D. Wilhelm

Implementation of a plate-type fuel model to a multi-physics code and benchmark modelling of special power excursion reactor tests. (2009)

Liu, P., Wilhelm, D., Rineiski, A., Gabrielli, F., Maschek, W., Bruna, G.B.

Internat.Conf.on Advances in Mathematics, Computational Methods, and Reactor Physics, Saratoga Springs, N.Y., May 3-7, 2009

Development of a plate-type fuel model for the neutronics and thermal-hydraulics coupled code -SIMMER-III- and its application to the analyses of SPERT. (2009)

Liu, P., Wilhelm, D., Rineiski, A., Gabrielli, F., Maschek, W.

Proc.of the 13th Internat.Topical Meeting on Nuclear Reactor Thermal Hydraulics (NURETH-13), Kanazawa, J, September 27 - October 2, 2009

SIMMER model of a low-enriched uranium non-power reactor. (2008)

Wilhelm, D., Biaut, G., Tobita, Y.

Nuclear Engineering and Design, 238(2008) S.41-48

A scientific strategy for preventing the misuse of reactor-grade plutonium as nuclear explosive. (2008)

Kessler, G., Broeders, C., Hoebel, W., Goel, B., Wilhelm, D.

2nd Internat.Science and Technology Forum on Protected Plutonium Utilization for Peace and Sustainable Prosperity, Tokyo, J, September 16-18, 2008

A new scientific solution for preventing the misuse of reactor-grade plutonium as nuclear explosive. (2008)

Kessler, G., Broeders, C., Hoebel, W., Goel, B., Wilhelm, D.

Nuclear Engineering and Design, 238(2008) S.3429-444

Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation (2007)

Svingen, T., Beverdam, A., Verma, P., Wilhelm, D., Koopman, P.

Aard (alanine and arginine rich domain) is a gene of unknown function, previously reported to show sexually dimorphic expression in fetal mouse gonads. Here we describe the spatio-temporal expression...

Comparative Analysis of Anti-Mouse SRY Antibodies (2007)

Bradford, S.T., Wilhelm, D., Koopman, P.

The Y chromosome gene SRY is the initiator of male sexual differentiation in mammals, but the molecular and cellular mechanisms operating downstream of SRY remain undefined. A deeper understanding of...

SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development (2007)

Wilhelm, D., Hiramatsu, R., Mizusaki, H., Widjaja, L., Combes, A. N., Kanai, Y., ...

In mammals, male sex is determined by the Y-chromosomal gene Sry ( sex-determining region of Y chromosome). The expression of Sry and subsequently Sox9 ( SRY box containing gene 9) in precursors of...

Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation (2007)

Svingen, T., Beverdam, A., Verma, P., Wilhelm, D., Koopman, P.

Aard (alanine and arginine rich domain) is a gene of unknown function, previously reported to show sexually dimorphic expression in fetal mouse gonads. Here we describe the spatio-temporal expression...

Comparative Analysis of Anti-Mouse SRY Antibodies (2007)

Bradford, S. T., Wilhelm, D., Koopman, P. A.

The Y chromosome gene SRY is the initiator of male sexual differentiation in mammals, but the molecular and cellular mechanisms operating downstream of SRY remain undefined. A deeper understanding of...

Sex determination and gonadal development in mammals (2007)

Wilhelm, D., Palmer, S., Koopman, P.

Arguably the most defining moment in our lives is fertilization, the point at which we inherit either an X or a Y chromosome from our father. The profoundly different journeys of male and female life...

SIMMER model of a low-enriched uranium non-power reactor. (2006)

Wilhelm, D., Biaut, G., Tobita, Y.

Technical Meeting on Severe Accident and Accident Management for Nuclear Power Plants, Tokyo, J, March 14-16, 2006

Evaluation of candidate markers for the peritubular myoid cell lineage in the developing mouse testis (2005)

Jeanes, A., Wilhelm, D., Wilson, M. J., Bowles, J., McClive, P. J., Sinclair, A. H., ...

Despite the importance of peritubular myoid (PM) cells in the histogenesis of the fetal testis, understanding the origin and function of these cells has been hampered by the lack of suitable markers....

SIMMER-III and SIMMER-IV safety code development for reactors with transmutation capability. (2005)

Maschek, W., Rineiski, A., Suzuki, T., Wang, S., Mori, Mg., Wiegner, E., ...

Mathematics and Computation, Supercomputing, Reactor Physics and Biological Applications : Proc.of the Internat.Topical Meeting, Avignon, F, September 12-15, 2005

The challenge of simplifying DCH modeling. (2005)

Wilhelm, D.

1st European Review Meeting on Severe Accident Research (ERMSAR-2005), Aix-en-Provence, F, November 14-16, 2005

Direct containment heating at low primary pressure: experimental investigation and multidimensional modeling. (2005)

Meignen, R., Plassart, D., Caroli, C., Meyer, L., Wilhelm, D.

Lemmonier, H. [Hrsg.]

Sox genes and cancer (2004)

Dong, C., Wilhelm, D., Koopman, P.

Sox genes encode transcription factors belonging to the HMG ( High Mobility Group) superfamily. They are conserved across species and involved in a number of developmental processes. In vitro studies...

Direct containment heating investigations for European pressurized water reactors. (2004)

Meyer, L., Albrecht, G., Wilhelm, D.

6th Internat.Conf.on Nuclear Thermal Hydraulics, Operations and Safety (NUTHOS- 6), Nara, J, October 4-8, 2004

SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro (2003)

Schepers, G., Wilson, M., Wilhelm, D., Koopman, P.

Sox8 is a member of the Sox family of developmental transcription factor genes and is closely related to Sox9, a key gene in the testis determination pathway in mammals. Like Sox9, Sox8 is expressed...

Recalculation of corium dispersion experiments at low system pressure. (2003)

Wilhelm, D.

NURETH-10 : The 10th Internat.Topical Meeting on Nuclear Reactor Thermal Hydraulics, Seoul, Korea, October 5-11, 2003

The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1 (2002)

Wilhelm, D., Englert, C.

In mammals, several genes including the Wilms tumor suppressor gene Wt1, the Lim homeobox gene Lhx9, and the gene encoding steroidogenic factor 1 (Sf1) have been implicated in the development of the...

The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation (2002)

Du, X. J., Hublitz, P., Gunther, T., Wilhelm, D., Englert, C., Schule, R.

An essential step during sex determination is the maintenance of the Mullerian duct in females and its regression in males caused by the expression of Mullerian inhibiting substance (MIS). In testes,...

Rechnungen zur Dispersion der Kernschmelze. (2002)

Wilhelm, D.

Programm Nukleare Sicherheitsforschung. Jahresbericht 2001. Teil 1

The Wilms' tumor gene Wt1 is required for normal development of the retina. (2002)

Wagner, K.D., Wagner, N., Vidal, V.P.I., Schley, G., Wilhelm, D., Schedl, A., ...

The EMBO Journal, 21(2002) S.1398-1405

The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1. (2002)

Wilhelm, D., Englert, C.

Genes and Development, 16(2002) S.1839-51

The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation. (2002)

Du, X., Hublitz, P., Günther, T., Wilhelm, D., Englert, C., Schüle, R.

Biochimica et Biophysica Acta - Gene Structure and Expression, 1577(2002) S.93-101

Chemical reaction models in a code of the SIMMER-family. (2002)

Wilhelm, D.

Joint IAEA/NEA Technical Meeting on the Use of Computational Fluid Dynamics Codes for Safety Analysis of Reactor Systems, Including Containment, Pisa, I, November 11-15, 2002

The Wilms tumor suppressor wt1 activates the steroidogenic factor 1 (Sf-1) gene. (2001)

Wilhelm, D., Englert, C.

14th Internat.Congress of Developmental Biology, Kyoto, J, July 8-12, 2001

Extrapolation of the thermite dispersion experiment SNL/Sup-1 to prototypic conditions. (2001)

Wilhelm, D.

16th Internat.Conf.on Structural Mechanics in Reactor Technology (SMiRT-16), Post Conf.Seminar 'Containment of Nuclear Reactors', Albuquerque, N.M., August 20-21, 2001

Analysis of a thermite experiment to study low pressure corium dispersion. (2001)

Wilhelm, D.

Wissenschaftliche Berichte, FZKA-6602 (August 2001)

Rechnungen zur Dispersion der Kernschmelze. (2001)

Wilhelm, D.

Programm Nukleare Sicherheitsforschung. Jahresbericht 2000

Experiments on corium dispersion after lower head failure at moderate pressure. (2000)

Meyer, L., Jacobs, G., Wilhelm, D., Gargallo, M., Blanchat, T.K.

Proc.of the Seminar on Containment of Nuclear Reactors held in Conjunction with the 15th Internat.Conf.on Structural Mechanics in Reactor Technology, Seoul, Korea, August 23-24, 1999

Transient code models for low pressure corium dispersion. (2000)

Wilhelm, D.

Proc.of the OECD Workshop on Ex-Vessel Debris Coolability, Karlsruhe, November 15-18, 1999

The Wilms tumor suppressor wt1 activates the steroidogenic factor 1 (Sf-1) gene. (2000)

Wilhelm, D., Englert, C.

EMBL Transcription Meeting, Heidelberg, August 26-30, 2000

Rechnungen zur Dispersion der Kernschmelze. (2000)

Wilhelm, D.

Projekt Nukleare Sicherheitsforschung. Jahresbericht 1999.

Experience with the multiphase code SIMMER and its models for interfacial area convection. (2000)

Wilhelm, D., Coste, P.

Trends in Numerical and Physical Modeling for Industrial Multiphase Flows, Cargese, F, September 27-29, 2000

JNK/SAPK activity is not sufficient for anticancer therapy-induced apoptosis involving CD95-L, trail and TNF-#a. (1999)

Herr, I., Wilhelm, D., Böhler, T., Angel, P., Debatin, K.M.

International Journal of Cancer, 80(1999) S.417-24

NF#kB activation is required for interferon regulatory factor-1-mediated interferon #b induction. (1999)

Kirchhoff, S., Wilhelm, D., Angel, P., Hauser, H.

European Journal of Biochemistry, 261(1999) S.546-54

JNK/SAPK activity contributes to TRAIL-induced apoptosis. (1999)

Herr, I., Wilhelm, D., Meyer, E., Jeremias, I., Angel, P., Debatin, K.M.

Cell Death and Differentiation, 6(1999) S.130-35

Mechanical problems after a fast reactor core melt-down. (1998)

Kayser, G., Wilhelm, D.

Bhandari, S. [Hrsg.]

Experiments on the behaviour of a hot melt injected into sodium. (1998)

Kaiser, A., Huber, F., Wilhelm, D.

Experimental Thermal and Fluid Science, 18(1998) S.48-69

Spezifische Signaltransduktionswege über die das E1A-Onkoprotein und alkylierende Substanzen die Expression zellulärer Gene modulieren. (1997)

Wilhelm, D.

Dissertation, Universität Karlsruhe 1996

Status and achievement of assessment program for SIMMER-III, a multiphase, multicomponent code for LMFR safety analysis. (1997)

Kondo, S., Brear, D.J., Tobita, Y., Morita, K., Maschek, W., Coste, P., ...

8th Internat.Topical Meeting on Nuclear Reactor Thermal Hydraulics (NURETH-8), Kyoto, J, September 30 - October 4, 1997

The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including jun N-terminal protein kinases and p38 kinase by alkylating agents. (1997)

Wilhelm, D., Bender, K., Knebel, A., Angel, P.

Molecular and Cellular Biology, 17(1997) S.4792-4800

Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. (1997)

Herr, I., Wilhelm, D., Böhler, T., Angel, P., Debatin, K.M.

The EMBO Journal, 16(1997) S.6200-08

Steady state and transient operation of a natural convection decay heat removal system in a LMR model. (1997)

Wilhelm, D.

Proc.of the Internat.Topical Meeting on Advanced Reactors Safety, Orlando, Fla., June 1-5, 1997 Vol. 1, S.164-70

Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. (1996)

Bannister, A.J., Oehler, T., Wilhelm, D., Angel, P., Kouzarides, T.

Oncogene, 11(1995) S.2509-14

Ligand-independent activation of receptor tyrosine kinases. (1996)

Herrlich, P., Knebel, A., Bender, K., Blattner, C., Wilhelm, D., Rahmsdorf, H.J.

35th National Scientific Conf.of the Australian Society for Medical Research, Gold Coast, AUS, November 24-27, 1996

Synthesis of research on boiling pool thermohydraulics at CEA and KfK. (1995)

Seiler, J.M., Kayser, G., Wilhelm, D.

Proc.of the IAEA/IWGFR Technical Committee Meeting on Material-Coolant Interactions and Material Movement and Relocation in Liquid Metal Fast Reactors, O'Arai, J, June 6-9, 1994

Regulation of AP-1 and AP-1-dependent genes by stress stimuli. (1995)

Wilhelm, D., Van Dam, H., Baumann, B., Herr, I., Angel, P.

Workshop on Regulation of Expression of Cell Stress Genes, Ravello, I, April 1-3, 1995

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. (1995)

Van Dam, H., Wilhelm, D., Herr, I., Steffen, A., Herrlich, P., Angel, P.

The EMBO Journal, 14(1995) S.1798-1811

Gene regulatory pathways triggered by chemical and physical carcinogens. (1995)

Iordanov, M., Knebel, A., Wilhelm, D., Angel, P., Rahmsdorf, H.J., Herrlich, P.

6th Charles Heidelberger Conf.'Control of Cell Proliferation and Differentiation: Molecular Targets in Carcinogenesis and Cancer Therapy', Essen, July 9-13, 1995

Both ATF-2 and c-Jun are phosphorylated by stress-activated protein kinases in response to UV irradiation. (1995)

Wilhelm, D., Van Dam, H., Herr, I., Baumann, B., Herrlich, P., Angel, P.

Immunobiology, 193(1995) S.143-48

Regulation of AP-1 activity and of AP-1-dependent target genes. (1995)

Iordanov, M., Wade, E., Knebel, A., Angel, P., Rahmsdorf, H.J., Wilhelm, D., ...

5th Internat.Congress: Hormones and Cancer, Quebec, CDN, September 16-20, 1995

Regulation of AP-1 transcription factor activity. (1995)

Herrlich, P., Angel, P., Wilhelm, D., Tuckermann, J., Knebel, A., Rahmsdorf, H.J., ...

Symp.on Cell Proliferation, Innsbruck, A, November 30 - December 1, 1995

Assessment of SIMMER-III performance on pool and depressurization experiments. (1995)

Wilhelm, D.

STR/LML/95-315 (Mai 95)

Investigation of the fluid dynamics of a gas jet expansion in a liquid pool. (1994)

Meyer, L., Wilhelm, D.

KfK-5307 (März 94)

Analyzing the SCARABEE BF2 and BF3 experiments with the AFDM code. (1994)

Wilhelm, D., Kayser, G.

Proc.of the Internat.Topical Meeting on Advanced Reactors Safety, Pittsburgh, Pa., April 17-21, 1994 Vol. 2 S.776-83

AFDM: An advanced fluid-dynamics model. Vol.VI: EOS-AFDM interface. (1994)

Henneges, G., Kleinheins, S., [Hrsg.], Bohl, W.R., Fischer, E.A., Goutagny, L., ...

LA-11692-MS Vol. VI (January 94)

Untersuchungen zur passiven Nachwärmeabfuhr für schnelle Reaktoren. (1994)

Hoffmann, H., Wilhelm, D., Weinberg, D.

Sammlung der Vorträge zum Statusbericht des Projektes Nukleare Sicherheitsforschung (PSF) vom 23.März 1994 im Kernforschungszentrum Karlsruhe.

Analyzing the fluid dynamics of in-pile experiments with a computer code for core-disruptive accidents. (1994)

Wilhelm, D., Kayser, G.

ENC '94 : Internat.Nuclear Congress Atoms for Energy ; a Dialogue with the Industry's Young Generation on Nuclear's Future, Lyon, F, October 2-6, 1994

Analyzing the SCARABEE BF2 and BF3 experiments with the AFDM code. (1994)

Wilhelm, D.

Interner Bericht 32.13.01/P02C (Dezember 93)

Steady-state performance of the KIWA chains of natural convection. (1994)

Wilhelm, D., Roth, A., Kirstahler, M.

Interner Bericht 32.22.02/06A (August 94)

Results on the behaviour of thermite melt injected into sodium. (1992)

Huber, F., Kaiser, A., Wilhelm, D.

14th Meeting of the Liquid Metal Boiling Working Group, ENEA, Brasimone, I, April 16 - 18, 1991 Proc. Vol.I S.207-20

Transient evaporation and stratification of two immiscible liquids for LMFBR transition phase analysis. (1992)

Wilhelm, D., Roth, A.

KfK-4968 (Februar 92)

The 1:10 scale chain of natural convection 'KIWA' for studying the LMR passive decay heat removal. (1992)

Wilhelm, D., Hansen, G., Stromann, H.

Internat.Conf.on Design and Safety of Advanced Nuclear Power Plants, Tokyo, J, October 25-29, 1992 Proc. Vol.III S.26.4/1-4/7

Numerical simulation of the THINA thermite injection into sodium with the AFDM-code. (1992)

Wilhelm, D., Huber, F., Kaiser, A.

Internat.Conf.on Design and Safety of Advanced Nuclear Power Plants, Tokyo, J, October 25-29, 1992 Proc. Vol.IV S.40.4/1-4/7

The advanced fluid dynamics model program: scope and accomplishment. (1992)

Bohl, W.R., Wilhelm, D.

Nuclear Technology, 99(1992) S.366-73

Charakterisierung der allelen Varianten des CD44-Gens bei der metastatischen Zellinie Bsp73 ASML. (1992)

Wilhelm, D.

Diplomarbeit, Universitaet Karlsruhe 1992

Test und Anwendung des Mehrphasen-Thermofluiddynamik-Codes AFDM. (1991)

Fischer, E.A., Kleinheins, S., Munz, C.D., Wilhelm, D.

Jahrestagung Kerntechnik 91. Bonn, 14.-16.Mai 1991

AFDM: An advanced fluid-dynamics model. Vol. I: Scope, approach, and summary. (1991)

Bohl, W.R., Wilhelm, D., Parker, F.R., Berthier, J., Goutagny, L., Ninokata, H.

LA-11692-MS, Vol.I (September 90)

AFDM: An advanced fluid-dynamics model. Vol. III: AFDM haet transfer and momentum-exchange coefficients. (1991)

Berthier, J., Wilhelm, D., Bohl, W.R.

LA-11692-MS, Vol.III (September 90)

AFDM: An advanced fluid-dynamics model. Vol. II : Topologies, flow regimes, and interfacial areas. (1991)

Wilhelm, D.

LA-11692-MS, Vol.II (1990)

THE AFDM program: scope and significance. (1990)

Bohl, W.R., Wilhelm, D., Berthier, J., Parker, F.R.

Proc.of the 1990 Internat.Fast Reactor Safety Meeting, Snowbird, Utah, August 12-16, 1990

The AFDM models for interfacial areas and their test on out-of-pile experiments. (1990)

Wilhelm, D., Bohl, W.R.

Proc.of the 1990 Internat.Fast Reactor Safety Meeting, Snowbird, Utah, August 12-16, 1990

Topologies, flow regimes, and interfacial surface aresas. (1990)

Wilhelm, D.

LA-11692-MS (September 90)

Multiphase flow in the advanced fluid dynamics model. (1988)

Bohl, W.R., Parker, F.R., Maudlin, P.J., Ichikawa, S., Wilhelm, D., Berthier, J., ...

ANS Proc.of the 1988 Nat.Heat Transfer Conf., Houston, Tex., July 24-27, 1988

Two simulant material experiments studying the fluid dynamics in core disruptive accidents. (1987)

Wilhelm, D., Kirstahler, M., Roth, A.

Science and Technology of Fast Reactor Safety : Proc.of an Internat.Conf.,

Expansion of fuel and fuel simulants through the upper core structures - a post-test analysis. (1987)

Meyer, L., Wilhelm, D.

Science and Technology of Fast Reactor Safety : Proc.of an Internat.Conf.,

Computational methods of the advanced fluid dynamics model. (1987)

Bohl, W.R., Wilhelm, D., Parker, F.R., Berthier, J., Maudlin, P.J., Schmuck, P., ...

Internat.Topical Meeting on Advances in Reactor Physics, Mathematics and Computation, Paris, F, April 27-30, 1987 Proc.

Versuchsanlage zur schnellen Gasinjektion in einen wassergefuellten Behaelter. (1987)

Wilhelm, D., Kirstahler, M.

KfK-4321 (November 87)

Extrapolation of data from simulant-material experiments to the work potential of fuel penetrating through upper core structures in core disruptive accidents. (1985)

Meyer, L., Wilhelm, D.

KfK-3845 (Maerz 85)

An experimental investigation of fuel expansion during core disruptive accidents in liquid-metal fast breeder reactors using simulant materials. (1985)

Wilhelm, D., Meyer, L.

Nuclear Technology, 71(1985) S.162-72

SIMMER analysis of the upper structure dynamics experiment. (1984)

Wilhelm, D.

Jones, A.V. [Hrsg.]

Expansion of flashing fuel simulants into the upper core structures using CRBR and SNR geometries. (1983)

Wilhelm, D., Meyer, L., Chapyak, E.J.

LMFBR Safety: Proc.of the Topical Meeting, Lyon, F, July 19-23, 1982

SIMMER-Analysen und Verifikation. (1983)

Schmuck, P., Dalle Donne, M., Kuefner, K., Maschek, W., Meyer, L., Wilhelm, D.

KfK-Nachrichten, 15(1983) S.262-71

A simulant material experimental investigation of flow dynamics in the CRBR upper core structure. (1982)

Wilhelm, D., Starkovich, V.S., Chapyak, E.J.

LA-9478-MS (1982)

Upper structure dynamics experiment and analyses. (1981)

Wilhelm, D., Starkovich, V.S., Chapyak, E.J.

Godlewski, N.Z. [Hrsg.]

A brief analysis of the transient fluid flow at the entrance of the upper core structure during a hypothetical core expansion. (1981)

Wilhelm, D.

NUREG/CR-2061 (April 81)

Latest results in GCFR safety analyses with the PHAETON 2 computer code. (1979)

Wilhelm, D.

Gas-Cooled Fast Reactor Safety and Associated Design Features, Specialist Meeting, Brussels, Belgium, March 13-15, 1979

PHAETON 2 flow coast-down calculations including natural convection in helium cooled fast reactors. (1979)

Wilhelm, D.

KfK-2822 (Juni 79)

Flow coast-down accidents with natural convection in GCFRs. (1979)

Wilhelm, D.

Fast Reactor Safety Technology. Proc.of the Internat.Meeting. Seattle, Wash., August 19-23, 1979. La Grange Park,Ill.: American Nuclear Soc.1979. Vol.III, S.1666-77

Transient analysis of a 1000MW gas-cooled fast reactor. (1978)

Wilhelm, D.

Nuclear Technology, 39(1978) S.30-40

F+E Arbeiten zur Gasbrueterentwicklung. (1978)

Dalle Donne, M., Dorner, S., Jacobs, G., Meyer, L., Rehme, K., Schumacher, G., ...

KfK-Nachrichten, 10(1978) No 3/4

The PHAETON 2 computer code for analysing accidents in a 1000 MWe helium cooled fast reactor. (1977)

Wilhelm, D.

KFK-2561 (Dezember 77)

Beitrag zur Stoerfallanalyse von gasgekuehlten Schnellen Brutreaktoren mit digitalen Simulationsprogrammen. (1976)

Wilhelm, D.

Dissertation, Univ.Karlsruhe 1976 KFK-2299 (Juni 76)

Entwurfstudien fuer gasgekuehlte Brutreaktoren. (1976)

Wilhelm, D.

In: Projekt Schneller Brueter. 2.Vierteljahresbericht 1976.