D. S.
A novel expression system of domain I of human beta2 glycoprotein I in Escherichia coli. (2006)
- Ioannou,
- Y.,
- Giles,
- I.,
- Lambrianides,
- A.,
- ...
Growth Response of Ricinus communis L (Castor Oil) in Spent Lubricating Oil Polluted Soil (2005)
- VWIOKO,
- D E; FASHEMI,
- D S
The growth response of castor oil plant, Ricinus communis , in spent lubricating oil (SLO) was investigated using 1-6% w/w SLO and a control. The result showed that highest percent germination of...
Preconditioning of the myocardium rapidly induces a number of transcription factors, which are likely to be responsible for a cascade of transcriptional changes underlying the development of delayed...
When purified under rigorous conditions, some murine anti-double-stranded-DNA (anti-dsDNA) antibodies actually bind chromatin rather than dsDNA. This suggests that they may actually be antinucleosome...
STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage (2005)
STAT-1 plays a role in mediating stress responses to various stimuli and has also been implied to be a tumour suppressor. Here, we report that STAT-1-deficient cells have defects both in...
BAG-1: a multifunctional pro-survival molecule (2005)
- Townsend,
- P.A.,
- Stephanou,
- A.,
- Packham,
- G.,
- ...
Neuroprotective effects of HSP70 overexpression after cerebral ischaemia-An MRI study (2005)
Heat shock proteins (HSPs) have been reported to increase cell survival in response to a wide range of cellular challenges. However, the role of HSP70 overexpression is still a matter of debate, with...
Assessment of hypoxia in children with cystic fibrosis (2005)
- Urquhart,
- D.S.,
- Montgomery,
- H.,
- Jaffe,
- A.
Hypoxia during sleep and exercise may occur in an important number of patients with cystic fibrosis (CF). Despite its recognition, no clear definition for hypoxia in CF exists, and nor do guidelines...
Opposing actions of STAT-1 and STAT-3 (2005)
- Stephanou,
- A.,
- Latchman,
- D.S.
Prevalence of childhood and adolescent disabilities in rural Nepal (2005)
- Sauvey,
- S.,
- Osrin,
- D.,
- Manandhar,
- D.S.,
- ...
The study aimed to determine the number of children and young people reported as having a disability by family members, and to classify, impairments leading to disability. A Cross-sectional census...
The achiasmia spectrum: congenitally reduced chiasmal decussation (2005)
AIM: To describe the clinical spectrum of achiasmia, a congenital disorder of reduced relative decussation at the optic chiasm. METHODS: A retrospective case note and patient review of nine children...
Amyotrophic lateral sclerosis (ALS) is an adult-onset degenerative disorder characterised by the death of motor neurons in the cortex, brainstem, and spinal cord; resulting in progressive muscle...
Raised levels of interleukin 6 in systemic lupus erythematosus correlate with anaemia (2005)
Objectives: Raised levels of the cytokines interleukin (IL) 6 and IL10 have been reported in patients with systemic lupus erythematosus (SLE). Objective: To determine if levels of IL6 and IL10...
- Osrin,
- D.,
- Vaidya,
- A.,
- Shrestha,
- Y.,
- ...
BACKGROUND: Neonatal mortality is the biggest contributor to global mortality of children younger than 5 years, and low birthweight is a crucial underlying factor. We tested the hypotheses that...
Micronutrient supplementation in pregnancy - Authors' response (2005)
- Osrin,
- D.,
- West,
- K.P.,
- Jr.,
- Christian,
- ...
- Otto,
- E.A.,
- Loeys,
- B.,
- Khanna,
- H.,
- ...
Nephronophthisis (NPHP) is the most frequent genetic cause of chronic renal failure in children(1-3). Identification of four genes mutated in NPHP subtypes 1- 4 (refs. 4- 9) has linked the...
- Kumar,
- S.,
- Nagl,
- S.,
- Kalsi,
- J.K.,
- ...
We have recently shown that the anti-cardiolipin activity of human anti-phospholipid antibody UK4 (lambda) resides on its heavy chain. We now show that UK4 possesses strong reactivity to the...
Cardioprotection mediated by urocortin is dependent upon PKCF epsilon activation (2005)
Urocortin (Ucn) is an endogenous cardioprotective agent that protects against the damaging effects of ischemia and reperfusion injury in vitro and in vivo. We have found that the mechanism of action...
- Lee,
- S.A.,
- Ndisang,
- D.,
- Patel,
- C.,
- ...
In breast cancer, overexpression of the small heat shock protein, HSP-27, is associated with increased anchorage-independent growth, increased invasiveness, and resistance to chemotherapeutic drugs...
- Latchman,
- D.S.
Herpes simplex virus-based vectors for the treatment of cancer and neurodegenerative disease (2005)
- Latchman,
- D.S.
Vectors based on herpes simplex virus (HSV) are being developed for use in human neurodegenerative diseases and cancer. In neurodegenerative disease, this involves the use of highly disabled,...
HSP27 and cell survival in neurones (2005)
- Latchman,
- D.S.
Although the majority of studies on the protective effect of individual hsps have concentrated on the major inducible heat shock protein Hsp70, a variety of evidence suggests that the small heat...
Lupus autoantibodies to native DNA preferentially bind DNA presented on PolIV (2005)
- Kumar,
- S.,
- Bunting,
- K.A.,
- Kalsi,
- J.,
- ...
A novel, efficient, expression system of domain I of human beta2 glycoprotein I in E-coli (2005)
- Ioannou,
- Y.,
- Giles,
- I.,
- Lambrianides,
- N.,
- ...
Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis (2005)
Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral to metastasis (e.g., proliferation, motility, secretion, and invasion), although their contribution to...
Brn-3a neuronal transcription factor functional expression in human prostate cancer (2005)
Neuroendocrine differentiation has been associated with prostate cancer (CaP). Brn-3a (short isoform) and Brn-3c, transcriptional controllers of neuronal differentiation, were readily detectable in...
Antenatal micronutrient supplements in Nepal (2005)
- Christian,
- P.,
- Osrin,
- D.,
- Manandhar,
- D.S.,
- ...
Background. We have recently reported that pretreatment of rats with endotoxin ( lipopolysaccharide, LPS) and selective agonists of the nuclear receptor peroxisome proliferator- activated...
Economic assessment of a women's group intervention to improve birth outcomes in rural Nepal (2005)
- Borghi,
- J.,
- Thapa,
- B.,
- Osrin,
- D.,
- ...
We did a cost-effectiveness analysis alongside a cluster-randomised controlled trial of a participatory intervention with women's groups to improve birth outcomes in rural Nepal. The average provider...
- Calissano,
- M.,
- Faulkes,
- D.,
- Latchman,
- D.S.
Brn-3a is a transcription factor expressed in a subset of neurons of the peripheral nervous system. Its role encompasses the activation of genes involved in neuronal differentiation and survival....
The study of eye movements and oculomotor disorders has, for four decades, greatly benefitted from the application of control theoretic concepts. This paper is an example of a complementary approach...
- Irshad,
- S.,
- Pedley,
- R.B.,
- Anderson,
- J.,
- ...
Neuroblastomas are the second most common solid tumor in children but the molecular mechanisms underlying the initiation and progression of this disease are poorly understood. We previously showed...
STAT-1 interacts with p53 to enhance DNA-damage induced apoptosis (2004)
The STAT-1 transcription factor has been implicated as a tumor suppressor by virtue of its ability to inhibit cell growth and promoting apoptosis. However, the mechanisms by which STAT-1 mediates...
Recent trends in HIV and other STIs in the United Kingdom: data to the end of 2002 (2004)
Sexual health in the United Kingdom has deteriorated in recent years with further increases in HIV and other sexually transmitted infections (STIs) reported in 2002. This paper describes results from...
- Gill,
- D.S.
Joubert syndrome: long-term follow-up (2004)
Twenty-nine patients (16 males, 13 females) with Joubert syndrome were identified from ophthalmology, neurology, and genetic databases covering a 15-year period at Great Ormond Street Hospital,...
SA023
Medical Implications of Biofilms (2003)
- An,
- Y.H.,
- Bhagwat,
- S.,
- Bokranz,
- W.,
- ...
Objectives. We compared microvessel density (MVD) in normal, benign, preneoplastic, and neoplastic (squamous cell carcinoma (SCQ) vulvar disease to ascertain if this parameter could identify cases...
Ocular tilt reaction due to a mesencephalic lesion in juvenile polyarteritis nodosa (2003)
PURPOSE: To describe a case of ocular tilt reaction caused by vasculitic lesions in the midbrain in a child with polyarteritis nodosa. DESIGN: Observational case report. METHODS: A 5-year-old girl...
A multi-shell algorithm to reconstruct EIT images of brain function (2002)
Electrical impedance tomography (EIT) may be used to image brain function, but an important consideration is the effect of the highly resistive skull and other extracerebral layers on the flow of...
- Perera,
- D.,
- Pizzey,
- A.,
- Campbell,
- A.,
- ...
Lefty antagonism of Squint is essential for normal gastrulation (2002)
- Feldman,
- B.,
- Concha,
- M.L.,
- Saude,
- L.,
- ...
Apoptosis contributes to myocardial cell death during ischemia and reperfusion, especially during reperfusion. Growth factor "survival" signaling attenuates apoptosis. We therefore examined the...
Ischemic preconditioning (IP) reduces infarct size in young animals; however, its impact on aging is underinvestigated. The effect of variations in IP stimuli was studied in young, middle-aged, and...
- Ndisang,
- D.,
- Budhram-Mahadeo,
- V.,
- Pedley,
- B.,
- ...
The cellular Brn-3a transcription factor is known to activate transcription of the genes encoding the human papilloma virus E6 and E7 proteins and is over-expressed in women with cervical neoplasia....
- Lilley,
- C.E.,
- Groutsi,
- F.,
- Han,
- Z.,
- ...
Herpes simplex virus (HSV) has several potential advantages as a vector for delivering genes to the nervous system. The virus naturally infects and remains latent in neurons and has evolved the...
The purpose was to determine the relative efficiency, toxicity and duration of expression following gene delivery by intramyocardial injection of naked DNA, naked DNA complexed to cationic liposomes,...
- Picton,
- T.W.,
- Bentin,
- S.,
- Berg,
- P.,
- ...
- Ndisang,
- D.,
- Budhram-Mahadeo,
- V.,
- Singer,
- A.,
- ...
Herpes simplex virus (HSV) has often been suggested as a suitable vector for gene delivery to the peripheral nervous system as it naturally infects sensory nerve terminals before retrograde transport...
Economic evaluation of a women's group intervention to improve birth outcomes in rural Nepal (1999)
- Borghi,
- J.,
- Thapa,
- B.,
- Osrin,
- D.,
- ...
A genetic linkage study of the D2 dopamine receptor locus in heavy drinking and alcoholism (1996)
- Cook,
- C.H.,
- Palsson,
- G.,
- Turner,
- A.,
- ...