy, G
HLA-DR-positive histiocytes in the lamina propria of the human intestine have been characterised using combined histochemical and immunohistological techniques. In the small intestine, 80-90% of the...
Assessment of fat malabsorption.
Teh, L B, Stopard, M, Anderson, S, Grant, A, Quantrill, D, Wilkinson, R H, ...
For the assessment of fat malabsorption, the standard method of measuring faecal fat excretion using a 5 day stool collection has been compared with the alternative methods: stool microscopy, a lipid...
Jejunal mucosal morphology in healthy north Indian subjects.
Bennett, M K, Sachdev, G K, Jewell, D P, Anand, B S
Morphometric measurements have been performed on small intestinal biopsy specimens obtained from 18 healthy adult Indian volunteers. The measurements were made using a computer aided measuring...
Histological features of sclerosing cholangitis in patients with chronic ulcerative colitis.
Barbatis, C, Grases, P, Shepherd, H A, Chapman, R W, Trowell, J, Jewell, D P, ...
Primary sclerosing cholangitis was diagnosed radiologically in 16 of 681 patients (2.2%) with chronic ulcerative colitis in a follow up study at the gastroenterology unit in Oxford. On the basis of...
Crypt cell proliferation and HLA-DR expression in pelvic ileal pouches.
De Silva, H J, Gatter, K C, Millard, P R, Kettlewell, M, Mortensen, N J, Jewell, D P
To investigate the nature of the morphological changes that occur in ileal pouches, 26 biopsy specimens from patients with functioning ileo-anal pouches (eight with pouchitis) were studied. Normal...
Eighty four colonic biopsy specimens were obtained from patients with ulcerative colitis, Crohn's disease, radiation colitis, infectious colitis, and from normal controls. Paired specimens were...
Immunoperoxidase staining of intermediate filaments in human small bowel.
Malik, A K, Rawcliffe, P, Morton, J A, Jewell, D P, McGee, J O
Gastric function and histology in chronic renal failure.
Mitchell, C J, Jewell, D P, Lewin, M R, McLaughlin, J E, Moorhead, J F
Gastric function and histology were investigated in 24 patients with untreated chronic renal failure. At endoscopy nine patients had oesophagitis, 12 patients were considered to have gastritis, and...
Monocytes in inflammatory bowel disease: absolute monocyte counts.
Mee, A S, Berney, J, Jewell, D P
Using a cytochemical staining technique, peripheral blood monocytes have been precisely identified and enumerated in patients with inflammatory bowel disease and compared with healthy and disease...
Monocytes in inflammatory bowel disease: phagocytosis and intracellular killing.
Mee, A S, Szawatakowski, M, Jewell, D P
The ability of peripheral blood monocytes from patients with ulcerative colitis and Crohn's disease to phagocytose and kill a standard strain of Staphyloccus aureus has been studied. Using...
Primary Sclerosing Cholangitis—An Immunologically Mediated Disease?
Chapman, R. W. G., Jewell, D. P.
Primary sclerosing cholangitis (PSC) is an uncommon, chronic disorder characterized by inflammatory fibrosis usually involving the entire biliary tree. The etiology has been unknown, but PSC is...
Olsalazine in active ulcerative colitis.
Selby, W S, Barr, G D, Ireland, A, Mason, C H, Jewell, D P
Olsalazine (azodisalicylate) is a new drug in which two molecules of 5-aminosalicylic acid are linked by an azo bond. Its role in the treatment of mildly active, distal ulcerative colitis was...
Azathioprine in Ulcerative Colitis: Final Report on Controlled Therapeutic Trial
Jewell, D. P., Truelove, S. C.
Eighty patients, all of whom were suffering from a frank clinical attack of ulcerative colitis, were admitted to the trial. The attack was treated with a standard course of corticosteroids and the...
Zimmerman, M J, Radford-Smith, G R, Jewell, D P
The aim of this study was to assess whether interleukin-10 (IL-10) and/or transforming growth factor beta-1 (TGFbeta1) downregulate HLA-DR expression using the HT29 cell line as a model of colonic...
Azathioprine in Ulcerative Colitis: An Interim Report on a Controlled Therapeutic Trial
Jewell, D. P., Truelove, S. C.
This interim report on a controlled therapeutic trial of azathioprine in ulcerative colitis deals with the first 40 patients to complete a one-year period of maintenance treatment with azathioprine...
Mahida, Y R, Wu, K C, Jewell, D P
Antigen-presenting activity in mononuclear cells, isolated from normal and inflamed human ileum and colon, has been characterized using allogeneic mixed lymphocyte reaction with resting T cells as...
Factors affecting the spontaneous cell-mediated cytotoxicity of intestinal mononuclear cells.
Gibson, P R, Hermanowicz, A, Jewell, D P
This study was performed to determine what factors related to the enzymatic isolation technique and assay conditions may influence the measurement of spontaneous cell-mediated cytotoxicity (SCMC) of...
Altered expression of mucins throughout the colon in ulcerative colitis.
Smithson, J E, Campbell, A, Andrews, J M, Milton, J D, Pigott, R, Jewell, D P
BACKGROUND/AIMS: Regional differences in the biology of the colonic epithelium may determine the extent of involvement by ulcerative colitis. Novel monoclonal antibodies (MAbs) were used in this...
Lowes, J R, Radwan, P, Priddle, J D, Jewell, D P
Epithelial histocompatibility locus antigen (HLA) class II expression was studied to evaluate its induction by mucosal mononuclear cells in inflammatory bowel disease and to characterise the...
Dalton, H R, Hoang, P, Jewell, D P
Using an autologous system, suppressor cell function to a range of mycobacterial antigens and Kunin antigen of peripheral blood mononuclear cells and lamina propria lymphocytes has been investigated...
Production of epithelial cell growth factors by lamina propria mononuclear cells.
Lowes, J R, Priddle, J D, Jewell, D P
The effects of lamina propria mononuclear cell culture supernatant on epithelial cell DNA synthesis were studied using cells isolated from patients with inflammatory bowel disease and normal...
Crotty, B, Hoang, P, Dalton, H R, Jewell, D P
Colonic epithelial cells express HLA-DR in inflammatory bowel disease. The effect of drugs used in the treatment of inflammatory bowel disease and colchicine on interferon-gamma (IFN-gamma) induced...
Sachdev, G K, Dalton, H R, Hoang, P, DiPaolo, M C, Crotty, B, Jewell, D P
Human colonic intraepithelial lymphocytes have been shown to suppress the proliferation of autologous lamina propria lymphocytes and allogeneic peripheral blood mononuclear cells. This study has...
Morita, H, Kettlewell, M G, Jewell, D P, Kent, P W
Studies have been made of mucus glycoprotein biosynthesis in different regions of the lower gastrointestinal tract in normal patients and those with ulcerative colitis (UC), active or inactive, by...
Cap polyposis--an unusual cause of diarrhoea.
Campbell, A P, Cobb, C A, Chapman, R W, Kettlewell, M, Hoang, P, Haot, B J, ...
'Cap polyposis' is a poorly recognised condition with distinct clinical, sigmoidoscopic, and pathological features that may be confused with other inflammatory conditions of the large intestine...
Optimum dose of olsalazine for maintaining remission in ulcerative colitis.
Travis, S P, Tysk, C, De Silva, H J, Sandberg-Gertzén, H, Jewell, D P, Järnerot, G
To evaluate the optimum dose of olsalazine for maintaining remission in ulcerative colitis, 198 patients in remission for more than three months were randomly assigned to receive 0.5 g, 1.0 g, or 2.0...
Snook, J A, Kelly, P, Chapman, R W, Jewell, D P
This case report describes the previously undocumented association between fibrolamellar hepatocellular carcinoma and ulcerative colitis complicated by primary sclerosing cholangitis.
Mantzaris, G J, Karagiannis, J A, Priddle, J D, Jewell, D P
The human intestinal adenovirus serotype 12 (Ad12) may be implicated in the pathogenesis of coeliac disease by virtue of immunological cross reactivity between epitopes shared by its early region E1b...
Serum and tissue autoantibodies to colonic epithelium in ulcerative colitis.
Snook, J A, Lowes, J R, Wu, K C, Priddle, J D, Jewell, D P
Sera and colonic tissue-bound immunoglobulin extracts from patients with ulcerative colitis and disease controls were examined immunohistochemically and by killer cell cytotoxicity assay for the...
Senju, M, Wu, K C, Mahida, Y R, Jewell, D P
Using two colour immunofluorescence with fluorescein isothiocyanate and phycoerythrin labelled monoclonal antibodies and multiparameter flow cytometry, we investigated the coexpression of CD4 and CD8...
Flow cytometric analysis of peripheral blood lymphocytes in ulcerative colitis and Crohn's disease.
Senju, M, Hulstaert, F, Lowder, J, Jewell, D P
Using two colour immunofluorescence with fluorescein isothiocyanate and phycoerythrin labelled monoclonal antibodies, multi-parameter flow cytometry was used to examine the antigenic characteristics...
Mucosal characteristics of pelvic ileal pouches.
De Silva, H J, Millard, P R, Kettlewell, M, Mortensen, N J, Prince, C, Jewell, D P
This study aimed to investigate the degree of colonic metaplasia in ileo - anal pouches. Biopsy specimens from 25 patients with functioning pouches, eight of whom had pouchitis, were studied using...
Small bowel gas in severe ulcerative colitis.
Chew, C N, Nolan, D J, Jewell, D P
The prognostic significance of excess small bowel gas on a plain abdominal radiograph has been assessed in 75 patients with severe attacks of ulcerative colitis requiring intravenous hydrocortisone....
Oral fluticasone propionate in active distal ulcerative colitis.
Angus, P, Snook, J A, Reid, M, Jewell, D P
Fluticasone propionate is a new corticosteroid with low systemic bioavailability. This study reports the outcome of a double blind clinical trial comparing oral fluticasone propionate (5 mg four...
Lymphocyte and macrophage subpopulations in pelvic ileal pouches.
De Silva, H J, Jones, M, Prince, C, Kettlewell, M, Mortensen, N J, Jewell, D P
This study aimed to characterise the mucosal cellular infiltrate in ileal reservoirs with and without pouchitis (reservoir ileitis). Intraepithelial lymphocyte counts were performed in biopsy...
Effects of the faecal stream and stasis on the ileal pouch mucosa.
De Silva, H J, Millard, P R, Soper, N, Kettlewell, M, Mortensen, N, Jewell, D P
This study aimed to investigate the effects of the faecal stream and stasis on the mucosa of ileal pouches. Nine patients were followed up. Two pouch biopsy specimens were obtained from each at the...
O'Donnell, L J, Arvind, A S, Hoang, P, Cameron, D, Talbot, I C, Jewell, D P, ...
Corticosteroid or 5-aminosalicylic acid enemas are the treatment of choice for distal ulcerative colitis but up to one third of patients may be unresponsive. As an alternative therapy might be...
Hoang, P, Crotty, B, Dalton, H R, Jewell, D P
HLA-DR+ gut epithelial cells may present antigen to intraepithelial lymphocytes (IEL). This study aimed to isolate an IEL population from the human colon to activate CD3 + IEL by a human colonic...
Detection of mRNAs for macrophage products in inflammatory bowel disease by in situ hybridisation.
Cappello, M, Keshav, S, Prince, C, Jewell, D P, Gordon, S
In situ hybridisation has been used to detect mRNAs to the macrophage secretory products, lysozyme, interleukin 1 beta and tumour necrosis factor-alpha. Sections of paraformaldehyde fixed, frozen...
Changing pattern of gastric cancer in Oxfordshire.
Rios-Castellanos, E, Sitas, F, Shepherd, N A, Jewell, D P
This study compares the incidence rates of histologically confirmed gastric carcinoma in Oxfordshire in two five year periods (1960-64, 1984-88). Data were available for 215 patients in the first...
Ireland, A, Priddle, J D, Jewell, D P
Isolated human colonic epithelial cell suspensions were incubated with either 0.1 mM 5-aminosalicylic acid (5-ASA) or 0.1 mM acetylaminosalicylic acid (Ac-ASA) for up to two hours. Intra- and...
Crotty, B, Rosenberg, W M, Aronson, J K, Jewell, D P
5-Aminosalicylic acid (5ASA), 4ASA, their N-acetylated metabolites N-acetyl-5ASA and N-acetyl-4ASA, olsalazine, and colchicine impair interferon-gamma (IFN gamma) induced HLA-DR expression on a...
Pelvic and perineal complications of Crohn's disease: assessment using magnetic resonance imaging.
Haggett, P J, Moore, N R, Shearman, J D, Travis, S P, Jewell, D P, Mortensen, N J
This study evaluated the role of magnetic resonance imaging (MRI) in the demonstration of the pelvic and perianal complications of Crohn's disease. Twenty five patients with active Crohn's disease...
HIV associated cytomegalovirus colitis as a mimic of inflammatory bowel disease.
Roskell, D E, Hyde, G M, Campbell, A P, Jewell, D P, Gray, W
Cytomegalovirus (CMV) colitis may cause symptoms and signs identical to those of idiopathic inflammatory bowel disease. Although difficult to diagnose with certainty, the histological finding of...
5-Aminosalicylic acid inhibits the impaired epithelial barrier function induced by gamma interferon.
Di Paolo, M C, Merrett, M N, Crotty, B, Jewell, D P
Gamma interferon (IFN gamma) impairs epithelial barrier function and induces HLA-DR expression on colonic cancer cell lines. Salicylates have been shown to reduce IFN gamma induced HLA-DR expression....
Lee, F I, Jewell, D P, Mani, V, Keighley, M R, Kingston, R D, Record, C O, ...
Distal ulcerative colitis can be treated with oral or rectal mesalazine, or both. A foam enema preparation has been developed and its efficacy investigated. The aim of this study was to evaluate the...
Samarasekera, D N, Stebbing, J F, Kettlewell, M G, Jewell, D P, Mortensen, N J
BACKGROUND--An increasing number of patients with severe or refractory ulcerative colitis involving only the rectum and sigmoid colon are being offered restorative proctocolectomy with ileal...
Clinical patterns of familial inflammatory bowel disease.
Satsangi, J, Grootscholten, C, Holt, H, Jewell, D P
BACKGROUND--Although many recent studies have shown the increased risk of inflammatory bowel disease in relatives of patients with Crohn's disease and ulcerative colitis, clinical patterns of disease...
Predicting outcome in severe ulcerative colitis.
Travis, S P, Farrant, J M, Ricketts, C, Nolan, D J, Mortensen, N M, Kettlewell, M G, ...
BACKGROUND: Simple criteria are needed to predict which patients with severe ulcerative colitis will respond poorly to intensive medical treatment and require colectomy. AIMS: To find out if the...
Intestinal permeability in the ileal pouch.
Merrett, M N, Soper, N, Mortensen, N, Jewell, D P
BACKGROUND: Villous atrophy, mucin changes ('colonic metaplasia'), and chronic inflammation occur to varying degrees in all patients with ileal pouchanal anastomosis whereas acute inflammation...
Pigbel-like syndrome in a vegetarian in Oxford.
Farrant, J M, Traill, Z, Conlon, C, Warren, B, Mortensen, N, Gleeson, F V, ...
Enterocolitis necroticans or pigbel is a rare condition characteristically affecting chronically malnourished people who abruptly increase their intake of protein. The classic presentation of the...
Jewell, D P, Katiyar, V N, Rees, C, Taylor, K B, Wright, J P
A method is described for the isolation of parietal cells from the gastric mucosa of the guinea pig by enzymatic digestion with collagenase. A suspension was obtained that contained 70-80% parietal...
Humoral immune system in inflammatory bowel disease: I. Complement levels.
Hodgson, H J, Potter, B J, Jewell, D P
Serum levels of complement components Clq, C4, C3, and Properdin factor B, from the classical and alternative pathways of complement activation, have been estimated in patients with ulcerative...
Selective IgA deficiency and Crohn's disease: report of two cases.
Two patients are described with Crohn's disease and selective IgA deficiency. Serum IgA was undetectable in each case, and immunoperoxidase studies of the lamina propria showed a gross diminution of...
Immune-complex mediated colitis in rabbits. An experimental model.
Hodgson, H J, Potter, B J, Skinner, J, Jewell, D P
An experimental colitis in rabbits is described, following the intravenous injection of preformed immune complexes of human serum albumin (HSA) and anti-HSA into non-sensitised rabbits. Tissue damage...
Reaginic hypersensitivity in ulcerative colitis
Jewell, D. P., Truelove, S. C.
Reaginic hypersensitivity in ulcerative colitis has been investigated in respect of a hypersensitivity to the cow's milk proteins and the frequency of atopic asthma, hay fever, and eczema....
Circulating antibodies to cow's milk proteins in ulcerative colitis
Jewell, D. P., Truelove, S. C.
Sera from patients with ulcerative colitis (51), Crohn's disease (30), hypolactasia (13), untreated adult coeliac disease (11), irritable colon syndrome (24), and sera from 38 healthy control...
Clq metabolism in ulcerative colitis and Crohn's disease.
Potter, B J, Hodgson, H J, Mee, A S, Jewell, D P
The metabolism of pure radioiodine labelled Clq has been observed in five patients with ulcerative colitis, five patients with Crohn's disease, and in five control subjects. Both the fractional...
Chronic immune colitis in rabbits.
Mee, A S, McLaughlin, J E, Hodgson, H J, Jewell, D P
A chronic colitis has been induced in rabbits having many of the histological features of human ulcerative colitis. Animals were first immunised with the common enterobacterial antigen of Kunin and...
Complement inhibitors and immunoconglutinins in ulcerative colitis and Crohn's disease.
Potter, B J, Brown, D J, Watson, A, Jewell, D P
The serum concentrations of the complement inactivators C1INH, C3bINA and beta 1H have been determined in patients with ulcerative colitis and Crohn's disease and their correlation with C3 and...
Selby, W S, Janossy, G, Jewell, D P
Intraepithelial lymphocytes (IEL) of the normal human stomach, small intestine, and large intestine have been characterised in tissue sections by a double marker immunofluorescent technique. A panel...
Rhodes, J M, McLaughlin, J E, Brown, D J, Nuttall, L A, Jewell, D P
The inhibitory effects of hydroxychloroquine on leucocyte motility have been compared with those of prednisolone. It has been shown to have similar potency to prednisolone as an inhibitor of human...
Motility of neutrophils and monocytes in Crohn's disease and ulcerative colitis.
Random motility and chemotaxis of peripheral blood neutrophils and monocytes from patients with Crohn's disease and ulcerative colitis have been measured using a modified Boyden Chamber filter assay....
Subcellular localisation of vitamin B12 during absorption in the guinea-pig ileum.
Jenkins, W J, Empson, R, Jewell, D P, Taylor, K B
The subcellular distribution of vitamin B12 was studied during its absorption in the guinea-pig ileum. Animals were fed either (57Co) or (58Co) cyanocobalamin and killed two or four hours later. At...
Inhibition of leucocyte motility by drugs used in ulcerative colitis.
Rhodes, J M, Bartholomew, T C, Jewell, D P
The effects on leucocyte motility of sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5 amino-salicylic acid have been compared with those of prednisolone and indomethacin....
In vitro model for the assessment of luminal factors on rectal mucosa.
An organ culture method for the maintenance of rectal biopsies over a period of 24 hours is described. Good preservation of histological architecture and continued crypt cell proliferation were shown...
T lymphocyte subsets in inflammatory bowel disease: peripheral blood.
Peripheral blood T lymphocytes and T lymphocyte subsets have been quantified in 28 patients with ulcerative colitis and 26 with Crohn's disease by an indirect immunofluorescence technique using...
Harper, P H, Truelove, S C, Lee, E C, Kettlewell, M G, Jewell, D P
The clinical course of 140 patients who have had a split ileostomy for ulcerative colitis or colonic Crohn's disease over a 20 year period is reported. In 37 patients with ulcerative colitis there...
Selby, W S, Janossy, G, Bofill, M, Jewell, D P
Lymphocyte subpopulations in the intestinal mucosa of patients with ulcerative colitis or Crohn's disease have been studied using a double marker immunofluorescence technique. Analysis of tissue...
Crohn's disease and pregnancy.
Khosla, R, Willoughby, C P, Jewell, D P
Infertility and the outcome of pregnancy has been examined in 112 married women with Crohn's disease who were below the age of 45 years. Fifty four patients were available for study. The infertility...
Makiyama, K, Bennett, M K, Jewell, D P
The magnified endoscopic appearances of the rectum are described in 12 patients with Crohn's disease with apparent rectal sparing on sigmoidoscopy. Five of them had minor abnormalities on colonoscopy...
Gibson, P R, Hermanowicz, A, Verhaar, H J, Ferguson, D J, Bernal, A L, Jewell, D P
Whether toxic or immunomodulatory factors are released during the collagenase digestion phase of the isolation of mononuclear cells from human intestinal mucosa was investigated by assessing the...
Role of the faecal stream in the maintenance of Crohn's colitis.
Harper, P H, Lee, E C, Kettlewell, M G, Bennett, M K, Jewell, D P
The role of the faecal stream in the maintenance of the inflammation in Crohn's disease has been studied. Small bowel effluent and a sterile ultrafiltrate of it were reintroduced into the...
Effects of olsalazine in the jejunum of the rat.
Mohsen, A Q, Mulvey, D, Priddle, J D, Parsons, D S, Jewell, D P
Olsalazine (ADS) is the azo-linked dimer of 5-aminosalicylic acid (5-ASA). It is of value for the management of patients with ulcerative colitis but may be associated with increasing diarrhoea in a...
Cellular hypersensitivity to gluten derived peptides in coeliac disease.
Guan, R, Rawcliffe, P M, Priddle, J D, Jewell, D P
Wheat gluten derived antigens have been tested for their ability to inhibit the migration of leucocytes from healthy subjects and patients with coeliac disease. Three preparations of a water soluble...
Tumour related inhibition of macrophage chemotaxis in patients with colon cancer.
Hermanowicz, A, Gibson, P R, Jewell, D P
The chemotactic migration in vitro of peripheral blood, intestinal mucosal, and mesenteric lymph node mononuclear cells has been assessed in patients with colorectal carcinoma. Peripheral blood...
Ulcerative colitis and HLA phenotype.
Cottone, M, Bunce, M, Taylor, C J, Ting, A, Jewell, D P
The distribution of HLA A, B, C, DR antigens was investigated in a British population with ulcerative colitis. Fifty six patients were typed for HLA, A, B, C and 46 additionally for DR. No...
Gebbers, J O, Ferguson, D J, Mason, C, Kelly, P, Jewell, D P
In two patients presenting with mild intestinal symptoms, rectal spirochaetosis was the only morphological abnormality diagnosed by light microscopy. A re-evaluation of the morphological changes...
Colonic bacterial proteases to IgA1 and sIgA in patients with ulcerative colitis.
Barr, G D, Hudson, M J, Priddle, J D, Jewell, D P
The colonic faecal and mucosal associated bacterial populations of five patients with ulcerative colitis and four control patients were studied in detail to assess their ability to produce...
Serum autoantibodies, ulcerative colitis and primary sclerosing cholangitis.
Chapman, R W, Cottone, M, Selby, W S, Shepherd, H A, Sherlock, S, Jewell, D P
The aetiology of primary sclerosing cholangitis is unknown, but it is closely associated with ulcerative colitis. Serum anticolon antibodies, crossreacting with portal tracts, have been reported in...
Colorectal cancer in ulcerative colitis: a cohort study of primary referrals from three centres.
Gyde, S N, Prior, P, Allan, R N, Stevens, A, Jewell, D P, Truelove, S C, ...
A retrospective cohort of 823 patients with ulcerative colitis who resided at the time of diagnosis in one of three defined geographical areas (West Midlands region, Oxford region, England and...
Expression of HLA-DR antigens on bile duct epithelium in primary sclerosing cholangitis.
Chapman, R W, Kelly, P M, Heryet, A, Jewell, D P, Fleming, K A
The expression of HLA class I (HLA-A, B, C) and class II (HLA-DR) antigens on the biliary epithelium of 10 patients (nine men) with primary sclerosing cholangitis (PSC) was investigated using an...
Ireland, A, Mason, C H, Jewell, D P
One hundred and sixty four patients with ulcerative colitis in remission were entered into a double blind, double dummy trial comparing olsalazine 500 mg bd and sulphasalazine 1 g bd. Clinical...
Chapman, R W, Selby, W S, Jewell, D P
A prospective double blind controlled trial was undertaken to examine the role of metronidazole as an adjunct to corticosteroids in the management of severe ulcerative colitis. Thirty nine patients...
Mahida, Y R, Wu, K, Jewell, D P
IL1-beta production by mononuclear cells isolated from normal and active inflammatory bowel disease mucosa was studied. Significantly more IL1-beta was produced spontaneously by mononuclear cells...
Macrophage subpopulations in lamina propria of normal and inflamed colon and terminal ileum.
Mahida, Y R, Patel, S, Gionchetti, P, Vaux, D, Jewell, D P
The aim of this study was to characterise human intestinal macrophages in normal and inflamed ileum and colon. Immunoperoxidase staining with a panel of monoclonal antibodies and histochemical...
Food intolerance and the irritable bowel syndrome.
Nanda, R, James, R, Smith, H, Dudley, C R, Jewell, D P
Two hundred patients (156 women) with the irritable bowel syndrome were treated with dietary exclusion for three weeks. Of the 189 who completed this study, 91 (48.2%) showed symptomatic improvement....
Respiratory burst activity of intestinal macrophages in normal and inflammatory bowel disease.
Mahida, Y R, Wu, K C, Jewell, D P
Macrophages isolated from normal mucosa (greater than 5 cm from tumour) and inflamed mucosa (from patients with inflammatory bowel disease) of colon and ileum were studied for their ability to...
The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review
Fraser, A G, Orchard, T R, Jewell, D P
Background: There are limited data on factors predicting response to azathioprine and uncertainty regarding the optimal duration of treatment.
Mitchell, S A, Thyssen, M, Orchard, T R, Jewell, D P, Fleming, K A, Chapman, R W
Background and aims: The strong clinical association between primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) suggests common factors in their pathogenesis. Smoking, previous...
Analysis of the IBD5 locus and potential gene-gene interactions in Crohn’s disease
Negoro, K, McGovern, D P B, Kinouchi, Y, Takahashi, S, Lench, N J, Shimosegawa, T, ...
Background and aims: Genetic variation in the chromosome 5q31 cytokine cluster (IBD5 risk haplotype) has been associated with Crohn’s disease (CD) in a Canadian population. We studied the IBD5 risk...
Mobilisation of enterocyte fat stores by oral glucose in humans
Robertson, M D, Parkes, M, Warren, B F, Ferguson, D J P, Jackson, K G, Jewell, D P, ...
Background and aims: When a high fat oral load is followed several hours later by further ingestion of nutrients, there is an early postprandial peak in plasma triacylglycerol (TG). The aim of this...
Genotype-phenotype analysis of the Crohn’s disease susceptibility haplotype on chromosome 5q31
Armuzzi, A, Ahmad, T, Ling, K-L, De Silva, A, Cullen, S, Van Heel, D, ...
Background and aims: Recent molecular data suggest that genetic factors may underlie the disease heterogeneity observed in both ulcerative colitis (UC) and Crohn’s disease (CD). A locus on...
Fulminant Crohn’s colitis after allogeneic stem cell transplantation
Sonwalkar, S A, James, R M, Ahmad, T, Zhang, L, Verbeke, C S, Barnard, D L, ...
We report a case of fulminant Crohn’s colitis that occurred following non-myeloablative allogeneic stem cell transplantation for Hodgkin’s lymphoma. Adoptive transfer of inflammatory bowel...
Wu, K C, Mahida, Y R, Priddle, J D, Jewell, D P
We studied immunoglobulin production by isolated intestinal mononuclear cells from 25 patients with active inflammatory bowel disease (IBD) and 17 controls undergoing surgical resections for...
Wu, K C, Mahida, Y R, Priddle, J D, Jewell, D P
The effect of macrophages on spontaneous immunoglobulin production by isolated human intestinal mononuclear cells (MNC) is unknown. Depletion of macrophages by adherence to fibronectin or by panning...
Selby, W S, Janossy, G, Bofill, M, Jewell, D P
Lymphocyte subpopulations in human small intestinal mucosa have been studied using an immunofluorescence technique on tissue sections. In the normal intestine, the majority of intraepithelial...
Human colonic intra-epithelial lymphocytes are suppressor cells.
Hoang, P, Dalton, H R, Jewell, D P
Human colonic intra-epithelial lymphocytes (IEL) suppress the proliferation of autologous lamina propria lymphocytes, but not autologous peripheral blood mononuclear cells, when stimulated with...
Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease.
Selby, W S, Janossy, G, Mason, D Y, Jewell, D P
The expression of HLA-DR and HLA-A,B,C antigens by human colonic epithelium has been examined in tissue sections of patients with inflammatory bowel disease using an immunohistological technique....
E rosetting lymphocytes in inflammatory bowel disease. An analysis using monoclonal antibodies.
Makiyama, K, Selby, W S, Jewell, D P
Lymphocytes rosetting with sheep red blood cells (SRBC) have been quantitated in the peripheral blood of patients with ulcerative colitis (UC) or Crohn's disease (CD) and the results compared with...
Gibson, P R, Verhaar, H J, Selby, W S, Jewell, D P
The proportions of T cell subsets and Leu 7+ cells and the spontaneous cell-mediated cytotoxicity (SCMC) of isolated mononuclear cells have been determined across the mesenteric vascular bed and...
Natural killer cells and spontaneous cell-mediated cytotoxicity in the human intestine.
Gibson, P R, Dow, E L, Selby, W S, Strickland, R G, Jewell, D P
Spontaneous cell-mediated cytotoxicity (SCMC) has been investigated in mononuclear cells (MNC) isolated from intestinal mucosa and autologous peripheral blood from human subjects. The proportion of...
The incidence of cold-reactive lymphocytotoxins in the serum of patients with Crohn's disease or ulcerative colitis has been investigated. Twenty-seven percent of patients with Crohn's disease and...
Selby, W S, Janossy, G, Goldstein, G, Jewell, D P
T lymphocytes in the normal human intestinal tract have been analysed in tissue sections by a double-marker immunofluorescence technique, combining antiserum to T lymphocyte antigen (HuTLA) with a...
Mee, A S, Nuttall, L, Potter, B J, Jewell, D P
The effect of endotoxin and immune complexes on monocyte lysosomal enzyme activity has been studied in patients with Crohn's disease and ulcerative colitis. Immune complexes made at equivalence or in...
Campbell, A C, Skinner, J M, Maclennan, I C, Hersey, P, Waller, C A, Wood, J, ...
Blood lymphocytes and rectal plasma cells have been studied in patients with ulcerative colitis taking part in a double-blind trial of treatment with azathioprine. Treatment for 1 year resulted in a...
C3 metabolism in ulcerative colitis and Crohn's disease.
Hodgson, H J, Potter, B J, Jewell, D P
The metabolism of the third component of complement (C3) has been investigated in four patients with ulcerative colitis, three patients with Crohn's disease and seven control subjects, using...
Immune complexes in ulcerative colitis and Crohn's disease.
Hodgson, H J, Potter, B J, Jewell, D P
Sera from 156 patients with ulcerative colitis and Crohn's disease were tested for the presence of immune complexes, by the detection of anti-complementary activity and 125I-labelled Clq...
Immune complexes in acute and chronic liver disease
Thomas, H. C., De Villiers, D., Potter, B., Hodgson, H., Jain, S., Jewell, D. P., ...
Anti-complementary (AC) activity and C1q-binding are increased in acute type A and B hepatitis, alcohol-induced hepatitis, HB surface antigen-positive and -negative chronic active hepatitis and...
Macrophage and lymphocyte subpopulations in magnifying endoscopic lesions of Crohn's disease.
Gionchetti, P, Mahida, Y R, Patel, S, Jewell, D P
Using dye staining and a magnifying colonoscope, small lesions in the rectum of patients with Crohn's disease (which had otherwise appeared normal on sigmoidoscopy) can be detected. Subpopulations of...
Snook, J A, Chapman, R W, Fleming, K, Jewell, D P
We have previously described circulating autoantibodies to a portal tract antigen in patients with primary sclerosing cholangitis. In this study the antigen has been shown by double-labelling studies...
Mahida, Y R, Patel, S, Jewell, D P
Macrophages in sections of human terminal ileal Peyer's patches were studied using a panel of monoclonal antibodies. Germinal centre macrophages were large and strongly positive for acid phosphatase...
Interleukin 2 receptor expression by macrophages in inflammatory bowel disease.
Mahida, Y R, Patel, S, Wu, K, Jewell, D P
The expression of interleukin 2 receptor by macrophages from normal and inflamed terminal ileum and colon has been studied by using two monoclonal antibodies. In tissue sections from normal ileum and...
Bloom, S, Simmons, D, Jewell, D P
Adhesion molecules are involved in facilitating cell-mediated immune events. Because lymphocyte-epithelial cell interaction has been implicated in the pathogenesis of colonic inflammation, we...
Circulating immune complexes in inflammatory bowel disease
Jewell, D. P., MacLennan, I. C. M.
Evidence for circulating immune complexes in sera of patients with ulcerative colitis or Crohn's disease is described. Such sera produced significantly greater inhibition of antibody-induced...
Dalton, H R, Dipaolo, M C, Sachdev, G K, Crotty, B, Hoang, P, Jewell, D P
Human colonic intraepithelial lymphocytes from control subjects down-regulate the proliferative responses of primed allogeneic peripheral blood mononuclear cells on rechallenge with antigens or...
The nature of the natural killer (NK) cell of human intestinal mucosa and mesenteric lymph node.
The relationship of the mononuclear cell (MNC) from human intestinal mucosa and mesenteric lymph node mediating anti-K-562 activity with that of peripheral blood has been assessed. Depletion of...
Orchard, T R, Dhar, A, Simmons, J D, Vaughan, R, Welsh, K I, Jewell, D P
MHC class I chain gene A (MICA) is a non-classical Class I gene which is expressed on the surface of epithelia without β2-microglobulin. The gene is found in the major histocompatibility complex...
The Role of Cytokines in Inflammatory Bowel Disease
Radford-Smith, G., Jewell, D. P.
Cytokines play an important role in the development and persistence of the inflammatory lesions seen in Crohn's disease and ulcerative colitis. This review discusses the current thinking of the role...
Cytokine Production by Human Colonic Intraepithelial Lymphocytes in Controls and Ulcerative Colitis
Hoang, P., Dalton, H. R., De Silv, H. J., Jewell, D. P.
Using an ELISA technique, concentrations of γ-interferon and interleukin-2 were assayed in the supernatants of colonic intraepithelial lymphocytes cultured with or without phytohaemagglutinin (PHA)....
Novel presentation of coeliac disease after following the Atkins’ low carbohydrate diet
Van Heel, D A, Dart, J, Nichols, S, Jewell, D P, Playford, R J
T cells in peripheral blood after gluten challenge in coeliac disease
Anderson, R P, Van Heel, D A, Tye-Din, J A, Barnardo, M, Salio, M, Jewell, D P, ...
Background: Current understanding of T cell epitopes in coeliac disease (CD) largely derives from intestinal T cell clones in vitro. T cell clones allow identification of gluten peptides that...
A 57-year-old man developed symptoms of a respiratory tract infection which was treated with erythromycin BP. He subsequently went into acute liver failure. Investigation of a very prolonged...
Yersinia colitis associated with Crohn's disease.
Treacher, D. F., Jewell, D. P.
A previously healthy patient developed serologically-proven Yersinia pseudotuberculosis enterocolitis and made a complete recovery. Over a year later, further gastrointestinal symptoms developed and...
Ulcerative colitis and sarcoidosis.
Barr, G. D., Shale, D. J., Jewell, D. P.
Ulcerative colitis is not commonly associated with recognizable pulmonary disease and only four sporadic cases of sarcoidosis in association with ulcerative colitis have been previously reported....
Gastrointestinal amyloidosis complicating psoriatic arthropathy
Willoughby, C. P., Banerji, A., Bennett, M. K., Jewell, D. P.
A patient is described who developed gastrointestinal amyloidosis complicating psoriatic arthropathy. The presenting symptom was progressive dysphagia due to oesophageal involvement. Other clinical...
Mahida, Y. R., Chapman, R. W., Jewell, D. P.
Three cases of chronic pancreatitis occurring in patients with small intestinal diverticulosis and bacterial overgrowth are reported. In two of the cases, pancreatic supplements were therapeutically...
Retinal periphlebitis in ulcerative colitis.
Kelly, I. M., Frith, P. A., Hyman, N. M., Jewell, D. P.
A man presented with unilateral visual blurring associated with bilateral retinal periphlebitis which was felt to be a complication of his biopsy-proven active ulcerative colitis. Retinal...
Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn’s disease
Van Heel, D A, Ghosh, S, Hunt, K A, Mathew, C G, Forbes, A, Jewell, D P, ...
Background: Nucleotide binding oligomerisation domain 2 (NOD2; also known as CARD15) mutations are associated with Crohn’s disease but how mutations cause disease is poorly understood. Innate...