D. Z. D'Argenio

The Triple Combination Indinavir-Zidovudine-Lamivudine Is Highly Synergistic

Snyder, Stuart, D'Argenio, D. Z., Weislow, Owen, Bilello, John A., Drusano, G. L.

Administration of the combination of indinavir-zidovudine-lamivudine has been demonstrated to cause a large fraction of treated patients to have a decline in human immunodeficiency virus type 1...

Use of Drug Effect Interaction Modeling with Monte Carlo Simulation To Examine the Impact of Dosing Interval on the Projected Antiviral Activity of the Combination of Abacavir and Amprenavir

Drusano, G. L., D'Argenio, D. Z., Preston, S. L., Barone, C., Symonds, W., LaFon, S., ...

The delineation of optimal regimens for combinations of agents is a difficult problem, in part because, to address it, one needs to (i) have effect relationships between the pathogen in question and...

Analysis of segmental phosphate absorption in intact rats. A compartmental analysis approach.

Kayne, L H, D'Argenio, D Z, Meyer, J H, Hu, M S, Jamgotchian, N, Lee, D B

Available information supports the dominance of the proximal intestine in inorganic phosphate (Pi) absorption. However, there is no strategy for analyzing segmental Pi absorption from a spontaneously...

The Triple Combination Indinavir-Zidovudine-Lamivudine Is Highly Synergistic

Snyder, Stuart, D'Argenio, D. Z., Weislow, Owen, Bilello, John A., Drusano, G. L.

Administration of the combination of indinavir-zidovudine-lamivudine has been demonstrated to cause a large fraction of treated patients to have a decline in human immunodeficiency virus type 1...

Use of Drug Effect Interaction Modeling with Monte Carlo Simulation To Examine the Impact of Dosing Interval on the Projected Antiviral Activity of the Combination of Abacavir and Amprenavir

Drusano, G. L., D'Argenio, D. Z., Preston, S. L., Barone, C., Symonds, W., LaFon, S., ...

The delineation of optimal regimens for combinations of agents is a difficult problem, in part because, to address it, one needs to (i) have effect relationships between the pathogen in question and...

Analysis of segmental phosphate absorption in intact rats. A compartmental analysis approach.

Kayne, L H, D'Argenio, D Z, Meyer, J H, Hu, M S, Jamgotchian, N, Lee, D B

Available information supports the dominance of the proximal intestine in inorganic phosphate (Pi) absorption. However, there is no strategy for analyzing segmental Pi absorption from a spontaneously...

A Time-Shared Computer Program for Adaptive Control of Lidocaine Therapy Using an Optimal Strategy for Obtaining Serum Concentrations

Jelliffe, R.W., D'Argenio, D.Z., Rodman, J., Schumitzky, A.

A time-shared computer program previously developed by this laboratory has now been improved to permit adaptive (open-loop feedback) control of lidocaine therapy by fitting a 2-compartment linear...