Mueller, L.A., Tanksley, S.D., Giovannoni, J.J., Stack, S., Choi, D., ...
The genome of tomato (Solanum lycopersicum) is being sequenced by an international consortium of 10 countries (Korea, China, the United Kingdom, India, The Netherlands, France, Japan, Spain, Italy...
Functional identification of unknown genes by integration of metabolomics and transcriptomics (2005)
Hirai, M. Y., Klein, M., Fujikawa, Y., Yano, M., Goodenowe, D. B., Yamazaki, Y., ...
Colorectal adenoma and cancer divergence: Evidence of multilineage progression (1999)
Tsao, J., Tavare, S., Salovaara, R., Jass, J. R., Aaltonen, L. A., Shibata, D.
Wang, W H, Takano, T, Shibata, D, Kitamura, K, Takeda, G
We have investigated the nucleotide sequence and expression of lox2, a mutant form of the gene encoding lipoxygenase 2, an enzyme responsible for unpleasant flavors in soybean [Glycine max (L) Merr.]...
BCL2 translocation frequency rises with age in humans.
Liu, Y, Hernandez, A M, Shibata, D, Cortopassi, G A
The background frequency of t(14;18) (q32;q21) chromosomal translocations at the locus associated with B-cell leukemia/lymphoma-2 (BCL2) was determined from a survey of the peripheral blood...
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.
Cortopassi, G A, Shibata, D, Soong, N W, Arnheim, N
An assay that selectively amplifies a specific deletion of the mitochondrial genome has been used to study the extent of the deletion's accumulation in a variety of human tissues. The deletion occurs...
Sato, Y, Watanabe, T, Komamine, A, Hibino, T, Shibata, D, Sugiyama, M, ...
Changes in the enzymatic activity of cinnamyl alcohol dehydrogenase (CAD) and in the expression of a gene for CAD during tracheary element (TE) differentiation were investigated in cultures of single...
Sequence of a soybean (Glycine max L.) phosphoenolpyruvate carboxylase cDNA.
Vazquez-Tello, A, Whittier, R F, Kawasaki, T, Sugimoto, T, Kawamura, Y, Shibata, D
Pandey, R, Ghosh, A K, Kumar, D V, Bachman, B A, Shibata, D, Roy-Burman, P
An important question in feline leukemia virus (FeLV) pathogenesis is whether, as in murine leukemia virus infection, homologous recombination between the infecting FeLV and the noninfectious...
Wang, W H, Takano, T, Shibata, D, Kitamura, K, Takeda, G
We have investigated the nucleotide sequence and expression of lox2, a mutant form of the gene encoding lipoxygenase 2, an enzyme responsible for unpleasant flavors in soybean [Glycine max (L) Merr.]...
BCL2 translocation frequency rises with age in humans.
Liu, Y, Hernandez, A M, Shibata, D, Cortopassi, G A
The background frequency of t(14;18) (q32;q21) chromosomal translocations at the locus associated with B-cell leukemia/lymphoma-2 (BCL2) was determined from a survey of the peripheral blood...
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.
Cortopassi, G A, Shibata, D, Soong, N W, Arnheim, N
An assay that selectively amplifies a specific deletion of the mitochondrial genome has been used to study the extent of the deletion's accumulation in a variety of human tissues. The deletion occurs...
Sato, Y, Watanabe, T, Komamine, A, Hibino, T, Shibata, D, Sugiyama, M, ...
Changes in the enzymatic activity of cinnamyl alcohol dehydrogenase (CAD) and in the expression of a gene for CAD during tracheary element (TE) differentiation were investigated in cultures of single...
Sequence of a soybean (Glycine max L.) phosphoenolpyruvate carboxylase cDNA.
Vazquez-Tello, A, Whittier, R F, Kawasaki, T, Sugimoto, T, Kawamura, Y, Shibata, D
Pandey, R, Ghosh, A K, Kumar, D V, Bachman, B A, Shibata, D, Roy-Burman, P
An important question in feline leukemia virus (FeLV) pathogenesis is whether, as in murine leukemia virus infection, homologous recombination between the infecting FeLV and the noninfectious...
Intestinal stem cell division and genetic diversity. A computer and experimental analysis.
Tsao, J. L., Davis, S. D., Baker, S. M., Liskay, R. M., Shibata, D.
Somatic mutations are expected to arise with age. This process is accelerated in mice lacking the DNA mismatch repair gene Pms2. The distributions of microsatellite alleles present in small patches...
Telomerase activity is commonly detected in hereditary nonpolyposis colorectal cancers.
Li, Z. H., Salovaara, R., Aaltonen, L. A., Shibata, D.
Telomerase activity can be detected in most human cancers. These findings are consistent with the telomere hypothesis, which predicts telomerase expression after a number of mitotic divisions to...
Effects of mutation and growth rates on patterns of microsatellite instability.
Li, Z. H., Aaltonen, L. A., Shu, Q., Srivastava, S., Grizzle, W. E., Shibata, D.
The detection of somatic microsatellite (MS) alterations in tumors is often interpreted as a sign of underlying genomic instability. However, it is unclear why the proportions of altered MS loci vary...
Somatic mitochondrial mutation in gastric cancer.
Burgart, L. J., Zheng, J., Shu, Q., Strickler, J. G., Shibata, D.
Likely hot spots for mutations are mitochondrial sequences as there is less repair and more damage by carcinogens compared with nuclear sequences. A somatic 50-bp mitochondrial D-loop deletion was...
Shibata, D., Brynes, R. K., Nathwani, B., Kwok, S., Sninsky, J., Arnheim, N.
Human immunodeficiency virus (HIV) DNA was detected in formalin-fixed, paraffin-embedded lymph node biopsies after in vitro DNA amplification by the polymerase chain reaction. Twenty-three of 25...
Shibata, D., Tokunaga, M., Uemura, Y., Sato, E., Tanaka, S., Weiss, L. M.
Some undifferentiated gastric carcinomas with intense lymphoid infiltration have a striking resemblance to nasopharyngeal lymphoepithelioma. The authors identified eight such cases (seven patients...
Epstein-Barr virus-associated gastric adenocarcinoma.
The Epstein-Barr virus (EBV) has been detected in certain types of lymphoma and some epithelial neoplasms including nasopharyngeal lymphoepithelioma, and rare lymphoepithelioma-like carcinomas...
Weiss, L. M., Chen, Y. Y., Liu, X. F., Shibata, D.
The authors studied typical Hodgkin's disease along with the nodular, lymphocyte predominance subtype by both the polymerase chain reaction (PCR) and in situ hybridization for evidence of the...
Shibata, D., Hawes, D., Li, Z. H., Hernandez, A. M., Spruck, C. H., Nichols, P. W.
A method using selective ultraviolet radiation fractionation followed by polymerase chain reaction (PCR) can analyze specific cell subsets present on a microscope section. Direct ultraviolet...
c-k-ras and p53 mutations occur very early in adenocarcinoma of the lung.
Li, Z. H., Zheng, J., Weiss, L. M., Shibata, D.
The topographical distribution of a mutation provides insight into past patterns of tumor evolution. This approach was applied to two loci commonly mutated in adenocarcinoma of the lung--p53 and...
Zheng, J., Shu, Q., Li, Z. H., Tsao, J. I., Weiss, L. M., Shibata, D.
Squamous cell carcinoma (SQCC) of the lung is thought to arise after the accumulation of multiple mutations, including p53. To better characterize when p53 mutations are acquired, 37 SQCC of the lung...
Further evidence that one of the earliest alterations in colorectal carcinogenesis involves APC.
Colorectal cancer is hypothesized to arise after the accumulation of multiple mutations in critical oncogenes or tumor suppressor genes. The relative timing of each mutation is unknown because the...