The penetration of aztreonam, a monobactam antibiotic, into intra-abdominal abscesses (1989)
Youngs, Denise J., Burdon, D. W., Keighley, M. R. B.
We have studied the penetration of aztreonam into pus with a low mortality intra-abdominal abscess model in the Wistar rat. The mean peak serum concentration (standard error) of aztreonam was 74ยท6...
Hall, C., Curran, F., Burdon, D. W., Keighley, M. R. B.
A randomized controlled trial was designed to compare antibiotic prophylaxis with a standard combination of agents, metronidazole and gentamicin, with a single preparation, amoxycillin/clavulanate in...
Silverman, S. H., Johnson, M., Burdon, D. W., Keighley, M. R. B.
The pharmacokinetics of single dose intravenous ciprofloxacin in patients undergoing gastrointestinal surgery (100 mg, n=8; 200 mg n=18) have been studied. Following 100 mg therapeutic...
Ambrose, N. S., Johnson, Margaret, Burdon, D. W., Keighley, M. R.B.
The influence of a single intravenous dose of antibiotic on faecal flora and the emergence of Clostridiwn digfficile was studied in volunteers. Seventy-eight volunteers (13 groups of 6 receiving 5...
Treatment of pseudomembranous colitis and antibiotic-associated diarrhoea (1984)
Pseudomembranous colitis is caused by release of toxins from Clostridium difficile when it colonizes the large intestine. This clostridium is susceptible to concentrations of vancomycin which are...
Evaluation of mezlocillin in elective gastrointestinal surgery (1983)
Keighley, M. R. B., Ambrose, N. S., Morris, D. L., Burdon, D. W.
We report the interim results of two trials to evaluate the place of mezlocillin in elective intestinal operations. Sixity-four operations for gastro-oesophageal disease have been performed where...
A study of the biliary excretion of mecillinam in patients with biliary disease (1982)
Hares, M. M., Hegarty, A., Tomkyns, Jennifer, Burdon, D. W., Keighley, M. R. B.
Fifty-three patients undergoing biliary surgery (11 jaundiced) received prophylactic mecillinam (800 mg) intramuscularly 1 h pre-operatively. Samples of bile and blood were taken for mecillinam assay...
Clindamycin and lincomycin provide effective prophylaxis against wound infection by Bacteroides fragilis for appendicectomy and colo-rectal operations. The use of these antibiotics may be followed by...
Antibiotic susceptibility of Clostridium difficile (1979)
Burdon, D. W., Brown, J. D., Youngs, D. J., Arabi, Y., Shinagawa, N., Alexander-Williams, J., ...
Strains of Clostridium difficile isolated from patients with pseudomembranous colitis or diarrhoea were all sensitive to concentrations of vancomycin which are readily attained in faeces by oral...
Influence of neomycin and metronidazole on colonic microflora of volunteers (1979)
Arabi, Y., Dimock, Frances, Burdon, D. W., Alexander-Williams, J., Keighley, M. R. B.
The influence on colonic microflora of neomycin and metronidazole alone, or in combination, was studied in volunteers taking a normal diet. Bacterial counts on daily faecal samples revealed that...
Faecal toxin and severity of antibiotic-associated pseudomembranous colitis.
Burdon, D W, George, R H, Mogg, G A, Arabi, Y, Thompson, H, Johnson, M, ...
The relationship between faecal toxin titre, histological evidence of pseudomembrane in the rectum, and severity of antibiotic-associated colitis has been analysed from data on 62 patients whose...
Borriello, S P, Barclay, F E, Reed, P J, Welch, A R, Brown, J D, Burdon, D W
Virulent toxigenic and avirulent non-toxigenic strains of Clostridium difficile gave a positive result in the latex agglutination test (LAT) for C difficile toxin A (D-1). Similar concentrations of...
Arthritis in pseudomembranous colitis associated with an antibody to Clostridium difficile toxin.
Fairweather, S D, Youngs, D, George, R H, Burdon, D W, Keighley, M R
Fatal pseudomembranous colitis despite eradication of Clostridium difficile.
Hawker, P C, Hine, K R, Burdon, D W, Thompson, H, Keighley, M R
Identification of Clostridium difficile as a cause of pseudomembranous colitis.
George, R H, Symonds, J M, Dimock, F, Brown, J D, Arabi, Y, Shinagawa, N, ...
Prophylactic use of cephazolin against wound sepsis after cholecystectomy.
Strachan, C J, Black, J, Powis, S J, Waterworth, T A, Wise, R, Wilkinson, A R, ...
A trial of antibiotic prophylaxis with cephazolin against postoperative wound sepsis was carried out on 201 patients undergoing routine cholecystectomy. Wound sepsis occurred in 11 out of 65 controls...
Randomised controlled trial of vancomycin for pseudomembranous colitis and postoperative diarrhoea.
Keighley, M R, Burdon, D W, Arabi, Y, Williams, J A, Thompson, H, Youngs, D, ...
The efficacy of vancomycin in pseudomembranous colitis was assessed in a prospective randomised controlled trial. Forty-four patients with postoperative diarrhoea were allocated to five days'...
Faecal toxin and severity of antibiotic-associated pseudomembranous colitis.
Burdon, D W, George, R H, Mogg, G A, Arabi, Y, Thompson, H, Johnson, M, ...
The relationship between faecal toxin titre, histological evidence of pseudomembrane in the rectum, and severity of antibiotic-associated colitis has been analysed from data on 62 patients whose...
Borriello, S P, Barclay, F E, Reed, P J, Welch, A R, Brown, J D, Burdon, D W
Virulent toxigenic and avirulent non-toxigenic strains of Clostridium difficile gave a positive result in the latex agglutination test (LAT) for C difficile toxin A (D-1). Similar concentrations of...
Arthritis in pseudomembranous colitis associated with an antibody to Clostridium difficile toxin.
Fairweather, S D, Youngs, D, George, R H, Burdon, D W, Keighley, M R
Fatal pseudomembranous colitis despite eradication of Clostridium difficile.
Hawker, P C, Hine, K R, Burdon, D W, Thompson, H, Keighley, M R
Identification of Clostridium difficile as a cause of pseudomembranous colitis.
George, R H, Symonds, J M, Dimock, F, Brown, J D, Arabi, Y, Shinagawa, N, ...
Prophylactic use of cephazolin against wound sepsis after cholecystectomy.
Strachan, C J, Black, J, Powis, S J, Waterworth, T A, Wise, R, Wilkinson, A R, ...
A trial of antibiotic prophylaxis with cephazolin against postoperative wound sepsis was carried out on 201 patients undergoing routine cholecystectomy. Wound sepsis occurred in 11 out of 65 controls...
Randomised controlled trial of vancomycin for pseudomembranous colitis and postoperative diarrhoea.
Keighley, M R, Burdon, D W, Arabi, Y, Williams, J A, Thompson, H, Youngs, D, ...
The efficacy of vancomycin in pseudomembranous colitis was assessed in a prospective randomised controlled trial. Forty-four patients with postoperative diarrhoea were allocated to five days'...
Immunoglobulins of normal human urine and urethral secretions
The immunoglobulins of normal human urine, collected per urethram, and by supra-pubic needle aspiration have been investigated. IgD has been demonstrated in normal urine in addition to IgG and IgA....
Influence of prophylaxis against bacteroides on incidence of sepsis after large-bowel surgery.
Keighley, M. R., Burdon, D. W., Cooke, W. T., Alexander-Williams, J.
Prophylactic antibiotics in bowel surgery.
Alexander-Williams, J., McLeish, A. R., Keighley, K. R., Burdon, D. W.
Keighley, M R, Drysdale, R B, Quoraishi, A H, Burdon, D W, Alexander-Willians, J
A randomised controlled trial has been performed in 150 patients undergoing biliary operations to determine whether an antibiotic which is excreted almost entirely in bile (rifamide) is to be...
Influence of inflammatory bowel disease on intestinal microflora.
Keighley, M R, Arabi, Y, Dimock, F, Burdon, D W, Allan, R N, Alexander-Williams, J
The microflora of the jejunum, ileum, and colon has been studied from operative samples in Crohn's disease (n = 30), ulcerative colitis (n = 15), and controls (n = 40). There was no significant...
Clostridium difficile toxin in acute diarrhoea complicating inflammatory bowel disease.
Keighley, M R, Youngs, D, Johnson, M, Allan, R N, Burdon, D W
The incidence of Clostridium difficile cytotoxin has been studied in 69 consecutive patients with inflammatory bowel disease complicated by severe diarrhoea or ileostomy flux during 74 admissions to...
Keighley, M R, Youngs, D, Poxon, V, Morris, D, Muscroft, T J, Burdon, D W, ...
Three groups of patients studied after operations which had cured their duodenal ulcer were compared with a control group (no operation, n = 8). The surgical procedures included: proximal gastric...
Mutagenicity in gastric juice.
Morris, D L, Youngs, D, Muscroft, T J, Cooper, J, Rojinski, C, Burdon, D W, ...
Mutagenicity has been measured in the gastric juice of 228 patients using the Ames bacteriological test system; while mutagenicity in control and duodenal ulcer patients did not differ from saline...
Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.
Mitchell, T J, Ketley, J M, Haslam, S C, Stephen, J, Burdon, D W, Candy, D C, ...
The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid...
The 24-hr urinary excretion and clearances of IgA, IgG, siderophilin and albumin have been determined on specimens from twenty-one hospital patients, nine of whom had urinary tract infection....