D. Sinnett

Publication List Details

Period

1991 - 1998

Number

17

Co-Authors

Linkage mapping by simultaneous screening of multiple polymorphic loci using Alu oligonucleotide-directed PCR.

Zietkiewicz, E, Labuda, M, Sinnett, D, Glorieux, F H, Labuda, D

We present the use of our recently described multiple-loci polymorphic DNA markers ("alumorphs") for linkage mapping of the human genome. By using the polymerase chain reaction (PCR) with an...

Determination of DNA replication kinetics in synchronized human cells using a PCR-based assay.

Sinnett, D, Flint, A, Lalande, M

Studies on the temporal order of DNA replication are difficult due to the lack of sensitivity of methods available for replication kinetic analysis. To overcome problems associated with the current...

Reverse transcriptase activity from human embryonal carcinoma cells NTera2D1.

Deragon, J M, Sinnett, D, Labuda, D

We have identified an RNA-dependent DNA polymerase activity in the microsomal fraction of human pluri-potential embryonal carcinoma cells NTera2D1, which are known to express the full length coding...

Risk of childhood leukemia associated with diagnostic irradiation and polymorphisms in DNA repair genes.

Infante-Rivard, C, Mathonnet, G, Sinnett, D

The purpose of the study was to measure risk of childhood acute lymphoblastic leukemia associated with reported postnatal diagnostic X rays and to determine if it was modified in the presence of...

High-resolution mapping of the gamma-aminobutyric acid receptor subunit beta 3 and alpha 5 gene cluster on chromosome 15q11-q13, and localization of breakpoints in two Angelman syndrome patients.

Sinnett, D, Wagstaff, J, Glatt, K, Woolf, E, Kirkness, E J, Lalande, M

The gamma-aminobutyric acid (GABAA) receptors are a family of ligand-gated chloride channels constituting the major inhibitory neurotransmitter receptors in the nervous system. In order to determine...

Linkage mapping by simultaneous screening of multiple polymorphic loci using Alu oligonucleotide-directed PCR.

Zietkiewicz, E, Labuda, M, Sinnett, D, Glorieux, F H, Labuda, D

We present the use of our recently described multiple-loci polymorphic DNA markers ("alumorphs") for linkage mapping of the human genome. By using the polymerase chain reaction (PCR) with an...

Determination of DNA replication kinetics in synchronized human cells using a PCR-based assay.

Sinnett, D, Flint, A, Lalande, M

Studies on the temporal order of DNA replication are difficult due to the lack of sensitivity of methods available for replication kinetic analysis. To overcome problems associated with the current...

Reverse transcriptase activity from human embryonal carcinoma cells NTera2D1.

Deragon, J M, Sinnett, D, Labuda, D

We have identified an RNA-dependent DNA polymerase activity in the microsomal fraction of human pluri-potential embryonal carcinoma cells NTera2D1, which are known to express the full length coding...

Risk of childhood leukemia associated with diagnostic irradiation and polymorphisms in DNA repair genes.

Infante-Rivard, C, Mathonnet, G, Sinnett, D

The purpose of the study was to measure risk of childhood acute lymphoblastic leukemia associated with reported postnatal diagnostic X rays and to determine if it was modified in the presence of...

High-resolution mapping of the gamma-aminobutyric acid receptor subunit beta 3 and alpha 5 gene cluster on chromosome 15q11-q13, and localization of breakpoints in two Angelman syndrome patients.

Sinnett, D, Wagstaff, J, Glatt, K, Woolf, E, Kirkness, E J, Lalande, M

The gamma-aminobutyric acid (GABAA) receptors are a family of ligand-gated chloride channels constituting the major inhibitory neurotransmitter receptors in the nervous system. In order to determine...

Genomic loci susceptible to replication errors in cancer cells.

Krajinovic, M., Richer, C., Gorska-Flipot, I., Gaboury, L., Novakovic, I., Labuda, D., ...

Microsatellite instability due to a deficiency in DNA mismatch repair is characteristic of a replication error (RER) phenotype. This widespread genomic instability is well documented in hereditary...

Frequent loss of heterozygosity at the DNA mismatch-repair loci hMLH1 and hMSH3 in sporadic breast cancer

Benachenhou, N, Guiral, S, Gorska-Flipot, I, Labuda, D, Sinnett, D

To study the involvement of DNA mismatch-repair genes in sporadic breast cancer, matched normal and tumoral DNA samples of 22 patients were analysed for genetic instability and loss of heterozygosity...