D. Sarsero

(-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta(2)-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling (2007)

Molenaar, P, Savarimuthu, SM, Sarsero, D, Chen, L, Semmler, ABT, Carle, A, ...

Activation of either coexisting beta(1)- or beta(2)-adrenoceptors with noradrenaline or adrenaline, respectively, causes maximum increases of contractility of human atrial myocardium. Previous...

(-)Adrenaline elicits positive inotropic,lusitropic, and biochemical effects through ß2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consisten with Gs coupling but not with Gi coupling. (2007)

Molenaar, P., Savarimuthu, S.M., Sarsero, D., Chen, L., Semmler, A.B.T., Carle, A., ...

(-)Adrenaline elicits positive inotropic,lusitropic, and biochemical effects through ß2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consisten with Gs coupling but not with Gi coupling. (2007)

Molenaar, P., Savarimuthu, S.M., Sarsero, D., Chen, L., Semmler, A.B.T., Carle, A., ...

(-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the β-adrenoceptor (2003)

Sarsero, D, Russell, F D, Lynham, J A, Rabnott, G, Yang, I, Fong, K M, ...

Two forms of the activated #1-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial agonists such...

Quantitative analysis of vascular to cardiac selectivity of L- and T-type voltage-operated calcium channel antagonists in human tissues (2000)

Angus, J, Sarsero, D, Fujiwara, T, Molenaar, P, Xi, Q

1. Classical L-type voltage-operated calcium channel (VOCC) antagonists dilate blood vessels, depress myocardial contractility and slow cardiac conduction. 2. We compared four L-type VOCC antagonists...

Quantitative analysis of vascular to cardiac selectivity of L- and T-type voltage-operated calcium channel antagonists in human tissues (2000)

Angus, J, Sarsero, D, Fujiwara, T, Molenaar, P, Xi, Q

1. Classical L-type voltage-operated calcium channel (VOCC) antagonists dilate blood vessels, depress myocardial contractility and slow cardiac conduction. 2. We compared four L-type VOCC antagonists...

Putative beta(4)-adrenoceptors in rat ventricle mediate increases in contractile force and cell Ca2+: comparison with atrial receptors and relationship to (-)-[H-3]-CGP 12177 binding (1999)

Sarsero, D., Molenaar, P., Kaumann, A. J., Freestone, N. S.

1 We identified putative beta(4)-adrenoceptors by radioligand binding, measured increases in ventricular contractile force by (-)-CGP 12177 and (+/-)-cyanopindolol and demonstrated increased Ca2+...

Putative b4-adrenoceptors in rat ventricle mediate increases in contractile force and cell Ca2+: comparison with atrial receptors and relationship to (-)-[3H]-CGP 12177 binding (1999)

Sarsero, D., Molenaar, P., Kaumann, A. J., Freestone, N. S.

Putative beta(4)-adrenoceptors in rat ventricle mediate increases in contractile force and cell Ca2+: comparison with atrial receptors and relationship to (-)-[H-3]-CGP 12177 binding (1999)

Sarsero, D., Molenaar, P., Kaumann, A. J., Freestone, N. S.

1 We identified putative beta(4)-adrenoceptors by radioligand binding, measured increases in ventricular contractile force by (-)-CGP 12177 and (+/-)-cyanopindolol and demonstrated increased Ca2+...

Validity of (-)-[H-3]-CGP 12177A as a radioligand for the 'putative beta(4)-adrenoceptor' in rat atrium (1998)

Sarsero, D, Molenaar, P, Kaumann, AJ

1 We have recently suggested the existence in the heart of a 'putative beta(4)-adrenoceptor' based on the cardiostimulant effects of non-conventional partial agonists, compounds that cause...

(-)-CGP 12177 causes cardiostimulation and binds to cardiac putative beta(4)-adrenoceptors in both wild-type and beta(3)-adrenoceptor knockout mice (1998)

Kaumann, AJ, Preitner, F, Sarsero, D, Molenaar, P, Revelli, JP, Giacobino, JP

Some blockers of beta(1)- and beta(2)-adrenoceptors cause cardiostimulant effects through an atypical beta-adrenoceptor (putative beta(4)-adrenoceptor) that resembles the beta(3)-adrenoceptor. It is...

The putative beta(4)-adrenoceptor activates the cyclic AMP pathway in human heart: Inhibition of positive inotropic responses by adenosine and carbachol (1998)

Molenaar, P, Sarsero, D, Lynham, JA, Kaumann, AJ

(-)-[H-3]-CGP 12177 radiolabels beta(1)-, beta(2)- and putative beta(4)-adrenoceptors in human atrium and ventricle. (1998)

Sarsero, D, Molenaar, P, Kaumann, AJ

Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists (1998)

Sarsero, D, Fujiwara, T, Molenaar, P, Angus, JA

1 Voltage-operated calcium channel (VOCC) antagonists are effective antihypertensive and antianginal agents but they also depress myocardial contractility. 2 We compared four L-type calcium channel...

Validity of (-)-[H-3]-CGP 12177A as a radioligand for the 'putative beta(4)-adrenoceptor' in rat atrium (1998)

Sarsero, D, Molenaar, P, Kaumann, AJ

1 We have recently suggested the existence in the heart of a 'putative beta(4)-adrenoceptor' based on the cardiostimulant effects of non-conventional partial agonists, compounds that cause...

(-)-CGP 12177 causes cardiostimulation and binds to cardiac putative beta(4)-adrenoceptors in both wild-type and beta(3)-adrenoceptor knockout mice (1998)

Kaumann, AJ, Preitner, F, Sarsero, D, Molenaar, P, Revelli, JP, Giacobino, JP

Some blockers of beta(1)- and beta(2)-adrenoceptors cause cardiostimulant effects through an atypical beta-adrenoceptor (putative beta(4)-adrenoceptor) that resembles the beta(3)-adrenoceptor. It is...

The putative beta(4)-adrenoceptor activates the cyclic AMP pathway in human heart: Inhibition of positive inotropic responses by adenosine and carbachol (1998)

Molenaar, P, Sarsero, D, Lynham, JA, Kaumann, AJ

(-)-[H-3]-CGP 12177 radiolabels beta(1)-, beta(2)- and putative beta(4)-adrenoceptors in human atrium and ventricle. (1998)

Sarsero, D, Molenaar, P, Kaumann, AJ

Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists (1998)

Sarsero, D, Fujiwara, T, Molenaar, P, Angus, JA

1 Voltage-operated calcium channel (VOCC) antagonists are effective antihypertensive and antianginal agents but they also depress myocardial contractility. 2 We compared four L-type calcium channel...

Effects of (-)-RO363 at human atrial beta-adrenoceptor subtypes, the human cloned beta(3)-adrenoceptor and rodent intestinal beta(3)-adrenoceptors (1997)

Molenaar, P, Sarsero, D, Arch, JRS, Kelly, J, Henson, SM, Kaumann, AJ

1 Chronic treatment of patients with beta-blockers causes atrial inotropic hyperresponsiveness through beta(2)-adrenoceptors, 5-HT4 receptors and H-2-receptors but apparently not through...

The atypical cardiostimulant beta-adrenoceptor is distinct from beta-adrenoceptors and coupled to a cyclic AMP-dependent pathway in human and rat myocardium (1997)

Kaumann, AJ, Lynham, JA, Sarsero, D, Molenaar, P

Proposal for the interaction of non-conventional partial agonists and catecholamines with the 'putative beta(4)-adrenoceptor' in mammalian heart (1997)

Molenaar, P, Sarsero, D, Kaumann, AJ

1. Evidence for a 'putative beta(4)-adrenoceptor' originated over 20 years ago when cardiostimulant effects were observed to nonconventional partial agonists, These agonists were originally described...

Effects of (-)-RO363 at human atrial beta-adrenoceptor subtypes, the human cloned beta(3)-adrenoceptor and rodent intestinal beta(3)-adrenoceptors (1997)

Molenaar, P, Sarsero, D, Arch, JRS, Kelly, J, Henson, SM, Kaumann, AJ

1 Chronic treatment of patients with beta-blockers causes atrial inotropic hyperresponsiveness through beta(2)-adrenoceptors, 5-HT4 receptors and H-2-receptors but apparently not through...

The atypical cardiostimulant beta-adrenoceptor is distinct from beta-adrenoceptors and coupled to a cyclic AMP-dependent pathway in human and rat myocardium (1997)

Kaumann, AJ, Lynham, JA, Sarsero, D, Molenaar, P

Proposal for the interaction of non-conventional partial agonists and catecholamines with the 'putative beta(4)-adrenoceptor' in mammalian heart (1997)

Molenaar, P, Sarsero, D, Kaumann, AJ

1. Evidence for a 'putative beta(4)-adrenoceptor' originated over 20 years ago when cardiostimulant effects were observed to nonconventional partial agonists, These agonists were originally described...

Validity of (-)-[H-3]-CGP 12177A as a radioligand for the 'putative beta(4)-adrenoceptor' in rat atrium

Sarsero, D, Molenaar, P, Kaumann, AJ

1 We have recently suggested the existence in the heart of a 'putative beta(4)-adrenoceptor' based on the cardiostimulant effects of non-conventional partial agonists, compounds that cause...

(-)-CGP 12177 causes cardiostimulation and binds to cardiac putative beta(4)-adrenoceptors in both wild-type and beta(3)-adrenoceptor knockout mice

Kaumann, AJ, Preitner, F, Sarsero, D, Molenaar, P, Revelli, JP, Giacobino, JP

Some blockers of beta(1)- and beta(2)-adrenoceptors cause cardiostimulant effects through an atypical beta-adrenoceptor (putative beta(4)-adrenoceptor) that resembles the beta(3)-adrenoceptor. It is...

The putative beta(4)-adrenoceptor activates the cyclic AMP pathway in human heart: Inhibition of positive inotropic responses by adenosine and carbachol

Molenaar, P, Sarsero, D, Lynham, JA, Kaumann, AJ

(-)-[H-3]-CGP 12177 radiolabels beta(1)-, beta(2)- and putative beta(4)-adrenoceptors in human atrium and ventricle.

Sarsero, D, Molenaar, P, Kaumann, AJ

Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists

Sarsero, D, Fujiwara, T, Molenaar, P, Angus, JA

1 Voltage-operated calcium channel (VOCC) antagonists are effective antihypertensive and antianginal agents but they also depress myocardial contractility. 2 We compared four L-type calcium channel...

Putative beta(4)-adrenoceptors in rat ventricle mediate increases in contractile force and cell Ca2+: comparison with atrial receptors and relationship to (-)-[H-3]-CGP 12177 binding

Sarsero, D, Molenaar, P, Kaumann, AJ, Freestone, NS

1 We identified putative beta(4)-adrenoceptors by radioligand binding, measured increases in ventricular contractile force by (-)-CGP 12177 and (+/-)-cyanopindolol and demonstrated increased Ca2+...

Quantitative analysis of vascular to cardiac selectivity of L- and T-type voltage-operated calcium channel antagonists in human tissues

Angus, J, Sarsero, D, Fujiwara, T, Molenaar, P, Xi, Q

1. Classical L-type voltage-operated calcium channel (VOCC) antagonists dilate blood vessels, depress myocardial contractility and slow cardiac conduction. 2. We compared four L-type VOCC antagonists...

(-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the beta(1)-adrenoceptor

Sarsero, D, Russell, FD, Lynham, JA, Rabnott, G, Yang, I, Fong, KM, ...

Two forms of the activated beta(1)-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial agonists...

Effects of (-)-RO363 at human atrial beta-adrenoceptor subtypes, the human cloned beta(3)-adrenoceptor and rodent intestinal beta(3)-adrenoceptors

Molenaar, P, Sarsero, D, Arch, JRS, Kelly, J, Henson, SM, Kaumann, AJ

1 Chronic treatment of patients with beta-blockers causes atrial inotropic hyperresponsiveness through beta(2)-adrenoceptors, 5-HT4 receptors and H-2-receptors but apparently not through...

The atypical cardiostimulant beta-adrenoceptor is distinct from beta-adrenoceptors and coupled to a cyclic AMP-dependent pathway in human and rat myocardium

Kaumann, AJ, Lynham, JA, Sarsero, D, Molenaar, P

Proposal for the interaction of non-conventional partial agonists and catecholamines with the 'putative beta(4)-adrenoceptor' in mammalian heart

Molenaar, P, Sarsero, D, Kaumann, AJ

1. Evidence for a 'putative beta(4)-adrenoceptor' originated over 20 years ago when cardiostimulant effects were observed to nonconventional partial agonists, These agonists were originally described...

Severe combined immunodeficient (SCID) mice: a model for investigating human thyroid autoantibody synthesis.

Macht, L, Fukuma, N, Leader, K, Sarsero, D, Pegg, C A, Phillips, D I, ...

We have studied the ability of lymphocytes from the blood, thyroid and lymph nodes of patients with autoimmune thyroid disease (AITD) to produce autoantibodies to thyroglobulin (Tg) and/or thyroid...