Hughes, D. T. D., Jenkins, G. C., Gurney, J. D.
Eleven patients who received co-trimoxazole at standard dosage for periods ranging from 3 to 30 months (mean 10 months), were studied. Nine suffered from severe chronic bronchitis, 1 had...
A haematological study of patients receiving long-term treatment with trimethoprim and sulphonamide
Jenkins, G. C., Hughes, D. T. D., Hall, P. C.
The haematological effects of long-term treatment for three months with a combination of trimethoprim and sulphamethoxazole were studied in 10 cases of chronic bronchitis. Trimethoprim selectively...
The response of foetal sheep and lambs to pulmonary inflation
Hughes, D. T. D., Parker, H. R., Williams, J. V.
1. Pulmonary inflation through a tracheostomy consistently produces an inspiratory response or gasp in the foetal lamb. This response is reversibly removed by vagal cooling or xylocaine local...
Fifty patients with exacerbations of chronic bronchitis were treated with either a combination of trimethoprim 320 mg. and sulphamethoxazole 1,600 mg. a day or ampicillin 2 g. a day. The trial,...
A haematological study of patients receiving long-term treatment with trimethoprim and sulphonamide
Jenkins, G. C., Hughes, D. T. D., Hall, P. C.
The haematological effects of long-term treatment for three months with a combination of trimethoprim and sulphamethoxazole were studied in 10 cases of chronic bronchitis. Trimethoprim selectively...
The response of foetal sheep and lambs to pulmonary inflation
Hughes, D. T. D., Parker, H. R., Williams, J. V.
1. Pulmonary inflation through a tracheostomy consistently produces an inspiratory response or gasp in the foetal lamb. This response is reversibly removed by vagal cooling or xylocaine local...
Fifty patients with exacerbations of chronic bronchitis were treated with either a combination of trimethoprim 320 mg. and sulphamethoxazole 1,600 mg. a day or ampicillin 2 g. a day. The trial,...
Ten Years' Experience in Running a Pulmonary Function Laboratory
Hughes, D. T. D., Empey, D. W.
A survey of the development and work of a pulmonary function laboratory in a teaching hospital over a 10-year period has shown an increasing demand for pulmonary function tests from all departments,...
Abnormal Chemoreceptor Response to Hypoxia in Patients with Tabes Dorsalis
Evans, R. J. Courtenay, Benson, M. K., Hughes, D. T. D.
Nine patients with tabes dorsalis and one patient with diabetic autonomic neuropathy were subjected to hypoxia to test the integrity of their carotid chemoreceptors. Ventilation and pulse rate...
Fibrosing Alveolitis Associated with Renal Tubular Acidosis
Mason, A. M. S., McIllmurray, M. B., Golding, P. L., Hughes, D. T. D.
The discovery of a case of renal tubular acidosis and fibrosing alveolitis led to the investigation of 19 further patients. Abnormal pulmonary function tests were found in a further four patients...
Bronchiolar carcinoma: a case report with pulmonary function studies
Dyer, N. H., Hughes, D. T. D., Thompson, J. M. A.
A patient with bilateral multinodular bronchiolar carcinoma is described in whom carbon monoxide transfer factor and arterial oxygen saturation were greatly impaired but lung volumes and ventilation...
Characteristics of the Vitalograph spirometer
Drew, C. D. M., Hughes, D. T. D.
The characteristics and performance of the Vitalograph dry spirometer were studied using the criteria suggested by the International Labour Organisation (I.L.O.) Report on the standardization of...
Pulmonary Hypersensitivity to the Grain Weevil
A case of inhalant allergy to the grain weevil is described. Provocation inhalations of the weevil protein produced immediate responses shown by falls of as much as 25% in the F.E.V.1·0. These...