Scientific Commons: D. Zangrilli

Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia (2005)

Ammatuna, E, Zangrilli, D, Lavorgna, S, Divona, M, Buccisano, F, ...

Mutations in the Nucleophosmin (NPM1) gene have been recently described to occur in about one-third of acute myeloid leukemias (AML) and represent the most frequent genetic alteration currently known...

Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.

Alcalay, M, Zangrilli, D, Fagioli, M, Pandolfi, P P, Mencarelli, A, Lo Coco, F, ...

Two chimeric genes, PML-RAR alpha and RAR alpha-PML, are formed as a consequence of the acute promyelocytic leukemia (APL)-specific reciprocal translocation of chromosomes 15 and 17 [t(15;17)]....

Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.

Alcalay, M, Zangrilli, D, Pandolfi, P P, Longo, L, Mencarelli, A, Giacomucci, A, ...

Acute promyelocytic leukemias (APLs) are characterized by a reciprocal balanced translocation that involves chromosomes 15 and 17 [t(15;17)]. We report the isolation and characterization of one of...

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.

Pandolfi, P P, Alcalay, M, Fagioli, M, Zangrilli, D, Mencarelli, A, Diverio, D, ...

The acute promyelocytic leukaemia (APL) 15;17 translocation generates a PML/RAR alpha chimeric gene which is transcribed as a fusion PML/RAR alpha mRNA. Molecular studies on a large series of APLs...