D. Passarella

Inhibitors of tubulin polymerization: Synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III (2008)

Passarella, D., Giardini, A., Peretto, B., Fontana, G., Sacchetti, A., Silvani, A., ...

A series of novel hybrid compounds obtained by the attachment of anhydrovinblastine, vinorelbine, and vindoline to thiocolchicine, podophyllotoxin, and baccatin III are described. Two types of diacyl...

Hybrids and dynamic libraries of natural products for the discovery of new anticancer compounds (2007)

PASSARELLA, DANIELE, D. Passarella

Hybrids and dynamic libraries of natural products for the discovery of new anticancer compounds / D. Passarella. - 2007. ((Intervento presentato al 6. Simposio Internacional de Quimica de Productos...

Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids (2004)

Danieli, B, Giardini, A, Lesma, G, Passarella, D, Silvani, A, Appendino, G, ...

The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but,...