D. William Provance

Myosin-Vb functions as a dynamic tether for peripheral endocytic compartments during transferrin trafficking (2008)

Provance, D William, Addison, Erin J, Wood, Patrick R, Chen, David Z, Silan, Colleen M, Mercer, John A

Abstract Background Myosin-Vb has been shown to be involved in the recycling of diverse proteins in multiple cell types. Studies on transferrin trafficking in HeLa cells using a dominant-negative...

Myosin Vb Is Associated with Plasma Membrane Recycling Systems

Lapierre, Lynne A., Kumar, Ravindra, Hales, Chadwick M., Navarre, Jennifer, Bhartur, Sheela G., Burnette, Jason O., ...

Myosin Va is associated with discrete vesicle populations in a number of cell types, but little is known of the function of myosin Vb. Yeast two-hybrid screening of a rabbit parietal cell cDNA...

Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic

Provance, D. William, Gourley, Christopher R., Silan, Colleen M., Cameron, L. C., Shokat, Kevan M., Goldenring, James R., ...

Selective, in situ inhibition of individual unconventional myosins is a powerful approach to determine their specific physiological functions. Here, we report the engineering of a myosin Vb mutant...

A Chemical-Genetic Strategy Implicates Myosin-1c in Adaptation by Hair Cells

Holt, Jeffrey R., Gillespie, Susan K.H., Provance, D. William, Shah, Kavita, Shokat, Kevan M., Corey, David P., ...

Myosin-1c (also known as myosin-Iβ) has been proposed to mediate the slow component of adaptation by hair cells, the sensory cells of the inner ear. To test this hypothesis, we mutated tyrosine-61...

Melanophilin, the Product of the Leaden Locus, is Required for Targeting of Myosin-Va to Melanosomes

Provance, D. William, James, Ted L., Mercer, John A.

The formation of complex subcellular organelles requires the coordinated targeting of multiple components. Melanosome biogenesis in mouse melanocytes is an excellent model system for studying the...

Myosin Vb Is Associated with Plasma Membrane Recycling Systems

Lapierre, Lynne A., Kumar, Ravindra, Hales, Chadwick M., Navarre, Jennifer, Bhartur, Sheela G., Burnette, Jason O., ...

Myosin Va is associated with discrete vesicle populations in a number of cell types, but little is known of the function of myosin Vb. Yeast two-hybrid screening of a rabbit parietal cell cDNA...

Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic

Provance, D. William, Gourley, Christopher R., Silan, Colleen M., Cameron, L. C., Shokat, Kevan M., Goldenring, James R., ...

Selective, in situ inhibition of individual unconventional myosins is a powerful approach to determine their specific physiological functions. Here, we report the engineering of a myosin Vb mutant...