Partial inversion for linear systems and partial closure of independence graphs (2009)
N. Wermuth, M. Wiedenbeck, D. R. Cox
We introduce and study a calculus for real-valued square matrices, called partial inversion, and an associated calculus for binary square matrices. The first, applied to systems of recursive linear...
On an internal method for deriving a summary measure (2008)
Some preliminary comments are made about the reasons for combining component observations into composite or derived variables. A method for forming derived variables sensitive to specified changes in...
On the consequences of overstratification (2008)
It is common, in particular in observational studies in epidemiology, to impose stratification to adjust for possible effects of age and other variables on the binary outcome of interest....
Undetected confounding may severely distort the effect of an explanatory variable on a response variable, as defined by a stepwise data-generating process. The best known type of distortion, which we...
Interpretation of interaction: A review (2007)
De González, Amy Berrington, Cox, D. R.
Several different types of statistical interaction are defined and distinguished, primarily on the basis of the nature of the factors defining the interaction. Illustrative examples, mostly...
[41] D. Slonim. Learning from Imperfect Data in Theory and Practice. PhD thesis, MIT, (2007)
W. H. Press, B. P. Flannery, S. A. Teukolsky, W. T. Vetterling, Numerical Recipes, D. Slonim, ...
[40] L. Rabiner. A tutorial on hidden markov models and selected applications in speech
On a generalization of a result of W. G. Cochran (2007)
A relationship due to W.G. Cochran showing the effect on least squares regression coefficients of marginalizing over or conditioning on an explanatory variable is generalized to quantile regression...
Applied statistics: A review (2007)
The main phases of applied statistical work are discussed in general terms. The account starts with the clarification of objectives and proceeds through study design, measurement and analysis to...
A genomewide admixture map for latino populations (2007)
Price, A.L., Patterson, N., Yu, F., Cox, D.R., Waliszewska, A., McDonald, G.J., ...
Admixture mapping is an economical and powerful approach for localizing disease genes in populations of recently mixed ancestry and has proven successful in African Americans. The method holds equal...
Frequentist statistics as a theory of inductive inference (2006)
After some general remarks about the interrelation between philosophical and statistical thinking, the discussion centres largely on significance tests. These are defined as the calculation of...
Wermuth, Nanny, Cox, D. R., Manchetti, Giovanni M.
Covariance matrices which can be arranged in tridiagonal form are called covariance chains. They are used to clarify some issues of parameter equivalence and of independence equivalence for linear...
Multiple randomizations - discussion on the paper by Brien and Bailey (2006)
Cox, D.R., Butler, N.A., Freeman, G.H, Preece, D.A., Lewis, S.M., Payne, R., ...
Nanny Wermuth, D. R. Cox, Giovanni M. Marchetti
Covariance matrices which can be arranged in tridiagonal form are called covariance chains. They are used to clarify some issues of parameter equivalence and of independence equivalence for linear...
Representation of space–time variability of soil moisture (2005)
Isham, V., Cox, D.R., Rodrguez-Iturbe, I., Porporato, A., Manfreda, S.
A simplified spatial-temporal soil moisture model driven by stochastic spatial rainfall forcing is proposed. The model is mathematically tractable, and allows the spatial and temporal structure of...
Johnston, W.T., Gettinby, G., Cox, D.R., Donnelly, C.A., Bourne, J., Clifton-Hadley, R., ...
A case–control study of the factors associated with the risk of a bovine tuberculosis (TB) breakdown in cattle herds was undertaken within the randomized badger culling trial (RBCT). TB breakdowns...
Johnston, W.T., Gettinby, G., Cox, D.R., Donnelly, C.A., Bourne, J., Clifton-Hadley, R., ...
A case-control study of the factors associated with the risk of a bovine tuberculosis (TB) breakdown in cattle herds was undertaken within the randomized badger culling trial (RBCT). TB breakdowns...
Johnston, W.T., Gettinby, G., Cox, D.R., Donnelly, C.A., Bourne, J., Clifton-Hadley, R., ...
A case-control study of the factors associated with the risk of a bovine tuberculosis (TB) breakdown in cattle herds was undertaken within the randomized badger culling trial (RBCT). TB breakdowns...
AN ANALYSIS OF TRANSFORMATIONS. (2005)
In the analysis of data it is often assumed that observations y1, y2, . . . , y sub n are independently normally distributed with constant variance and with expectations specified by a model linear...
Additive and multiplicative models for the joint effect of two risk factors (2005)
Simple tests are given for consistency of the data with additive and with multiplicative effects of two risk factors on a binary outcome. A combination of the procedures will show whether data are...
Methods for Estimating the Case Fatality Ratio for a Novel, Emerging Infectious Disease (2005)
Ghani, A. C., Donnelly, C. A., Cox, D. R., Griffin, J. T., Fraser, C., Lam, T. H., ...
During the course of an epidemic of a potentially fatal disease, it is important that the case fatality ratio be well estimated. The authors propose a novel method for doing so based on the...
On the relation between initial value and slope (2005)
Suppose measurements of a particular feature are collected at baseline and at a number of subsequent time points and that for each individual there is a roughly linear trend in time. This paper takes...
Methods for Estimating the Case Fatality Ratio for a Novel, Emerging Infectious Disease (2005)
Ghani, A. C., Donnelly, C. A., Cox, D. R., Griffin, J. T., Fraser, C., Lam, T. H., ...
During the course of an epidemic of a potentially fatal disease, it is important that the case fatality ratio be well estimated. The authors propose a novel method for doing so based on the...
Methods for Estimating the Case Fatality Ratio for a Novel, Emerging Infectious Disease (2005)
Ghani, A. C., Donnelly, C. A., Cox, D. R., Griffin, J. T., Fraser, C., Lam, T. H., ...
During the course of an epidemic of a potentially fatal disease, it is important that the case fatality ratio be well estimated. The authors propose a novel method for doing so based on the...
Causality: a Statistical View (2004)
Statistical aspects of causality are reviewed in simple form and the impact of recent work discussed. Three distinct notions of causality are set out and implications for densities and for linear...
A note on pseudolikelihood constructed from marginal densities (2004)
For likelihood‐based inference involving distributions in which high‐dimensional dependencies are present it may be useful to use approximate likelihoods based, for example, on the...
Impact of localized badger culling on tuberculosis incidence in British cattle (2003)
Donnelly, Christl A, Woodroffe, Rosie, Cox, D R, Bourne, John, Gettinby, George, Le Fevre, Andrea M, ...
Pathogens that are transmitted between wildlife, livestock and humans present major challenges for the protection of human and animal health, the economic sustainability of agriculture, and the...
Impact of localized badger culling on tuberculosis incidence in British cattle (2003)
Donnelly, Christl A, Woodroffe, Rosie, Cox, D R, Bourne, John, Gettinby, George, Le Fevre, Andrea M, ...
Pathogens that are transmitted between wildlife, livestock and humans present major challenges for the protection of human and animal health, the economic sustainability of agriculture, and the...
Impact of localized badger culling on tuberculosis incidence in British cattle (2003)
Donnelly, Christl, Woodroffe, Rosie, Cox, D.R., Bourne, John, Gettinby, George, Le Fevre, Andrea, ...
Pathogens that are transmitted between wildlife, livestock and humans present major challenges for the protection of human and animal health, the economic sustainability of agriculture, and the...
Impact of localized badger culling on tuberculosis incidence in British cattle (2003)
Donnelly, Christl, Woodroffe, Rosie, Cox, D.R., Bourne, John, Gettinby, George, Le Fevre, Andrea, ...
Pathogens that are transmitted between wildlife, livestock and humans present major challenges for the protection of human and animal health, the economic sustainability of agriculture, and the...
Impact of localized badger culling on tuberculosis incidence in British cattle (2003)
Donnelly, Christl, Woodroffe, Rosie, Cox, D.R., Bourne, John, Gettinby, George, Le Fevre, Andrea, ...
Pathogens that are transmitted between wildlife, livestock and humans present major challenges for the protection of human and animal health, the economic sustainability of agriculture, and the...
Reflections on Fourteen Cryptic Issues Concerning the Nature of Statistical Inference (2003)
Salomé, D., Schaafsma, W., Steerneman, A. G. M., Willems, J. C., Cox, D. R.
The present paper provides the original formulation and a joint response of a group of statistically trained scientists statisticians to fourteen cryptic issues for discussion, which were handed out...
Generalized least squares for the synthesis of correlated information (2003)
This paper deals with the synthesis of information from different studies when there is lack of independence in some of the contrasts to be combined. This problem can arise in several different...
Reflections on fourteen cryptic issues concerning the nature of statistical inference (2003)
Salome,D., Schaafsma,W., Steerneman,A. G. M., Willems,J. C., Cox,D. R.
The present paper provides the original formulation and a joint response of a group of statistically trained scientists to fourteen cryptic issues for discussion, which were handed out to the public...
Reflections on fourteen cryptic issues concerning the nature of statistical inference (2003)
Salome, D., Schaafsma, W., Steerneman, A. G. M., Willems, J. C., Cox, D. R.
The present paper provides the original formulation and a joint response of a group of statistically trained scientists to fourteen cryptic issues for discussion, which were handed out to the public...
The Oxford Dictionary of Statistical Terms (2003)
Cox, D. R., Commenges, D., Davison, A. C., Solomon, P. J., Wilson, S. R., Dodge, Y.
Optimal dynamic treatment regimes - Discussion on the paper by Murphy (2003)
Arjas, E., Jennison, C., Dawid, A. P., Cox, D. R., Cowell, R. G., Didelez, V., ...
Floods: some probabilistic and statistical approaches (2002)
Cox, D.R., Isham, V.S., Northrop, P.J.
Some of the many statistical aspects of floods are discussed and some new results are given on a number of features. The probability theory of extreme values is briefly reviewed and its potential for...
An Analysis of Transformations Revisited, Rebutted. (2002)
In a paper written in 1964, Box and Cox described a method for estimating transformations and showed how in suitable cases valuable increases in simplicity and efficiency were possible. Since that...
It is shown that both the simple form of the Rasch model for binary data and a generalisation are essentially equivalent to special dichotomised Gaussian models. In these the underlying Gaussian...
Estimation in a simple random effects model with nonnormal distributions (2002)
A simple structural model is considered involving the addition of two random variables representing between‐ and within‐group variation. Methods for estimating the cumulants of the two...
Law, G. R., Cox, D. R., Machonochie, N. E. S., Simpson, J., Roman, E., Carpenter, L. M.
The traditional exploration of large contingency tables leads to multiple comparisons with the inherent generation of chance associations. To allow for this, a simple empirical Bayesian approach is...
Some Statistical Aspects of Causality (2001)
A general review of approaches to causality is given from a statistical perspective. Three broad notions are distinguished. In the final part of the paper the challenges of reaching potentially...
Integration of cytogenetic landmarks into the draft sequence of the human genome (2001)
Cheung, V. G., Nowak, N., Jang, W., Kirsch, I. R., Zhao, S., Chen, X., ...
© 2001 Nature Publishing Group
Epidemiological evidence for the risk of cancer from diagnostic x-rays / (2001)
Darby, Sarah., Cox, D. R. (David Roxbee)
University supervisor: Sarah Darby; college supervisor: David Cox.
Integration of cytogenetic landmarks into the draft sequence of the human genome (2001)
Cheung, V. G., Nowak, N., Jang, W., Kirsch, I. R., Zhao, S., Chen, X., ...
© 2001 Nature Publishing Group
Law, G. R., Cox, D. R., Machonochie, N. E. S., Simpson, J., Roman, E., Carpenter, L. M.
The traditional exploration of large contingency tables leads to multiple comparisons with the inherent generation of chance associations. To allow for this, a simple empirical Bayesian approach is...
Some Statistical Aspects of Causality (2001)
A general review of approaches to causality is given from a statistical perspective. Three broad notions are distinguished. In the final part of the paper the challenges of reaching potentially...
Biometrika: The first 100 years (2001)
A broad sketch is given of the origins of Biometrika, of the contents of the early volumes and of the progression of the journal over the century.
Design of the HYREX raingauge network (2000)
R. J. Moore, D. A. Jones, D. R. Cox, V. S. Isham
Dense raingauge experiments in the past have experienced difficulties in the automated recording of rainfall amount and timing which with the benefit of modern instrument technology are now less...
Spatial-temporal rainfall fields: modelling and statistical aspects (2000)
H. S. Wheater, V. S. Isham, D. R. Cox, R. E. Chandler, A. Kakou, P. J. Northrop, ...
The HYREX experiment has provided a data set unique in the UK, with a dense network of raingauges available for studying the rainfall at a fine local scale and a network of radar stations allowing...
Spatial-temporal rainfall fields: modelling and statistical aspects (2000)
Wheater, H. S., Isham, V. S., Cox, D. R., Chandler, R. E., Kakou, A., Northrop, P. J., ...
The HYREX experiment has provided a data set unique in the UK, with a dense network of raingauges available for studying the rainfall at a fine local scale and a network of radar stations allowing...
Design of the HYREX raingauge network (2000)
Moore, R. J., Jones, D. A., Cox, D. R., Isham, V. S.
Dense raingauge experiments in the past have experienced difficulties in the automated recording of rainfall amount and timing which with the benefit of modern instrument technology are now less...
Spatial-temporal rainfall fields: modelling and statistical aspects (2000)
Wheater, H. S., Isham, V. S., Cox, D. R., Chandler, R. E., Kakou, A., Northrop, P. J., ...
The HYREX experiment has provided a data set unique in the UK, with a dense network of raingauges available for studying the rainfall at a fine local scale and a network of radar stations allowing...
Design of the HYREX raingauge network (2000)
Moore, R. J., Jones, D. A., Cox, D. R., Isham, V. S.
Dense raingauge experiments in the past have experienced difficulties in the automated recording of rainfall amount and timing which with the benefit of modern instrument technology are now less...
A note on the quadratic exponential binary distribution (1994)
The joint distribution of p binary variables is studied in the quadratic exponential form containing only ‘main effects’ and ‘two-factor interactions’ in the log probabilities. Approximate...
Unbiased estimating equations derived from statistics that are functions of a parameter (1993)
The formation of a combination of the observed random variables and a parameter of interest ψ having a distribution depending only on ψ provides one approach to the analysis of problems with many...
A note on the difference between profile and modified profile likelihood (1992)
The difference between profile likelihood and modified profile likelihood depends primarily on the expected value of a certain third order derivative of the log likelihood. It is shown that in...
Nonlinear component of variance models (1992)
General aspects of nonlinearity in the context of component of variance models are discussed, and two special topics are examined in detail. Firstly, simple procedures, both formal and informal, are...
An approximation to maximum likelihood estimates in reduced models (1990)
An approximation to the maximum likelihood estimates of the parameters in a model can be obtained from the corresponding estimates and information matrices in an extended model, i.e. a model with...
Dinucleotide repeat polymorphism located at D21S120 (1990)
Burmeister, M., Cox, D.R., Myers, R.M.
The name of the first author was misspelled during production of this article. The corrected spelling appears above.
A time series illustration of approximate conditional likelihood (1989)
CRUDDAS, A. M., REID, N., COX, D. R.
We consider the calculation of confidence intervals for the correlation parameter, based on observations of a large number of short Gaussian first-order autoregressive processes with different means...
On testing for serial correlation in large numbers of small samples (1988)
Methods are outlined for testing for serial correlation in large numbers of small samples, emphasis being placed on samples of size three. Some data on pulse rates are analysed in illustration.
A note on design when response has an exponential family distribution (1988)
Some simple design problems are considered when responses have an exponential family distribution with the difference between ‘treatment’ groups in the canonical parameter being the objective of...
Analysis of variability with large numbers of small samples (1986)
Procedures are discussed for the detailed analysis of distributional form, based on many samples of size r, where especially r =2, 3, 4. The possibility of discriminating between different...
Effective degrees of freedom and the likelihood ratio test (1984)
Normal-theory problems involving several unknown variances may require use of estimates not having simple chi-squared distributions. Confidence intervals are then commonly based on the use of...
Asymptotic theory: some recent developments (1983)
A review is given of recent work on asymptotic theory leading to a recommendation to use ratio likelihood rests with, where available, a Bartlett adjustment factor.
Asymptotic theory: some recent developments (1983)
A review is given of recent work on asymptotic theory leading to a recommendation to use ratio likelihood rests with, where available, a Bartlett adjustment factor.
Asymptotic theory: some recent developments (1983)
A review is given of recent work on asymptotic theory leading to a recommendation to use ratio likelihood rests with, where available, a Bartlett adjustment factor
Some remarks on overdispersion (1983)
It is shown that maximum likelihood estimation of a simple model retains high efficiency in the presence of modest amounts of overdispersion. The main requirement is that the target parameter should...
On the role of data of possibly lowered sensitivity (1982)
Data are available to examine some phenomenon and there is the possibility of further data in which, however, the effect under study may have reduced magnitude. The testing of a null hypothesis of...
Non-Bayesian inference is considered for a scalar unknown parameter. When the minimal sufficient statistic is of dimension greater than one and no suitable exactly ancillary statistic is available,...
On sampling and the estimation of rare errors (1979)
For each individual in a finite population a recorded value is available. A small proportion of the values is in error, all the errors being of the same sign and the maximum fractional error being...
A note on the graphical analysis of survival data (1979)
Two graphical procedures for analysing distributions of survival time are compared. One works with the survivor function, or with the order statistics, and the other is based on estimates of log...
Testing multivariate normality (1978)
Previous work on testing multivariate normality is reviewed. Coordinate-dependent and invariant procedures are distinguished. The arguments for concentrating on tests of linearity of regression are...
Robust regression via discriminant analysis (1977)
For linear regression with grouped data, and with an equal number of observations per grouping point, linear discriminant analysis is applied to the ordered response variables to find that...
A definition is given of partial likelihood generalizing the ideas of conditional and marginal likelihood. Applications include life tables and inference in stochastic processes. It is shown that the...
A note on data-splitting for the evaluation of significance levels (1975)
It has sometimes been suggested that to overcome difficulties arising in significance tests when the effects tested are selected in the light of the data, the data should be split randomly into two...
A note on partially Bayes inference and the linear model (1975)
Some results are outlined for estimation in a replicated linear model in which the variance changes from cell to cell in accordance with an inverse gamma prior density. The primary parameters of the...
A note on empirical Bayes inference in a finite Poisson process (1975)
A Poisson process of events is considered which terminates after a random time. Termination is not direotly observable but has to be inferred from the nonoccurrence of events. The analysis of data...
Some optimal designs for interpolation and extrapolation (1972)
HERZBERG, AGNES M., COX, D. R.
Designs are given for minimizing the effect of random error in interpolation or extrapolation. The case most intensively studied is that for first-degree polynomial models in k factors, although some...
On test statistics calculated from residuals (1971)
In an earlier paper the authors gave a general definition of residuals and derived some asymptotic properties. In the present paper the results are extended to study test statistics computed from...
A note on polynomial response functions for mixtures (1971)
An alternative is given to the canonical polynomials of Scheff� for experiments with mixtures. The object is to obtain individual parameters with an interpretation closer to that of parameters in...
The continuity correction (1970)
An elementary analytical derivation of the continuity correction is outlined.
Fieller's theorem and a generalization (1967)
The relation is discussed between Fieller's theorem for a ratio of normal means and the conditional distributions used to obtain similar regions in the Neyman-Pearson theory of testing hypotheses....
Discrimination between alternative binary response models (1967)
CHAMBERS, ELIZABETH A., COX, D. R.
The logistic and integrated normal binary response curves are known to agree closely except in the tails. For experiments based on three dose levels the power of a signifacance test is found for the...
‘The null distribution of the first serial correlation coefficient’ by D. R. Cox Professor P. A. P. Moran, by comparing his theoretical results (see pp. 395–401 of the present issue) with the...
The null distribution of the first serial correlation coefficient (1966)
The null sampling distribution of the first serial correlation coefficient for random samples from populations of various shepes has been investigated by experimental sampling. The sampling...
A simple example of a comparison involving quanta* (1966)
An example is given of the comparison of two matched groups of observation the response is quantal. Alternative methods of analysis are sketched. Un model, the theoretically appropriate procedure is...
ON THE SUPERPOSITION OF RENEWAL PROCESSES (1954)
Suppose that there are a number of independent sources at each of which events occur from time to time. The intervals between successive events at any one source are assumed to be independant random...
THE MEAN AND COEFFICIENT OF VARIATION OF RANGE IN SMALL SAMPLES FROM NON-NORMAL POPULATIONS (1954)
By examining special populations, a, table is obtained for predicting approximately the mean and coefficient of variation of the range of random samples of n (nβ 5), drawn from a population of...
Derived variables for longitudinal studies
Suppose that for each individual a vector of features is measured at a number of time points. We look for a transformation of the features, the same at all time points, that will induce a simple...
Human cystathionine beta-synthase (CBS; EC 4.2.1.22) deficiency results in a recessive genetic disorder whose clinical and biochemical manifestations vary greatly among affected individuals. In an...
Lawrence, S, Morton, N E, Cox, D R
A theory is developed to predict marker retention and conditional retention or loss in radiation hybrids. Applied to multiple pairwise analysis of a human chromosome 21 data set, this theory fits...
Pritchard, C, Casher, D, Bull, L, Cox, D R, Myers, R M
Genetic linkage studies have mapped the Huntington disease (HD) mutation to the distal region of the short arm of human chromosome 4. Analysis of recombination events in this region has produced...
Duyk, G M, Kim, S W, Myers, R M, Cox, D R
Identification and recovery of transcribed sequences from cloned mammalian genomic DNA remains an important problem in isolating genes on the basis of their chromosomal location. We have developed a...
Sheffield, V C, Cox, D R, Lerman, L S, Myers, R M
Denaturing gradient gel electrophoresis (DGGE) can be used to distinguish two DNA molecules that differ by as little as a single-base substitution. This method detects approximately 50% of all...
Patel, K, Cox, R, Shipley, J, Kiely, F, Frazer, K, Cox, D R, ...
We describe a simple PCR based technique which can be used to isolate sequences adjacent to rare cutter sites and can subsequently be employed for the construction of long range physical maps. The...
Burmeister, M, DiSibio, G, Cox, D R, Myers, R M
Genomic Denaturing Gradient Gel Electrophoresis (gDGGE) provides an alternative to the standard method of restriction fragment length polymorphism (RFLP) analysis for identifying polymorphic sequence...
Assignment of the gene for beta 2-microglobulin (B2m) to mouse chromosome 2.
Cox, D R, Sawicki, J A, Yee, D, Appella, E, Epstein, C J
We have assigned the gene (B2m) coding for murine beta 2-microglobulin (B2M) to mouse chromosome 2 by using a novel panel of Chinese hamster-mouse somatic cell hybrid clones. Because of 35...
Production of viable adult trisomy 17 reversible diploid mouse chimeras.
Epstein, C J, Smith, S A, Zamora, T, Sawicki, J A, Magnuson, T R, Cox, D R
Aneuploid mouse embryos and fetuses are an important system for investigating the pathogenesis of the developmental and functional consequences of chromosome imbalance in mammals. However, the fact...
Cox, D R, Epstein, L B, Epstein, C J
By using 12 hamster-mouse hybrids segregating a mouse T(16;17)Bnr Robertsonian translocation chromosome in conjunction with 10 similar hybrids segregating normal mouse chromosomes, we have shown that...
Structure and variability of human chromosome ends.
De Lange, T, Shiue, L, Myers, R M, Cox, D R, Naylor, S L, Killery, A M, ...
Mammalian telomeres are thought to be composed of a tandem array of TTAGGG repeats. To further define the type and arrangement of sequences at the ends of human chromosomes, we developed a direct...
The chromosomal location of mouse interferon alpha genes.
Lovett, M, Cox, D R, Yee, D, Boll, W, Weissmann, C, Epstein, C J, ...
The chromosomal location of mouse leukocyte-interferon (IFN-alpha) genes was determined by Southern blot analysis of DNA from a panel of Chinese hamster x mouse somatic cell hybrids using a mouse...
On class differentials in educational attainment
Erikson, Robert, Goldthorpe, John H., Jackson, Michelle, Yaish, Meir, Cox, D. R.
Social class differentials in educational attainment have been extensively studied in numerous countries. In this paper, we begin by examining class differentials in the progression to higher...
Simple model for tuberculosis in cattle and badgers
Cox, D. R., Donnelly, Christl A., Bourne, F. John, Gettinby, George, McInerney, John P., Morrison, W. Ivan, ...
As an aid to the study of bovine tuberculosis (TB), a simple model has been developed of an epidemic involving two species, cattle and badgers. Each species may infect the other. The proportion of...
Richard, C W, Boehnke, M, Berg, D J, Lichy, J H, Meeker, T C, Hauser, E, ...
We describe a high-resolution radiation hybrid (RH) map of the distal short arm of human chromosome 11 containing the Beckwith-Wiedemann gene and the associated embryonal tumor disease loci. Thirteen...
Analysis of chromosome 22 deletions in neurofibromatosis type 2-related tumors.
Wolff, R K, Frazer, K A, Jackler, R K, Lanser, M J, Pitts, L H, Cox, D R
The neurofibromatosis type 2 (NF2) gene has been hypothesized to be a recessive tumor suppressor, with mutations at the same locus on chromosome 22 that lead to NF2 also leading to sporadic tumors of...
Cloning of a candidate gene for ataxia-telangiectasia group D.
Kapp, L N, Painter, R B, Yu, L C, Van Loon, N, Richard, C W, James, M R, ...
Transfection, with a human cosmid clone library, of an ataxia-telangiectasia (AT) cell line (AT5BIVA) from complementation group D previously resulted in the isolation of a cell line (1B3) with...
Isolation and regional mapping of DNA sequences unique to human chromosome 21.
Korenberg, J R, Croyle, M L, Cox, D R
To isolate DNA sequences unique to chromosome 21 we have used a recombinant-DNA library, constructed from a mouse-human somatic-cell hybrid line containing chromosome 21 as the only human chromosome....
Cox, D R, Francke, U, Epstein, C J
The technique of two-dimensional (2-D) gel electrophoresis was sued to identify five human X-linked gene products in crude cell extracts of mouse-human and Chinese hamster-human somatic cell hybrids....
Statistical methods for multipoint radiation hybrid mapping.
Boehnke, M, Lange, K, Cox, D R
On the basis of the earlier work of Goss and Harris, Cox et al. introduced radiation hybrid (RH) mapping, a somatic cell genetic technique for constructing fine-structure maps of human chromosomes....
Richard, C W, Withers, D A, Meeker, T C, Maurer, S, Evans, G A, Myers, R M, ...
We describe a high-resolution radiation hybrid map of the proximal long arm of human chromosome 11 containing the bcl-1 and multiple endocrine neoplasia type 1 (MEN-1) disease gene loci. We used...
Derived variables for longitudinal studies
Suppose that for each individual a vector of features is measured at a number of time points. We look for a transformation of the features, the same at all time points, that will induce a simple...
Human cystathionine beta-synthase (CBS; EC 4.2.1.22) deficiency results in a recessive genetic disorder whose clinical and biochemical manifestations vary greatly among affected individuals. In an...
Lawrence, S, Morton, N E, Cox, D R
A theory is developed to predict marker retention and conditional retention or loss in radiation hybrids. Applied to multiple pairwise analysis of a human chromosome 21 data set, this theory fits...
Pritchard, C, Casher, D, Bull, L, Cox, D R, Myers, R M
Genetic linkage studies have mapped the Huntington disease (HD) mutation to the distal region of the short arm of human chromosome 4. Analysis of recombination events in this region has produced...
Duyk, G M, Kim, S W, Myers, R M, Cox, D R
Identification and recovery of transcribed sequences from cloned mammalian genomic DNA remains an important problem in isolating genes on the basis of their chromosomal location. We have developed a...
Sheffield, V C, Cox, D R, Lerman, L S, Myers, R M
Denaturing gradient gel electrophoresis (DGGE) can be used to distinguish two DNA molecules that differ by as little as a single-base substitution. This method detects approximately 50% of all...
Patel, K, Cox, R, Shipley, J, Kiely, F, Frazer, K, Cox, D R, ...
We describe a simple PCR based technique which can be used to isolate sequences adjacent to rare cutter sites and can subsequently be employed for the construction of long range physical maps. The...
Burmeister, M, DiSibio, G, Cox, D R, Myers, R M
Genomic Denaturing Gradient Gel Electrophoresis (gDGGE) provides an alternative to the standard method of restriction fragment length polymorphism (RFLP) analysis for identifying polymorphic sequence...
Assignment of the gene for beta 2-microglobulin (B2m) to mouse chromosome 2.
Cox, D R, Sawicki, J A, Yee, D, Appella, E, Epstein, C J
We have assigned the gene (B2m) coding for murine beta 2-microglobulin (B2M) to mouse chromosome 2 by using a novel panel of Chinese hamster-mouse somatic cell hybrid clones. Because of 35...
Production of viable adult trisomy 17 reversible diploid mouse chimeras.
Epstein, C J, Smith, S A, Zamora, T, Sawicki, J A, Magnuson, T R, Cox, D R
Aneuploid mouse embryos and fetuses are an important system for investigating the pathogenesis of the developmental and functional consequences of chromosome imbalance in mammals. However, the fact...
Cox, D R, Epstein, L B, Epstein, C J
By using 12 hamster-mouse hybrids segregating a mouse T(16;17)Bnr Robertsonian translocation chromosome in conjunction with 10 similar hybrids segregating normal mouse chromosomes, we have shown that...
Structure and variability of human chromosome ends.
De Lange, T, Shiue, L, Myers, R M, Cox, D R, Naylor, S L, Killery, A M, ...
Mammalian telomeres are thought to be composed of a tandem array of TTAGGG repeats. To further define the type and arrangement of sequences at the ends of human chromosomes, we developed a direct...
The chromosomal location of mouse interferon alpha genes.
Lovett, M, Cox, D R, Yee, D, Boll, W, Weissmann, C, Epstein, C J, ...
The chromosomal location of mouse leukocyte-interferon (IFN-alpha) genes was determined by Southern blot analysis of DNA from a panel of Chinese hamster x mouse somatic cell hybrids using a mouse...
On class differentials in educational attainment
Erikson, Robert, Goldthorpe, John H., Jackson, Michelle, Yaish, Meir, Cox, D. R.
Social class differentials in educational attainment have been extensively studied in numerous countries. In this paper, we begin by examining class differentials in the progression to higher...
Simple model for tuberculosis in cattle and badgers
Cox, D. R., Donnelly, Christl A., Bourne, F. John, Gettinby, George, McInerney, John P., Morrison, W. Ivan, ...
As an aid to the study of bovine tuberculosis (TB), a simple model has been developed of an epidemic involving two species, cattle and badgers. Each species may infect the other. The proportion of...
Richard, C W, Boehnke, M, Berg, D J, Lichy, J H, Meeker, T C, Hauser, E, ...
We describe a high-resolution radiation hybrid (RH) map of the distal short arm of human chromosome 11 containing the Beckwith-Wiedemann gene and the associated embryonal tumor disease loci. Thirteen...
Analysis of chromosome 22 deletions in neurofibromatosis type 2-related tumors.
Wolff, R K, Frazer, K A, Jackler, R K, Lanser, M J, Pitts, L H, Cox, D R
The neurofibromatosis type 2 (NF2) gene has been hypothesized to be a recessive tumor suppressor, with mutations at the same locus on chromosome 22 that lead to NF2 also leading to sporadic tumors of...
Cloning of a candidate gene for ataxia-telangiectasia group D.
Kapp, L N, Painter, R B, Yu, L C, Van Loon, N, Richard, C W, James, M R, ...
Transfection, with a human cosmid clone library, of an ataxia-telangiectasia (AT) cell line (AT5BIVA) from complementation group D previously resulted in the isolation of a cell line (1B3) with...
Isolation and regional mapping of DNA sequences unique to human chromosome 21.
Korenberg, J R, Croyle, M L, Cox, D R
To isolate DNA sequences unique to chromosome 21 we have used a recombinant-DNA library, constructed from a mouse-human somatic-cell hybrid line containing chromosome 21 as the only human chromosome....
Cox, D R, Francke, U, Epstein, C J
The technique of two-dimensional (2-D) gel electrophoresis was sued to identify five human X-linked gene products in crude cell extracts of mouse-human and Chinese hamster-human somatic cell hybrids....
Statistical methods for multipoint radiation hybrid mapping.
Boehnke, M, Lange, K, Cox, D R
On the basis of the earlier work of Goss and Harris, Cox et al. introduced radiation hybrid (RH) mapping, a somatic cell genetic technique for constructing fine-structure maps of human chromosomes....
Richard, C W, Withers, D A, Meeker, T C, Maurer, S, Evans, G A, Myers, R M, ...
We describe a high-resolution radiation hybrid map of the proximal long arm of human chromosome 11 containing the bcl-1 and multiple endocrine neoplasia type 1 (MEN-1) disease gene loci. We used...
O'Donnell, J J, Vannas-Sulonen, K, Shows, T B, Cox, D R
Gyrate atrophy of the choroid and retina is an autosomal recessive, blinding human disease caused by a deficiency of the mitochondrial matrix enzyme ornithine aminotransferase (OAT). Since human OAT...
The flock-to-flock force of infection for scrapie in Britain.
Gravenor, M B, Cox, D R, Hoinville, L J, Hoek, A, McLean, A R
A postal survey of British sheep farmers provided information on the proportion of farms that experienced their first case of scrapie in each year between 1962 and 1998. We found no evidence of a...
A general condition for avoiding effect reversal after marginalization
The paper examines the effect of marginalizing over a possibly unobserved background variable on the conditional relation between a response and an explanatory variable. In particular it is shown...
A simple procedure for the selection of significant effects
Given a large number of test statistics, a small proportion of which represent departures from the relevant null hypothesis, a simple rule is given for choosing those statistics that are indicative...
Joint response graphs and separation induced by triangular systems
We consider joint probability distributions generated recursively in terms of univariate conditional distributions satisfying conditional independence restrictions. The independences are captured by...
Quality of life measures in health care. III: Resource allocation.
Spiegelhalter, D. J., Gore, S. M., Fitzpatrick, R., Fletcher, A. E., Jones, D. R., Cox, D. R.
Selected locus and multiple panel models for radiation hybrid mapping.
Lunetta, K. L., Boehnke, M., Lange, K., Cox, D. R.
We develop two new types of models for whole-genome radiation hybrid mapping using the general multipoint framework. The first, selected locus models, are appropriate for mapping markers in the...
Johnston, W. T, Gettinby, G, Cox, D. R, Donnelly, C. A, Bourne, J, Clifton-Hadley, R, ...
A case–control study of the factors associated with the risk of a bovine tuberculosis (TB) breakdown in cattle herds was undertaken within the randomized badger culling trial (RBCT). TB breakdowns...
Communication of risk: health hazards from mobile phones
Possible health hazards from mobile phones arise from the use of the phones themselves and via the base stations that relay signals. Except for an increase in traffic accidents induced by the use of...
On the Screening of Large Numbers of Significance Tests
A brief review is given of procedures for the collective analysis of a large number of significance tests. A simple procedure previously supplied for isolating 'real' effects on the basis of a large...
It is shown that both the simple form of the Rasch model for binary data and a generalisation are essentially equivalent to special dichotomised Gaussian models. In these the underlying Gaussian...
Estimation in a simple random effects model with nonnormal distributions
A simple structural model is considered involving the addition of two random variables representing between- and within-group variation. Methods for estimating the cumulants of the two components of...
Conditional and marginal association for binary random variables
The relationship between marginal and conditional distributions of binary random variables is analysed via a log-linear model. Conditions for the Yule--Simpson effect are established and the...
A note on pseudolikelihood constructed from marginal densities
For likelihood-based inference involving distributions in which high-dimensional dependencies are present it may be useful to use approximate likelihoods based, for example, on the univariate or...
On a generalization of a result of W. G. Cochran
A relationship due to W.G. Cochran showing the effect on least squares regression coefficients of marginalizing over or conditioning on an explanatory variable is generalized to quantile regression...
Distortion of effects caused by indirect confounding
Undetected confounding may severely distort the effect of an explanatory variable on a response variable, as defined by a stepwise data-generating process. The best known type of distortion, which we...
On the consequences of overstratification
It is common, in particular in observational studies in epidemiology, to impose stratification to adjust for possible effects of age and other variables on the binary outcome of interest....
On an internal method for deriving a summary measure
Some preliminary comments are made about the reasons for combining component observations into composite or derived variables. A method for forming derived variables sensitive to specified changes in...
A Test of Multivariate Independence Based on a Single Factor Model
A test of the independence of two sets of variables is developed to have high power against a special family of dependence. In this each set of variables has the structure of a single factor model...
On the calculation of derived variables in the analysis of multivariate responses
The multivariate regression of a p - 1 vector Y of random variables on a q - 1 vector X of explanatory variables is considered. It is assumed that linear transformations of the components of Y can be...
D. R. Cox, Michelle Jackson, Shiwei Lu
Square contingency tables with matching ordinal rows and columns arise in particular as empirical transition matrices and the paper considers these in the context of social class and income mobility...
Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., ...
The Medical Research Council has for some years encouraged collaborative clinical trials in leukaemia and other cancers, reporting the results in the medical literature. One unreported result which...
Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., ...
Part I of this report appeared in the previous issue (Br. J. Cancer (1976) 34,585), and discussed the design of randomized clinical trials. Part II now describes efficient methods of analysis of...