D. Ron

An autoregulatory region in protein kinase C: the pseudoanchoring site.

Ron, D, Mochly-Rosen, D

We have previously identified receptors for activated C kinase (RACKs) as components of protein kinase C (PKC) signaling. RACK1, a recently cloned 36-kDa RACK, has short sequences of homology to PKC....

Inducible growth arrest: new mechanistic insights.

Ron, D

C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements.

Vallejo, M, Ron, D, Miller, C P, Habener, J F

Members of the C/EBP family of basic-leucine zipper (bZip) transcription factors form heterodimers and bind to the CAAT box and other sequence-related enhancer motifs. Using a 32P-labeled protein...

Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II.

Immanuel, D, Zinszner, H, Ron, D

Many oncogenes associated with human sarcomas are composed of a fusion between transcription factors and the N-terminal portions of two similar RNA-binding proteins, TLS and EWS. Though the oncogenic...

Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element.

Ubeda, M, Wang, X Z, Zinszner, H, Wu, I, Habener, J F, Ron, D

CHOP (GADD153) is a mammalian nuclear protein that dimerizes with members of the C/EBP family of transcriptional factors. Absent under normal conditions, CHOP is induced by the stress encountered...

Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

Wang, X Z, Lawson, B, Brewer, J W, Zinszner, H, Sanjay, A, Mi, L J, ...

The gene encoding C/EBP-homologous protein (CHOP), also known as growth arrest and DNA-damage-inducible gene 153 (GADD153), is activated by agents that adversely affect the function of the...

Spontaneous curing of a minute virus of mice carrier state by selection of cells with an intracellular block of viral replication.

Ron, D, Tal, J

We previously described a persistent infection established by the lymphotropic minute virus of mice in mouse L cells at the level of the cell population (D. Ron, P. Tattersall, and J. Tal, J. Virol....

Formation of a host range mutant of the lymphotropic strain of minute virus of mice during persistent infection in mouse L cells.

Ron, D, Tattersall, P, Tal, J

Minute virus of mice (i), the lymphotropic strain of minute virus of mice, established a persistent infection in normally restrictive L cells. The carrier state, which lasted 150 days, exhibited...

Coevolution of cells and virus as a mechanism for the persistence of lymphotropic minute virus of mice in L-cells.

Ron, D, Tal, J

Infection of L-cells with minute virus of mice (i), a lymphotropic strain of minute virus of mice, resulted in the emergence of host range mutant viruses capable of a lytic infection that destroys...

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

Zhan, Q, Lord, K A, Alamo, I, Hollander, M C, Carrier, F, Ron, D, ...

A remarkable overlap was observed between the gadd genes, a group of often coordinately expressed genes that are induced by genotoxic stress and certain other growth arrest signals, and the MyD...

Angiotensinogen gene-inducible enhancer-binding protein 1, a member of a new family of large nuclear proteins that recognize nuclear factor kappa B-binding sites through a zinc finger motif.

Ron, D, Brasier, A R, Habener, J F

Transcriptional activation of the rat angiotensinogen gene during the acute-phase response is dependent on a previously characterized acute-phase response element (APRE) that binds at least two types...

An inducible 50-kilodalton NF kappa B-like protein and a constitutive protein both bind the acute-phase response element of the angiotensinogen gene.

Ron, D, Brasier, A R, Wright, K A, Tate, J E, Habener, J F

The rat angiotensinogen gene is induced in the course of the hepatic acute-phase response. We demonstrate that monocyte conditioned medium can stimulate transcription of a stably introduced reporter...

The permissive role of glucocorticoids on interleukin-1 stimulation of angiotensinogen gene transcription is mediated by an interaction between inducible enhancers.

Ron, D, Brasier, A R, Wright, K A, Habener, J F

The acute-phase activation of the rat angiotensinogen (rAT) gene in liver cells is a transcriptional event mediated through an interleukin-1-inducible, NF kappa B-binding, cis-acting element (the...

Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153).

Batchvarova, N, Wang, X Z, Ron, D

Adipocytic conversion of 3T3-L1 cells is dependent on induction of transcription factors from the C/EBP family that activate promoters of adipogenic genes. We find that expression of CHOP, a nuclear...

Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP).

Ron, D, Brasier, A R, McGehee, R E, Habener, J F

Tumor necrosis factor (TNF)-treated 3T3-L1 adipocytes were used as a model for studying the effects of systemic inflammation on adipose tissue. Lipopolysaccharide-treated monocyte-conditioned medium...

Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells.

Ron, D, Tronick, S R, Aaronson, S A, Eva, A

We isolated cDNA clones representing the human dbl proto-oncogene transcript. Nucleotide sequence analysis revealed an open reading frame encoding a predicted protein of 925 amino acids. Using...

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.

Ron, D, Chen, C H, Caldwell, J, Jamieson, L, Orr, E, Mochly-Rosen, D

Protein kinase C (PKC) translocates from the soluble to the cell particulate fraction on activation. Intracellular receptors that bind activated PKC in the particulate fraction have been implicated...

Keratinocyte growth factor functions in epithelial induction during seminal vesicle development.

Alarid, E T, Rubin, J S, Young, P, Chedid, M, Ron, D, Aaronson, S A, ...

Development of the seminal vesicle (SV) is elicited by androgens and is dependent on epithelial-mesenchymal interactions. Androgenic signal transmission from the androgen-receptor-positive mesenchyme...

A family of constitutive C/EBP-like DNA binding proteins attenuate the IL-1 alpha induced, NF kappa B mediated trans-activation of the angiotensinogen gene acute-phase response element.

Brasier, A R, Ron, D, Tate, J E, Habener, J F

The gene encoding angiotensinogen, the glycoprotein precursor of the potent vasopressor peptide angiotensin II, is transcriptionally activated in hepatocytes during the acute-phase response through...

Identification of novel stress-induced genes downstream of chop.

Wang, X Z, Kuroda, M, Sok, J, Batchvarova, N, Kimmel, R, Chung, P, ...

CHOP (GADD153) is a small nuclear protein that dimerizes avidly with members of the C/EBP family of transcription factors. Normally undetectable, it is expressed at high levels in cells exposed to...

Cloning of mammalian Ire1 reveals diversity in the ER stress responses.

Wang, X Z, Harding, H P, Zhang, Y, Jolicoeur, E M, Kuroda, M, Ron, D

Cells modify their gene expression pattern in response to stress signals emanating from the endoplasmic reticulum (ER). The well-characterized aspect of this response consists of the activation of...

An autoregulatory region in protein kinase C: the pseudoanchoring site.

Ron, D, Mochly-Rosen, D

We have previously identified receptors for activated C kinase (RACKs) as components of protein kinase C (PKC) signaling. RACK1, a recently cloned 36-kDa RACK, has short sequences of homology to PKC....

Inducible growth arrest: new mechanistic insights.

Ron, D

C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements.

Vallejo, M, Ron, D, Miller, C P, Habener, J F

Members of the C/EBP family of basic-leucine zipper (bZip) transcription factors form heterodimers and bind to the CAAT box and other sequence-related enhancer motifs. Using a 32P-labeled protein...

Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II.

Immanuel, D, Zinszner, H, Ron, D

Many oncogenes associated with human sarcomas are composed of a fusion between transcription factors and the N-terminal portions of two similar RNA-binding proteins, TLS and EWS. Though the oncogenic...

Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element.

Ubeda, M, Wang, X Z, Zinszner, H, Wu, I, Habener, J F, Ron, D

CHOP (GADD153) is a mammalian nuclear protein that dimerizes with members of the C/EBP family of transcriptional factors. Absent under normal conditions, CHOP is induced by the stress encountered...

Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

Wang, X Z, Lawson, B, Brewer, J W, Zinszner, H, Sanjay, A, Mi, L J, ...

The gene encoding C/EBP-homologous protein (CHOP), also known as growth arrest and DNA-damage-inducible gene 153 (GADD153), is activated by agents that adversely affect the function of the...

Spontaneous curing of a minute virus of mice carrier state by selection of cells with an intracellular block of viral replication.

Ron, D, Tal, J

We previously described a persistent infection established by the lymphotropic minute virus of mice in mouse L cells at the level of the cell population (D. Ron, P. Tattersall, and J. Tal, J. Virol....

Formation of a host range mutant of the lymphotropic strain of minute virus of mice during persistent infection in mouse L cells.

Ron, D, Tattersall, P, Tal, J

Minute virus of mice (i), the lymphotropic strain of minute virus of mice, established a persistent infection in normally restrictive L cells. The carrier state, which lasted 150 days, exhibited...

Coevolution of cells and virus as a mechanism for the persistence of lymphotropic minute virus of mice in L-cells.

Ron, D, Tal, J

Infection of L-cells with minute virus of mice (i), a lymphotropic strain of minute virus of mice, resulted in the emergence of host range mutant viruses capable of a lytic infection that destroys...

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

Zhan, Q, Lord, K A, Alamo, I, Hollander, M C, Carrier, F, Ron, D, ...

A remarkable overlap was observed between the gadd genes, a group of often coordinately expressed genes that are induced by genotoxic stress and certain other growth arrest signals, and the MyD...

Angiotensinogen gene-inducible enhancer-binding protein 1, a member of a new family of large nuclear proteins that recognize nuclear factor kappa B-binding sites through a zinc finger motif.

Ron, D, Brasier, A R, Habener, J F

Transcriptional activation of the rat angiotensinogen gene during the acute-phase response is dependent on a previously characterized acute-phase response element (APRE) that binds at least two types...

An inducible 50-kilodalton NF kappa B-like protein and a constitutive protein both bind the acute-phase response element of the angiotensinogen gene.

Ron, D, Brasier, A R, Wright, K A, Tate, J E, Habener, J F

The rat angiotensinogen gene is induced in the course of the hepatic acute-phase response. We demonstrate that monocyte conditioned medium can stimulate transcription of a stably introduced reporter...

The permissive role of glucocorticoids on interleukin-1 stimulation of angiotensinogen gene transcription is mediated by an interaction between inducible enhancers.

Ron, D, Brasier, A R, Wright, K A, Habener, J F

The acute-phase activation of the rat angiotensinogen (rAT) gene in liver cells is a transcriptional event mediated through an interleukin-1-inducible, NF kappa B-binding, cis-acting element (the...

Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153).

Batchvarova, N, Wang, X Z, Ron, D

Adipocytic conversion of 3T3-L1 cells is dependent on induction of transcription factors from the C/EBP family that activate promoters of adipogenic genes. We find that expression of CHOP, a nuclear...

Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP).

Ron, D, Brasier, A R, McGehee, R E, Habener, J F

Tumor necrosis factor (TNF)-treated 3T3-L1 adipocytes were used as a model for studying the effects of systemic inflammation on adipose tissue. Lipopolysaccharide-treated monocyte-conditioned medium...

Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells.

Ron, D, Tronick, S R, Aaronson, S A, Eva, A

We isolated cDNA clones representing the human dbl proto-oncogene transcript. Nucleotide sequence analysis revealed an open reading frame encoding a predicted protein of 925 amino acids. Using...

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.

Ron, D, Chen, C H, Caldwell, J, Jamieson, L, Orr, E, Mochly-Rosen, D

Protein kinase C (PKC) translocates from the soluble to the cell particulate fraction on activation. Intracellular receptors that bind activated PKC in the particulate fraction have been implicated...

Keratinocyte growth factor functions in epithelial induction during seminal vesicle development.

Alarid, E T, Rubin, J S, Young, P, Chedid, M, Ron, D, Aaronson, S A, ...

Development of the seminal vesicle (SV) is elicited by androgens and is dependent on epithelial-mesenchymal interactions. Androgenic signal transmission from the androgen-receptor-positive mesenchyme...

A family of constitutive C/EBP-like DNA binding proteins attenuate the IL-1 alpha induced, NF kappa B mediated trans-activation of the angiotensinogen gene acute-phase response element.

Brasier, A R, Ron, D, Tate, J E, Habener, J F

The gene encoding angiotensinogen, the glycoprotein precursor of the potent vasopressor peptide angiotensin II, is transcriptionally activated in hepatocytes during the acute-phase response through...

Identification of novel stress-induced genes downstream of chop.

Wang, X Z, Kuroda, M, Sok, J, Batchvarova, N, Kimmel, R, Chung, P, ...

CHOP (GADD153) is a small nuclear protein that dimerizes avidly with members of the C/EBP family of transcription factors. Normally undetectable, it is expressed at high levels in cells exposed to...

Cloning of mammalian Ire1 reveals diversity in the ER stress responses.

Wang, X Z, Harding, H P, Zhang, Y, Jolicoeur, E M, Kuroda, M, Ron, D

Cells modify their gene expression pattern in response to stress signals emanating from the endoplasmic reticulum (ER). The well-characterized aspect of this response consists of the activation of...